Issue 39, 2021

Multicomponent crystals of an artemisinin derivative and cinchona alkaloids for use as antimalarial drugs

Abstract

Pharmaceutical multicomponent crystals (MCCs) including salts and co-crystals of active pharmaceutical ingredients (APIs), are an active focus of research to improve various physicochemical properties of drugs. In this work, we demonstrate that the pharmaceutical artesunate (AS), a derivative of artemisinin (ART), forms a 1 : 1 salt with two cinchona alkaloids: quinine (QN) and cinchonidine (CND), representing the first report of MCCs combining two major types of antimalarial drugs.

Graphical abstract: Multicomponent crystals of an artemisinin derivative and cinchona alkaloids for use as antimalarial drugs

Supplementary files

Article information

Article type
Communication
Submitted
26 Maw 2021
Accepted
19 Mha 2021
First published
19 Mha 2021

CrystEngComm, 2021,23, 6843-6847

Multicomponent crystals of an artemisinin derivative and cinchona alkaloids for use as antimalarial drugs

Q. Jiang, D. A. Hirsh, Y. Tu and L. Luo, CrystEngComm, 2021, 23, 6843 DOI: 10.1039/D1CE00974E

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