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A highly thermostable peptoid cyclo-octamer can reversibly accommodate and release water molecules from central channels formed by the macrocycles in a crystalline array. We report the first single-crystal-to-single-crystal transformation for a peptidomimetic oligomer.

Graphical abstract: Peptoid nanotubes: an oligomer macrocycle that reversibly sequesters water via single-crystal-to-single-crystal transformations

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