A new two-step, one-pot synthesis of benzo[f][1,2]thiazepine 1,1-dioxides was developed based on a visible-light mediated aza Paternò–Büchi reaction and a Lewis acid catalyzed ring-expansion of azetidine.
We report an unexpected route for synthesizing pyrrole-fused dibenzoxazepines/thiazepines with high chemoselectivity via a pseudo-Joullié–Ugi reaction from cyclic imines with isocyanides and acetylenedicarboxylates under catalyst-free conditions.
Highly efficient asymmetric hydrogenation of dibenzo-fused azepines derivatives with chiral cationic Ru diamine catalysts has been developed, giving diverse chiral seven-membered N-heterocycles with excellent results (up to 99% yield and 99% ee).
Reaction scheme of (Z)-2-benzylidene-3-oxobutanamide derivatives against resistant pathogens.
The in vitro, in vivo, antioxidant, molecular docking, and physiochemical studies supported the potential development of β-lactam B9 as an orally active antidiabetic drug due to its significant α-glucosidase inhibitory activity.