Octafunctionalized polyhedral oligosilsesquioxanes as scaffolds: synthesis of peptidyl silsesquioxanes‡

Abstract

The first use of polyhedral silsesquioxanes to organize ensembles of biologically relevant motifs is described. N-Protected amino acids and peptides can be attached to [H₂N(CH₂)₃]₈Si₈O₁₂ 1 and [p-HOCH₂C₆H₄]₈Si₈O₁₂ 2 in either a convergent fashion or a divergent fashion to produce peptidyl silsesquioxanes in excellent yield and purity.

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