Wei Zhang, Xinwei Lu and Jicun Ren
Analyst, 2025,150, 2029-2038
Abstract
Drug-mediated protein–protein interaction and drug–protein interaction form the basis of drug development and pharmacological research.
Michael Salcius, Antonin Tutter, Marianne Fouché, Halil Koc, Dan King, Anxhela Dhembi, Andrei Golosov, Wolfgang Jahnke, Chrystèle Henry, Dayana Argoti, Weiping Jia, Liliana Pedro, Lauren Connor, Philippe Piechon, Francesca Fabbiani, Regis Denay, Emine Sager, Juergen Kuehnoel, Marie-Anne Lozach, Fabio Lima, Angela Vitrey, Shu-Yu Chen, Gregory Michaud and Hans-Joerg Roth
RSC Chem. Biol., 2025,6, 788-799
Abstract
Protein array screening revealed a macrocyclic glue that recruits MAPRE1 to FKBP12. The corresponding ternary complex was characterized and the compound-dependent inhibition of a native MAPRE1 interaction was demonstrated in a cellular assay.
Shoko Shinya, Ritsuko Katahira, Kyoko Furuita, Toshihiko Sugiki, Young-Ho Lee, Yoshikazu Hattori, Kohei Takeshita, Atsushi Nakagawa, Aoi Kokago, Ken-ichi Akagi, Muneki Oouchi, Fumiaki Hayashi, Takanori Kigawa, Midori Takimoto-Kamimura, Toshimichi Fujiwara and Chojiro Kojima
RSC Med. Chem., 2022,13, 1100-1111
From themed collection:
Fragment-based drug discovery
Abstract
19F-NMR analysis using the optimized 19F chemical library enables the modeling of the structure of the weakly bound protein–compound complex, overcoming the difficulty in fragment-based drug discovery.
Jason Yun, Yimeng Huang, Austin D. C. Miller, Brandon L. Chang, Logan Baldini, Kaamini M. Dhanabalan, Eugene Li, Honghao Li and Arnab Mukherjee
Chem. Sci., 2024,15, 11108-11121
Abstract
Biochemically destabilized aquaporin allows for small-molecule modulation of genetically encoded MRI signals, enabling the detection of transcriptional activity in deep tissues in a background-free, drug-gated, and chemically multiplexed manner.
Huan Rui, Kate S. Ashton, Jaeki Min, Connie Wang and Patrick Ryan Potts
RSC Chem. Biol., 2023,4, 192-215
From themed collection:
Molecular Glues
Abstract
This review surveys molecular glue-induced ternary complexes in the PDB and provides an overview of computational methods that can be utilized to predict them.