Perspective
The workings of ferritin: a crossroad of opinions
Widely divergent views emerge on the central steps in the uptake, catalytic oxidation, and transfer of iron ions by ferritin.
Minireview
Iron homeostasis in plants – a brief overview
Iron plays a crucial role in biochemistry and is an essential micronutrient for plants and humans alike. Recent progress in the field has led to a better understanding of iron homeostasis in plants, and aided the production of high iron crops for improved human nutrition.
Methanobactins: from genome to function
Recent advances in the biosynthesis, regulation, and transport of methanobactin, a ribosomally produced, post-translationally modified copper-binding natural product.
Application of imaging mass spectrometry approaches to facilitate metal-based anticancer drug research
Mass spectrometry imaging is being increasingly used in metal-based anticancer drug development to study elemental and/or molecular drug distributions in different biological systems.
Selenium in the prevention of atherosclerosis and its underlying mechanisms
Selenium and selenoproteins may prevent atherosclerosis by blocking many key events in the development of atherosclerosis.
Tight binding of heme to Staphylococcus aureus IsdG and IsdI precludes design of a competitive inhibitor
A new fluorescence-based assay reveals that the affinities of Staphylococcus aureus IsdG and IsdI for heme are 2–3 orders of magnitude greater than previously realized.
Paper
Phosphorylation of zinc channel ZIP7 drives MAPK, PI3K and mTOR growth and proliferation signalling
Many important carcinogenesis-related signalling pathways are activated downstream of zinc channel ZIP7-mediated zinc store release.
Paper
Comparative studies of oxaliplatin-based platinum(IV) complexes in different in vitro and in vivo tumor models
New perspectives for the development of platinum(IV) prodrugs of the anticancer agent oxaliplatin, combining bioreductive properties and immunogenic aspects, are shown.
Paper
Defining the human copper proteome and analysis of its expression variation in cancers
Differential gene expression analysis of TCGA RNAseq data for the human copper proteome unravels its potential involvement in various types of cancers.
Chemical and functional properties of metal chelators that mobilize copper to elicit fungal killing of Cryptococcus neoformans
Select metal-binding agents form strong, lipophilic complexes with copper(II) that alter the cellular metal status of the opportunistic fungal pathogen Cryptococcus neoformans and demonstrate copper-dependent antifungal activity.
About this collection
This themed collection features the top 10 most downloaded articles published in Metallomics in 2017. Congratulations to all of the authors whose articles have been featured.