The search for new anticancer agents targeting apoptotic and autophagic pathways is crucial due to their roles in cellular homeostasis and cancer cell elimination.
Simple, efficient, and robust method established in this study will contribute to clarify how tungsten (W) isotopes behave in the Earth system relative to molybdenum (Mo) isotopes.
Pyrrol-2-yl-phenyl allylidene hydrazine carboximidamide derivatives as AChE/BACE 1 dual inhibitors.
Compound 1z, a thermostable silicon-containing aryl/penta-1,4-dien-3-one/amine hybrid kills breast cancer cells by targeting the HSP90 C-terminus without inducing heat-shock response.
A formal [3 + 2] annulation reaction of crotonate-derived sulfur ylides and β-ketothioamides (KTAs) was successfully developed to produce good-to-excellent yields of thiazoline and spiro[indoline-3,3′-thiophene] scaffolds.