Themed collection 2022 CRSI Medal Winners Collection

14 items
Highlight

Recent advances in transition metal-mediated trifluoromethylation reactions

This review provides a complete demonstration of amalgamating significant pieces of work in the metal-mediated trifluoromethylation genre of recent past years.

Graphical abstract: Recent advances in transition metal-mediated trifluoromethylation reactions
From the themed collection: 2022 CRSI Medal Winners Collection
Feature Article

Beyond darunavir: recent development of next generation HIV-1 protease inhibitors to combat drug resistance

We describe design and syntheses of a new generation of exceptionally highly potent non-peptidic HIV-1 protease inhibitors.

Graphical abstract: Beyond darunavir: recent development of next generation HIV-1 protease inhibitors to combat drug resistance
From the themed collection: 2022 CRSI Medal Winners Collection
Communication

Unraveling the origin of the cooperative adsorption of carbon monoxide in an Fe(II) metal–organic framework

Using periodic DFT calculations, we unveil the mechanism of cooperative CO adsorption in an Fe(II) bistriazolate MOF, where both structural distortion and electronic effects are found to play an active role.

Graphical abstract: Unraveling the origin of the cooperative adsorption of carbon monoxide in an Fe(ii) metal–organic framework
From the themed collection: 2022 CRSI Medal Winners Collection
Communication

Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex

A new class of 5′-morpholino modified nucleoside building blocks was synthesized. Among them, Mo2 exhibited better off-target mitigation for RNAi compared to other analogues Pip and Mo3 and the previously reported morpholino derivative Mo1.

Graphical abstract: Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex
From the themed collection: 2022 CRSI Medal Winners Collection
Communication

Palladium-catalyzed remote meta-C–H olefination of cinnamates

Palladium-catalyzed novel remote meta-C–H olefination of geometrically challenging cinnamates using nitrile directing group derived from 2-cyanobenzoic acid has been described. A variety of bioactive molecules tethered acrylates have been coupled.

Graphical abstract: Palladium-catalyzed remote meta-C–H olefination of cinnamates
From the themed collection: 2022 CRSI Medal Winners Collection
Communication

Palladium-catalyzed intramolecular oxypalladation-initiated cascade: solvent-dependent chemodivergent approach to functionalized benzazepines and tetrahydroquinolines

A palladium-catalyzed, solvent-dependent, intramolecular oxypalladation-initiated chemodivergent approach was established for the synthesis of functionalized benzazepines and tetrahydroquinolines.

Graphical abstract: Palladium-catalyzed intramolecular oxypalladation-initiated cascade: solvent-dependent chemodivergent approach to functionalized benzazepines and tetrahydroquinolines
From the themed collection: 2022 CRSI Medal Winners Collection
Communication

Visualization of domain structure and piezoelectric energy harvesting in a ferroelectric metal–ligand cage

A metal–organic cage exhibits ferro- and piezoelectric properties as visualized by its domain structure using PFM and utility in piezoelectric energy harvesting properties. This is a rare observation in supramolecular metal–organic cages.

Graphical abstract: Visualization of domain structure and piezoelectric energy harvesting in a ferroelectric metal–ligand cage
From the themed collection: 2022 CRSI Medal Winners Collection
Communication

Comparing the reactivity of an oxoiron(IV) cation radical and its oxoiron(V) tautomer towards C–H bonds

An oxoiron(IV) cation radical is generated upon two-electron oxidation of an iron(III) complex bearing an electron-rich methoxy substituted bTAML framework and characterized via multiple spectroscopic techniques and density functional theory (DFT).

Graphical abstract: Comparing the reactivity of an oxoiron(iv) cation radical and its oxoiron(v) tautomer towards C–H bonds
From the themed collection: 2022 CRSI Medal Winners Collection
Communication

Temperature driven charge transfer process in quantum confined two-dimensional Mn-doped CsPbBr3 perovskite nanoplatelets

Understanding of the energy/charge transfer processes in Mn–CsPbBr3 NPLs is achieved using temperature-dependent femtosecond TA spectroscopy. Charge transfer process which is efficient at 300 K is seen to be inhibited at 5 K.

Graphical abstract: Temperature driven charge transfer process in quantum confined two-dimensional Mn-doped CsPbBr3 perovskite nanoplatelets
From the themed collection: Chemical Communications HOT Articles 2022
Communication

Pd(II)-catalyzed annulation of terminal alkynes with 2-pyridinyl-substituted p-quinone methides: direct access to indolizines

A Pd-catalysed 100% atom-economical method has been developed for the synthesis of 1,3-disubstituted indolizine derivatives in good yields through a regiospecific formal [3 + 2]-annulation from 2-pyridinyl-substituted p-quinone methides and terminal alkynes.

Graphical abstract: Pd(ii)-catalyzed annulation of terminal alkynes with 2-pyridinyl-substituted p-quinone methides: direct access to indolizines
From the themed collection: 2022 CRSI Medal Winners Collection
Communication

Residue-specific N-terminal glycine to aldehyde transformation renders analytically pure single-site labeled proteins

Here, we demonstrate the residue-specific transformation of N-Gly into N-Gly-glyoxamide. The aldehyde introduction opens the residue-specific synthetic flexibility for the N-Gly proteome.

Graphical abstract: Residue-specific N-terminal glycine to aldehyde transformation renders analytically pure single-site labeled proteins
From the themed collection: 2022 CRSI Medal Winners Collection
Communication

A cascade reaction of indolyl-migratory isocyanide insertion, scaffold rearrangement and redox-neutral event with isocyanide as a C(sp3)H–N synthon efficiently constructs indolylisoindolinones

Herein, we report a Pd(0)-catalyzed cascade reaction with multifunction of isocyanide as a nucleophile promoter for rearrangement and a hydride source.

Graphical abstract: A cascade reaction of indolyl-migratory isocyanide insertion, scaffold rearrangement and redox-neutral event with isocyanide as a C(sp3)H–N synthon efficiently constructs indolylisoindolinones
From the themed collection: 2022 CRSI Medal Winners Collection
Communication

Configurational ligand isomerism in conjoined-cages

Isomeric coordination complexes of different configurations (hour-glass and double-decker) but prepared from regioisomeric tridentate ligands are described.

Graphical abstract: Configurational ligand isomerism in conjoined-cages
From the themed collection: #RSCPoster Conference
Communication

Transition-metal-free regioselective hydroamination of styrenes with amino-heteroarenes

The base-mediated anti-Markovnikov hydroamination of functionally varied styrenes with amino-substituted pyridine, quinoline, pyrimidine, pyrazine, and phenanthridine with excellent regioselectivity has been described.

Graphical abstract: Transition-metal-free regioselective hydroamination of styrenes with amino-heteroarenes
From the themed collection: 2022 CRSI Medal Winners Collection
14 items

About this collection

This special collection showcases research carried out by some of the 2022 Chemical Research Society of India (CRSI) medal winners. These medals seek to recognise Indian researchers who have contributed significantly at various levels in Chemistry. Please join us in celebrating their success!

Spotlight

Advertisements