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Interactions between mitochondria-damaging platinum(iv) prodrugs and cytochrome c
Amarasooriya M. D. S. Jayawardhana and Yao-Rong Zheng
Dalton Trans., 2022, 51, 2012
DOI: 10.1039/D1DT03875C

Unlocking the potential of platinum drugs: organelle-targeted small-molecule platinum complexes for improved anticancer performance
Zhiqin Deng, Shu Chen, Gongyuan Liu and Guangyu Zhu
RSC Chem. Biol., 2023, 4, 1003
DOI: 10.1039/D3CB00087G

Synthesis of monofunctional platinum(iv) carboxylate precursors for use in Pt(iv)–peptide bioconjugates
Dariusz Śmiłowicz and Nils Metzler-Nolte
Dalton Trans., 2018, 47, 15465
DOI: 10.1039/C8DT03082K

Platinum(iv) combo prodrugs containing cyclohexane-1R,2R-diamine, valproic acid, and perillic acid as a multiaction chemotherapeutic platform for colon cancer
Elisabetta Gabano, Marzia Bruna Gariboldi, Emanuela Marras, Francesca Barbato and Mauro Ravera
Dalton Trans., 2023, 52, 11349
DOI: 10.1039/D3DT01876H

Fatty acid-like Pt(iv) prodrugs overcome cisplatin resistance in ovarian cancer by harnessing CD36
Amarasooriya M. D. S. Jayawardhana, Morgan Stilgenbauer, Payel Datta, Zihan Qiu, Sarine Mckenzie, Han Wang, David Bowers, Manabu Kurokawa and Yao-Rong Zheng
Chem. Commun., 2020, 56, 10706
DOI: 10.1039/D0CC02174A

Structure elucidation and quantification of the reduction products of anticancer Pt(iv) prodrugs by electrochemistry/mass spectrometry (EC-MS)
L. M. Frensemeier, J. Mayr, G. Koellensperger, B. K. Keppler, C. R. Kowol and U. Karst
Analyst, 2018, 143, 1997
DOI: 10.1039/C8AN00258D

Synthesis and characterization of cyclohexane-1R,2R-diamine-based Pt(iv) dicarboxylato anticancer prodrugs: their selective activity against human colon cancer cell lines
E. Gabano, M. Ravera, E. Perin, I. Zanellato, B. Rangone, M. J. McGlinchey and D. Osella
Dalton Trans., 2019, 48, 435
DOI: 10.1039/C8DT03950J

Multifunctional Pt(iv) prodrug candidates featuring the carboplatin core and deferoxamine
Sophia Harringer, Michaela Hejl, Éva A. Enyedy, Michael A. Jakupec, Mathea S. Galanski, Bernhard K. Keppler, Paul J. Dyson and Hristo P. Varbanov
Dalton Trans., 2021, 50, 8167
DOI: 10.1039/D1DT00214G

Advances in technical strategies for monitoring the reduction of platinum(iv) complexes
Shu Chen, Qiyuan Zhou, Ka-Yan Ng, Zoufeng Xu, Weikang Xu and Guangyu Zhu
Inorg. Chem. Front., 2024, 11, 3085
DOI: 10.1039/D4QI00459K

Engineering liposomal nanoparticles of cholesterol-tethered amphiphilic Pt(iv) prodrugs with prolonged circulation time in blood
Payel Datta, Scott Bang, Zhizhou Yue, Travis Beach, Morgan Stilgenbauer, Han Wang, David J. Bowers, Manabu Kurokawa, Haihua Xiao and Yao-Rong Zheng
Dalton Trans., 2020, 49, 8107
DOI: 10.1039/D0DT01297A

Alternative mechanism of action of the DNP PtIV prodrug: intracellular cisplatin release and the mitochondria-mediated apoptotic pathway
Olga Krasnovskaya, Daniil Spector, Alexander Erofeev, Peter Gorelkin, Roman Akasov, Dmitry Skvortsov, Alexander Trigub, Ksenia Vlasova, Alevtina Semkina, Nikolay Zyk, Elena Beloglazkina and Alexander Majouga
Dalton Trans., 2021, 50, 7922
DOI: 10.1039/D1DT00898F

Synthesis, characterization and biological activity of new cyclometallated platinum(iv) iodido complexes
Emma Bauer, Xavier Domingo, Cristina Balcells, Ibrahim H. Polat, Margarita Crespo, Josefina Quirante, Josefa Badía, Laura Baldomà, Mercè Font-Bardia and Marta Cascante
Dalton Trans., 2017, 46, 14973
DOI: 10.1039/C7DT03448B

Complexes of oxoplatin with rhein and ferulic acid ligands as platinum(iv) prodrugs with high anti-tumor activity
Ming-Xiong Tan, Zhen-Feng Wang, Qi-Pin Qin, Bi-Qun Zou and Hong Liang
Dalton Trans., 2020, 49, 1613
DOI: 10.1039/C9DT04594E

Platinum-based chemotherapyviananocarriers and co-delivery of multiple drugs
Caihong Xian, Haolin Chen, Fei Xiong, Yifen Fang, Hai Huang and Jun Wu
Biomater. Sci., 2021, 9, 6023
DOI: 10.1039/D1BM00879J

An erythrocyte-delivered photoactivatable oxaliplatin nanoprodrug for enhanced antitumor efficacy and immune response
Na Wang, Zhiqin Deng, Qi Zhu, Jianxiong Zhao, Kai Xie, Peng Shi, Zhigang Wang, Xianfeng Chen, Feng Wang, Jiahai Shi and Guangyu Zhu
Chem. Sci., 2021, 12, 14353
DOI: 10.1039/D1SC02941J

Tumor-targeted dual-action NSAID-platinum(iv) anticancer prodrugs
Alexander Kastner, Theresa Mendrina, Florian Bachmann, Walter Berger, Bernhard K. Keppler, Petra Heffeter and Christian R. Kowol
Inorg. Chem. Front., 2023, 10, 4126
DOI: 10.1039/D3QI00968H

Effect of chirality on the anticancer activity of Pt(ii) and Pt(iv) complexes containing 1R,2R and 1S,2S enantiomers of the trans-1,2-diamino-4-cyclohexene ligand (DACHEX), an analogue of diaminocyclohexane used in oxaliplatin
Paride Papadia, Alessandra Barbanente, Nicoletta Ditaranto, James D. Hoeschele, Giovanni Natile, Cristina Marzano, Valentina Gandin and Nicola Margiotta
Dalton Trans., 2021, 50, 15655
DOI: 10.1039/D1DT02255E

Emerging platinum(iv) prodrugs to combat cisplatin resistance: from isolated cancer cells to tumor microenvironment
Zhigang Wang, Zhiqin Deng and Guangyu Zhu
Dalton Trans., 2019, 48, 2536
DOI: 10.1039/C8DT03923B

How to obtain Pt(iv) complexes suitable for conjugation to nanovectors from the oxidation of [PtCl(terpyridine)]+
E. Gabano, E. Perin, C. Fielden, J. A. Platts, A. Gallina, B. Rangone and M. Ravera
Dalton Trans., 2017, 46, 10246
DOI: 10.1039/C7DT01706E

Application of the anthraquinone drug rhein as an axial ligand in bifunctional Pt(iv) complexes to obtain antiproliferative agents against human glioblastoma cells
Elisabetta Gabano, Marzia Bruna Gariboldi, Giulia Caron, Giuseppe Ermondi, Emanuela Marras, Maura Vallaro and Mauro Ravera
Dalton Trans., 2022, 51, 6014
DOI: 10.1039/D2DT00235C

Metallodrugs in cancer nanomedicine
Quim Peña, Alec Wang, Orysia Zaremba, Yang Shi, Hans W. Scheeren, Josbert M. Metselaar, Fabian Kiessling, Roger M. Pallares, Stefan Wuttke and Twan Lammers
Chem. Soc. Rev., 2022, 51, 2544
DOI: 10.1039/D1CS00468A

The influence of different carbonate ligands on the hydrolytic stability and reduction of platinum(iv) prodrugs
Shu Chen, Ka-Yan Ng, Qiyuan Zhou, Houzong Yao, Zhiqin Deng, Man-Kit Tse and Guangyu Zhu
Dalton Trans., 2022, 51, 885
DOI: 10.1039/D1DT03959H

Disruption of lipid metabolism to induce ferroptosis using multifunctional fibrate-Pt(iv) prodrugs for cancer treatment
Peng Sun, Jia-Qian Wang, Qiang Xie, Xuan-Lin Ren, Xin Qiao and Jing-Yuan Xu
Inorg. Chem. Front., 2024, 11, 2914
DOI: 10.1039/D4QI00386A

A computational mechanistic investigation into the reduction of Pt(iv) prodrugs with two axial chlorides by biological reductants
Zeinab Ejehi and Alireza Ariafard
Chem. Commun., 2017, 53, 1413
DOI: 10.1039/C6CC07834F

Anionic cyclometalated Pt(ii) and Pt(iv) complexes respectively bearing one or two 1,2-benzenedithiolate ligands
Andreea Ionescu, Nicolas Godbert, Iolinda Aiello, Loredana Ricciardi, Massimo La Deda, Alessandra Crispini, Emilia Sicilia and Mauro Ghedini
Dalton Trans., 2018, 47, 11645
DOI: 10.1039/C8DT02444H

Cis,cis,trans-[PtIVCl2(NH3)2(perillato)2], a dual-action prodrug with excellent cytotoxic and antimetastatic activity
Mauro Ravera, Elisabetta Gabano, Ilaria Zanellato, Beatrice Rangone, Elena Perin, Beatrice Ferrari, Maria Grazia Bottone and Domenico Osella
Dalton Trans., 2021, 50, 3161
DOI: 10.1039/D0DT04051G

Ruthenium(ii) arene NSAID complexes: inhibition of cyclooxygenase and antiproliferative activity against cancer cell lines
Poulami Mandal, Bidyut Kumar Kundu, Komal Vyas, Vidya Sabu, A. Helen, Sandeep Singh Dhankhar, C. M. Nagaraja, Debojit Bhattacherjee, Krishna Pada Bhabak and Suman Mukhopadhyay
Dalton Trans., 2018, 47, 517
DOI: 10.1039/C7DT03637J

Cisplatin−cyclooxygenase inhibitor conjugates, free and immobilised in mesoporous silica SBA-15, prove highly potent against triple-negative MDA-MB-468 breast cancer cell line
Ivana Predarska, Mohamad Saoud, Ibrahim Morgan, Thomas Eichhorn, Goran N. Kaluđerović and Evamarie Hey-Hawkins
Dalton Trans., 2022, 51, 857
DOI: 10.1039/D1DT03265H

An albumin-based tumor-targeted oxaliplatin prodrug with distinctly improved anticancer activity in vivo
Josef Mayr, Petra Heffeter, Diana Groza, Luis Galvez, Gunda Koellensperger, Alexander Roller, Beatrix Alte, Melanie Haider, Walter Berger, Christian R. Kowol and Bernhard K. Keppler
Chem. Sci., 2017, 8, 2241
DOI: 10.1039/C6SC03862J

Stepwise optimization of tumor-targeted dual-action platinum(iv)-gemcitabine prodrugs
Alexander Kastner, Theresa Mendrina, Tomer Babu, Subhendu Karmakar, Isabella Poetsch, Walter Berger, Bernhard K. Keppler, Dan Gibson, Petra Heffeter and Christian R. Kowol
Inorg. Chem. Front., 2024, 11, 534
DOI: 10.1039/D3QI02032K

On the hydrolytic stability of unsymmetric platinum(iv) anticancer prodrugs containing axial halogens
Zoufeng Xu, Wai Kit Tang, Qiyuan Zhou, Shu Chen, Chi-Kit Siu and Guangyu Zhu
Inorg. Chem. Front., 2021, 8, 3794
DOI: 10.1039/D1QI00208B

Design, synthesis and biological evaluation of dihydro-2-quinolone platinum(iv) hybrids as antitumor agents displaying mitochondria injury and DNA damage mechanism
Zhifang Liu, Zuojie Li, Tao Du, Yan Chen, Qingpeng Wang, Guoshuai Li, Min Liu, Ning Zhang, Dacheng Li and Jun Han
Dalton Trans., 2021, 50, 362
DOI: 10.1039/D0DT03194A

Synthesis, structures and cytotoxic effects in vitro of cis- and trans-[PtIVCl4(NHC)2] complexes and their PtII precursors
Tobias Rehm, Matthias Rothemund, Thomas Dietel, Rhett Kempe and Rainer Schobert
Dalton Trans., 2019, 48, 16358
DOI: 10.1039/C9DT02438G

Novel oxaliplatin(iv) complexes conjugated with ligands bearing pendant 1,2-dithiolane/1,2-diselenolane/cyclopentyl motifs
Xiao Liu, Dominik Wenisch, Marie-Christin Barth, Klaudia Cseh, Christian R. Kowol, Michael A. Jakupec, Dan Gibson, Bernhard K. Keppler and Wolfgang Weigand
Dalton Trans., 2022, 51, 16824
DOI: 10.1039/D2DT02217F

The impact of whole human blood on the kinetic inertness of platinum(iv) prodrugs – an HPLC-ICP-MS study
Sarah Theiner, Márkó Grabarics, Luis Galvez, Hristo P. Varbanov, Nadine S. Sommerfeld, Mathea S. Galanski, Bernhard K. Keppler and Gunda Koellensperger
Dalton Trans., 2018, 47, 5252
DOI: 10.1039/C7DT04537A

Autophagy-targeted Pt(iv) agents: a new horizon in antitumor drug development
Suying Li, Yan Chen, Shuaiqi Feng, Zhifang Liu, Linling Gan and Qingpeng Wang
Dalton Trans., 2025, 54, 1770
DOI: 10.1039/D4DT03162H

Coupling approaches for [Pt(1,10-phenanthroline)(1S,2S-diamminocyclohexane)dihydroxide]2+ using hydrazone and oxime ligation
Ashley Jurisinec, Jennette Sakoff, Jayne Gilbert, Christopher P. Gordon and Janice R. Aldrich-Wright
Dalton Trans., 2025, 54, 7105
DOI: 10.1039/D5DT00303B

Flavin-mediated photoactivation of Pt(iv) anticancer complexes: computational insights on the catalytic mechanism
Stefano Scoditti, Eslam Dabbish, German E. Pieslinger, Elixabete Rezabal, Xabier Lopez, Emilia Sicilia and Luca Salassa
Phys. Chem. Chem. Phys., 2022, 24, 5323
DOI: 10.1039/D1CP05507K

Flavoplatins: photoactivated platinum(iv) prodrugs bearing axial N-donors that trigger pyroptosis and reduce drug resistance
Qiyuan Zhou, Nang-Hei Chu, Jiaqian Xu, Kwok-Chung Law and Guangyu Zhu
Inorg. Chem. Front., 2026
DOI: 10.1039/D6QI00078A

A platinum-based fluorescent “turn on” sensor to decipher the reduction of platinum(iv) prodrugs
Houzong Yao and Guangyu Zhu
Dalton Trans., 2022, 51, 5394
DOI: 10.1039/D2DT00124A

Synthesis and antiproliferative activity of a series of new platinum and palladium diphosphane complexes
Carleen Cullinane, Glen B. Deacon, Penny R. Drago, Anja P. Erven, Peter C. Junk, Jenny Luu, Gerd Meyer, Simon Schmitz, Ingo Ott, Julia Schur, Lorraine K. Webster and Axel Klein
Dalton Trans., 2018, 47, 1918
DOI: 10.1039/C7DT04615D

Exploring diversity in platinum(iv) N-heterocyclic carbene complexes: synthesis, characterization, reactivity and biological evaluation
Mathilde Bouché, Antoine Bonnefont, Thierry Achard and Stéphane Bellemin-Laponnaz
Dalton Trans., 2018, 47, 11491
DOI: 10.1039/C8DT02113A

A chemical perspective on the clinical use of platinum-based anticancer drugs
Shoohb Alassadi, Michelle J. Pisani and Nial J. Wheate
Dalton Trans., 2022, 51, 10835
DOI: 10.1039/D2DT01875F

An unsymmetric cisplatin-based Pt(iv) derivative containing 2-(2-propynyl)octanoate: a very efficient multi-action antitumor prodrug candidate
Elisabetta Gabano, Mauro Ravera, Ilaria Zanellato, Stefano Tinello, Andrea Gallina, Beatrice Rangone, Valentina Gandin, Cristina Marzano, Maria Grazia Bottone and Domenico Osella
Dalton Trans., 2017, 46, 14174
DOI: 10.1039/C7DT02928D

Cisplatin and valproate released from the bifunctional [Pt(IV)Cl2(NH3)2(valproato)2] antitumor prodrug or from liposome formulations: who does what?
M. Ravera, E. Gabano, I. Zanellato, A. Gallina, E. Perin, A. Arrais, S. Cantamessa and D. Osella
Dalton Trans., 2017, 46, 1559
DOI: 10.1039/C6DT03749F

Reprogramming axial ligands facilitates the self-assembly of a platinum(iv) prodrug: overcoming drug resistance and saferin vivodelivery of cisplatin
Tao Fang, Zhijian Ye, Jiaping Wu and Hangxiang Wang
Chem. Commun., 2018, 54, 9167
DOI: 10.1039/C8CC03763A

Novel recognition mechanism based on oxidative addition of Pt(ii) complex-based luminescent probes for hypochlorite ion detection
Jingjie Tang, Guoxun Zhu, Peng Li, Pingjun Zhang, Fang Peng and Fei Meng
Analyst, 2021, 146, 5691
DOI: 10.1039/D1AN01048D

Exploring the effect of the axial ligands on the anticancer activity of [C,N,N′] Pt(iv) cyclometallated compounds
Ariadna Lázaro, Ramón Bosque, Silvia Marín, Raúl Pérez-León, Josefa Badia, Laura Baldomà, Laura Rodríguez, Margarita Crespo and Marta Cascante
Dalton Trans., 2024, 53, 13030
DOI: 10.1039/D4DT01225A

Synthesis, characterization and in vitro and in vivo anticancer activity of Pt(iv) derivatives of [Pt(1S,2S-DACH)(5,6-dimethyl-1,10-phenanthroline)]
Benjamin W. J. Harper, Emanuele Petruzzella, Roman Sirota, Fernanda Fabiola Faccioli, Janice R. Aldrich-Wright, Valentina Gandin and Dan Gibson
Dalton Trans., 2017, 46, 7005
DOI: 10.1039/C7DT01054K

The Platin-X series: activation, targeting, and delivery
Uttara Basu, Bhabatosh Banik, Ru Wen, Rakesh K. Pathak and Shanta Dhar
Dalton Trans., 2016, 45, 12992
DOI: 10.1039/C6DT01738J

A cancer specific oxaliplatin-releasing Pt(iv)-prodrug
Viktor Reshetnikov, Anton Arkhypov, Purushottam Reddy Julakanti and Andriy Mokhir
Dalton Trans., 2018, 47, 6679
DOI: 10.1039/C8DT01458B

Reduction of a platinum(iv) prodrug model by sulfur containing biological reductants: computational mechanistic elucidation
Antony Chipman, Brian F. Yates, Allan J. Canty and Alireza Ariafard
Chem. Commun., 2018, 54, 10491
DOI: 10.1039/C8CC05682J

Necrosis inducing tetranuclear Ru(ii)–Re(i) metal complex for anticancer therapy
Julia Schleisiek, Eleni Michaltsis, Stephan Mayer, Nicolás Montesdeoca and Johannes Karges
Dalton Trans., 2025, 54, 942
DOI: 10.1039/D4DT02992E

Synthesis of 2-deoxy-d-glucose coated Fe3O4 nanoparticles for application in targeted delivery of the Pt(iv) prodrug of cisplatin – a novel approach in chemotherapy
K. Shitaljit Sharma, Akhil K. Dubey, Arunkumar S. Koijam, Chandan Kumar, Anand Ballal, Sudip Mukherjee, Prasad P. Phadnis and Rajesh K. Vatsa
New J. Chem., 2020, 44, 13863
DOI: 10.1039/C9NJ05989J

Photochemistry and in vitro anticancer activity of Pt(iv)Re(i) conjugates
Zhouyang Huang, A. Paden King, James Lovett, Barry Lai, Joshua J. Woods, Hugh H. Harris and Justin J. Wilson
Chem. Commun., 2021, 57, 11189
DOI: 10.1039/D1CC04669A

Cisplatin and zoledronic acid: two drugs combined in a Pt(ii) complex with potential antitumor activity towards bone tumors and metastases
Alessandra Barbanente, Nicoletta Ditaranto, Antonio Laghezza, Paolo Tortorella, Francesco P. Intini, Concetta Pacifico, Giovanni Natile and Nicola Margiotta
Dalton Trans., 2023, 52, 6117
DOI: 10.1039/D3DT00734K

The cisplatin-based Pt(iv)-diclorofibrato multi-action anticancer prodrug exhibits excellent performances also under hypoxic conditions
Elisabetta Gabano, Mauro Ravera, Francesca Trivero, Stefano Tinello, Andrea Gallina, Ilaria Zanellato, Marzia B. Gariboldi, Elena Monti and Domenico Osella
Dalton Trans., 2018, 47, 8268
DOI: 10.1039/C7DT04614F

Pt(ii) and Pt(iv) complexes with a major component of royal jelly as innovative antitumor drug candidates
Alessandra Barbanente, Valentina Gandin, Chiara Donati, Carmela Ilaria Pierro, Giovanni Natile and Nicola Margiotta
New J. Chem., 2023, 47, 18386
DOI: 10.1039/D3NJ03617K

Synthesis, characterization and biological activity of new cyclometallated platinum(iv) complexes containing a para-tolyl ligand
Mònica Solé, Cristina Balcells, Margarita Crespo, Josefina Quirante, Josefa Badia, Laura Baldomà, Mercè Font-Bardia and Marta Cascante
Dalton Trans., 2018, 47, 8956
DOI: 10.1039/C8DT01124A

Platinum(iv) N-heterocyclic carbene complexes: their synthesis, characterisation and cytotoxic activity
M. Bouché, G. Dahm, M. Wantz, S. Fournel, T. Achard and S. Bellemin-Laponnaz
Dalton Trans., 2016, 45, 11362
DOI: 10.1039/C6DT01846G

Fluorogenic platinum(iv) complexes as potential predictors for the design of hypoxia-activated platinum(iv) prodrugs
Jevon W. Marsh, Lina Hacker, Shitong Huang, Marie H. C. Boulet, Jhanelle R. G. White, Louise A. W. Martin, Megan A. Yeomans, Hai-Hao Han, Ismael Diez-Perez, Rebecca A. Musgrave, Ester M. Hammond and Adam C. Sedgwick
Dalton Trans., 2024, 53, 14811
DOI: 10.1039/D4DT02173H

The current status in computational exploration of Pt(iv) prodrug activation by reduction
Fortuna Ponte, Stefano Scoditti, Gloria Mazzone and Emilia Sicilia
Phys. Chem. Chem. Phys., 2023, 25, 15586
DOI: 10.1039/D3CP01150J

Synthesis and characterization of thiocarbonato-linked platinum(iv) complexes
Marie-Christin Barth, Stefanie Lange, Norman Häfner, Nico Ueberschaar, Helmar Görls, Ingo B. Runnebaum and Wolfgang Weigand
Dalton Trans., 2022, 51, 5567
DOI: 10.1039/D2DT00318J

Pt(iv) antitumor prodrugs: dogmas, paradigms, and realities
Mauro Ravera, Elisabetta Gabano, Michael J. McGlinchey and Domenico Osella
Dalton Trans., 2022, 51, 2121
DOI: 10.1039/D1DT03886A

Reactions of a photoactivatable diazido Pt(iv) anticancer complex with a single-stranded oligodeoxynucleotide
Zujun Liang, Jiafan Lin, Xianxian Gong, Yiyu Cheng, Chao Huang, Jishuai Zhang, Xiaoqin Wu, Fuyi Wang, Yao Zhao and Kui Wu
Dalton Trans., 2020, 49, 11249
DOI: 10.1039/D0DT02208J

Is antitumor Pt(IV) complex containing two axial lonidamine ligands a true dual- or multi-action prodrug?
Jana Kasparkova, Hana Kostrhunova, Vojtech Novohradsky, Lili Ma, Guangyu Zhu, Elena R Milaeva, Alexender A Shtill, Robin Vinck, Gilles Gasser, Viktor Brabec and Alexey A Nazarov
Metallomics, 2022, 14
DOI: 10.1093/mtomcs/mfac048

A view on multi-action Pt(IV) antitumor prodrugs
Mauro Ravera, Elisabetta Gabano, Michael J. McGlinchey and Domenico Osella
Inorganica Chimica Acta, 2019, 492, 32
DOI: 10.1016/j.ica.2019.04.025

Impact of the equatorial coordination sphere on the rate of reduction, lipophilicity and cytotoxic activity of platinum(IV) complexes
Doris Höfer, Hristo P. Varbanov, Michaela Hejl, Michael A. Jakupec, Alexander Roller, Mathea S. Galanski and Bernhard K. Keppler
Journal of Inorganic Biochemistry, 2017, 174, 119
DOI: 10.1016/j.jinorgbio.2017.06.005

Crystal structure, optical properties, spectroscopic characterization and density functional theory studies of a new rhodium(i)-imidazolidin-2-ylidene complexes: Synthesis, characterization and cytotoxic properties
Emine Özge Karaca, Osman Çiftçi, İlknur Özdemir, Hande Karabıyık, Hasan Karabıyık, Nevin Gürbüz, İsmail Özdemir, Lamjed Mansour, Arfaoui Youssef and Naceur Hamdi
Inorganica Chimica Acta, 2022, 537, 120936
DOI: 10.1016/j.ica.2022.120936

Tuning the Optical Properties of Phenanthriplatin: Towards New Photoactivatable Analogues
José Pedro Cerón‐Carrasco and Denis Jacquemin
ChemPhotoChem, 2017, 1, 504
DOI: 10.1002/cptc.201700090

A Pt(IV) Prodrug Combining Chlorambucil and Cisplatin: A Dual-Acting Weapon for Targeting DNA in Cancer Cells
Diego Montagner, Dina Tolan, Emma Andriollo, Valentina Gandin and Cristina Marzano
IJMS, 2018, 19, 3775
DOI: 10.3390/ijms19123775

Cyclometallated platinum(IV) compounds as promising antitumour agents
Margarita Crespo
Journal of Organometallic Chemistry, 2019, 879, 15
DOI: 10.1016/j.jorganchem.2018.10.008

Antiproliferative Activity of Pt(IV) Conjugates Containing the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Ketoprofen and Naproxen †
Mauro Ravera, Ilaria Zanellato, Elisabetta Gabano, Elena Perin, Beatrice Rangone, Marco Coppola and Domenico Osella
IJMS, 2019, 20, 3074
DOI: 10.3390/ijms20123074

An Anticancer PtIV Prodrug That Acts by Mechanisms Involving DNA Damage and Different Epigenetic Effects
Hana Kostrhunova, Emanuele Petruzzella, Dan Gibson, Jana Kasparkova and Viktor Brabec
Chemistry A European J, 2019, 25, 5235
DOI: 10.1002/chem.201805626

Zwitterionic Ru(III) Complexes: Stability of Metal–Ligand Bond and Host–Guest Binding with Cucurbit[7]uril
Sanaz Malali, Jan Chyba, Michal Knor, Michal Horní, Marek Nečas, Jan Novotný and Radek Marek
Inorg. Chem., 2020, 59, 10185
DOI: 10.1021/acs.inorgchem.0c01328

19F NMR Allows the Investigation of the Fate of Platinum(IV) Prodrugs in Physiological Conditions
Siming Yuan, Yang Zhu, Yi Dai, Yu Wang, Duo Jin, Manman Liu, Liqin Tang, Fabio Arnesano, Giovanni Natile and Yangzhong Liu
Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202114250

Rate-Tunable, Metal-Mediated Amide Bond Cleavage for the Controlled Release of Pharmaceuticals
Zhuoran Zhong, Dariusz Śmiłowicz, Mallory J. Gork, Leah C. Garman, Ilia A. Guzei and Eszter Boros
J. Am. Chem. Soc., 2025
DOI: 10.1021/jacs.5c13166

Trans-palladium complexes with 1-adamantanamine and various halide ions: Synthesis, characterization, DNA and protein binding and in vitro cytotoxicity
Jan Svoboda, Aram Zolal, František Králík, Václav Eigner, Tomáš Ruml, Jaroslav Zelenka and Kamila Syslová
Polyhedron, 2021, 209, 115458
DOI: 10.1016/j.poly.2021.115458

Formulations of highly antiproliferative hydrophobic Pt(IV) complexes into lipidic nanoemulsions as delivery vehicles
Elisabetta Gabano, Chiara Ferraris, Domenico Osella, Luigi Sebastiano Battaglia and Mauro Ravera
Inorganica Chimica Acta, 2022, 535, 120859
DOI: 10.1016/j.ica.2022.120859

Terpyridyl oxovanadium(IV) complexes for DNA crosslinking and mito-targeted photocytotoxicity
Arun Kumar, Ila Pant, Akanksha Dixit, Samya Banerjee, Bhabatosh Banik, Rupak Saha, Paturu Kondaiah and Akhil R. Chakravarty
Journal of Inorganic Biochemistry, 2017, 174, 45
DOI: 10.1016/j.jinorgbio.2017.05.015

Protonation of Pt(IV) Anticancer Complexes Assayed by Vibrational Ion Spectroscopy
Davide Corinti, Elisabetta Gabano, Barbara Chiavarino, Maria Elisa Crestoni, Domenico Osella and Simonetta Fornarini
ChemPlusChem, 2025, 90
DOI: 10.1002/cplu.202400754

BODI-Pt, a Green-Light-Activatable and Carboplatin-Based Platinum(IV) Anticancer Prodrug with Enhanced Activation and Cytotoxicity
Houzong Yao, Shu Chen, Zhiqin Deng, Man-Kit Tse, Yudai Matsuda and Guangyu Zhu
Inorg. Chem., 2020, 59, 11823
DOI: 10.1021/acs.inorgchem.0c01880

Biodegradable Polymeric Delivery Systems of Ruthenium(II) Polypyridyl Complexes for the Treatment of High-Grade Epithelial Ovarian Cancer
Marta Redrado, Kanokon Upitak, Fariba Nemati, Pierre Mesdom, Giulia Salluce, Fan Sun, Carine Robert, Olivier Blacque, Didier Decaudin, Christophe M. Thomas and Gilles Gasser
Chem. Mater., 2025, 37, 9231
DOI: 10.1021/acs.chemmater.5c02113

Study on the Mechanism of Action of the Pt(IV) Complex with Lonidamine Ligands by Ultrafast Chemical Proteomics
Ekaterina A. Imaikina, Ivan I. Fedorov, Daria D. Emekeeva, Elizaveta M. Kazakova, Leyla A. Garibova, Mark V. Ivanov, Ilya A. Shutkov, Alexey A. Nazarov, Mikhail V. Gorshkov and Irina A. Tarasova
ACS Pharmacol. Transl. Sci., 2025, 8, 1106
DOI: 10.1021/acsptsci.4c00718

Biodistribution and efficacy of the anticancer drug, oxaliplatin palmitate acetate, in mice
Nikhil Biswas, Aiman Abu Ammar, Marina Frušić-Zlotkin, Naama Adi-Hen, Yonat Lehman-Katabi, Yael Levi-Kalisman, Taher Nassar and Simon Benita
International Journal of Pharmaceutics, 2021, 604, 120740
DOI: 10.1016/j.ijpharm.2021.120740

Oral Anticancer Heterobimetallic PtIV−AuIComplexes Show High In Vivo Activity and Low Toxicity
Tomer Babu, Hiba Ghareeb, Uttara Basu, Hemma Schueffl, Sarah Theiner, Petra Heffeter, Gunda Koellensperger, Norman Metanis, Valentina Gandin, Ingo Ott, Claudia Schmidt and Dan Gibson
Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202217233

A Quadruple‐Action Platinum(IV) Prodrug with Anticancer Activity Against KRAS Mutated Cancer Cell Lines
Emanuele Petruzzella, Jeremy Phillip Braude, Janice R. Aldrich‐Wright, Valentina Gandin and Dan Gibson
Angew Chem Int Ed, 2017, 56, 11539
DOI: 10.1002/anie.201706739

Recent Advances in Light-Controlled Activation of Pt(IV) Prodrugs
Daniil Spector, Kirill Pavlov, Elena Beloglazkina and Olga Krasnovskaya
IJMS, 2022, 23, 14511
DOI: 10.3390/ijms232314511

Mono-functionalized glycosylated platinum(IV) complexes possessed both pH and redox dual-responsive properties: Exhibited enhanced safety and preferentially accumulated in cancer cells in vitro and in vivo
Jing Ma, Xiande Yang, Wenpei Hao, Zhonglv Huang, Xin Wang and Peng George Wang
European Journal of Medicinal Chemistry, 2017, 128, 45
DOI: 10.1016/j.ejmech.2017.01.032

A New Manganese Superoxide Dismutase Mimetic Improves Oxaliplatin-Induced Neuropathy and Global Tolerance in Mice
Caroline Prieux-Klotz, Henri Chédotal, Martha Zoumpoulaki, Sandrine Chouzenoux, Charlotte Chêne, Alvaro Lopez-Sanchez, Marine Thomas, Priya Ranjan Sahoo, Clotilde Policar, Frédéric Batteux, Hélène C. Bertrand, Carole Nicco and Romain Coriat
IJMS, 2022, 23, 12938
DOI: 10.3390/ijms232112938

Overcoming Cancer Resistance to Platinum Drugs by Inhibiting Cholesterol Metabolism
Ying Wang, Linxiang Cai, Hui Li, Hanhua Chen, Tao Yang, Yehong Tan, Zijian Guo and Xiaoyong Wang
Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202309043

Synthesis, Characterization and Biological Investigation of the Platinum(IV) Tolfenamato Prodrug–Resolving Cisplatin-Resistance in Ovarian Carcinoma Cell Lines
Marie-Christin Barth, Norman Häfner, Ingo B. Runnebaum and Wolfgang Weigand
IJMS, 2023, 24, 5718
DOI: 10.3390/ijms24065718

Crizotinib- or Ceritinib-Conjugated Platinum(IV) Prodrugs As Potent Multiaction Agents Inducing Antiproliferative Effects in 2D and 3D Cancer Cell Models
Sofia Sharkawy, Sourav Acharya, Hana Kostrhunová, Moumita Maji, Lenka Marková, Vojtěch Novohradský, Dan Gibson and Viktor Brabec
J. Med. Chem., 2025, 68, 24094
DOI: 10.1021/acs.jmedchem.5c01858

Platinum(IV)-Estramustine Multiaction Prodrugs Are Effective Antiproliferative Agents against Prostate Cancer Cells
Subhendu Karmakar, Hana Kostrhunova, Tereza Ctvrtlikova, Vojtech Novohradsky, Dan Gibson and Viktor Brabec
J. Med. Chem., 2020, 63, 13861
DOI: 10.1021/acs.jmedchem.0c01400

Oxidation of the Platinum(II) Anticancer Agent [Pt{(p-BrC6F4)NCH2CH2NEt2}Cl(py)] to Platinum(IV) Complexes by Hydrogen Peroxide
Ruchika Ojha, Peter C. Junk, Alan M. Bond and Glen B. Deacon
Molecules, 2023, 28, 6402
DOI: 10.3390/molecules28176402

Combination of Drug Delivery Properties of PAMAM Dendrimers and Cytotoxicity of Platinum(IV) Complexes—A More Selective Anticancer Treatment?
Yvonne Lerchbammer-Kreith, Michaela Hejl, Petra Vician, Michael A. Jakupec, Walter Berger, Mathea S. Galanski and Bernhard K. Keppler
Pharmaceutics, 2023, 15, 1515
DOI: 10.3390/pharmaceutics15051515

Oxali(IV)Fluors: Fluorescence Responsive Oxaliplatin(IV) Complexes Identify a Hypoxia-Dependent Reduction in Cancer Cells
Marie H. C. Boulet, Hannah R. Bolland, Ester M. Hammond and Adam C. Sedgwick
J. Am. Chem. Soc., 2023, 145, 12998
DOI: 10.1021/jacs.3c03320

Synthesis, characterization, and in vitro cytotoxicity of a Kiteplatin-Ibuprofen Pt(IV) prodrug
Alessandra Curci, Nunzio Denora, Rosa Maria Iacobazzi, Nicoletta Ditaranto, James D. Hoeschele, Nicola Margiotta and Giovanni Natile
Inorganica Chimica Acta, 2018, 472, 221
DOI: 10.1016/j.ica.2017.07.019

Conjugation between maleimide-containing Pt(IV) prodrugs and furan or furan-containing drug delivery vectors via Diels-Alder cycloaddition
Elisabetta Gabano, Elena Perin, Diego Bonzani and Mauro Ravera
Inorganica Chimica Acta, 2019, 488, 195
DOI: 10.1016/j.ica.2019.01.014

Oxaliplatin(IV) Prodrugs Functionalized with Gemcitabine and Capecitabine Induce Blockage of Colorectal Cancer Cell Growth—An Investigation of the Activation Mechanism and Their Nanoformulation
Carlo Marotta, Damiano Cirri, Ioannis Kanavos, Luisa Ronga, Ryszard Lobinski, Tiziana Funaioli, Chiara Giacomelli, Elisabetta Barresi, Maria Letizia Trincavelli, Tiziano Marzo and Alessandro Pratesi
Pharmaceutics, 2024, 16, 278
DOI: 10.3390/pharmaceutics16020278

Emerging platinum(IV) prodrug nanotherapeutics: A new epoch for platinum-based cancer therapy
Shunzhe Zheng, Guanting Li, Jianbin Shi, Xinying Liu, Meng Li, Zhonggui He, Chutong Tian and Ken-ichiro Kamei
Journal of Controlled Release, 2023, 361, 819
DOI: 10.1016/j.jconrel.2023.08.035

Strategy for Traceless Codrug Delivery with Platinum(IV) Prodrug Complexes Using Self-Immolative Linkers
Violet Eng Yee Lee, Zhi Chiaw Lim, Suet Li Chew and Wee Han Ang
Inorg. Chem., 2021, 60, 1823
DOI: 10.1021/acs.inorgchem.0c03299

Monochalcoplatin: An Actively Transported, Quickly Reducible, and Highly Potent PtIV Anticancer Prodrug
Lili Ma, Na Wang, Rong Ma, Cai Li, Zoufeng Xu, Man‐Kit Tse and Guangyu Zhu
Angewandte Chemie, 2018, 130, 9236
DOI: 10.1002/ange.201804314

Mitochondrial dynamics in cisplatin resistance: molecular mechanisms and therapeutic targeting
Wei Huang, Wei Sun, Zhiyuan Yang, Yiwen Li and Ziliang Wang
Front. Oncol., 2026, 15
DOI: 10.3389/fonc.2025.1736487

Photoactivated platinum-based anticancer drugs
Muhammad Imran, Wagma Ayub, Ian S. Butler and Zia-ur-Rehman
Coordination Chemistry Reviews, 2018, 376, 405
DOI: 10.1016/j.ccr.2018.08.009

A potent aminonaphthalimide platinum(IV) complex with effective antitumor activities in vitro and in vivo displaying dual DNA damage effects on tumor cells
Qingpeng Wang, Yan Chen, Guoshuai Li, Yanna Zhao, Zhifang Liu, Ruiyan Zhang, Min Liu, Dacheng Li and Jun Han
Bioorganic & Medicinal Chemistry Letters, 2019, 29, 126670
DOI: 10.1016/j.bmcl.2019.126670

Anticancer Metallodrugs: Where is the Next Cisplatin?
Muhammad Hanif and Christian G Hartinger
Future Med. Chem., 2018, 10, 615
DOI: 10.4155/fmc-2017-0317

Effective monitoring of Platinum-DNA adducts formation under simulated physiological conditions by CE-ICP-MS/MS
Joanna Zajda, Paweł Borowiecki and Magdalena Matczuk
Talanta, 2023, 264, 124749
DOI: 10.1016/j.talanta.2023.124749

Insights from Computations on the Mechanism of Reduction by Ascorbic Acid of PtIV Prodrugs with Asplatin and Its Chlorido and Bromido Analogues as Model Systems
Fortuna Ponte, Nino Russo and Emilia Sicilia
Chemistry A European J, 2018, 24, 9572
DOI: 10.1002/chem.201800488

Multitargeting Prodrugs that Release Oxaliplatin, Doxorubicin and Gemcitabine are Potent Inhibitors of Tumor Growth and Effective Inducers of Immunogenic Cell Death
Amrita Sarkar, Vojtech Novohradsky, Moumita Maji, Tomer Babu, Lenka Markova, Hana Kostrhunova, Jana Kasparkova, Valentina Gandin, Viktor Brabec and Dan Gibson
Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202310774

Structure–Activity Relationships of Triple-Action Platinum(IV) Prodrugs with Albumin-Binding Properties and Immunomodulating Ligands
Philipp Fronik, Isabella Poetsch, Alexander Kastner, Theresa Mendrina, Sonja Hager, Katharina Hohenwallner, Hemma Schueffl, Dietmar Herndler-Brandstetter, Gunda Koellensperger, Evelyn Rampler, Joanna Kopecka, Chiara Riganti, Walter Berger, Bernhard K. Keppler, Petra Heffeter and Christian R. Kowol
J. Med. Chem., 2021, 64, 12132
DOI: 10.1021/acs.jmedchem.1c00770

What blocks more anticancer platinum complexes from experiment to clinic: Major problems and potential strategies from drug design perspectives
Kun Peng, Bing-Bing Liang, Wenting Liu and Zong-Wan Mao
Coordination Chemistry Reviews, 2021, 449, 214210
DOI: 10.1016/j.ccr.2021.214210

Non-platinum complexes containing releasable biologically active ligands
Pavel Štarha and Zdeněk Trávníček
Coordination Chemistry Reviews, 2019, 395, 130
DOI: 10.1016/j.ccr.2019.06.001

Quaternary Ammonium Palmitoyl Glycol Chitosan (GCPQ) Loaded with Platinum-Based Anticancer Agents—A Novel Polymer Formulation for Anticancer Therapy
Yvonne Lerchbammer-Kreith, Michaela Hejl, Nadine S. Sommerfeld, Xian Weng-Jiang, Uchechukwu Odunze, Ryan D. Mellor, David G. Workman, Michael A. Jakupec, Andreas G. Schätzlein, Ijeoma F. Uchegbu, Mathea S. Galanski and Bernhard K. Keppler
Pharmaceuticals, 2023, 16, 1027
DOI: 10.3390/ph16071027

Combining cisplatin and a STING agonist into one molecule for metalloimmunotherapy of cancer
Shuren Zhang, Dongfan Song, Wenhao Yu, Ji Li, Xiaoyu Wang, Yachao Li, Zihan Zhao, Qi Xue, Jing Zhao, Jie P Li and Zijian Guo
National Science Review, 2023, 11
DOI: 10.1093/nsr/nwae020

A Quadruple‐Action Platinum(IV) Prodrug with Anticancer Activity Against KRAS Mutated Cancer Cell Lines
Emanuele Petruzzella, Jeremy Phillip Braude, Janice R. Aldrich‐Wright, Valentina Gandin and Dan Gibson
Angewandte Chemie, 2017, 129, 11697
DOI: 10.1002/ange.201706739

Mitochondria as a Novel Target for Cancer Chemoprevention: Emergence of Mitochondrial-targeting Agents
Mofei Huang, Charles R. Myers, Yian Wang and Ming You
Cancer Prevention Research, 2021, 14, 285
DOI: 10.1158/1940-6207.CAPR-20-0425

Preparation and Some Characterization Analyses of Cobalt (II) Complex with Schiff Base Derived from Acetyleacetone and 2-Aminopyridine
Abduljalal Adam Muhammad, Ashiru Maidabino Hassan and Ibrahim Abdullahi Umar
IJRISE, 2022, 22
DOI: 10.55529/ijrise.22.22.29

Synthesis and biological evaluation of new mono naphthalimide platinum(IV) derivatives as antitumor agents with dual DNA damage mechanism
Zuojie Li, Yan Chen, Zhifang Liu, Qingpeng Wang, Yanna Zhao, Jinjian Wei, Min Liu, Zhengping Wang, Dacheng Li and Jun Han
Monatsh Chem, 2020, 151, 353
DOI: 10.1007/s00706-020-02561-1

Patterns of platinum drug use in an acute care setting: a retrospective study
Evangeline Armstrong-Gordon, Danijela Gnjidic, Andrew J. McLachlan, Bayan Hosseini, Andrew Grant, Philip J. Beale and Nial J. Wheate
J Cancer Res Clin Oncol, 2018, 144, 1561
DOI: 10.1007/s00432-018-2669-6

A Prodrug of Two Approved Drugs, Cisplatin and Chlorambucil, for Chemo War Against Cancer
Rakesh K. Pathak, Ru Wen, Nagesh Kolishetti and Shanta Dhar
Molecular Cancer Therapeutics, 2017, 16, 625
DOI: 10.1158/1535-7163.MCT-16-0445

A series of nanoscaled Pt(0)‐phosphorus ylide complexes based on [60]fullerene: Synthesis, characterization, and in vitro biological assessments
Abed Yousefi, Seyyed Javad Sabounchei, Seyed Hamed Moazzami Farida and Nosrat Rahmani
Applied Organom Chemis, 2022, 36
DOI: 10.1002/aoc.6472

Noble Metal Complexes in Cancer Therapy: Unlocking Redox Potential for Next-Gen Treatments
Alina Stefanache, Alina Monica Miftode, Marcu Constantin, Roxana Elena Bogdan Goroftei, Iulia Olaru, Cristian Gutu, Alexandra Vornicu and Ionut Iulian Lungu
Inorganics, 2025, 13, 64
DOI: 10.3390/inorganics13020064

Current Developments in Pt(IV) Prodrugs Conjugated with Bioactive Ligands
Xuejiao Li, Yahong Liu and Hongqi Tian
Bioinorganic Chemistry and Applications, 2018, 2018, 1
DOI: 10.1155/2018/8276139

Multifunctional polymeric micellar nanomedicine in the diagnosis and treatment of cancer
Nidhi Raval, Rahul Maheshwari, Havish Shukla, Kiran Kalia, Vladimir P. Torchilin and Rakesh K. Tekade
Materials Science and Engineering: C, 2021, 126, 112186
DOI: 10.1016/j.msec.2021.112186

Homogeneous Pt nanostructures surface functionalized with phenylboronic acid phosphonic acid derivatives as potential biochemical nanosensors and drugs: SERS and TERS studies
Edyta Proniewicz, Barbara Gralec and Yukihiro Ozaki
J Biomed Mater Res, 2023, 111, 1197
DOI: 10.1002/jbm.b.35225

Synthesis, characterization, cytotoxic activity, and 19F NMR spectroscopic investigations of (OC-6-33)-diacetato(ethane-1,2-diamine)bis(3,3,3-trifluoropropanoato)platinum(IV) and its platinum(II) counterpart
Doris Höfer, Klaudia Cseh, Michaela Hejl, Alexander Roller, Michael A. Jakupec, Mathea S. Galanski and Bernhard K. Keppler
Inorganica Chimica Acta, 2019, 490, 190
DOI: 10.1016/j.ica.2019.02.017

RETRACTED: Pt(IV) Bifunctional Prodrug Containing 2-(2-Propynyl)octanoato Axial Ligand: Induction of Immunogenic Cell Death on Colon Cancer
Maurizio Sabbatini, Ilaria Zanellato, Mauro Ravera, Elisabetta Gabano, Elena Perin, Beatrice Rangone and Domenico Osella
J. Med. Chem., 2019, 62, 3395
DOI: 10.1021/acs.jmedchem.8b01860

Nanomaterial‐mediated platinum drug‐based combinatorial cancer therapy
Zhiqin Deng, Na Wang, Fujin Ai, Zhigang Wang and Guangyu Zhu
VIEW, 2021, 2
DOI: 10.1002/VIW.20200030

Improvement of Kiteplatin Efficacy by a Benzoato Pt(IV) Prodrug Suitable for Oral Administration
Alessandra Barbanente, Valentina Gandin, Cecilia Ceresa, Cristina Marzano, Nicoletta Ditaranto, James D. Hoeschele, Giovanni Natile, Fabio Arnesano, Concetta Pacifico, Francesco P. Intini and Nicola Margiotta
IJMS, 2022, 23, 7081
DOI: 10.3390/ijms23137081

Exploring the Hydrolytic Behavior of the Platinum(IV) Complexes with Axial Acetato Ligands
Jian Zhao, Zichen Xu, Jing Lin and Shaohua Gou
Inorg. Chem., 2017, 56, 9851
DOI: 10.1021/acs.inorgchem.7b01355

A Survey of the Mechanisms of Action of Anticancer Transition Metal Complexes
Mickaël Marloye, Gilles Berger, Michel Gelbcke and François Dufrasne
Future Med. Chem., 2016, 8, 2263
DOI: 10.4155/fmc-2016-0153

Stability, Reduction, and Cytotoxicity of Platinum(IV) Anticancer Prodrugs Bearing Carbamate Axial Ligands: Comparison with Their Carboxylate Analogues
Shu Chen, Houzong Yao, Qiyuan Zhou, Man-Kit Tse, Yuliana F. Gunawan and Guangyu Zhu
Inorg. Chem., 2020, 59, 11676
DOI: 10.1021/acs.inorgchem.0c01541

Click Pt(IV)-Carbohydrates Pro-Drugs for Treatment of Osteosarcoma
Eoin Moynihan, Giada Bassi, Andrea Ruffini, Silvia Panseri, Monica Montesi, Trinidad Velasco-Torrijos and Diego Montagner
Front. Chem., 2021, 9
DOI: 10.3389/fchem.2021.795997

Potent Platinum(IV) Prodrugs That Incorporate a Biotin Moiety to Selectively Target Cancer Cells
Aleen Khoury, Jennette A. Sakoff, Jayne Gilbert, Shawan Karan, Christopher P. Gordon and Janice R. Aldrich-Wright
Pharmaceutics, 2022, 14, 2780
DOI: 10.3390/pharmaceutics14122780

Photoactivatable Platinum-Based Anticancer Drugs: Mode of Photoactivation and Mechanism of Action
Ziwen Dai and Zhigang Wang
Molecules, 2020, 25, 5167
DOI: 10.3390/molecules25215167

Probing the Interactions of Cytotoxic [Pt(1S,2S‐DACH)(5,6‐dimethyl‐1,10‐phenanthroline)] and Its PtIV Derivatives with Human Serum
Benjamin W. J. Harper, Aviva Friedman‐Ezra, Roman Sirota, Emanuele Petruzzella, Janice R. Aldrich‐Wright and Dan Gibson
ChemMedChem, 2017, 12, 510
DOI: 10.1002/cmdc.201700092

Reactive Cysteines in Proteins are the Dominant Reductants for Platinum(IV) Prodrug Activation in Live Cells
Shu Chen, Wang Peng, Houzong Yao, Zhiqin Deng, Zhao Yue, Gongyuan Liu, Jiaqian Xu, Naixin Lin, Weikang Xu, Jianbo Yue and Guangyu Zhu
Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202416396

Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin
Yulia N. Nosova, Ilia V. Zenin, Varvara P. Maximova, Ekaterina M. Zhidkova, Kirill I. Kirsanov, Ekaterina A. Lesovaya, Anna A. Lobas, Mikhail V. Gorshkov, Olga N. Kovaleva, Elena R. Milaeva, Markus Galanski, Bernhard K. Keppler and Alexey A. Nazarov
Bioinorganic Chemistry and Applications, 2017, 2017, 1
DOI: 10.1155/2017/4736321

Enhanced potency of a chloro-substituted polyaromatic platinum(II) complex and its platinum(IV) prodrug against lung cancer
Joy Baz, Aleen Khoury, Maria George Elias, Najwa Mansour, Stephanie Mehanna, Omar Hammoud, Christopher P. Gordon, Robin I. Taleb, Janice R. Aldrich-Wright and Costantine F. Daher
Chemico-Biological Interactions, 2024, 388, 110834
DOI: 10.1016/j.cbi.2023.110834

Cobalt(III) prodrug-based nanomedicine for inducing immunogenic cell death and enhancing chemo-immunotherapy
Kun Shang, Nicolás Montesdeoca, Hanchen Zhang, Elizaveta Efanova, Ganghao Liang, Jasmine Ochs, Johannes Karges, Haiqin Song and Lingpu Zhang
Journal of Controlled Release, 2024, 373, 493
DOI: 10.1016/j.jconrel.2024.07.042

Molecular Dynamics Simulation of Passive Diffusion across a Human Breast Cancer Cell Membrane Model. Comparison between Cisplatin and Its Pt(IV) Derivatives
Daniele Belletto, Stefano Scoditti, Stefano Borocci, Nico Sanna, Costantino Zazza and Emilia Sicilia
J. Chem. Inf. Model., 2026
DOI: 10.1021/acs.jcim.5c02819

Platinum(IV) Complex-Loaded nanoparticles with photosensitive activity for cancer therapy
Quan-Bing Chen, Ling-Yue Zhou, Ling-Xin Shi, Yang Cheng, Kui Wu, Qiong Yuan, Zhi-Jun Dong, Hua-Zhi Gu, Xian-Zheng Zhang and Tao Zou
Coordination Chemistry Reviews, 2022, 472, 214789
DOI: 10.1016/j.ccr.2022.214789

Inhibition of histone deacetylases, topoisomerases and epidermal growth factor receptor by metal-based anticancer agents: Design & synthetic strategies and their medicinal attributes
Manpreet Kaur, Loveleen and Raj Kumar
Bioorganic Chemistry, 2020, 105, 104396
DOI: 10.1016/j.bioorg.2020.104396

Targeting ROS-AMPK pathway by multiaction Platinum(IV) prodrugs containing hypolipidemic drug bezafibrate
Xin Qiao, Yu-Yang Gao, Li-Xia Zheng, Xiao-Jing Ding, Ling-Wen Xu, Juan-Juan Hu, Wei-Zhen Gao and Jing-Yuan Xu
European Journal of Medicinal Chemistry, 2021, 223, 113730
DOI: 10.1016/j.ejmech.2021.113730

The Strange Case: The Unsymmetric Cisplatin‐Based Pt(IV) Prodrug [Pt(CH3COO)Cl2(NH3)2(OH)] Exhibits Higher Cytotoxic Activity with respect to Its Symmetric Congeners due to Carrier‐Mediated Cellular Uptake
Elisabetta Gabano, Ilaria Zanellato, Giulia Pinton, Laura Moro, Mauro Ravera, Domenico Osella and Patrick Bednarski
Bioinorganic Chemistry and Applications, 2022, 2022
DOI: 10.1155/2022/3698391

Synthesis, properties, DFT calculations, and cytotoxic activity of phosphorescent iridium(III) complexes with heteroatom ancillary ligands
Xiao-Han Yang, Qian Zhang, Shao-Bin Dou, Lu Xiao, Xing-Liang Jia, Rui-Lian Yang, Gao-Nan Li and Zhi-Gang Niu
Journal of Coordination Chemistry, 2020, 73, 2004
DOI: 10.1080/00958972.2020.1802721

Oxidation of cis‐Diamminediacetato PtII with Hydrogen Peroxide Can Give Rise to Two Isomeric PtIV Products
D. Khattib, M. Ishan, S. Karmakar, H. Kostrhunova, V. Brabec and D. Gibson
Chemistry A European J, 2020, 26, 9475
DOI: 10.1002/chem.202001472

Hybrid micelles based on Pt (IV) polymeric prodrug and TPGS for the enhanced cytotoxicity in drug-resistant lung cancer cells
Le He, Jiaxi Xu, Xu Cheng, Min Sun, Bing Wei, Nanchi Xiong, Jiayu Song, Xin Wang and Rupei Tang
Colloids and Surfaces B: Biointerfaces, 2020, 195, 111256
DOI: 10.1016/j.colsurfb.2020.111256

Click Chemistry-Assisted Synthesis of a β-d-Galactose-Targeted SiO2@RC Shell–Core Structure as a Nanoplatform for Metal-Based Complex Delivery
Xiuling Xu, Fan Hu and Qi Shuai
Inorg. Chem., 2018, 57, 10694
DOI: 10.1021/acs.inorgchem.8b01335

Preparation of trans,trans-[Pt(py)2(N3)2(OH)2] via Photoinduced Reactivity of [Pt(NO3)6]2– Anion
Alexei Zazulya, Semen Berdyugin, Sergey Tkachev, Varvara Lagunova, Dmitriy Sheven, Pavel Abramov, Evgeni Glebov and Danila Vasilchenko
Inorg. Chem., 2025, 64, 2336
DOI: 10.1021/acs.inorgchem.4c04536

Mechanistic Fingerprints from Chloride to Iodide: Halide vs. Ammonia Release in Platinum Anticancer Complexes
Lorenzo Chiaverini, Luca Famlonga, Davide Piroddu, Matteo Pacini, Riccardo Di Leo, Emma Baglini, Damiano Cirri, Tiziano Marzo, Diego La Mendola, Alessandro Pratesi, Paola Ferrari, Andrea Nicolini, Alessandro Zucchi, Alessandro Marrone and Iogann Tolbatov
IJMS, 2025, 26, 12138
DOI: 10.3390/ijms262412138

Reduction of platinum(IV) prodrug model complex trans-[PtCl2(CN)4]2− by a peptide containing cysteine and methionine groups: HPLC and MS studies
Tiantian Niu, Wenfang Wan, Xiaofang Li, Dan Su, Shuying Huo and Shigang Shen
Journal of Molecular Liquids, 2018, 252, 24
DOI: 10.1016/j.molliq.2017.12.134

Spectrophotometric and physicochemical studies on the interaction of a new platinum(IV) complex containing the drug pregabalin with calf thymus DNA
Nahid Shahabadi, Sara Amiri and Hossein Zhaleh
Journal of Coordination Chemistry, 2020, 73, 35
DOI: 10.1080/00958972.2019.1710743

A Subset of New Platinum Antitumor Agents Kills Cells by a Multimodal Mechanism of Action Also Involving Changes in the Organization of the Microtubule Cytoskeleton
Hana Kostrhunova, Juraj Zajac, Vojtech Novohradsky, Jana Kasparkova, Jaroslav Malina, Janice R. Aldrich-Wright, Emanuele Petruzzella, Roman Sirota, Dan Gibson and Viktor Brabec
J. Med. Chem., 2019, 62, 5176
DOI: 10.1021/acs.jmedchem.9b00489

From Basics of Coordination Chemistry to Understanding Cisplatin-analogue Pt Drugs
Takashiro Akitsu, Dobrina Tsvetkova, Yuma Yamamoto, Daisuke Nakane and Irena Kostova
CPD, 2023, 29, 1747
DOI: 10.2174/1381612829666230809094251

Pt(IV) Prodrugs with Non-Steroidal Anti-inflammatory Drugs in the Axial Position
Daniil V. Spector, Kirill G. Pavlov, Roman A. Akasov, Alexander N. Vaneev, Alexander S. Erofeev, Petr V. Gorelkin, Vita N. Nikitina, Elena V. Lopatukhina, Alevtina S. Semkina, Kseniya Yu. Vlasova, Dmitrii A. Skvortsov, Vitaly A. Roznyatovsky, Nikolay V. Ul’yanovskiy, Ilya I. Pikovskoi, Sergey A. Sypalov, Anastasiia S. Garanina, Stepan S. Vodopyanov, Maxim A. Abakumov, Yulia L. Volodina, Alina A. Markova, Albina S. Petrova, Dmitrii M. Mazur, Dmitry A. Sakharov, Nikolay V. Zyk, Elena K. Beloglazkina, Alexander G. Majouga and Olga O. Krasnovskaya
J. Med. Chem., 2022, 65, 8227
DOI: 10.1021/acs.jmedchem.1c02136

Selective speciation improves efficacy and lowers toxicity of platinum anticancer and vanadium antidiabetic drugs
Kaitlin A. Doucette, Kelly N. Hassell and Debbie C. Crans
Journal of Inorganic Biochemistry, 2016, 165, 56
DOI: 10.1016/j.jinorgbio.2016.09.013

Abplatin(IV) inhibited tumor growth on a patient derived cancer model of hepatocellular carcinoma and its comparative multi-omics study with cisplatin
Xing Li, Lingpu Zhang, Tuo Li, Shumu Li, Wenjing Wu, Lingyu Zhao, Peng Xie, Jinqi Yang, Peipei Li, Yangyang Zhang, Haihua Xiao, Yingjie Yu and Zhenwen Zhao
J Nanobiotechnol, 2022, 20
DOI: 10.1186/s12951-022-01465-y

Monochalcoplatin: An Actively Transported, Quickly Reducible, and Highly Potent PtIV Anticancer Prodrug
Lili Ma, Na Wang, Rong Ma, Cai Li, Zoufeng Xu, Man‐Kit Tse and Guangyu Zhu
Angew Chem Int Ed, 2018, 57, 9098
DOI: 10.1002/anie.201804314

trans‐Platinum(II) Thionate Complexes: Synthesis, Structural Characterization, and in vitro Biological Assessment as Potent Anticancer Agents
Yoshie Sakamaki, Hasti Ahmadi Mirsadeghi, Masood Fereidoonnezhad, Faezeh Mirzaei, Zahra Moghimi Dehkordi, Samira Chamyani, Mia Alshami, Sedigheh Abedanzadeh, Hamid R. Shahsavari and M. Hassan Beyzavi
ChemPlusChem, 2019, 84, 1525
DOI: 10.1002/cplu.201900394

Can the Self-Assembling of Dicarboxylate Pt(IV) Prodrugs Influence Their Cell Uptake?
Mauro Ravera, Elisabetta Gabano, Elena Perin, Beatrice Rangone, Diego Bonzani, Domenico Osella and Giovanni Natile
Bioinorganic Chemistry and Applications, 2021, 2021, 1
DOI: 10.1155/2021/9489926

Platinum coordination compounds with potent anticancer activity
Krishant M. Deo, Dale L. Ang, Brondwyn McGhie, Adeline Rajamanickam, Ankita Dhiman, Aleen Khoury, Jason Holland, Aleksandra Bjelosevic, Benjamin Pages, Christopher Gordon and Janice R. Aldrich-Wright
Coordination Chemistry Reviews, 2018, 375, 148
DOI: 10.1016/j.ccr.2017.11.014

A novel therapy to combat non-small cell lung carcinoma (A549) using platinum (IV) and barium titanate conjugate
Moumita Maji, Praveen Kivale and Monidipa Ghosh
Journal of Drug Delivery Science and Technology, 2022, 75, 103617
DOI: 10.1016/j.jddst.2022.103617

Chemical and Photophysical Triggers for the Reduction of Pt(IV) Prodrugs for Anticancer Therapy
Johannes Karges
ChemNanoMat, 2023, 9
DOI: 10.1002/cnma.202300295

Synthesis, Structure, and Cytotoxicity of Oxaliplatin-Based Platinum(IV) Anticancer Prodrugs Bearing One Axial Fluoride
Zoufeng Xu, Ho Ming Chan, Cai Li, Zhigang Wang, Man-Kit Tse, Zixuan Tong and Guangyu Zhu
Inorg. Chem., 2018, 57, 8227
DOI: 10.1021/acs.inorgchem.8b00706

Can an Elusive Platinum(III) Oxidation State be Exposed in an Isolated Complex?
Davide Corinti, Gilles Frison, Barbara Chiavarino, Elisabetta Gabano, Domenico Osella, Maria Elisa Crestoni and Simonetta Fornarini
Angew Chem Int Ed, 2020, 59, 15595
DOI: 10.1002/anie.202007597

Multiaction Pt(IV) Carbamate Complexes Can Codeliver Pt(II) Drugs and Amine Containing Bioactive Molecules
Tomer Babu, Amrita Sarkar, Subhendu Karmakar, Claudia Schmidt and Dan Gibson
Inorg. Chem., 2020, 59, 5182
DOI: 10.1021/acs.inorgchem.0c00445

Unsymmetric Cisplatin-Based Pt(IV) Conjugates Containing a PARP-1 Inhibitor Pharmacophore Tested on Malignant Pleural Mesothelioma Cell Lines
Elisabetta Gabano, Giulia Pinton, Cecilia Balzano, Sara Boumya, Domenico Osella, Laura Moro and Mauro Ravera
Molecules, 2021, 26, 4740
DOI: 10.3390/molecules26164740

Metal-Based Antitumor Compounds: Beyond Cisplatin
Peter V Simpson, Nima Maheshkumar Desai, Ilaria Casari, Massimiliano Massi and Marco Falasca
Future Med. Chem., 2019, 11, 119
DOI: 10.4155/fmc-2018-0248

Flavin-Conjugated Pt(IV) Anticancer Agents
Juan Sánchez-Camacho, Sonia Infante-Tadeo, Ana C. Carrasco, Stefano Scoditti, Álvaro Martínez, Fabienne Barroso-Bujans, Emilia Sicilia, Ana M. Pizarro and Luca Salassa
Inorg. Chem., 2023, 62, 5644
DOI: 10.1021/acs.inorgchem.3c00193

EGFR-targeting peptide-coupled platinum(IV) complexes
Josef Mayr, Sonja Hager, Bettina Koblmüller, Matthias H. M. Klose, Katharina Holste, Britta Fischer, Karla Pelivan, Walter Berger, Petra Heffeter, Christian R. Kowol and Bernhard K. Keppler
J Biol Inorg Chem, 2017, 22, 591
DOI: 10.1007/s00775-017-1450-7

Three Is Better than One: A Multimetal Complex that Triggers Immunogenic Cell Death
Tomer Babu, Matthew S. Levine, Sourav Acharya, Esther Y. Maier and Jonathan L. Sessler
Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202514351

Veratricplatin inhibits the progression of hypopharyngeal squamous cell carcinoma FaDu cells in vitro and in vivo
Dongbo Wang, Huina Wu, Qian Wu, Qi Liu, Yamei Li, Jiyong Wu and Jing Nie
Cancer Chemother Pharmacol, 2023, 92, 211
DOI: 10.1007/s00280-023-04560-5

Stimuli-Responsive Therapeutic Metallodrugs
Xiaohui Wang, Xiaoyong Wang, Suxing Jin, Nafees Muhammad and Zijian Guo
Chem. Rev., 2019, 119, 1138
DOI: 10.1021/acs.chemrev.8b00209

Chlorambucil-conjugated platinum(IV) prodrugs to treat triple-negative breast cancer in vitro and in vivo
Zhong-Ying Ma, Dong-Bo Wang, Xue-Qing Song, Yi-Gang Wu, Qian Chen, Chun-Lai Zhao, Jing-Yi Li, Shi-Hao Cheng and Jing-Yuan Xu
European Journal of Medicinal Chemistry, 2018, 157, 1292
DOI: 10.1016/j.ejmech.2018.08.065

Synthesis and evaluation of bi-functional 7-hydroxycoumarin platinum(IV) complexes as antitumor agents
Qingpeng Wang, Yan Chen, Guoshuai Li, Zhifang Liu, Jing Ma, Min Liu, Dacheng Li, Jun Han and Bingquan Wang
Bioorganic & Medicinal Chemistry, 2019, 27, 2112
DOI: 10.1016/j.bmc.2019.04.009

Biological Evaluation of Dinuclear Platinum(II) Complexes with Aromatic N-Heterocycles as Bridging Ligands
Desimir Luković, Andjela A. Franich, Marija D. Živković, Snežana Rajković, Bojan Stojanović, Nevena Gajović, Milena Jurišević, Slađana Pavlović, Bojana Simović Marković, Marina Jovanović, Bojana S. Stojanović, Radiša Pavlović and Ivan Jovanović
IJMS, 2024, 25, 8525
DOI: 10.3390/ijms25158525

Maloplatin-B, a Cisplatin-Based BODIPY-Tagged Mito-Specific “Chemo-PDT” Agent Active in Red Light
Vanitha Ramu, Paramita Kundu, Paturu Kondaiah and Akhil R. Chakravarty
Inorg. Chem., 2021, 60, 6410
DOI: 10.1021/acs.inorgchem.1c00124

Reactive Cysteines in Proteins are the Dominant Reductants for Platinum(IV) Prodrug Activation in Live Cells
Shu Chen, Wang Peng, Houzong Yao, Zhiqin Deng, Zhao Yue, Gongyuan Liu, Jiaqian Xu, Naixin Lin, Weikang Xu, Jianbo Yue and Guangyu Zhu
Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202416396

Expanding the Arsenal of PtIV Anticancer Agents: Multi‐action PtIV Anticancer Agents with Bioactive Ligands Possessing a Hydroxy Functional Group
Thirumal Yempala, Tomer Babu, Subhendu Karmakar, Alina Nemirovski, Maisaloon Ishan, Valentina Gandin and Dan Gibson
Angewandte Chemie, 2019, 131, 18386
DOI: 10.1002/ange.201910014

Application of Approved Cisplatin Derivatives in Combination Therapy against Different Cancer Diseases
Dobrina Tsvetkova and Stefka Ivanova
Molecules, 2022, 27, 2466
DOI: 10.3390/molecules27082466

Synthesis and Cytotoxicity of Water-Soluble Dual- and Triple-Action Satraplatin Derivatives: Replacement of Equatorial Chlorides of Satraplatin by Acetates
Subhendu Karmakar, Isabella Poetsch, Christian R. Kowol, Petra Heffeter and Dan Gibson
Inorg. Chem., 2019, 58, 16676
DOI: 10.1021/acs.inorgchem.9b02796

Can an Elusive Platinum(III) Oxidation State be Exposed in an Isolated Complex?
Davide Corinti, Gilles Frison, Barbara Chiavarino, Elisabetta Gabano, Domenico Osella, Maria Elisa Crestoni and Simonetta Fornarini
Angewandte Chemie, 2020, 132, 15725
DOI: 10.1002/ange.202007597

Platinum‐Based Chemotherapeutics in the Modern Era: From Classical DNA‐Targeting Mechanisms to Next‐Generation Innovations in Cancer Therapy
Mohammad Bagher Shahsavani, Mahsa Heidari, Reza Yousefi and Ali Akbar Moosavi‐Movahedi
Chem Biol Drug Des, 2025, 106
DOI: 10.1111/cbdd.70208

Platinum(IV) Complexes of trans-1,2-diamino-4-cyclohexene: Prodrugs Affording an Oxaliplatin Analogue that Overcomes Cancer Resistance
Paride Papadia, Katia Micoli, Alessandra Barbanente, Nicoletta Ditaranto, James D. Hoeschele, Giovanni Natile, Cristina Marzano, Valentina Gandin and Nicola Margiotta
IJMS, 2020, 21, 2325
DOI: 10.3390/ijms21072325

Design and synthesis of a new series of low toxic naphthalimide platinum(IV) antitumor complexes with dual DNA damage mechanism
Qingpeng Wang, Xiaoxiao Tan, Zhifang Liu, Guoshuai Li, Ruiyan Zhang, Jinjian Wei, Shiben Wang, Dacheng Li, Bingquan Wang and Jun Han
European Journal of Pharmaceutical Sciences, 2018, 124, 127
DOI: 10.1016/j.ejps.2018.08.032

Strategy to Regulate the Stability and Reduction Rate of Oxaliplatin-Based Pt(IV) Complexes: Cocrystallization
Bin Zhu, Mei Guo, Yi-Chen Yao, Yu-Qian Yao, Minghuang Hong, Ming-Hui Qi and Guo-Bin Ren
Crystal Growth & Design, 2023, 23, 6506
DOI: 10.1021/acs.cgd.3c00480

Epigenetic and antitumor effects of platinum(IV)-octanoato conjugates
Vojtech Novohradsky, Ilaria Zanellato, Cristina Marzano, Jitka Pracharova, Jana Kasparkova, Dan Gibson, Valentina Gandin, Domenico Osella and Viktor Brabec
Sci Rep, 2017, 7
DOI: 10.1038/s41598-017-03864-w

Rethinking Alkylating(-Like) Agents for Solid Tumor Management
Hélène Lajous, Bénédicte Lelièvre, Elodie Vauléon, Philippe Lecomte and Emmanuel Garcion
Trends in Pharmacological Sciences, 2019, 40, 342
DOI: 10.1016/j.tips.2019.03.003

A Dual Stimuli‐Responsive Nanoplatform Loaded PtIV‐Triptolide Prodrug for Achieving Synergistic Therapy toward Breast Cancer
Kang Fang, Yanting Sun, Jingxian Yang, Xiaochun Hu, Mengyao Chen, Ruihao Li, Xinda Yang, Ting Fan, Junjie Wu, Xiaohan Tong, Chunyan Dong and Shuo Shi
Adv Healthcare Materials, 2023, 12
DOI: 10.1002/adhm.202301328

Oral Anticancer Heterobimetallic PtIV−AuIComplexes Show High In Vivo Activity and Low Toxicity
Tomer Babu, Hiba Ghareeb, Uttara Basu, Hemma Schueffl, Sarah Theiner, Petra Heffeter, Gunda Koellensperger, Norman Metanis, Valentina Gandin, Ingo Ott, Claudia Schmidt and Dan Gibson
Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202217233

Recent Advances on Pt-Based Compounds for Theranostic Applications
Giulia Ferrari, Ines Lopez-Martinez, Thomas Wanek, Claudia Kuntner and Diego Montagner
Molecules, 2024, 29, 3453
DOI: 10.3390/molecules29153453

Unexpected Thymine Oxidation and Collision-Induced Thymine-Pt-guanine Cross-Linking on 5′-TpG and 5′-GpT by a Photoactivatable Diazido Pt(IV) Anticancer Complex
Jishuai Zhang, Wenjuan Zeng, Kui Wu, Juan Ye, Yiyu Cheng, Yang Cheng, Tao Zou, Na Peng, Xiaoqin Wu, Yao Zhao and Fuyi Wang
Inorg. Chem., 2020, 59, 8468
DOI: 10.1021/acs.inorgchem.0c00894

New oxaliplatin-zoledronate derivatives with potential antitumor activity towards bone tumors and metastases
Alessandra Barbanente, Anna Maria Di Cosola, Mauro Niso, Luisa D'Anna, Simona Rubino, Sergio Indelicato, Concetta Pacifico, Alessio Terenzi and Nicola Margiotta
Journal of Inorganic Biochemistry, 2025, 270, 112916
DOI: 10.1016/j.jinorgbio.2025.112916

Novel Pt(IV) prodrug self-assembled nanoparticles with enhanced blood circulation stability and improved antitumor capacity of oxaliplatin for cancer therapy
Yuanlei Fu, Ying Kong, Xiangping Li, Dongfang Cheng, Yuqian Hou, Yan Li, Tongfang Li, Yani Xiao, Qiuyan Zhang and Rong Rong
Drug Delivery, 2023, 30
DOI: 10.1080/10717544.2023.2171158

Using an RNAi Signature Assay To Guide the Design of Three-Drug-Conjugated Nanoparticles with Validated Mechanisms, In Vivo Efficacy, and Low Toxicity
Jonathan C. Barnes, Peter M. Bruno, Hung V.-T. Nguyen, Longyan Liao, Jenny Liu, Michael T. Hemann and Jeremiah A. Johnson
J. Am. Chem. Soc., 2016, 138, 12494
DOI: 10.1021/jacs.6b06321

Synthesis and Cytotoxic Study of a Platinum(IV) Anticancer Prodrug with Selectivity toward Luteinizing Hormone-Releasing Hormone (LHRH) Receptor-Positive Cancer Cells
Houzong Yao, Zoufeng Xu, Cai Li, Man-Kit Tse, Zixuan Tong and Guangyu Zhu
Inorg. Chem., 2019, 58, 11076
DOI: 10.1021/acs.inorgchem.9b01583

Platinum(IV) Complexes of the 1,3,5-Triamino Analogue of the Biomolecule Cis-Inositol Designed as Innovative Antineoplastic Drug Candidates
Vyara Velcheva, Kaspar Hegetschweiler, Georgi Momekov, Stefka Ivanova, Angel Ugrinov, Bernd Morgenstern and Galina Gencheva
Pharmaceutics, 2022, 14, 2057
DOI: 10.3390/pharmaceutics14102057

Reductions of the cisplatin-based platinum(IV) prodrug cis,cis,trans-[Pt(NH3)2Cl2Br2] by predominant biological thiols: kinetic and mechanistic studies
Wenfang Wan, Jingjing Sun, Wanru Liu, Shuying Huo and Shigang Shen
Transit Met Chem, 2019, 44, 535
DOI: 10.1007/s11243-019-00311-9

Novel Cytotoxic Pt(IV) Compounds with Improved Safety Profiles
Anastasia A. Antonets, Ksenia M. Voroshilkina, Ilya A. Shutkov, Dmitrii M. Mazur, Tatiana P. Serkova, Elena F. Shevtsova, Dmitrii S. Yakovlev, Mariya S. Pshenichnikova, Umida M. Ibragimova, Roman A. Litvinov, Alexander A. Spasov, Elena R. Milaeva and Alexey A. Nazarov
IJMS, 2026, 27, 1750
DOI: 10.3390/ijms27041750

Anticancer platinum agents and light
Juan Gurruchaga-Pereda, Álvaro Martínez, Alessio Terenzi and Luca Salassa
Inorganica Chimica Acta, 2019, 495, 118981
DOI: 10.1016/j.ica.2019.118981

New Platinum-Based Prodrug Pt(IV)Ac-POA: Antitumour Effects in Rat C6 Glioblastoma Cells
Beatrice Ferrari, Francesca Urselli, Martina Gilodi, Serena Camuso, Erica Cecilia Priori, Beatrice Rangone, Mauro Ravera, Paola Veneroni, Ilaria Zanellato, Elisa Roda, Domenico Osella and Maria Grazia Bottone
Neurotox Res, 2020, 37, 183
DOI: 10.1007/s12640-019-00076-0

Oxaliplatin-Based Platinum(IV) Prodrug Bearing Toll-like Receptor 7 Agonist for Enhanced Immunochemotherapy
Li Tang, Demin Cai, Mian Qin, Shuo Lu, Ming-Hao Hu, Shuangchen Ruan, Guangyi Jin and Zhigang Wang
ACS Omega, 2020, 5, 726
DOI: 10.1021/acsomega.9b03381

19F NMR Allows the Investigation of the Fate of Platinum(IV) Prodrugs in Physiological Conditions
Siming Yuan, Yang Zhu, Yi Dai, Yu Wang, Duo Jin, Manman Liu, Liqin Tang, Fabio Arnesano, Giovanni Natile and Yangzhong Liu
Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202114250

Solution stability and storage effect on selected metallodrugs: a multi-technique evaluation
Luca Famlonga, Riccardo Di Leo, Lorenzo Chiaverini, Luca Menichetti, Tiziano Marzo and Diego La Mendola
Metallomics, 2025, 17
DOI: 10.1093/mtomcs/mfaf039

Development of a series of 4-hydroxycoumarin platinum(IV) hybrids as antitumor agents: Synthesis, biological evaluation and action mechanism investigation
Guoshuai Li, Junfeng Zhang, Zhifang Liu, Qingpeng Wang, Yan Chen, Min Liu, Dacheng Li, Jun Han and Bingquan Wang
Journal of Inorganic Biochemistry, 2019, 194, 34
DOI: 10.1016/j.jinorgbio.2019.02.011

Platinum(IV) and platinum(II) anticancer complexes with biologically active releasable ligands
Pavel Štarha and Radka Křikavová
Coordination Chemistry Reviews, 2024, 501, 215578
DOI: 10.1016/j.ccr.2023.215578

Oxoplatin‐Based Pt(IV) Lipoate Complexes and Their Biological Activity
Xiao Liu, Marie‐Christin Barth, Klaudia Cseh, Christian R. Kowol, Michael A. Jakupec, Bernhard K. Keppler, Dan Gibson and Wolfgang Weigand
Chemistry & Biodiversity, 2022, 19
DOI: 10.1002/cbdv.202200695

Cancer‐Specific, Intracellular, Reductive Activation of Anticancer PtIV Prodrugs
Viktor Reshetnikov, Steffen Daum and Andriy Mokhir
Chemistry A European J, 2017, 23, 5678
DOI: 10.1002/chem.201701192

N‐Heterocyclic Carbene Platinum Complexes: A Big Step Forward for Effective Antitumor Compounds
Stéphane Bellemin‐Laponnaz
Eur J Inorg Chem, 2020, 2020, 10
DOI: 10.1002/ejic.201900960

Ultrasound irradiation synthesis of novel copper(II) complex with the 2-thiophenimidazoline ligand: SC-XRD, HSA, and DFT study
Hadi Kargar, Mehdi Fallah-Mehrjardi, Necmi Dege, Muhammad Ashfaq, Khurram Shahzad Munawar, Muhammad Nawaz Tahir, Mehdi Sahihi and Mahdieh Asgari Bajgirani
Struct Chem, 2024, 35, 1437
DOI: 10.1007/s11224-024-02295-4

Novel 4-Amino-Quinazoline moieties ligated Platinum(IV) prodrugs overcome cisplatin resistance in EGFRWT human lung cancer
Rui Li, Weiheng Zhao, Chen Jin and Huihua Xiong
Bioorganic Chemistry, 2023, 135, 106499
DOI: 10.1016/j.bioorg.2023.106499

Kinetico-mechanistic study on the reduction/complexation sequence of PtIV/PtII organometallic complexes by thiol-containing biological molecules
Margarita Crespo, Mercè Font-Bardia, Peyman Hamidizadeh, Manuel Martínez and S. Masoud Nabavizadeh
Inorganica Chimica Acta, 2019, 486, 8
DOI: 10.1016/j.ica.2018.10.021

Recent advances in the synthesis, stability, and activation of platinum(IV) anticancer prodrugs
Zoufeng Xu, Zhigang Wang, Zhiqin Deng and Guangyu Zhu
Coordination Chemistry Reviews, 2021, 442, 213991
DOI: 10.1016/j.ccr.2021.213991

Novel Platinum(II) and Platinum(IV) Antitumor Agents that Exhibit Potent Cytotoxicity and Selectivity
Aleen Khoury, Elias Elias, Stephanie Mehanna, Wassim Shebaby, Krishant M. Deo, Najwa Mansour, Christian Khalil, Katia Sayyed, Jennette A. Sakoff, Jayne Gilbert, Costantine F. Daher, Christopher P. Gordon, Robin I. Taleb and Janice R. Aldrich-Wright
J. Med. Chem., 2022, 65, 16481
DOI: 10.1021/acs.jmedchem.2c01310

Multitargeting Prodrugs that Release Oxaliplatin, Doxorubicin and Gemcitabine are Potent Inhibitors of Tumor Growth and Effective Inducers of Immunogenic Cell Death
Amrita Sarkar, Vojtech Novohradsky, Moumita Maji, Tomer Babu, Lenka Markova, Hana Kostrhunova, Jana Kasparkova, Valentina Gandin, Viktor Brabec and Dan Gibson
Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202310774

Traceable Nanocluster–Prodrug Conjugate for Chemo-photodynamic Combinatorial Therapy of Non-small Cell Lung Cancer
Yuvasri Genji Srinivasulu, Anbu Mozhi, Nirmal Goswami, Qiaofeng Yao and Jianping Xie
ACS Appl. Bio Mater., 2021, 4, 3232
DOI: 10.1021/acsabm.0c01611

Platinum(IV)-based prodrugs as an alternative to Pt(II)-based drugs: synthesis and biological action
D. V. Spector, A. A. Bubley, E. K. Beloglazkina and O. O. Krasnovskaya
RUSS CHEM REV, 2023, 92, RCR5096
DOI: 10.59761/RCR5096

Biotinylated platinum(IV) complexes designed to target cancer cells
Jian Zhao, Wuyang Hua, Gang Xu and Shaohua Gou
Journal of Inorganic Biochemistry, 2017, 176, 175
DOI: 10.1016/j.jinorgbio.2017.08.017

Recent advancements in Nanotechnology-Mediated Platinum-Based cancer therapy
Asif Mohd Itoo, Balaram Ghosh and Swati Biswas
Coordination Chemistry Reviews, 2024, 508, 215796
DOI: 10.1016/j.ccr.2024.215796

Electrochemical Detection of a Novel Pt(IV) Prodrug with the Metronidazole Axial Ligand in the Hypoxic Area
Daniil V. Spector, Alexander S. Erofeev, Petr V. Gorelkin, Alexander N. Vaneev, Roman A. Akasov, Nikolay V. Ul’yanovskiy, Vita N. Nikitina, Alevtina S. Semkina, Kseniya Yu Vlasova, Mikhail A. Soldatov, Alexander L. Trigub, Dmitry A. Skvortsov, Alexander V. Finko, Nikolay V. Zyk, Dmitry A. Sakharov, Alexander G. Majouga, Elena K. Beloglazkina and Olga O. Krasnovskaya
Inorg. Chem., 2022, 61, 14705
DOI: 10.1021/acs.inorgchem.2c02062

A new platinum-based prodrug candidate: Its anticancer effects in B50 neuroblastoma rat cells
Beatrice Rangone, Beatrice Ferrari, Valentina Astesana, Irene Masiello, Paola Veneroni, Ilaria Zanellato, Domenico Osella and Maria Grazia Bottone
Life Sciences, 2018, 210, 166
DOI: 10.1016/j.lfs.2018.08.048

Novel NF-κB Inhibitor-Conjugated Pt(IV) Prodrug to Enable Cancer Therapy through ROS/ER Stress and Mitochondrial Dysfunction and Overcome Multidrug Resistance
Meng Wang, Guimei Li, Guiyang Jiang, Jinyuan Cai, Zhikun Liu, Rizhen Huang, Xiaochao Huang and Hengshan Wang
J. Med. Chem., 2024, 67, 6218
DOI: 10.1021/acs.jmedchem.3c02182

Antiproliferative activity of Pt(IV) complexes with lonidamine and bexarotene ligands attached via succinate-ethylenediamine linker
Y.N. Okulova, I.V. Zenin, I.A. Shutkov, K.I. Kirsanov, O.N. Kovaleva, E.A. Lesovaya, T.I. Fetisov, E.R. Milaeva and A.A Nazarov
Inorganica Chimica Acta, 2019, 495, 119010
DOI: 10.1016/j.ica.2019.119010

An overview of recent advancements in anticancer Pt(IV) prodrugs: New smart drug combinations, activation and delivery strategies
Carlo Marotta, Ester Giorgi, Francesca Binacchi, Damiano Cirri, Chiara Gabbiani and Alessandro Pratesi
Inorganica Chimica Acta, 2023, 548, 121388
DOI: 10.1016/j.ica.2023.121388

Self‐assembled Lipid Nanoparticles for Ratiometric Codelivery of Cisplatin and siRNA Targeting XPF to Combat Drug Resistance in Lung Cancer
Cai Li, Tianzhong Li, Linfeng Huang, Mengsu Yang and Guangyu Zhu
Chemistry — An Asian Journal, 2019, 14, 1570
DOI: 10.1002/asia.201900005

Special Issue “Cisplatin in Cancer Therapy: Molecular Mechanisms of Action 3.0”
Valentina Gandin, James D. Hoeschele and Nicola Margiotta
IJMS, 2023, 24, 7917
DOI: 10.3390/ijms24097917

Expanding the Arsenal of PtIV Anticancer Agents: Multi‐action PtIV Anticancer Agents with Bioactive Ligands Possessing a Hydroxy Functional Group
Thirumal Yempala, Tomer Babu, Subhendu Karmakar, Alina Nemirovski, Maisaloon Ishan, Valentina Gandin and Dan Gibson
Angew Chem Int Ed, 2019, 58, 18218
DOI: 10.1002/anie.201910014

Classification of Metal-Based Drugs according to Their Mechanisms of Action
Eszter Boros, Paul J. Dyson and Gilles Gasser
Chem, 2020, 6, 41
DOI: 10.1016/j.chempr.2019.10.013

Cherchez l'Electron
Pascal Mäser
Molecular Microbiology, 2017, 106, 183
DOI: 10.1111/mmi.13773

Encapsulation of Cu(II) Terpyridine Complexes into Polymeric Nanoparticles for Enhanced Anticancer Therapy
Nicolás Montesdeoca, Kaixin Ni and Johannes Karges
Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202401988

Synthesis and Structures of 9-Oxabispidine Analogues of Cisplatin, Carboplatin, and Oxaliplatin
David Pollak, Richard Goddard and Klaus-Richard Pörschke
Inorg. Chem., 2016, 55, 9424
DOI: 10.1021/acs.inorgchem.6b01690

Platinum(IV) Complexes Featuring Axial Michael Acceptor Ligands – Synthesis, Characterization, and Cytotoxicity
Nadine S. Sommerfeld, Daniel Strohhofer, Klaudia Cseh, Sarah Theiner, Michael A. Jakupec, Gunda Koellensperger, Mathea Sophia Galanski and Bernhard K. Keppler
Eur J Inorg Chem, 2017, 2017, 4049
DOI: 10.1002/ejic.201700753

Novel Pt(IV) Prodrug with Long-Wavelength Absorption in the NIR Range
Daniil Spector, Anastasia Zharova, Vladislav Bykusov, Roman Akasov, Maxim Stepanov, Vladimir Kuzmin, Anton Egorov, Ivan Burtsev, Elena Beloglazkina and Olga Krasnovskaya
Russ J Gen Chem, 2025, 95, 3958
DOI: 10.1134/S1070363225607744

A Pt(IV)-based mononitro-naphthalimide conjugate with minimized side-effects targeting DNA damage response via a dual-DNA-damage approach to overcome cisplatin resistance
Yingguang Li, Kexin Yue, Linrong Li, Jie Niu, Hanfang Liu, Jing Ma and Songqiang Xie
Bioorganic Chemistry, 2020, 101, 104011
DOI: 10.1016/j.bioorg.2020.104011

Strategies for the Improvement of Metal-Based Chemotherapeutic Treatments
Damiano Cirri, Francesco Bartoli, Alessandro Pratesi, Emma Baglini, Elisabetta Barresi and Tiziano Marzo
Biomedicines, 2021, 9, 504
DOI: 10.3390/biomedicines9050504

In-vitro antiproliferative evaluation of newly synthesized titanium(IV) metallacyclic complexes on HeLa and MCF7 cell lines
Shivabasayya V. Salimath, Kavita B. Hiremath, Sathish Thanigachalam, Arjita Ghosh, Selva Kumar Ramasamy, Anbalagan Moorthy, S. K. Ashok Kumar, Murugesh Shivashankar and Madhvesh Pathak
Sci Rep, 2025, 15
DOI: 10.1038/s41598-025-13995-0

Experiment versus theory of copper (II) complexes based imidazole derivatives as anti-cancer agents
Nujud S. Alshehri, Abeer A. Sharfalddin, Doaa Domyati, Amal S. Basaleh and Mostafa A. Hussien
Journal of the Indian Chemical Society, 2022, 99, 100692
DOI: 10.1016/j.jics.2022.100692

Overcoming Cancer Resistance to Platinum Drugs by Inhibiting Cholesterol Metabolism
Ying Wang, Linxiang Cai, Hui Li, Hanhua Chen, Tao Yang, Yehong Tan, Zijian Guo and Xiaoyong Wang
Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202309043

Novel Nickel(II), Palladium(II), and Platinum(II) Complexes with O,S Bidendate Cinnamic Acid Ester Derivatives: An In Vitro Cytotoxic Comparison to Ruthenium(II) and Osmium(II) Analogues
Jana Hildebrandt, Norman Häfner, Helmar Görls, Marie-Christin Barth, Matthias Dürst, Ingo B. Runnebaum and Wolfgang Weigand
IJMS, 2022, 23, 6669
DOI: 10.3390/ijms23126669

Three Is Better than One: A Multimetal Complex that Triggers Immunogenic Cell Death
Tomer Babu, Matthew S. Levine, Sourav Acharya, Esther Y. Maier and Jonathan L. Sessler
Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202514351

Effect of the aniline fragment in Pt(II) and Pt(IV) complexes as anti-proliferative agents. Standard reduction potential as a more reliable parameter for Pt(IV) compounds than peak reduction potential
Jorge Leal, Lucia Santos, Diego M. Fernández-Aroca, J. Vicente Cuevas, M. Angeles Martínez, Anna Massaguer, Felix A. Jalón, M. José Ruiz-Hidalgo, Ricardo Sánchez-Prieto, Ana M. Rodríguez, Gregorio Castañeda, Gema Durá, M. Carmen Carrión, Sílvia Barrabés and Blanca R. Manzano
Journal of Inorganic Biochemistry, 2021, 218, 111403
DOI: 10.1016/j.jinorgbio.2021.111403

Synthesis, structure, and cytotoxicity of platinum(iv) complexes bearing aminoxyl and dichloroacetate ligands
V. D. Sen’, N. V. Filatova, G. V. Shilov and A. A. Terentiev
Russ Chem Bull, 2023, 72, 1680
DOI: 10.1007/s11172-023-3948-1

New Oxaliplatin-Pyrophosphato Analogs with Improved In Vitro Cytotoxicity
Alessandra Barbanente, Rosa Maria Iacobazzi, Amalia Azzariti, James D. Hoeschele, Nunzio Denora, Paride Papadia, Concetta Pacifico, Giovanni Natile and Nicola Margiotta
Molecules, 2021, 26, 3417
DOI: 10.3390/molecules26113417

Piano Stool Aminoalkylidene‐Ferracyclopentenone Complexes from Bimetallic Precursors: Synthesis and Cytotoxicity Data
Dalila Rocco, Lucinda K. Batchelor, Eleonora Ferretti, Stefano Zacchini, Guido Pampaloni, Paul J. Dyson and Fabio Marchetti
ChemPlusChem, 2020, 85, 110
DOI: 10.1002/cplu.201900639

Antibody-platinum (IV) prodrugs conjugates for targeted treatment of cutaneous squamous cell carcinoma
Xiangye Yin, Yingjie Zhuang, Haiqin Song, Yujian Xu, Fan Zhang, Jianxin Cui, Lei Zhao, Yingjie Yu, Qixu Zhang, Jun Ye, Youbai Chen and Yan Han
Journal of Pharmaceutical Analysis, 2024, 14, 389
DOI: 10.1016/j.jpha.2023.11.002

Transition Metal-Based Prodrugs for Anticancer Drug Delivery
Ana M.F. Phillips and Armando J.L. Pombeiro
CMC, 2020, 26, 7476
DOI: 10.2174/0929867326666181203141122

Preparation and Some Characterization Analyses of Cobalt (II) Complex with Schiff Base Derived from Acetyleacetone and 2-Aminopyridine
Abduljalal Adam Muhammad, Ashiru Maidabino Hassan and Ibrahim Abdullahi Umar
JHMD, 2022, 22
DOI: 10.55529/ijrise.22.22.28

Oxoplatin-B, a cisplatin-based platinum(IV) complex with photoactive BODIPY for mitochondria specific “chemo-PDT” activity
Arpan Bera, Srishti Gautam, Md Kausar Raza, Paturu Kondaiah and Akhil R. Chakravarty
Journal of Inorganic Biochemistry, 2021, 223, 111526
DOI: 10.1016/j.jinorgbio.2021.111526

Mass spectrometry techniques for imaging and detection of metallodrugs
Sarah Theiner, Anna Schoeberl, Andreas Schweikert, Bernhard K. Keppler and Gunda Koellensperger
Current Opinion in Chemical Biology, 2021, 61, 123
DOI: 10.1016/j.cbpa.2020.12.005

Thermoresponsive carboplatin-releasing prodrugs
Aemilia D. McAdam, Lucinda K. Batchelor, Jan Romano-deGea, Dmitry Vasilyev and Paul J. Dyson
Journal of Inorganic Biochemistry, 2024, 254, 112505
DOI: 10.1016/j.jinorgbio.2024.112505

Tumor Niche Influences the Activity and Delivery of Anticancer Drugs: Pharmacology Meets Chemistry
Mauro Ravera, Elisabetta Gabano, Stelvio Tonello and Donato Colangelo
Pharmaceuticals, 2025, 18, 1047
DOI: 10.3390/ph18071047

Harnessing platinum(IV) prodrugs as versatile photoinitiators and photocrosslinkers for multifunctional hydrogels and protein labeling
Jiaqian Xu, Qiyuan Zhou, Guohan Sun, Gongyuan Liu, Shu Chen, Zhao Yue, Ka-Yan Ng, Houzong Yao, Fu Shing Li, Yung-Kang Peng and Guangyu Zhu
Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-63958-2

Platinum-Based Combination Therapy: Molecular Rationale, Current Clinical Uses, and Future Perspectives
Chunqiu Yu, Zhibin Wang, Zeren Sun, Lei Zhang, Wanwan Zhang, Yungen Xu and Jing-Jing Zhang
J. Med. Chem., 2020, 63, 13397
DOI: 10.1021/acs.jmedchem.0c00950

Therapeutic and Diagnostic Agents based on Bioactive Endogenous and Exogenous Coordination Compounds
Irena Kostova
CMC, 2024, 31, 358
DOI: 10.2174/0929867330666230321110018