Themed collection ISACS19: Challenges in Organic Chemistry

Stimulated Raman scattering (SRS) microscopy in tandem with bioorthogonal Raman labelling enables intracellular drug concentrations, distribution and therapeutic response to be measured in living cells.

A highly regio- and stereoselective cobalt catalyzed allylic selective dehydrogenative Heck reaction with internal aliphatic olefins was developed. Both internal and terminal aliphatic olefins can be employed, thereby significantly expanding the scope of alkenylation chemistry.

The core structure of the potent antimalarial alkaloid ocimicide A₁ was prepared by a complex stereochemical relay. Computational studies suggest a structural revision of the metabolite is necessary.

A mild palladium-catalyzed ligand-controlled regioselective 1,3-arylfluorination of 2[H]-chromenes has been developed.

In the presence of Au–Pd/TiO₂, various kinds of symmetrically and unsymmetrically substituted diarylamines could effectively be synthesized starting from various combinations of substrates.

The use of a weakly coordinating monodentate directing group for copper-mediated ortho-hydroxylation and amination reactions allows for the identification of an external oxazoline ligand as a promoter.

A rhodium-catalysed stitching reaction between 2-(silylethynyl)arylboronates and 2-(silylethynyl)aryl bromides has been developed for the synthesis of unsymmetric dibenzo[a,e]pentalenes.

The highly enantioselective sulfa-Michael addition of alkyl thiols to unactivated β-substituted-α,β-unsaturated esters catalyzed by a bifunctional iminophosphorane (BIMP) organocatalyst is described.

A multidisciplinary approach, composed of organic synthesis, electrochemistry, electrocatalysis and cellular studies, for correlating the molecular features of a 1,2-naphthoquinone scaffold with its ROS generating ability.

X-ray crystallography reveals that a macrocyclic peptide derived from transthyretin (TTR) assembles to form square channels.

Regioselective ring-opening at a flexible N-acyl aziridine enables conformational control of α₃β cyclic tetrapeptides through torsional strain.

A novel Pd-catalyzed intermolecular dehydrogenative annulation of aryl iodides and aryl carbamic chlorides for the efficient synthesis of phenanthridinone derivatives was developed.

Ir-catalyzed asymmetric allylic dearomatization affords five-membered aza-spiroindolenines, from which enantioenriched Pictet–Spengler-type products are obtained via a highly stereoselective migration.

The first template assisted meta-hydroxylation strategy and its use in the synthesis of resveratrol precursor and QR-activity inducer with detailed experimental and in-silico mechanistic understanding.

Asymmetric addition of unactivated α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid catalyst, generates an all-carbon quaternary stereocenter with broad substrate scope and high enantioselectivity.

This study describes the rational design of a DNA-based chloride reporter.

A rhodium-catalyzed regio- and enantioselective synthesis of silicon-stereogenic silicon-bridged arylpyridinones was developed. A reasonable catalytic cycle was also experimentally established.

The rhodium-catalyzed oxidative amidation of allylic alcohols and aldehydes is reported.

A new method for the alkynylation of aryldiazonium salts with TMS-alkynes via dual gold and photoredox catalysis is described.