Therapeutic synthetic and natural materials for immunoengineering

Anna Slezak, Kevin Chang, Samir Hossainy, Aslan Mansurov, Stuart J. Rowan, Jeffrey A. Hubbell and Mustafa O. Guler

Chem. Soc. Rev., 2024, 53, 1789
DOI: 10.1039/D3CS00805C

Advances in block copolymer-phospholipid hybrid vesicles: from physical–chemical properties to applications

Edit Brodszkij and Brigitte Städler

Chem. Sci., 2024, 15, 10724
DOI: 10.1039/D4SC01444H

Marine-origin polysaccharides-based free-standing multilayered membranes as sustainable nanoreservoirs for controlled drug delivery

Cristiana F. V. Sousa, Luís P. G. Monteiro, João M. M. Rodrigues, João Borges and João F. Mano

J. Mater. Chem. B, 2023, 11, 6671
DOI: 10.1039/D3TB00796K

Current state and potential of polymersomes as ocular drug delivery systems

Abuzer Alp Yetisgin, Ponnurengam Malliappan Sivakumar and Sibel Cetinel

Nanoscale, 2025, 17, 14458
DOI: 10.1039/D5NR01273B

Modular Software for Generating and Modeling Diverse Polymer Databases

Alejandro Santana-Bonilla, Raquel López-Ríos de Castro, Peike Sun, Robert M. Ziolek and Christian D. Lorenz

J. Chem. Inf. Model., 2023, 63, 3761
DOI: 10.1021/acs.jcim.3c00081

Bioresponsive Polymeric Nanoparticles: From Design, Targeted Therapy to Cancer Immunotherapy

Huanli Sun and Zhiyuan Zhong

Biomacromolecules, 2025, 26, 33
DOI: 10.1021/acs.biomac.4c01257

Targeted Delivery of Anticancer Therapeutics with Polymers by Harnessing Tumor Microenvironment Acidity

Jiahao Shi, Bin Ma, Yuhe Zhang, Haiyang Yong, Zhili Li, Sigen A, Xiaobei Huang and Dezhong Zhou

Chem. Mater., 2023, 35, 6573
DOI: 10.1021/acs.chemmater.3c01151

Green polymer‐based materials as promising therapeutical agents for non‐communicable diseases

Manuel Humberto Cháirez‐Ramírez, Jesus Omar Díaz‐Rivas, Javier Isaac Contreras‐Ramírez, Ruben Francisco González‐Laredo and José Alberto Gallegos‐Infante

Polymer International, 2025, 74, 483
DOI: 10.1002/pi.6708

Artificial cell synthesis using biocatalytic polymerization-induced self-assembly

Andrea Belluati, Sètuhn Jimaja, Robert J. Chadwick, Christopher Glynn, Mohamed Chami, Dominic Happel, Chao Guo, Harald Kolmar and Nico Bruns

Nat. Chem., 2024, 16, 564
DOI: 10.1038/s41557-023-01391-y

Cyclical endometrial repair and regeneration: Molecular mechanisms, diseases, and therapeutic interventions

Xulin Hu, Haoming Wu, Xin Yong, Yao Wang, Shuhao Yang, Diyi Fan, Yibo Xiao, Lanyu Che, Kun Shi, Kainan Li, Chengdong Xiong, Huili Zhu and Zhiyong Qian

MedComm, 2023, 4
DOI: 10.1002/mco2.425

Targeted protein delivery based on stimuli‐triggered nanomedicine

Jinzhao Liu, Yang Zhou, Qingyang Lyu, Xiaotong Yao and Weiping Wang

Exploration, 2024, 4
DOI: 10.1002/EXP.20230025

Nano‐ and Micro‐Platforms in Therapeutic Proteins Delivery for Cancer Therapy: Materials and Strategies

Huijie Han and Hélder A. Santos

Advanced Materials, 2024, 36
DOI: 10.1002/adma.202409522

Polystyrene–Poly(acrylic acid) Block Copolymers for Encapsulation of Butyrylcholinesterase into Injectable Nanoreactors

Petr A. Fetin, Ivan M. Zorin, Zukhra M. Shaihutdinova, Patrick Masson and Tatiana N. Pashirova

Biomolecules, 2024, 14, 1555
DOI: 10.3390/biom14121555

Current Strategies for Exosome Cargo Loading and Targeting Delivery

Haifeng Zeng, Shaoshen Guo, Xuancheng Ren, Zhenkun Wu, Shuwen Liu and Xingang Yao

Cells, 2023, 12, 1416
DOI: 10.3390/cells12101416

Large-area, self-healing block copolymer membranes for energy conversion

Christian C. M. Sproncken, Peng Liu, Justin Monney, William S. Fall, Carolina Pierucci, Philip B. V. Scholten, Brian Van Bueren, Marcos Penedo, Georg Ernest Fantner, Henricus H. Wensink, Ullrich Steiner, Christoph Weder, Nico Bruns, Michael Mayer and Alessandro Ianiro

Nature, 2024, 630, 866
DOI: 10.1038/s41586-024-07481-2

Polymersomes for Therapeutic Protein and Peptide Delivery: Towards Better Loading Properties

Chengxu Hua and Liyan Qiu

IJN, 2024, Volume 19, 2317
DOI: 10.2147/IJN.S444910

Unlocking Intracellular Protein Delivery by Harnessing Polymersomes Synthesized at Microliter Volumes using Photo‐PISA

Chalaisorn Thanapongpibul, Omar Rifaie‐Graham, Miina Ojansivu, Adrian Najer, Hyemin Kim, Saskia E. Bakker, Mohamed Chami, David J. Peeler, Chenchen Liu, Jonathan Yeow and Molly M. Stevens

Advanced Materials, 2024, 36
DOI: 10.1002/adma.202408000

Biocompatible Glycopolymer-PLA Amphiphilic Hybrid Block Copolymers with Unique Self-Assembly, Uptake, and Degradation Properties

Kevin A. Green, Anuja S. Kulkarni, Penelope E. Jankoski, Thomas B. Newton, Blaine Derbigny, Tristan D. Clemons, Davita L. Watkins and Sarah E. Morgan

Biomacromolecules, 2024, 25, 6681
DOI: 10.1021/acs.biomac.4c00885

Design and Applications of Polymersomes for Oral Drug Administration

Wing-Fu Lai

ACS Appl. Mater. Interfaces, 2025, 17, 30423
DOI: 10.1021/acsami.5c04658

Biomimetic Protocells Featuring Macrophage‐Like Capture and Digestion of Protein Pathogens

Xiaoying Xu, Silvia Moreno, Marc Gentzel, Kehu Zhang, Dishi Wang, Brigitte Voit and Dietmar Appelhans

Small Methods, 2023, 7
DOI: 10.1002/smtd.202300257

Evaluating the impact of chaotropic salts on protein corona formation on polyethylene glycol-b-polylactic acid polymersomes

Owen Tabah, Daniel Nichols, Ashley Blake, Grace Witt, Chau-wen Chou and Jessica Larsen

Journal of Colloid and Interface Science, 2025, 699, 138195
DOI: 10.1016/j.jcis.2025.138195

Polymer-mediated nanoformulations: a promising strategy for cancer immunotherapy

Simranjit Kaur, Adesh K. Saini, Hardeep Singh Tuli, Nancy Garg, Hemant Joshi, Mehmet Varol, Jagjit Kaur, Anil K. Chhillar and Reena V. Saini

Naunyn-Schmiedeberg's Arch Pharmacol, 2024, 397, 1311
DOI: 10.1007/s00210-023-02699-9

Polymersomes as Next Generation Nanocarriers for Drug Delivery: Recent Advances, Patents, Synthesis and Characterization

Surya Goel, Ruchi Singh and Megha Tonk

CNANO, 2024, 20, 753
DOI: 10.2174/0115734137271094231101062844

Pharmacokinetics and fate of free and encapsulated IRD800CW-labelled human BChE intravenously administered in mice

Tatiana Pashirova, Zukhra Shaihutdinova, Dmitry Tatarinov, Angelina Titova, Albina Malanyeva, Olga Vasileva, Kamil Gabdurakhmanov, Sergei Dudnikov, Lawrence M. Schopfer, Oksana Lockridge and Patrick Masson

International Journal of Biological Macromolecules, 2024, 282, 137305
DOI: 10.1016/j.ijbiomac.2024.137305

Polymersomes as Novel Drug Delivery Alternative to Conventional Liposomes

Marwa malik Kamil, Mohammed J. Neamah and Yasir Qasim almajidi

AJPS, 2025, 24, 396
DOI: 10.32947/ajps.v24i4.955

Engineered extracellular vesicles enable high-efficient delivery of intracellular therapeutic proteins

Ding Ma, An Xie, Jiahui Lv, Xiaolin Min, Xinye Zhang, Qian Zhou, Daxing Gao, Enyu Wang, Lei Gao, Linzhao Cheng and Senquan Liu

Protein & Cell, 2024, 15, 724
DOI: 10.1093/procel/pwae015

Advanced coacervation-driven nanoscale polymeric assemblies for biomedical applications

Lilei Shu, Yiyu Gong, Min Lin, Jing Sun and Xuesi Chen

Applied Physics Reviews, 2024, 11
DOI: 10.1063/5.0197742

Polymersome Membrane Engineering with Active Targeting or Controlled Permeability for Responsive Drug Delivery

Anum Kayani, Arsalan Raza, Jiale Si, Debabrata Dutta, Qinghao Zhou and Zhishen Ge

Biomacromolecules, 2023, 24, 4622
DOI: 10.1021/acs.biomac.3c00839

Synthesis and Structure Optimization of Star Copolymers as Tunable Macromolecular Carriers for Minimal Immunogen Vaccine Delivery

Gabriela Mixová, Eva Tihlaříková, Yaling Zhu, Lucie Schindler, Ladislav Androvič, Lucie Kracíková, Eliška Hrdá, Bedřich Porsch, Michal Pechar, Christopher M. Garliss, David Wilson, Hugh C. Welles, Jake Holechek, Qiuyin Ren, Geoffrey M. Lynn, Vilém Neděla and Richard Laga

Bioconjugate Chem., 2024, 35, 1218
DOI: 10.1021/acs.bioconjchem.4c00273

Metal–Organic Framework Induced Stabilization of Proteins in Polymeric Nanoparticles

Md Rakib Hasan Khan, Zoe Armstrong, Mary Lenertz, Briana Saenz, Narendra Kale, Qiaobin Li, Austin MacRae, Zhongyu Yang and Mohiuddin Quadir

ACS Appl. Mater. Interfaces, 2024, 16, 14405
DOI: 10.1021/acsami.3c16534

Stimuli-Responsive Polymersomes: Reshaping the Immunosuppressive Tumor Microenvironment

Yaohua Wei, Xiao Weng, Yayun Wang and Weijing Yang

Biomacromolecules, 2024, 25, 4663
DOI: 10.1021/acs.biomac.4c00706

Achieving Endo/Lysosomal Escape Using Smart Nanosystems for Efficient Cellular Delivery

Nimeet Desai, Dhwani Rana, Sagar Salave, Derajram Benival, Dignesh Khunt and Bhupendra G. Prajapati

Molecules, 2024, 29, 3131
DOI: 10.3390/molecules29133131

Optimized Biotinylation-Based Loading of Therapeutic Peptides/Proteins into Nanoscale Extracellular Vesicles for Targeted Cancer Therapy

Misako Takenaka, Yuki Takahashi and Yoshinobu Takakura

ACS Appl. Nano Mater., 2025, 8, 13639
DOI: 10.1021/acsanm.5c01185

Monodisperse Giant Unilamellar Niosomes as Minimal Synthetic Cells

Zhen-Hong Luo, Xuan-Yan He and Nan-Nan Deng

J. Am. Chem. Soc., 2025, 147, 27081
DOI: 10.1021/jacs.5c09950

Polymeric Nanoarchitectures: Advanced Cargo Systems for Biological Applications

Yingtong Luo, Yudong Li, Loai K. E. A. Abdelmohsen, Jingxin Shao and Jan C. M. van Hest

Macromolecular Bioscience, 2025, 25
DOI: 10.1002/mabi.202400540

Review of Shape Transformation Pathways of Polymersomes: Implications for Nanomotor, Biomedicine, and Artificial Cell Mimics

Xurui Zhang, Jan C. M. van Hest and Yongjun Men

ACS Appl. Nano Mater., 2024, 7, 14865
DOI: 10.1021/acsanm.4c02200

Zinc ions-modified trypsin nanoparticles as fluorescent probe for rapid detection of tetracyclines antibiotics

Shu Pang, Yan Zhao, Lin Xu and Jiazhen Wu

Spectroscopy Letters, 2025, 58, 405
DOI: 10.1080/00387010.2024.2445698

Nanocarriers for cutting-edge cancer immunotherapies

Joyce Hu, Pooria M. Arvejeh, Sydney Bone, Erik Hett, Francesco M. Marincola and Kyung-Ho Roh

J Transl Med, 2025, 23
DOI: 10.1186/s12967-025-06435-0

Degradable Diblock Copolymer Vesicles via Radical Ring-Opening Polymerization-Induced Self-Assembly in Aqueous Media

Panagiotis G. Georgiou, Thomas J. Neal, Mark A. Newell, Kyle S. Hepburn, Joshua J. S. Tyler, Matthew A. H. Farmer, Priyanka Chohan, Peter J. Roth, Julien Nicolas and Steven P. Armes

J. Am. Chem. Soc., 2025, 147, 19817
DOI: 10.1021/jacs.5c03744

Amphiphilic Block Copolymer Nanostructures as a Tunable Delivery Platform: Perspective and Framework for the Future Drug Product Development

Gaurav Sinsinbar, Anivind Kaur Bindra, Shaoqiong Liu, Teck Wan Chia, Eunice Chia Yoong Eng, Ser Yue Loo, Jian Hang Lam, Katherine Schultheis and Madhavan Nallani

Biomacromolecules, 2024, 25, 541
DOI: 10.1021/acs.biomac.3c00858

Polymer vesicles as nanoreactors for biomedical applications

Zhuo Zhang, Zhen Fan and Jianzhong Du

Precision Medicine and Engineering, 2024, 1, 100004
DOI: 10.1016/j.preme.2024.100004

Membrane and Lumen-Compartmentalized Polymersomes for Biocatalysis and Cell Mimics

Qingmei Sun, Junqiu Shi, Hui Sun, Yunqing Zhu and Jianzhong Du

Biomacromolecules, 2023, 24, 4587
DOI: 10.1021/acs.biomac.3c00726

Hyaluronic acid based nanoparticles that mediate sustained thanatin release protect against NDM-1–resistant bacterial infections in a murine model

Xiaojun Deng, HaiBo Wang, Chao Fang, Min Xu, Zhufei Chu, Miaomiao Li, Zheng Hou and Hongyan Qin

Nanomedicine: Nanotechnology, Biology and Medicine, 2025, 63, 102796
DOI: 10.1016/j.nano.2024.102796

Current updated review on preparation of polymeric nanoparticles for drug delivery and biomedical applications

Harish Bhardwaj and Rajendra Kumar Jangde

Next Nanotechnology, 2023, 2, 100013
DOI: 10.1016/j.nxnano.2023.100013

Advances in targeted therapy for tumor with nanocarriers: A review

Hongxia Cheng, Juan Liao, Yuhan Ma, Muhammad Tariq Sarwar and Huaming Yang

Materials Today Bio, 2025, 31, 101583
DOI: 10.1016/j.mtbio.2025.101583

Hyperbranched polyglycerol grafted poly(N,N-diethylacrylamide) thermoresponsive copolymers as biocompatible, highly efficient encapsulation and sustained release systems of curcumin

György Kasza, Ákos Fábián, Dóra Fecske, Attila Kardos, Róbert Mészáros, Kata Horváti and Béla Iván

European Polymer Journal, 2024, 219, 113378
DOI: 10.1016/j.eurpolymj.2024.113378

Controlling the function of bioactive worm micelles by enzyme-cleavable non-covalent inter-assembly cross-linking

Alina Romanovska, Martin Schmidt, Volker Brandt, Jonas Tophoven and Joerg C. Tiller

Journal of Controlled Release, 2024, 368, 15
DOI: 10.1016/j.jconrel.2024.02.013

Nanomaterials in tumor immunotherapy: new strategies and challenges

Xudong Zhu and Shenglong Li

Mol Cancer, 2023, 22
DOI: 10.1186/s12943-023-01797-9

Charge Conversional Biomimetic Nanosystem for Synergistic Photodynamic/Protein Therapy

Shulun Ai, Peisen Zhao, Kaixuan Fang, Hemei Cheng, Sixue Cheng, Zhihong Liu and Caixia Wang

Small, 2024, 20
DOI: 10.1002/smll.202307193

Polymersomes as Innovative, Stimuli-Responsive Platforms for Cancer Therapy

Irina Negut and Bogdan Bita

Pharmaceutics, 2024, 16, 463
DOI: 10.3390/pharmaceutics16040463

Streamlined Formation and Manipulation of Charged Polymersomes

Rebecca Y. Lai, Chin Ken Wong and Martina H. Stenzel

Small, 2024
DOI: 10.1002/smll.202310202

Analyzing Molecular Determinants of Nanodrugs’ Cytotoxic Effects

Alicia Calé, Petra Elblová, Hana Andělová, Mariia Lunova and Oleg Lunov

IJMS, 2025, 26, 6687
DOI: 10.3390/ijms26146687

Designing blend polymersomes co-loaded with HRH peptide and sphingosine for the treatment of ocular neovascularization

Abuzer Alp Yetisgin, Ozlem Kutlu and Sibel Cetinel

Journal of Drug Delivery Science and Technology, 2025, 111, 107156
DOI: 10.1016/j.jddst.2025.107156

Recent progress in functionalized and targeted polymersomes and chimeric polymeric nanotheranostic platforms for cancer therapy

Mohammad Beygi, Fatemeh Oroojalian, Seyed Samad Hosseini, Ahad Mokhtarzadeh, Prashant Kesharwani and Amirhossein Sahebkar

Progress in Materials Science, 2023, 140, 101209
DOI: 10.1016/j.pmatsci.2023.101209

Tumor-targeting and redox-responsive photo-cross-linked nanogel derived from multifunctional hyaluronic acid-lipoic acid conjugates for enhanced in vivo protein delivery

Wei Sun, Moon-Sun Jang, Siqi Zhan, Changling Liu, Li Sheng, Jung Hee Lee, Yan Fu and Hong Yu Yang

International Journal of Biological Macromolecules, 2025, 314, 144444
DOI: 10.1016/j.ijbiomac.2025.144444

Lessons Learned from Liver-on-Chip Platform

Zahra Sadat Razavi, Fateme Sadat Razavi, Madjid Soltani, Hamidreza Pazoki-Toroudi, Simin Farokhi, Iraj Azimi and Nahid Ahmadi

Ann Biomed Eng, 2025
DOI: 10.1007/s10439-025-03779-y

Hallmarks of Polymersome Characterization

Simon Matoori

ACS Mater. Au, 2025, 5, 223
DOI: 10.1021/acsmaterialsau.4c00107

Influence of the Saccharide Structure on Cargo Loading, Thermal Properties, and Lectin Binding of Amphiphilic Glycopolymer-Polylactic Acid Block Copolymer Nanoparticles

Kevin A. Green, Anuja S. Kulkarni, Penelope E. Jankoski, Rachel M. Worden, Bayleigh M. Loving, Blaine Derbigny, Tristan D. Clemons, Davita L. Watkins and Sarah E. Morgan

Bioconjugate Chem., 2025
DOI: 10.1021/acs.bioconjchem.5c00217

Encapsulation of Fragrances in Micro‐ and Nano‐Capsules, Polymeric Micelles, and Polymersomes

Sam Russell and Nico Bruns

Macromol. Rapid Commun., 2023, 44
DOI: 10.1002/marc.202300120

Optimizing Enzyme-Responsive Polymersomes for Protein-Based Therapies

Dorian Foster, Alaura Cakley and Jessica Larsen

Nanomedicine (Lond.), 2024, 19, 213
DOI: 10.2217/nnm-2023-0300

Current advance of nanotechnology in diagnosis and treatment for malignant tumors

Bilan Wang, Shiqi Hu, Yan Teng, Junli Chen, Haoyuan Wang, Yezhen Xu, Kaiyu Wang, Jianguo Xu, Yongzhong Cheng and Xiang Gao

Sig Transduct Target Ther, 2024, 9
DOI: 10.1038/s41392-024-01889-y

Advances in supported-biomimetic lipid membranes for the study of biomolecular interactions

Eya BenSalem, Mathilde Manceau, Carole Farre, Chokri Messaoud, Laurène Tétard and Carole Chaix

TrAC Trends in Analytical Chemistry, 2025, 192, 118384
DOI: 10.1016/j.trac.2025.118384

Vesicle-like Nanocapsules Formed by Self-Assembly of Peptides with Oligoproline and -Leucine

Yui Okamoto, Masahiro Higuchi and Shogo Matsubara

Langmuir, 2024, 40, 12802
DOI: 10.1021/acs.langmuir.4c01412

Biomedical applications of nanomaterials in the advancement of nucleic acid therapy: Mechanistic challenges, delivery strategies, and therapeutic applications

Krishna Yadav, Kantrol Kumar Sahu, Sucheta, S. Princely Ebenezer Gnanakani, Pavani Sure, R. Vijayalakshmi, V.D. Sundar, Versha Sharma, Ruchita Antil, Megha Jha, Sunita Minz, Anindya Bagchi and Madhulika Pradhan

International Journal of Biological Macromolecules, 2023, 241, 124582
DOI: 10.1016/j.ijbiomac.2023.124582

Recent Progress of Rational Modified Nanocarriers for Cytosolic Protein Delivery

Xiao He, Su Xiong, Yansun Sun, Min Zhong, Nianting Xiao, Ziwei Zhou, Ting Wang, Yaqin Tang and Jing Xie

Pharmaceutics, 2023, 15, 1610
DOI: 10.3390/pharmaceutics15061610

An Outer Membrane‐Inspired Polymer Coating Protects and Endows Escherichia coli with Novel Functionalities

Andrea Belluati, Iain Harley, Ingo Lieberwirth and Nico Bruns

Small, 2023, 19
DOI: 10.1002/smll.202303384

Transferrin-guided liposomal nanocarriers: A strategy for targeted cancer treatment

Mohd Saeed, Mohd Altamash, Mohammad Ali Abdullah Almoyad, Shadma Wahab, Garima Gupta, Khang Wen Goh and Prashant Kesharwani

International Journal of Biological Macromolecules, 2025, 319, 145377
DOI: 10.1016/j.ijbiomac.2025.145377

Fabrication of pH- and Ultrasound-Responsive Polymeric Micelles: The Effect of Amphiphilic Block Copolymers with Different Hydrophilic/Hydrophobic Block Ratios for Self-Assembly and Controlled Drug Release

Hong-Xiang Wei, Ming-Hsin Liu, Tzu-Ying Wang, Meng-Hsiu Shih, Jiashing Yu and Yi-Cheun Yeh

Biomacromolecules, 2025, 26, 2116
DOI: 10.1021/acs.biomac.4c01202

A Perspective of Engineered Lipids and Liposomes: Chemical Design and Functional Application Based on Therapeutic Safety

Shengran Li, Wenliang Wang and Xifei Yu

Chem. Mater., 2023, 35, 4587
DOI: 10.1021/acs.chemmater.3c00842

Lipoprotein-mimicking nanodiscs for precise glioblastoma therapy and immune microenvironment modulation

Taiyu Liu, Lisha Liu, Dandan Gao, Wenqing Li, Xianggui Wu, Shuo Li, Beiyuan Zhang, Yaohua Liu, Qiao Shan, Meiqing Lou, Lifang Yin and Yunke Bi

Chemical Engineering Journal, 2025, 516, 164171
DOI: 10.1016/j.cej.2025.164171

Recent Progress of Supramolecular Chemotherapy Based on Host–Guest Interactions

Miaomiao Yan, Sha Wu, Yuhao Wang, Minghao Liang, Mengbin Wang, Wenting Hu, Guocan Yu, Zhengwei Mao, Feihe Huang and Jiong Zhou

Advanced Materials, 2024, 36
DOI: 10.1002/adma.202304249

Polymer-mediated protein/peptide therapeutic stabilization: Current progress and future directions

Rajalakshmi P. Sivasankaran, Katherine Snell, Grace Kunkel, Panagiotis G. Georgiou, Ellie G. Puente and Heather D. Maynard

Progress in Polymer Science, 2024, 156, 101867
DOI: 10.1016/j.progpolymsci.2024.101867