Issue 18, 2019

Model study on trapping of protein selenenic acids by utilizing a stable synthetic congener

Abstract

A stable primary-alkyl-substituted selenenic acid was developed as a synthetic model of selenocysteine–derived selenenic acid (Sec–SeOH) by taking advantage of a huge cavity-shaped substituent. The primary-alkyl model compound was successfully applied to model studies on the trapping reaction of protein Sec–SeOH generated in the active site of selenoenzymes with several reagents.

Graphical abstract: Model study on trapping of protein selenenic acids by utilizing a stable synthetic congener

Supplementary files

Article information

Article type
Letter
Submitted
28 Yan 2019
Accepted
18 Kul 2019
First published
18 Kul 2019

New J. Chem., 2019,43, 6830-6833

Model study on trapping of protein selenenic acids by utilizing a stable synthetic congener

S. Sase, R. Kimura, R. Masuda and K. Goto, New J. Chem., 2019, 43, 6830 DOI: 10.1039/C9NJ01072F

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