Issue 78, 2022
From the journal:

Chemical Communications

SIWV tetrapeptide and ROS-responsive prodrug conjugate for advanced glioblastoma therapy†

Yoon Kyung Park,‡a   Paramesh Jangili,‡b   Soyu Zi, ORCID logo b   Rae Hyung Kang,*c   Dokyoung Kim ORCID logo *acdef  and  Jong Seung Kim ORCID logo *b  

* Corresponding authors

a Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea
E-mail: dkim@khu.ac.kr

b Department of Chemistry, Korea University, Seoul 02841, Republic of Korea
E-mail: jongskim@korea.ac.kr

c Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, Kyung Hee University, Seoul 02447, Republic of Korea
E-mail: hpohpo2000@khu.ac.kr

d KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul 02447, Republic of Korea

e Department of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea

f Center for Converging Humanities, Kyung Hee University, Seoul 02447, Republic of Korea

Abstract

A new conjugate formulation, SIWV-PB-SN, based on glioblastoma (GBM)-homing SIWV tetrapeptide and an ROS-responsive prodrug is reported. SIWV-PB-SN selectively penetrates the GBM cells and releases anti-GBM drug (SN-38) via ROS-induced linker cleavage. This study presents a new insight for a more advanced therapeutic approach to overcoming GBM.

Graphical abstract: SIWV tetrapeptide and ROS-responsive prodrug conjugate for advanced glioblastoma therapy

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D2CC03777G
Article type
Communication
Submitted
07 Maw 2022
Accepted
01 Ndz 2022
First published
09 Ndz 2022

Chem. Commun., 2022,58, 10941-10944

Permissions

Request permissions

SIWV tetrapeptide and ROS-responsive prodrug conjugate for advanced glioblastoma therapy

Y. K. Park, P. Jangili, S. Zi, R. H. Kang, D. Kim and J. S. Kim, Chem. Commun., 2022, 58, 10941 DOI: 10.1039/D2CC03777G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements