Developments in the synthesis of indolizines during the last decade are reviewed, with special emphasis given to strategies relying on pyrrole derivatives and on π-expanded systems.
4-(Trimethylsilyl)-3-butyn-2-one is an effective dipolarophile in the [3+2] cycloaddition reaction with cycloimmonium salts to obtain bioactive non-silicon adducts, namely 1-acetylindolizines, but also trimethylsilyl-containing adducts.
This review summarizes recent advances in electrochemical and photocatalytic C–H functionalization of indolizines, with an emphasis on the construction of C–C and C–X (X = S, Se, N, Cl, Br, etc.) bonds.
This study introduces enantioselective indolizine alkylation with aminals via chiral phosphoric acid catalysis, featuring scalable, functional group-tolerant processes, enabling access to diverse C1/C3-alkylated indolizines.
A sustainable electrochemical approach for site-selective C–H mono and bis-chalcogenation (sulfenylation or selenylation) of indolizine frameworks is described.