Enzyme-responsive targeted nanomedicines: a novel strategy for cancer therapy

Mingtang Zeng, Zhongzhen Yang, Liuxuan Yang, Xueyan Wang, Yao Wang, Tao Chen, Xi Yin and Fengbo Wu

J. Mater. Chem. B, 2026, 14, 3661
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Development of Cathepsin B-Activatable Cell-Penetrating Peptides for Tumor Targeting

Konstantin Kuhne, Lydia Strohbach, Christin Neuber, Robert Wodtke, Gloria Ruiz-Gómez, Birgit Belter, Florian Brandt, Lara Gluhacevic von Krüchten, Max Keller, M. Teresa Pisabarro, Klaus Kopka, Jens Pietzsch and Reik Löser

ACS Pharmacol. Transl. Sci., 2026
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Stefin A Regulation of Cathepsin B Expression and Localization in Cancerous and Non-Cancerous Cells

Anastasiia O. Syrocheva, Ekaterina P. Kolesova, Alessandro Parodi and Andrey A. Zamyatnin

IJMS, 2025, 26, 9321
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Role of Cathepsin B Expression in Oral Squamous Cell Carcinoma: A Comprehensive Review

Shakti Sagar, Pravin Gadkari, K.M. Hiwale, Miheer M Jagtap and Suhit Naseri

Cureus, 2024
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Enzyme‐Activatable Near‐Infrared Hemicyanines as Modular Scaffolds for in vivo Photodynamic Therapy

Zhiming Cheng, Sam Benson, Lorena Mendive‐Tapia, Eleni Nestoros, Charles Lochenie, Deborah Seah, Kai Yee Chang, Yi Feng and Marc Vendrell

Angewandte Chemie, 2024, 136
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Development of a Peptide-Based Nano-Sized Cathepsin B Inhibitor for Anticancer Therapy

So-Hyeon Park, Jun-Hyuck Lee, Seong-Bin Yang, Dong-Nyeong Lee, Tae-Bong Kang and Jooho Park

Pharmaceutics, 2023, 15, 1131
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Improved recombinant expression of soluble cathepsin B and L in Escherichia coli

Christina Möller, Niklas Rimkus, Ferdinand F. O. Skala, Maëlle Merouze, Dominique Böttcher, Mark Dörr and Uwe T. Bornscheuer

Appl Microbiol Biotechnol, 2024, 108
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Enzyme‐Activatable Near‐Infrared Hemicyanines as Modular Scaffolds for in vivo Photodynamic Therapy

Zhiming Cheng, Sam Benson, Lorena Mendive‐Tapia, Eleni Nestoros, Charles Lochenie, Deborah Seah, Kai Yee Chang, Yi Feng and Marc Vendrell

Angew Chem Int Ed, 2024, 63
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Low-side-effect phototherapy using aggregation-induced emission agents with “turn-on” and “turn-off” strategies

Qiang Wang, Yifei Yang, Yajun Lin, Haijian Zhong and Fang Hu

Journal of Photochemistry and Photobiology C: Photochemistry Reviews, 2025, 65, 100723
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Comparative Enzymatic and Stability Assays Reveal GPLG as an Effective Cathepsin B Cleavable Linker for Tumor-Targeting Drug Conjugates

Giulia Cazzaniga, Marco Zambra, Samuele Bongiolo, Helena Prpić, Elettra Fasola, Federico Arrigoni, Umberto Piarulli and Silvia Gazzola

ACS Omega, 2025, 10, 41783
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Unveiling Cathepsin B inhibition with repurposed drugs for anticancer and anti-Alzheimer’s drug discovery

Mohammed Alrouji, Sabina Yasmin, Mohammed S. Alshammari, Fahad A. Alhumaydhi, Sharaf E. Sharaf, Moyad Shahwan, Anas Shamsi and Ahmed A. Al-Karmalawy

PLoS ONE, 2024, 19, e0316010
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Tumor-specific biochemical nanoconversion of self-assembled peptide-conjugated paclitaxel-docetaxel-based nanoparticles

Hansol Lim, Jae-Hyeon Lee, So-Hyeon Park, Jun-Hyuck Lee, Hyesu Jang, Seong-Bin Yang, Minho Seo, Seokwoo Lee and Jooho Park

Nano Convergence, 2025, 12
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Exploring therapeutic and diagnostic potential of cysteine cathepsin as targets for cancer therapy with nanomedicine

Anil Giri, In-Sun Hong, Taeg Kyu Kwon, Jong-Sun Kang, Jee-Heon Jeong, Seho Kweon and Simmyung Yook

International Journal of Biological Macromolecules, 2025, 315, 144324
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Design of cathepsin-sensitive linkers for tumor-selective bioconjugate drug delivery

Anil Giri, Yulim Shin, Jin Ha, Siyeon Chae, Prabhat Shrestha, Khang-Yen Pham, Taeg Kyu Kwon, Jong Ho Park, Jee-Heon Jeong, Na Kyeong Lee and Simmyung Yook

Journal of Controlled Release, 2025, 387, 114197
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Protease-Responsive Bitext Editing Biopolymer for Breast Cancer Imaging In Vivo

Yixi Dong, Gang Wang, Noshin Afshan, Tao Cheng, Bin Ning, Jianwei Jiao and Jin Jiao

ACS Materials Lett., 2024, 6, 3815
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Peptide vaccine formulations with structurally distinct STING agonist drugamers induce discrete, efficacious antitumor responses

Kefan Song, Dinh Chuong Nguyen, Yonghui Wang, Simbarashe Jokonya, Omeed Yazdani, Drew L. Sellers, Patrick S. Stayton and Suzie H. Pun

Proc. Natl. Acad. Sci. U.S.A., 2025, 122
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Cathepsin B: Plasma Expression and Concentration in Non-Hodgkin Lymphoma Patients

Zana Radic Savic, Natasa Bogavac-Stanojevic, Dragana Malcic-Zanic, Sinisa Stankovic, Natasa Egeljic-Mihailovic, Đorđe Stojisavljević, Miron Sopić and Bosa Mirjanic-Azaric

Hemato, 2025, 6, 13
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Responsive Photosensitizer Precursors Reverse Drug-Induced Secondary Immunosuppression

Shan Zuo, Huiyi Liu, Gangwei Jiang, Yushi Chen, Tianbing Ren, Zhixuan Zhou, Xiao-Bing Zhang and Lin Yuan

J. Am. Chem. Soc., 2025
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