A dual-responsive probe for detecting cellular hypoxia using 19F magnetic resonance and fluorescence

Rahul T. Kadakia; Da Xie; Daniel Martinez; Meng Yu; Emily L. Que

doi:10.1039/C9CC00375D

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A dual-responsive probe for detecting cellular hypoxia using ¹⁹F magnetic resonance and fluorescence†

Rahul T. Kadakia,

^a Da Xie,

^a Daniel Martinez, Jr,

^a Meng Yu

^a and Emily L. Que

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of Texas at Austin, 105 E 24th St. Stop A5300, Austin, TX, USA
E-mail: emilyque@cm.utexas.edu

Abstract

We report the first dual-responsive ¹⁹F MRI and fluorescence imaging probe for cellular hypoxia. The Cu²⁺-based probe exhibits no ¹⁹F MR signal and reduced fluorescence signal due to paramagnetic quenching; however, the probe turns-on in both modes following reduction to Cu⁺. This bimodal agent can differentiate hypoxic and normoxic cells in both modalities.

This article is part of the themed collection: 2019 Emerging Investigators

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Article information

DOI: https://doi.org/10.1039/C9CC00375D
Article type: Communication
Submitted: 15 Sun 2019
Accepted: 13 Kho 2019
First published: 13 Kho 2019

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Chem. Commun., 2019,55, 8860-8863

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A dual-responsive probe for detecting cellular hypoxia using ¹⁹F magnetic resonance and fluorescence

R. T. Kadakia, D. Xie, D. Martinez, M. Yu and E. L. Que, Chem. Commun., 2019, 55, 8860 DOI: 10.1039/C9CC00375D

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