Engineering perfusion to meet tumor biology: are vascularized tumor-on-a-chip models ready to drive therapy innovation?

Ines Poljak, Ciro Chiappini and Giulia Adriani

Lab Chip, 2026, 26, 1162
DOI: 10.1039/D5LC01060H

Dual-channel six-step linear concentration gradient microfluidic chip for orthogonal combination drug screening in head and neck tumor cells

Jingru Liao, Zhimi Zhang, Guiquan Zhu, Dan Liu, Zhihao Tu, Wangang Zhu, Tao Dong, Ling Li and Zhuqing Wang

Lab Chip, 2025, 25, 6490
DOI: 10.1039/D5LC00572H

Organ-Specific Migration License (OSML) theory: a novel paradigm for spatiotemporal regulation and intervention of cross-organ immune cell migration in tumor immune responses

Jiaming Cui, Jingru Han, Yang Dai, Shengqiang Li, Xinyu Wang, Ting Ge, Guixin He, Juyue Zhou, Li Yang, Yuanyuan Tian, Yingying Xie, Lefan Liu, Jinghui Du, Wentao Li and Jianchun Yu

Cell Commun Signal, 2026
DOI: 10.1186/s12964-026-02846-8

Hydrogels incorporated with graphene-based nanomaterials for cancer therapy: A review

Bruna L. Melo, Manuel R. Pouso, João Rolo-da-Cunha, Pedro Infante-Marques, Carolina Dias-Urbano, Gonçalo Fernandes-da-Silva, Ilídio J. Correia and Duarte de Melo-Diogo

Applied Materials Today, 2026, 50, 103215
DOI: 10.1016/j.apmt.2026.103215

Harnessing Cancer Stem Cells and 3D Organoids in Unravelling Spatial and Cellular Heterogeneity in Cancer

Eunsong Kwak, Haneul Kim and Eunhye Kim

IJMS, 2026, 27, 3790
DOI: 10.3390/ijms27093790

RESEARCH CHALLENGES IN STAGE III AND IV RAS-ASSOCIATED CANCERS: A Narrative Review of the Complexities and Functions of the Family of RAS Genes and Ras Proteins in Housekeeping and Tumorigenesis

Richard A. McDonald, Armando Varela-Ramirez and Amanda K. Ashley

Biology, 2025, 14, 936
DOI: 10.3390/biology14080936

Advances in 3D Organoids and Organ‐on‐a‐Chip Systems for Biomedical Research

Vignesh Sakthivel, Santhanam Sanjai Dharshan, S. Karthick Raja Namasivayam and Jesu Arockiaraj

J Biomedical Materials Res, 2026, 114
DOI: 10.1002/jbma.70028

Phytochemical nanoencapsulation and microfluidics drive gene and tumor microenvironment modulation

Ana Belen Peñaherrera-Pazmiño, Mishell Criollo and Rebeca Gonzalez-Pastor

Front. Pharmacol., 2025, 16
DOI: 10.3389/fphar.2025.1694752

Choice of Animal Models to Investigate Cell Migration and Invasion in Glioblastoma

Piyanka Hettiarachchi and Taeju Park

Cancers, 2025, 17, 2776
DOI: 10.3390/cancers17172776

Advances in engineering immune–tumor microenvironments on-a-chip: integrative microfluidic platforms for immunotherapy and drug discovery

Farnaz Dabbagh Moghaddam, Ali Anvar, Ehsan Ilkhani, Delara Dadgar, Maedeh Rafiee, Najmeh Ranjbaran, Pejman Mortazavi, Seyed Majid Ghoreishian, Yun Suk Huh and Pooyan Makvandi

Mol Cancer, 2025, 24
DOI: 10.1186/s12943-025-02479-4

Integrating New Approach Methodologies (NAMs) into Preclinical Regulatory Evaluation of Oncology Drugs

Maryam Sadat Mirlohi, Tooba Yousefi, Amir Reza Aref and Amir Seyfoori

Biomimetics, 2025, 10, 796
DOI: 10.3390/biomimetics10120796

Tumor organoids in translational cancer research: Models for personalized therapy

Himanshu Agrawal, Himanshu Tanwar and Nikhil Gupta

World J Transl Med, 2026, 12
DOI: 10.5528/wjtm.v12.i1.113050

An Integrated Microfluidic Platform Possessing Uniform Tumor Spheroids for Evaluating Radio-Therapeutic Nanomaterials

Chunyu Huang, Shukun Zhao, Zhuhao Wu, Qian Zhu, Keying Zhou, Miaomiao Wang, Rui Li, Bo Cai, Danyi Zou, Wei Liu and Xingzhong Zhao

J. Anal. Test., 2026
DOI: 10.1007/s41664-026-00423-z

Overcoming intratumoral transport barriers: Advances in local immunotherapy delivery platforms

Madison A. Deeson, Corrine Ying Xuan Chua and Alessandro Grattoni

Advanced Drug Delivery Reviews, 2026, 235, 115888
DOI: 10.1016/j.addr.2026.115888

Cancer: From a Genetic Disorder to a Systemic Disease

Ada Hang‐Heng Wong and Yuming Hu

Advanced Science, 2025, 12
DOI: 10.1002/advs.202518885

Cancer and Aging Biomarkers: Classification, Early Detection Technologies and Emerging Research Trends

Mi-Ran Ki, Dong Hyun Kim, Mohamed A. A. Abdelhamid and Seung Pil Pack

Biosensors, 2025, 15, 737
DOI: 10.3390/bios15110737

Organ-on-a-chip in oral medicine: Emerging approaches and applications

Fushuang Liu, Tianyi Wang, Yang Song and Yongwen Guo

Dental Materials, 2026, 42, 863
DOI: 10.1016/j.dental.2026.01.009

Tumor-on-chip’s alliance with molecular pathology against metastatic disease

Emma Di Carlo

J Biomed Sci, 2026, 33
DOI: 10.1186/s12929-025-01209-8

High-Throughput 3D Bioprinted Organoids of Skin Cancer Utilized for Diagnosis and Personalized Therapy

Arvind Kumar Shukla, Sandhya Shukla, Sonali Pradeep Suryawanshi, Adarsha Mahendra Upadhyay, Navin Ray, Govindhan Thiruppathi, Sayan Deb Dutta and Raj Kumar Mongre

Current Oncology, 2025, 32, 653
DOI: 10.3390/curroncol32120653

When microfluidics meets pharmaceutical analysis

Yongjian Ai, Lili Li, Ruoxiao Xie, Pengjie Wang, Huiyuan Guo, Fazheng Ren, Meng-Qi He and Qionglin Liang

TrAC Trends in Analytical Chemistry, 2026, 194, 118518
DOI: 10.1016/j.trac.2025.118518

Nasal carriage of staphylococcus aureus in rural China: Molecular epidemiology and antimicrobial susceptibility

Lu Liu, Shuang Wang, Yanru Chen, Xinyu Xian, Xiaolin Yu, Yan Li, Yuzhen Chen, Gaoxiang Sun, Lixiao Cheng, Ti Liu and Zengqiang Kou

Journal of Global Antimicrobial Resistance, 2025, 45, 41
DOI: 10.1016/j.jgar.2025.08.004

Molecular Oncodiagnostics in Precision Oncology: Integrating Tumor Transcriptomics, Patient Pharmacogenetics, and Ex Vivo Chemoresistance Testing to Improve Individual Chemotherapy Response

Dario Rusciano

JPM, 2026, 16, 176
DOI: 10.3390/jpm16040176