Issue 47, 2020

Aptamer protective groups tolerate different reagents and reactions for regioselective modification of neomycin B

Abstract

The aptameric protective group strategy for the one-step regioselective transformation of aminoglycoside antibiotics was found to be compatible with diverse reagents and reaction conditions. New derivatives of neomycin B were synthesized with regioselectivities of >99%. This result extends the scope of applicability of APGs facilitating access to novel aminoglycoside derivatives.

Graphical abstract: Aptamer protective groups tolerate different reagents and reactions for regioselective modification of neomycin B

Supplementary files

Article information

Article type
Communication
Submitted
18 Nhl 2020
Accepted
13 Huk 2020
First published
16 Huk 2020

Org. Biomol. Chem., 2020,18, 9606-9610

Aptamer protective groups tolerate different reagents and reactions for regioselective modification of neomycin B

A. A. Bastian, A. Gruszka, P. Jung and A. Herrmann, Org. Biomol. Chem., 2020, 18, 9606 DOI: 10.1039/D0OB02104K

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