Advances in the study of the vascular protective effects and molecular mechanisms of hawthorn (Crataegus anamesaSarg.) extracts in cardiovascular diseases

Mengkai Lu, Lei Zhang, Jinyuan Pan, Huishan Shi, Muxin Zhang and Chao Li

Food Funct., 2023, 14, 5870
DOI: 10.1039/D3FO01688A

Chemical basis of hawthorn processed with honey protecting against myocardial ischaemia

Nannan Ao, Yang Qu, Yangyang Deng, Qian Cai, Tianjiao Suo and Yu Zheng

Food Funct., 2020, 11, 3134
DOI: 10.1039/C9FO02406A

Puerarin induces mouse mesenteric vasodilation and ameliorates hypertension involving endothelial TRPV4 channels

Tingting Zhou, Zhiwei Wang, Mengting Guo, Ka Zhang, Li Geng, Aiqin Mao, Yujiao Yang and Fan Yu

Food Funct., 2020, 11, 10137
DOI: 10.1039/D0FO02356F

Sacha inchi (Plukenetia volubilisL.) shell extract alleviates hypertension in association with the regulation of gut microbiota

Pan Li, Xin Cai, Nan Xiao, Xiaowei Ma, Liping Zeng, Lian-Hui Zhang, Lanhua Xie and Bing Du

Food Funct., 2020, 11, 8051
DOI: 10.1039/D0FO01770A

Supplementation of amino acids and organic acids prevents the increase in blood pressure induced by high salt in Dahl salt-sensitive rats

Pengfei Yang, Luxin Zhou, Meng Chen, Li Zeng, Yanan Ouyang, Xuewei Zheng, Xiangbo Chen, Zhe Yang and Zhongmin Tian

Food Funct., 2022, 13, 891
DOI: 10.1039/D1FO03577K

Inhibition of Maternal c-Src Ameliorates the Male Offspring Hypertension by Suppressing Inflammation and Neurotransmitters in the Paraventricular Nucleus

Qing Su, Xiao-Jing Yu, Qing Yang, Xiao-Min Wang, Wen-Jie Xia, Hong-Bao Li, Kai-Li Liu, Qiu-Yue Yi and Yu-Ming Kang

Cardiovasc Toxicol, 2021, 21, 820
DOI: 10.1007/s12012-021-09672-z

Metabolomics reveals the defense mechanism of histidine supplementation on high-salt exposure-induced hepatic oxidative stress

Pengfei Yang, Fenfen Deng, Mengdi Yuan, Meng Chen, Li Zeng, Yanan Ouyang, Xiangbo Chen, Bin Zhao, Zhe Yang and Zhongmin Tian

Life Sciences, 2023, 314, 121355
DOI: 10.1016/j.lfs.2022.121355

Hawthorn (Crataegus spp.): An Updated Overview on Its Beneficial Properties

Amirhossein Nazhand, Massimo Lucarini, Alessandra Durazzo, Massimo Zaccardelli, Santo Cristarella, Selma B. Souto, Amélia M. Silva, Patrícia Severino, Eliana B. Souto and Antonello Santini

Forests, 2020, 11, 564
DOI: 10.3390/f11050564

Novel insights into plasma biomarker candidates in patients with chronic mountain sickness based on proteomics

Peili Zhang, Zhanquan Li, Faman Yang, Linhua Ji, Yingzhong Yang, Chuanchuan Liu, Huihui Liu, Jie Ma, Jie Liu, Zhancui Dang, Shengyan Wang, Rili Ge and Sen Cui

Bioscience Reports, 2021, 41
DOI: 10.1042/BSR20202219

Roles and Mechanisms of Hawthorn and Its Extracts on Atherosclerosis: A Review

Min Wu, Longtao Liu, Yanwei Xing, Shengjie Yang, Hao Li and Yu Cao

Front. Pharmacol., 2020, 11
DOI: 10.3389/fphar.2020.00118

Roles and mechanisms of puerarin on cardiovascular disease：A review

Zhilin Jiang, Xiangning Cui, Peirong Qu, Chang Shang, Mi Xiang and Jie Wang

Biomedicine & Pharmacotherapy, 2022, 147, 112655
DOI: 10.1016/j.biopha.2022.112655

Beneficial effects of Hawthorn extract on metabolic hypertensive rats by regulating Treg/Th17 immune balance

Bing-Bing Cheng, Ze-Qi Hu, Bo Li, Xiang Zheng, Lin-Zi Li, Ying-Jie Dong, Xing-Li-Shang He, Gui-Yuan Lv, Su-Hong Chen and Ning-Hua Jiang

Journal of Functional Foods, 2023, 108, 105750
DOI: 10.1016/j.jff.2023.105750

Human plasma metabolomics reveals metabolic targets for intervention in salt-sensitive hypertension

Pengfei Yang, Xiangbo Chen, Mingxiao Liu, Xian Li, Yang Wang, Jianjun Mu, Yanan Ouyang, Tailin Wu, Zhe Yang, Di Gao and Zhongmin Tian

Hypertens Res, 2025, 48, 2567
DOI: 10.1038/s41440-025-02280-2

High salt diet contributes to hypertension by weakening the medullary tricarboxylic acid cycle and antioxidant system in Dahl salt-sensitive rats

Xuewei Zheng, Xinrui Zhao, Yuexin Jin, Luxin Zhou, Pengfei Yang, Hussain Ahmad and Zhongmin Tian

Biochimie, 2021, 181, 154
DOI: 10.1016/j.biochi.2020.12.010

Effect of DHA-Enriched Phospholipids from Fish Roe on Rat Fecal Metabolites: Untargeted Metabolomic Analysis

Xiaodan Lu, Luyao Huang, Yanjun Chen, Ling Hu, Rongbin Zhong, Lijiao Chen, Wenjian Cheng, Baodong Zheng and Peng Liang

Foods, 2023, 12, 1687
DOI: 10.3390/foods12081687

Botany, traditional uses, phytochemistry and pharmacological activity of Crataegus pinnatifida (Chinese hawthorn): a review

Shi-Yao Zhang, Xiao-Lei Sun, Xing-Liang Yang, Peng-Liang Shi, Ling-Chuan Xu and Qing-Mei Guo

Journal of Pharmacy and Pharmacology, 2022, 74, 1507
DOI: 10.1093/jpp/rgac050

Protective effect of hawthorn extract against genotoxicity induced by benzo()pyrene in C57BL/6 mice

Jie Deng, Ximiao Chen, Da Wang, Ya Song, Yongchun Chen, Dongmei Ouyang, Yuxuan Liang, Yuanming Sun and Meiying Li

Ecotoxicology and Environmental Safety, 2020, 200, 110761
DOI: 10.1016/j.ecoenv.2020.110761

Revealing metabolic pathways relevant to prediabetes based on metabolomics profiling analysis

Ya-nan OuYang, Yue-xin Jin, Xin-rui Zhao, Meng Chen, Peng-fei Yang, Xue-wei Zheng, Li Zeng, Lan Chen and Zhongmin Tian

Biochemical and Biophysical Research Communications, 2020, 533, 188
DOI: 10.1016/j.bbrc.2020.09.016

Effects of Dietary BCAAs Intake on the Blood Pressure in Dahl Salt‐Sensitive Rats

Meng Chen, Li Zeng, Xiangbo Chen, Lan Chen, Di Gao, Zhe Yang and Zhongmin Tian

Acta Physiologica, 2025, 241
DOI: 10.1111/apha.70070

Effect of Flavonoids in Hawthorn and Vitamin C Prevents Hypertension in Rats Induced by Heat Exposure

Wei Du, Hong-Min Fan, Yu-Xin Zhang, Xiao-Hua Jiang and Yun Li

Molecules, 2022, 27, 866
DOI: 10.3390/molecules27030866

Effects of almonds on ameliorating salt‐induced hypertension in dahl salt‐sensitive rats

Li Zeng, Zerong Liu, Luxin Zhou, Meng Chen, Xuewei Zheng, Pengfei Yang, Xinrui Zhao and Zhongmin Tian

J Sci Food Agric, 2022, 102, 2710
DOI: 10.1002/jsfa.11611

Detection of active vasodilatory compounds from hawthorn: Screening and determination of mechanism of action

Magdalena Šajnová, Ganesh Dussa, Patrícia Harčárová, Zuzana Lomozová, Milan Pour, Přemysl Mladěnka and Jana Pourová

Fitoterapia, 2026, 190, 107167
DOI: 10.1016/j.fitote.2026.107167

Colorimetric Sensor Array for Identification of Proteins and Classification of Metabolic Profiles under Various Osmolyte Conditions

Peng Yan, Xuewei Zheng, Shuang Liu, Yanhua Dong, Tao Fu, Zhongmin Tian and Yayan Wu

ACS Sens., 2023, 8, 133
DOI: 10.1021/acssensors.2c01847

Hordeum vulgare ethanolic extract mitigates high salt-induced cerebellum damage via attenuation of oxidative stress, neuroinflammation, and neurochemical alterations in hypertensive rats

O. A. Ahmed-Farid, Areeg M. Abdelrazek, Hend Elwakel and Maha M. Mohamed

Metab Brain Dis, 2023, 38, 2427
DOI: 10.1007/s11011-023-01277-5

Protective effect of oral histidine on hypertension in Dahl salt-sensitive rats induced by high-salt diet

Pengfei Yang, Xinrui Zhao, Luxin Zhou, Yuexin Jin, Xuewei Zheng, Yanan Ouyang, Meng Chen, Li Zeng, Sa Chen, Xiangbo Chen and Zhongmin Tian

Life Sciences, 2021, 270, 119134
DOI: 10.1016/j.lfs.2021.119134

β-Aminoisobutyric acid supplementation attenuated salt-sensitive hypertension in Dahl salt-sensitive rats through prevention of insufficient fumarase

Xuewei Zheng, Luxin Zhou, Yuexin Jin, Xinrui Zhao, Hussain Ahmad, Yanan OuYang, Sa Chen, Jie Du, Xiangbo Chen, Lan Chen, Di Gao, Zhe Yang and Zhongmin Tian

Amino Acids, 2022, 54, 169
DOI: 10.1007/s00726-021-03092-7

Effects of different pretreatments on physicochemical properties and phenolic compounds of hawthorn wine

Jiechao Liu, Wenbo Yang, Zhenzhen Lv, Hui Liu, Chunling Zhang and Zhonggao Jiao

CyTA - Journal of Food, 2020, 18, 518
DOI: 10.1080/19476337.2020.1791962

Application of metabolomics for revealing the interventional effects of functional foods on metabolic diseases

Jia Fu, Le-Le Zhang, Wei Li, Yan Zhang, Yamei Zhang, Fang Liu and Liang Zou

Food Chemistry, 2022, 367, 130697
DOI: 10.1016/j.foodchem.2021.130697

High-Salt Diet in the Pre- and Postweaning Periods Leads to Amygdala Oxidative Stress and Changes in Locomotion and Anxiety-Like Behaviors of Male Wistar Rats

Pedro Ernesto de Pinho Tavares Leal, Alexandre Alves da Silva, Arthur Rocha-Gomes, Tania Regina Riul, Rennan Augusto Cunha, Christoph Reichetzeder and Daniel Campos Villela

Front. Behav. Neurosci., 2022, 15
DOI: 10.3389/fnbeh.2021.779080

Identification and phylogenetic analysis of five Crataegus species (Rosaceae) based on complete chloroplast genomes

Liwei Wu, Yingxian Cui, Qing Wang, Zhichao Xu, Yu Wang, Yulin Lin, Jingyuan Song and Hui Yao

Planta, 2021, 254
DOI: 10.1007/s00425-021-03667-4

Dietary vitamin E and selenium supplementation improve hematological responses and productivity of growing goats consuming diluted seawater under tropical conditions

Nguyen Thiet, Nguyen Thanh, Nguyen Trong Ngu, Narongsak Chaiyabutr and Sumpun Thammacharoen

Vet. World, 2026, 481
DOI: 10.14202/vetworld.2026.481-492

Na+/K+-ATPase Alpha 2 Isoform Elicits Rac1-Dependent Oxidative Stress and TLR4-Induced Inflammation in the Hypothalamic Paraventricular Nucleus in High Salt-Induced Hypertension

Qing Su, Xiao-Jing Yu, Xiao-Min Wang, Bo Peng, Juan Bai, Hong-Bao Li, Ying Li, Wen-Jie Xia, Li-Yan Fu, Kai-Li Liu, Jin-Jun Liu and Yu-Ming Kang

Antioxidants, 2022, 11, 288
DOI: 10.3390/antiox11020288

Food Applications and Potential Health Benefits of Hawthorn

Juan Zhang, Xiaoyun Chai, Fenglan Zhao, Guige Hou and Qingguo Meng

Foods, 2022, 11, 2861
DOI: 10.3390/foods11182861

Preventive Potential of the Aqueous Extract of the Mixture of Bidens pilosa (Asteraceae) and Cymbopogon citratus (Poaceae) Aerial Parts on Hypertension Induced by a Chronic Salt and Alcohol Consumption on the Rats

Yannick Carlos Tcheutchoua, Danielle Claude Bilanda, Paul Désiré Djomeni Dzeufiet, Oriane Corine Djunie Neali, Pascal Emmanuel Owona, Ronald à Goufani Bidingha, Rodrigue Fifen Ngapout, Lohik Nguegan Mbolang, Michel Noubom, Théophile Dimo, Pierre Kamtchouing and Azizah Ugusman

Evidence-Based Complementary and Alternative Medicine, 2022, 2022, 1
DOI: 10.1155/2022/1980622

Extraction Method Optimization and Comparison of Flavonoids in 15 Chinese Hawthorn Germplasms and Their Correlations With Antioxidant Activity

Jia’ao Wang, Qiong Lin, Jiaxin Wang, Yuting Huang, Wei Wang, Shihe Lin, Muhammad Azam, Jia Yao and El Hassan Sakar

Journal of Food Quality, 2025, 2025
DOI: 10.1155/jfq/1208832

Metabolic effect of AOS-iron in rats with iron deficiency anemia using LC-MS/MS based metabolomics

Hong He, Fengping An, Qun Huang, Yuting Kong, Dan He, Lei Chen and Hongbo Song

Food Research International, 2020, 130, 108913
DOI: 10.1016/j.foodres.2019.108913