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Induction of apoptosis by HBI‐8000 in adult T‐cell leukemia/lymphoma is associated with activation of Bim and NLRP3

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Design, synthesis, and in vitro biological evaluation of novel HDAC inhibitors bearing C-1 phenyl substituted tetrahydroisoquinoline Cap moiety as anti-tumor therapeutic agents

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Discovery of HDAC6-Selective Inhibitor NN-390 with in Vitro Efficacy in Group 3 Medulloblastoma

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First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation

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Chidamide, a histone deacetylase inhibitor, induces growth arrest and apoptosis in multiple myeloma cells in a caspase‑dependent manner

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Epigenetic agents plus anti-PD-1 reprogram the tumor microenvironment and restore antitumor efficacy in Hodgkin lymphoma

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Synthesis and Crystal Structure Analysis of Histone Deacetylase Inhibitor Chidamide

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The Status and Prospects of Epigenetics in the Treatment of Lymphoma

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Histone deacetylase inhibitor chidamide induces growth inhibition and apoptosis in NK/T lymphoma cells through ATM-Chk2-p53-p21 signalling pathway

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Chem-map profiles drug binding to chromatin in cells

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Comparison of tucidinostat with CHOP-like versus CHOP-like in first-line treatment of peripheral T-cell lymphoma: a single-center real-world study

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Review of bioanalytical assays for the quantitation of various HDAC inhibitors such as vorinostat, belinostat, panobinostat, romidepsin and chidamine

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Design and synthesis of tranylcypromine derivatives as novel LSD1/HDACs dual inhibitors for cancer treatment

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A Phase II Trial of the Double Epigenetic Priming Regimen Including Chidamide and Decitabine for Relapsed/Refractory Acute Myeloid Leukemia

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Design, synthesis, and biological activity evaluation of novel HDAC3 selective inhibitors for combination with Venetoclax against acute myeloid leukemia

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Effective treatment with programmed cell death protein‐1 antibody, chidamide and conventional chemotherapy for hepatosplenic γδ T‐cell lymphoma: A case report and literature review

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Discovery of phthalazino[1,2-b]-quinazolinone derivatives as multi-target HDAC inhibitors for the treatment of hepatocellular carcinoma via activating the p53 signal pathway

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Noval advance of histone modification in inflammatory skin diseases and related treatment methods

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Development of Hydrazide-Based HDAC6 Selective Inhibitors for Treating NLRP3 Inflammasome-Related Diseases

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Clinical pharmacokinetics of panobinostat, a novel histone deacetylase (HDAC) inhibitor: review and perspectives

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Design, synthesis and biological evaluation of novel HDAC inhibitors with improved pharmacokinetic profile in breast cancer

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Tucidinostat plus exemestane for postmenopausal patients with advanced, hormone receptor-positive breast cancer (ACE): a randomised, double-blind, placebo-controlled, phase 3 trial

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Synthesis of the molecular hybrid inspired by Largazole and Psammaplin A

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Chidamide Inhibits Glioma Cells by Increasing Oxidative Stress via the miRNA-338-5p Regulation of Hedgehog Signaling

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Zinc-Dependent Histone Deacetylase (HDAC) Inhibitors: Therapeutic Potential, Pharmacophore Structure, and Methods for Testing Deacylase Activity

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Selective non-zinc binding MMP-2 inhibitors: Novel benzamide Ilomastat analogs with anti-tumor metastasis

Jiao Song, Peng Peng, Jun Chang, Ming-Ming Liu, Jian-Ming Yu, Lu Zhou and Xun Sun

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Chidamide Maintenance Therapy Following Induction Therapy in Patients With Peripheral T-Cell Lymphoma Who Are Ineligible for Autologous Stem Cell Transplantation: Case Series From China

Wei Guo, Xingtong Wang, Jia Li, Xianying Yin, Yangzhi Zhao, Yang Tang, Anna Wang and Ou Bai

Front. Oncol., 2022, 12
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The epigenetic immunomodulator, HBI-8000, enhances the response and reverses resistance to checkpoint inhibitors

Reid P. Bissonnette, Rosemary M. Cesario, Bob Goodenow, Farbod Shojaei and Mireille Gillings

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Natural and Synthetic Macrocyclic Inhibitors of the Histone Deacetylase Enzymes

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Therapeutic potential of tucidinostat, a subtype-selective HDAC inhibitor, in cancer treatment

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Front. Pharmacol., 2022, 13
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Perspectives and new aspects of histone deacetylase inhibitors in the therapy of CNS diseases

Bo Han, Mengfei Wang, Jiayi Li, Qiushi Chen, Niubing Sun, Xuezhi Yang and Qingwei Zhang

European Journal of Medicinal Chemistry, 2023, 258, 115613
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Ganoderma immunomodulatory protein and chidamide down-regulate integrin-related signaling pathway result in migration inhibition and apoptosis induction

Chun-Te Lu, Pui-Ying Leong, Ting-Yi Hou, Sheng-Jia Huang, Yu-Ping Hsiao and Jiunn-Liang Ko

Phytomedicine, 2018, 51, 39
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