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Kamil Świątek, Greta Utecht-Jarzyńska and Marcin Jasiński

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Denitrogenative dismantling of heteroaromatics by nucleophilic substitution reactions with diazomethyl compounds

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Chem. Sci., 2024, 15, 11065
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Regioselective [3 + 2] cycloaddition of di/trifluoromethylated hydrazonoyl chlorides with fluorinated nitroalkenes: a facile access to 3-di/trifluoroalkyl-5-fluoropyrazoles

Nan Zhang, Hai Ma, Chi Wai Cheung, Fa-Guang Zhang, Marcin Jasiński, Jun-An Ma and Jing Nie

Org. Biomol. Chem., 2023, 21, 5040
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Dithiane-initiated cascade to eight-membered sulfur-containing pyrazoles via decarboxylative aromatization

Zhuzhu Zhang, Rui-Peng Li, Xiaomeng Gong, Weiwei Zhang and Shouchu Tang

Chem. Commun., 2025, 61, 12401
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CsF-mediated reaction of diazo compounds with 3-nitroindoles: access to cyano- and phosphonylpyrazolo[4,3-b]indoles

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Applications of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in heterocyclic ring formations

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Org. Biomol. Chem., 2025, 23, 9285
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Innovative approaches to the synthesis of five-membered heteroaromatics with emerging synthetic methodologies

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A base-dependent reactivity switch in Baylis–Hillman ketones: access to N’-alkyl benzohydrazides and fluorescent dihydropyrazoles

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Org. Biomol. Chem., 2025, 23, 5863
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Novel pyrazole and imidazolone compounds: synthesis, X-ray crystal structure with theoretical investigation of new pyrazole and imidazolone compounds anticipated insecticide’s activities against targeting Plodia interpunctella and nilaparvata lugens

Mona A. Shalaby, Mohammad H. BinSabt, Sameh A. Rizk and Asmaa M. Fahim

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The [3+2] annulation of in situ formed trifluorodiazoethane with 4-nitroisoxazoles: access to trifluoromethylpyrazolo[3,4-d]isoxazoles

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Chem. Commun., 2024, 60, 12425
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Ir(iii)/Ag(i)-catalyzed directly C–H amidation of arenes with OH-free hydroxyamides as amidating agents

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Nucleophilic addition of sulfoxonium ylides to hypervalent iodine diazo compounds as N-terminal electrophiles: direct access to novel functionalized hydrazones

Varun Anand, Ruchir Kant and Namrata Rastogi

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Recent advances in the synthesis of anticancer pyrazole derivatives using microwave, ultrasound, and mechanochemical techniques

Diana Becerra and Juan-Carlos Castillo

RSC Adv., 2025, 15, 7018
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Harnessing the power of α-diazo compounds: emerging strategies and expanding applications

Mumtaz Ahmad, Anuj Kumar, Shakir Ahamad and Kishor Mohanan

Chem. Commun., 2025, 61, 14823
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[4+1] cyclization of α-diazo esters and mesoionic N-heterocyclic olefins

Qiuming Liang, Yimin Zeng, Pedro A. Mendez Ocampo, Hui Zhu, Zheng-Wang Qu, Stefan Grimme and Datong Song

Chem. Commun., 2023, 59, 4770
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Rh(iii)-catalysed C–H annulation of cis-stilbene acids with 2-diazo-1,3-diketones: facile access to 6,7-dihydrobenzofuran-4(5H)-one and α-pyrone scaffolds

Mary Sravani Galla, Nandini B. Kale, Akshay Kumawat, Darshana Bora and Nagula Shankaraiah

Org. Biomol. Chem., 2024, 22, 3933
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Synthesis of pyrazoles from sulfonyl hydrazone and benzyl acrylate under transition-metal-free conditions

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Org. Biomol. Chem., 2023, 21, 7611
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Bridging terpenyl aldehydes and terpenes with hydrazine

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Elucidating the mechanism, origin of regioselectivity and substrate scope of the synthesis of structurally diverse 1,2,4-triazoles via a rare type of diazo compound reactivity

Roman Kuznetsov, Grigory Kantin, Alexander Sapegin, Mikhail Novikov and Dmitry Dar'in

Org. Biomol. Chem., 2026, 24, 169
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Pyrazole Ligands in Supramolecular Chemistry: Self-Assembly and Their Applications─A Comprehensive Review

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ACS Omega, 2025, 10, 52097
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Reagent- and solvent-controlled product divergence in the reaction of trifluorodiazoethane with arylidene-1,3-indanediones

Mumtaz Ahmad, Lubina Fatma, Ruchir Kant and Kishor Mohanan

Journal of Fluorine Chemistry, 2024, 274, 110256
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Synthesis and Characterization of New Bases Derived from Nitrophenylpyrazoles, Coordination to Palladium and Antifungal Activity and Catalytic Activity in Mizoroki–Heck Reactions

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Polycyclic Pyrazolidines by Tandem Diazomalonate Dipolar Cycloadditions and CpRu‐Catalyzed Carbene Additions

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Chemistry A European J, 2024, 30
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Synthesis of a Novel Pyrazolone-Based N-Heterocyclic Compound via Diazocoupling and In Situ Nitrogen Insertion

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Conjugated diazochalcone-phosphazene hybrids: Design, synthesis, and substituent effects on optical and electrical properties

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Journal of Molecular Structure, 2026, 1352, 144564
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Current progress in synthetic and medicinal chemistry of pyrazole hybrids as potent anticancer agents with SAR studies

Bhupender Nehra, Manoj Kumar, Viney Chawla and Pooja A. Chawla

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One-Pot (3 + 2) Cycloaddition–Isomerization–Oxidation of 2,2,2-Trifluorodiazoethane and Styryl Derivatives

Julia Altarejos, Estíbaliz Merino, David Sucunza, Juan J. Vaquero and Javier Carreras

J. Org. Chem., 2023, 88, 11258
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Photoinduced [3+2] Cycloaddition of Alkyl–Acceptor Diazoalkanes: Diversity-Oriented Synthesis of Pyrazolines Containing a Quaternary Center

Fengya He, Ziyi Sun, Yiwei Xu, Jingwen Yu, Wenyong Li, Hui Miao and Chenggui Wu

Org. Lett., 2024, 26, 4031
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Recent highlights in the synthesis and biological significance of pyrazole derivatives

Ziad Moussa, Mani Ramanathan, Shaikha Mohammad Alharmoozi, Shahad Ali Saeed Alkaabi, Salamah Hamdan Mohammed Al Aryani, Saleh A. Ahmed and Harbi Tomah Al-Masri

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Sustainable one-pot synthesis, digital ADMET modelling, DFT analysis, molecular docking and biological screening of dibutyl((5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)(aryl)methyl) phosphonates

Sumithra Poreddy, Mohan Gundluru, Surendra Pothuraju, Poojitha Bellala, Jyothibabu Sajila Arya and Suresh Reddy Cirandur

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Solvent‐Directed Regioselective Cascade Reaction with Diazo Compounds

Menghua Dong, Chunan Wang, Lewan Li, Yufan Chen, Jie Zeng, Jian Lv, Jie Liao, Haifeng Wang, Shuangxi Gu and Fener Chen

Eur J Org Chem, 2025, 28
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Switchable and Selective Synthesis of Unsymmetrical N-Aryl Pyrazoles from 1,2,3-Thiadiazine S-Oxides

Alexander Fanourakis, Yaning Liu, Poulami Mukherjee, Amira Garipov, Christopher A. Reiher, Christopher B. Kelly, Sarah E. Reynolds, Paul J. Saucedo, Osvaldo Gutierrez and Mark D. Levin

J. Am. Chem. Soc., 2026, 148, 10002
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Electron Donor–Acceptor Complex Enabled Radical Cyclization of α-Diazodifluoroethyl Sulfonium Salt with Unactivated Alkynes

Ming-Yue He, Xiaodong Tang, Hao-Yan Wu, Jing Nie, Jun-An Ma and Fa-Guang Zhang

Org. Lett., 2023, 25, 9041
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Urea-ZnCl₂ deep eutectic solvent-promoted metal-free synthesis of potent antimicrobial fused 2,5-substituted cyanoanilines with tunable photophysical and electrochemical properties

Neeli Satyanarayana, Kapilavayi V Basava Ranjitha, Qing Zhu, Xia Liu, Gottumukkala Devi Sree, Sampath Karingula, Gottumukkala Devi Priya and Boggu Jagan Mohan Reddy

Journal of Molecular Structure, 2026, 1349, 143743
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Monoacetylated bishydroperoxide-derived singlet molecular oxygen-mediated oxidative coupling of primary and secondary alcohols with phenylhydrazine: Synthesis of 1,3,5-trisubstituted pyrazoles

Z Najminejad, D Azarifar and S-M Khatami

J Chem Sci, 2025, 137
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One‐pot Synthesis and Antitubercular Activity of Imidazo[2,1‐b]thiazol‐1H‐pyrazolylphosphonates

Nagaraju Chirra, Varshitha Shanigarapu, Balasubramanian Sridhar and Srinivas Kantevari

Asian J Org Chem, 2025, 14
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Molecular docking and in-silico screening of novel pyrazoline hybrids as potential bioactive agents

Malathi Balasubramaniyan, Vimalraj Vinayagam, K. Pandiarajan and Moni Philip Jacob Kizhakedathil

Journal of Molecular Structure, 2026, 1353, 144711
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Synthesis and antifungal evaluation of novel triazole derivatives bearing a pyrazole-methoxyl moiety

Yumeng Hao, Ruina Wang, Tingjunhong Ni, Brian C. Monk, Joel D.A. Tyndall, Junhe Bao, Mengyuan Wang, Xiaochen Chi, Shichong Yu, Yongsheng Jin, Dazhi Zhang, Lan Yan and Fei Xie

European Journal of Medicinal Chemistry, 2024, 275, 116637
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Iodine‐Mediated One‐Pot Synthesis of 1,4,5‐Substituted Pyrazoles from MBH Acetates via Allyl Hydrazone Intermediate

Dipak J. Dahatonde, Aritra Ghosh, Adilakshmi Vutla and Sanjay Batra

Eur J Org Chem, 2023, 26
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Photoinduced 1,3‐Dipolar Cycloadditions of Cyclic Enones and 2,5‐Disubstituted Tetrazoles: An Unprecedented Pathway to Polysubstituted Pyrazolines and Pyrazoles

Chiraz Labassi, Nicolas Fournier‐Le Ray, Fabienne Gauffre, Jean‐Luc Fillaut and Rafik Gatri

Eur J Org Chem, 2023, 26
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Trifluoromethylated 4,5-Dihydro-1,2,4-triazin-6(1H)-ones via (3+3)-Annulation of Nitrile Imines with α-Amino Esters

Anna Kowalczyk, Kamil Świątek, Małgorzata Celeda, Greta Utecht-Jarzyńska, Agata Jaskulska, Katarzyna Gach-Janczak and Marcin Jasiński

Materials, 2023, 16, 856
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Ag-Catalyzed Annulation of o-Alkynylaryl Aldehydes, Amines, and Diazo Compounds: Construction of Trifluoromethyl- and Cyano-Functionalized Benzo[d]azepines

Sanoop P. Chandrasekharan, Anamika Dhami and Kishor Mohanan

Org. Lett., 2023, 25, 5806
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Recent advances in the synthesis of pyrazoline derivatives from chalcones as potent pharmacological agents: A comprehensive review

Chandra Shekhar Yadav, Iqbal Azad, Abdul Rahman Khan, Malik Nasibullah, Naseem Ahmad, Dhananjoy Hansda, Saud Nusrat Ali, Kajal Shrivastav, Mohd Akil and Minaxi B. Lohani

Results in Chemistry, 2024, 7, 101326
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Spiro-C(sp 3 )-atom transfer: Creating rigid three-dimensional structures with Ph 2 SCN 2

Qiu Sun, Jan-Niklas Belting, Julian Hauda, David Tymann, Patrick W. Antoni, Richard Goddard and Max M. Hansmann

Science, 2025, 387, 885
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Copper catalyzed cyclization of N-propargyl-N-tosyl hydrazines: Facile preparation of 1,5-disubstituted pyrazoles

Cheng-Cheng Wei, Yu-Mei Zhang, Yi Li, Mei-Hua Shen and Hua-Dong Xu

Tetrahedron Letters, 2025, 168, 155721
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Organocatalyzed, Three‐Component Construction of Cyanopyrazoles Using Diazoacetonitrile

Anamika Dhami, Anuj Kumar, Kalathingal Nasreen Hisana and Kishor Mohanan

Adv Synth Catal, 2024, 366, 2551
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A Comprehensive Review on Traditional and Modern Synthetic Approaches to Pyrazole and Its Analogs

R. Ramajayam

Journal of Heterocyclic Chem, 2025, 62, 1424
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Trinuclear Copper(I) and Silver(I) Complexes of a Pentafluorosulfanyl-Decorated Pyrazolate

Mukundam Vanga, Benjamin T. Diroll, Alvaro Muñoz-Castro, Andrii Boretskyi, Pavel Mykhailiuk and H. V. Rasika Dias

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Greener preparation and reactivity of diazo compounds: Moving from harmful chemistry to more environmentally benign methods

Marcus M. Sá

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Regioselective Synthesis of N-Vinyl Pyrazoles from Vinyl Sulfonium Salts with Diazo Compounds

Shichong Wang, Huayan Xu, Ruoyu Zhang, Siyu Zhang, Yun Chai, Bingchuan Yang, Jingjing Zhao, Yuanqing Xu and Pan Li

Org. Lett., 2023, 25, 6746
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Multicomponent syntheses of pyrazoles via (3 + 2)-cyclocondensation and (3 + 2)-cycloaddition key steps

Ignaz Betcke, Alissa C Götzinger, Maryna M Kornet and Thomas J J Müller

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Solvent‐Assisted Efficient Syntheses of 1,3,5‐Triaryl‐1H‐Pyrazoles via Ring Opening and Cyclization in Chalcone Epoxides

Avijit Bhakta and Naseem Ahmed

ChemistrySelect, 2025, 10
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Polycyclic Pyrazoles from Alkynyl Cyclohexadienones and Nonstabilized Diazoalkanes via [3 + 2]-Cycloaddition/[1,5]-Sigmatropic Rearrangement/Aza-Michael Reaction Cascade

Raj Kumar Patel, Priyankar Jha, Anil Chauhan, Ruchir Kant and Ravindra Kumar

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Oxygen-, Nitrogen-, and Sulfur-Containing Heterocycles: Recent Advances in De Novo Synthesis and Prospect

Yongpeng Zheng, Jianxiao Li, Wanqing Wu, Chaorong Qi and Huanfeng Jiang

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Exploring Three Avenues: Chemo- and Regioselective Transformations of 1,2,4-Triketone Analogs into Pyrazoles and Pyridazinones

Yulia O. Edilova, Ekaterina A. Osipova, Pavel A. Slepukhin, Victor I. Saloutin and Denis N. Bazhin

IJMS, 2023, 24, 14234
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Three-Component Synthesis of Cyanopyrazoles Employing Diazoacetonitrile

Rekha Singroha, Patrick Onen, Usha Yadav, Ruchir Kant and Kishor Mohanan

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Synthesis of Pyrazolesulfoximines Using α-Diazosulfoximines with Alkynes

Zhenhao Zhong, Tsz-Kan Ma, Andrew J. P. White and James A. Bull

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CsF-Mediated Reaction of Trifluorodiazoethane with 3-Nitroindoles Enables Access to Trifluoromethylpyrazolo[4,3-b]indoles

Sandeep Kumar, Lubina Fatma, Narendra Kumar Vaishanv and Kishor Mohanan

J. Org. Chem., 2024, 89, 761
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Synthesis of 4-Trifluoromethylselenolated Pyrazoles via Tf2O-Promoted Intramolecular Cyclization of α,β-Alkynic Tosylhydrazones with Benzyl Trifluoromethyl Selenoxide

Nan Sun, Jiazhi Gu, Dandan Shi, Liqun Jin and Xinquan Hu

J. Org. Chem., 2025, 90, 15670
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Divergent Synthesis of Pyrazoles via Manganese Pincer Complex Catalyzed Acceptorless Dehydrogenative Coupling Reactions

Koushik Sarkar, Pramod Kumar, Arjun Mule and Biplab Maji

Chemistry A European J, 2024, 30
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Direct Construction of 1,4-Dihydropyridazines and Pyrazoles via Annulation of Alkyl 2-Aroyl-1-chlorocyclopropanecarboxylates

Pengwei Zhang, Huili Liu, Shuo Xu, Yiqun He, Xinhao He, Bing Sun and Junhao Hu

J. Org. Chem., 2024, 89, 9853
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