Issue 23, 2021

Point-of-care diagnostics: recent developments in a pandemic age

Abstract

In this review, we provide an overview of developments in point-of-care (POC) diagnostics during the COVID-19 pandemic. We review these advances within the framework of a holistic POC ecosystem, focusing on points of interest – both technological and non-technological – to POC researchers and test developers. Technologically, we review design choices in assay chemistry, microfluidics, and instrumentation towards nucleic acid and protein detection for severe acute respiratory coronavirus 2 (SARS-CoV-2), and away from the lab bench, developments that supported the unprecedented rapid development, scale up, and deployment of POC devices. We describe common features in the POC technologies that obtained Emergency Use Authorization (EUA) for nucleic acid, antigen, and antibody tests, and how these tests fit into four distinct POC use cases. We conclude with implications for future pandemics, infectious disease monitoring, and digital health.

Graphical abstract: Point-of-care diagnostics: recent developments in a pandemic age

Supplementary files

Article information

Article type
Critical Review
Submitted
16 Maw 2021
Accepted
31 Nhl 2021
First published
15 Huk 2021

Lab Chip, 2021,21, 4517-4548

Author version available

Point-of-care diagnostics: recent developments in a pandemic age

H. Harpaldas, S. Arumugam, C. Campillo Rodriguez, B. A. Kumar, V. Shi and S. K. Sia, Lab Chip, 2021, 21, 4517 DOI: 10.1039/D1LC00627D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements