Metallomics: Emerging Investigators 2019
Welcome to this Metallomics themed issue highlighting the work of emerging investigators in metallomics, Guest Edited by Metallomics Editorial Board member Katherine Franz (Duke University, USA).
Perspective
Across the spectrum: integrating multidimensional metal analytics for in situ metallomic imaging
Taking a systems analytical approach to systems biology questions requires a network of multidimensional analytical tools to illuminate the many different functional and structural aspects of metals in biology.
Zinc finger domains as therapeutic targets for metal-based compounds – an update
The design of novel metal-based compounds and the elucidation of the mechanisms of zinc substitution have renewed the possibilities of selective zinc-finger inhibition.
Metal-dependent hormone function: the emerging interdisciplinary field of metalloendocrinology
Advances in understanding of hormones and metal micronutrients show critical interactions between the two in a newly-termed field of metalloendocrinology.
Handling of nutrient copper in the bacterial envelope
The insertion of copper into bacterial cuproenzymes in vivo does not always require a copper-binding metallochaperone – why?
Cu and Zn interactions with Aβ peptides: consequence of coordination on aggregation and formation of neurotoxic soluble Aβ oligomers
The coordination chemistry of transition metal ions (Fe, Cu, Zn) with the amyloid-β (Aβ) peptides has attracted a lot of attention in recent years due to its repercussions in Alzheimer's disease (AD).
Genetic, structural, and functional diversity of low and high-affinity siderophores in strains of nitrogen fixing Azotobacter chroococcum
Conserved patterns of siderophore production by Azotobacters related to siderophore gene evolution and Fe bioavailability.
Paper
Copper stress in Staphylococcus aureus leads to adaptive changes in central carbon metabolism
Pathogenic Staphylococcus aureus respond to copper stress by altering central carbon metabolism in response to a specific inhibition of the glycolytic enzyme, glyceraldehyde-3-phosphate dehydrogenase.
Cytoprotective effects of imidazole-based [S1] and [S2]-donor ligands against mercury toxicity: a bioinorganic approach
[S2]-Donor ligands L2 and L3 showed remarkable ability to protect liver cell against HgCl2 induced toxicity and the strength of their efficacy is in the order of L3 > L2 > L1. Interestingly, 60% decrease of ROS production was observed in liver cells co-treated with HgCl2 and L3 in comparison to the cells treated with HgCl2 only.
Siderophore profiling of co-habitating soil bacteria by ultra-high resolution mass spectrometry
Calcareous soil microbes complete for scarce iron by synthesizing diverse suites of siderophores detectable by ultra-high resolution mass spectrometry.
Characterization of the metal status of natively purified alpha-synuclein from human blood, brain tissue, or recombinant sources using size exclusion ICP-MS reveals no significant binding of Cu, Fe or Zn
The binding of Cu, Fe or Zn to alpha-synuclein has been implicated in neurodegenerative disease, such as Parkinson's.
Inhibition of arsenite methylation induces synergistic genotoxicity of arsenite and benzo(a)pyrene diol epoxide in SCC-7 cells
A comprehensive analytical method was developed to investigate the synergistic genotoxicity of BPDE and As(III) in SCC-7 cells.
Paper
Elemental characterisation of the pyramidal neuron layer within the rat and mouse hippocampus
X-ray fluorescence microscopy reveals unique elemental signatures within sub-populations of hippocampal pyramidal neurons.
Anatomical redistribution of endogenous copper in embryonic mice overexpressing SOD1
Detailed quantitative in situ imaging of embryonic mice reveals overt Cu redistribution associated with SOD1-overexpression.
Organelle-specific analysis of labile Fe(II) during ferroptosis by using a cocktail of various colour organelle-targeted fluorescent probes
Fluorescence imaging analysis of labile Fe(II) during ferroptosis.
Paper
Time-dependent shotgun proteomics revealed distinct effects of an organoruthenium prodrug and its activation product on colon carcinoma cells
The target spectrum and cellular effects of a metallo-prodrug can be separated from its activated species by time-dependent shotgun proteomics.
About this collection
This collection of invited papers highlights the excellent work being carried out by leading scientists at an early stage of their career, typically within approximately 10 years of completing their PhD. The collection is Guest Edited by Metallomics Editorial Board member Katherine Franz (Duke University, USA).