Removal of micropollutants, facultative pathogenic and antibiotic resistant bacteria in a full-scale retention soil filter receiving combined sewer overflow

Marco Scheurer, Stefanie Heß, Frauke Lüddeke, Frank Sacher, Hans Güde, Herbert Löffler and Claudia Gallert

Environ. Sci.: Processes Impacts, 2015, 17, 186
DOI: 10.1039/C4EM00494A

Target and non-target screening of biomarkers in wastewater: towards a unique analytical methodology for sample preparation

Gauthier Bernier-Turpin, Thomas Thiebault, Fabrice Alliot, Emmanuelle Mebold, Sabrina Guérin-Rechdaoui, Marcos Oliveira, Julien Le Roux and Régis Moilleron

Anal. Methods, 2024, 16, 6241
DOI: 10.1039/D4AY00843J

Emerging investigators series: occurrence and fate of emerging organic contaminants in wastewater treatment plants with an enhanced nitrification step

Yue Xing, Yaochun Yu and Yujie Men

Environ. Sci.: Water Res. Technol., 2018, 4, 1412
DOI: 10.1039/C8EW00278A

A novel GC-MS method for the determination and quantification of metformin in surface water

C. Goedecke, I. Fettig, C. Piechotta, R. Philipp and S. U. Geissen

Anal. Methods, 2017, 9, 1580
DOI: 10.1039/C6AY02606K

Effectively designed molecularly imprinted polymers for selective isolation of the antidiabetic drug metformin and its transformation product guanylurea from aqueous media

George Z. Kyzas, Stavroula G. Nanaki, Anastasia Koltsakidou, Myrsini Papageorgiou, Maria Kechagia, Dimitrios N. Bikiaris and Dimitra A. Lambropoulou

Analytica Chimica Acta, 2015, 866, 27
DOI: 10.1016/j.aca.2015.01.045

Influence and efficiency of an anti-diabetic drug Metformin hydrochloride as an uncoupler: Reducing sludge production

Jun Li and Salma Tabassum

Cleaner Engineering and Technology, 2021, 4, 100203
DOI: 10.1016/j.clet.2021.100203

A critical review of the current environmental risks posed by the antidiabetic Metformin and the status, advances, and trends in adsorption technologies for its remediation

Yasmin Vieira, Tatiane Horta Ribeiro, Jandira Leichtweis, Guilherme Luiz Dotto, Edson Luiz Foletto, Jordana Georgin, Dison Stracke Pfingsten Franco and Eder C. Lima

Journal of Water Process Engineering, 2023, 54, 103943
DOI: 10.1016/j.jwpe.2023.103943

Uptake and translocation of metformin, ciprofloxacin and narasin in forage- and crop plants

Trine Eggen, Tone Normann Asp, Kari Grave and Victor Hormazabal

Chemosphere, 2011, 85, 26
DOI: 10.1016/j.chemosphere.2011.06.041

Predicting concentrations of trace organic compounds in municipal wastewater treatment plant sludge and biosolids using the PhATE™ model

Virginia L Cunningham, Vincent J D'Aco, Danielle Pfeiffer, Paul D Anderson, Mary E Buzby, Robert E Hannah, James Jahnke and Neil J Parke

Integrated Environmental Assessment and Management, 2012, 8, 530
DOI: 10.1002/ieam.1274

Solar photocatalytic degradation of metformin by TiO2 synthesized using Calotropis gigantea leaf extract

Venkatesan Prashanth, Kumari Priyanka and Neelancherry Remya

Water Science and Technology, 2021, 83, 1072
DOI: 10.2166/wst.2021.040

Ultraviolet photolysis of metformin: mechanisms of environmental factors, identification of intermediates, and density functional theory calculations

Wenting Lin, Xiaohan Zhang, Ping Li, Yongzhen Tan and Yuan Ren

Environ Sci Pollut Res, 2020, 27, 17043
DOI: 10.1007/s11356-020-08255-9

Dinickel enzyme evolved to metabolize the pharmaceutical metformin and its implications for wastewater and human microbiomes

Lambros J. Tassoulas, Joel A. Rankin, Mikael H. Elias and Lawrence P. Wackett

Proc. Natl. Acad. Sci. U.S.A., 2024, 121
DOI: 10.1073/pnas.2312652121

Application of hydrophilic interaction chromatography for the analysis of polar contaminants in food and environmental samples

Alexander L.N. van Nuijs, Isabela Tarcomnicu and Adrian Covaci

Journal of Chromatography A, 2011, 1218, 5964
DOI: 10.1016/j.chroma.2011.01.075

Evaluating the degradation, sorption, and negative mass balances of pharmaceuticals and personal care products during wastewater treatment

Benjamin Blair, Adam Nikolaus, Curtis Hedman, Rebecca Klaper and Timothy Grundl

Chemosphere, 2015, 134, 395
DOI: 10.1016/j.chemosphere.2015.04.078

A global perspective on the use, occurrence, fate and effects of anti-diabetic drug metformin in natural and engineered ecosystems

Rowena M. Briones, Ajit K. Sarmah and Lokesh P. Padhye

Environmental Pollution, 2016, 219, 1007
DOI: 10.1016/j.envpol.2016.07.040

Salting-out assisted liquid-liquid extraction coupled with hydrophilic interaction chromatography for the determination of biguanides in biological and environmental samples

Anas Alshishani, Salizawati Muhamad Salhimi and Bahruddin Saad

Journal of Chromatography B, 2018, 1073, 51
DOI: 10.1016/j.jchromb.2017.12.013

Short term uptake and transport process for metformin in roots of Phragmites australis and Typha latifolia

H. Cui, B.A. Hense, J. Müller and P. Schröder

Chemosphere, 2015, 134, 307
DOI: 10.1016/j.chemosphere.2015.04.072

Biodegradation of metformin and its transformation product, guanylurea, by natural and exposed microbial communities

Baptiste A.J. Poursat, Rob J.M. van Spanning, Martin Braster, Rick Helmus, Pim de Voogt and John R. Parsons

Ecotoxicology and Environmental Safety, 2019, 182, 109414
DOI: 10.1016/j.ecoenv.2019.109414

Talaromyces sayulitensis as a Potential Bioremediation Agent for Metformin

Joel Augustine and Jayanthi Abraham

Appl Biochem Biotechnol, 2025, 197, 7674
DOI: 10.1007/s12010-025-05418-7

Occurrence of 1153 organic micropollutants in the aquatic environment of Vietnam

H. T. C. Chau, K. Kadokami, H. T. Duong, L. Kong, T. T. Nguyen, T. Q. Nguyen and Y. Ito

Environ Sci Pollut Res, 2018, 25, 7147
DOI: 10.1007/s11356-015-5060-z

Emerging contaminants in water environments: progress, evolution, and prospects

Ruiqi Wang, Huanchen Tang, Ruitao Yang and Jingduo Zhang

Water Science & Technology, 2024, 89, 2763
DOI: 10.2166/wst.2024.151

Screening strategy for 1210 exogenous chemicals in serum by two-dimensional liquid chromatography-mass spectrometry

Yuting Wang, Lina Zhou, Tiantian Chen, Lei You, Xianzhe Shi, Xinyu Liu, Sijia Zheng, Jie Jiang, Yuebin Ke and Guowang Xu

Environmental Pollution, 2023, 331, 121914
DOI: 10.1016/j.envpol.2023.121914

A Preliminary Study on the Occurrence of Pharmaceutically Active Compounds in the River Basins and Their Removal in Two Conventional Drinking Water Treatment Plants in Chongqing, China

Qing Yan, Yi‐Xin Zhang, Jia Kang, Xiu‐Mei Gan, Peng Xu‐Y, Jin‐Song Guo and Xu Gao

CLEAN Soil Air Water, 2015, 43, 794
DOI: 10.1002/clen.201400039

New Electrochemical Sensor of Prolonged Application for Metformin Determination Based on Hydrated Ruthenium Dioxide‐Carbon Black‐Nafion Modified Glassy Carbon Electrode

Anna Górska, Beata Paczosa‐Bator, Jan Wyrwa and Robert Piech

Electroanalysis, 2020, 32, 1875
DOI: 10.1002/elan.202060012

Occurrence and fate of the antidiabetic drug metformin and its metabolite guanylurea in the environment and during drinking water treatment

Marco Scheurer, Amandine Michel, Heinz-Jürgen Brauch, Wolfgang Ruck and Frank Sacher

Water Research, 2012, 46, 4790
DOI: 10.1016/j.watres.2012.06.019

Combined effects of micropollutants and their degradation on prokaryotic communities at the sediment–water interface

Adrien Borreca, Stéphane Vuilleumier and Gwenaël Imfeld

Sci Rep, 2024, 14
DOI: 10.1038/s41598-024-67308-y

Primary degradation of antidiabetic drugs

Marta Markiewicz, Christian Jungnickel, Stefan Stolte, Anna Białk-Bielińska, Jolanta Kumirska and Wojciech Mrozik

Journal of Hazardous Materials, 2017, 324, 428
DOI: 10.1016/j.jhazmat.2016.11.008

Degradation of metformin in water by TiO2–ZrO2 photocatalysis

Caroline F. Carbuloni, Jaqueline E. Savoia, Jaqueline S.P. Santos, Cíntia A.A. Pereira, Rubiane G. Marques, Valquíria A.S. Ribeiro and Ana M. Ferrari

Journal of Environmental Management, 2020, 262, 110347
DOI: 10.1016/j.jenvman.2020.110347

Zipper-like thermosensitive molecularly imprinted polymers based on konjac glucomannan for metformin hydrochloride

Kai An, Lianxiong Guan, Huiting Kang and Dating Tian

Iran Polym J, 2021, 30, 331
DOI: 10.1007/s13726-020-00892-8

Different compositions of pharmaceuticals in Dutch and Belgian rivers explained by consumption patterns and treatment efficiency

Thomas L. ter Laak, Pascal J. F. Kooij, Harry Tolkamp and Jan Hofman

Environ Sci Pollut Res, 2014, 21, 12843
DOI: 10.1007/s11356-014-3233-9

Assessing the trend of diabetes mellitus by analyzing metformin as a biomarker in wastewater

Yang Xiao, Xue-Ting Shao, Dong-Qin Tan, Ji-Hao Yan, Wei Pei, Zhuang Wang, Meng Yang and De-Gao Wang

Science of The Total Environment, 2019, 688, 281
DOI: 10.1016/j.scitotenv.2019.06.117

Estimation of anti‐diabetes drug metformin in Turkiye using wastewater‐based epidemiology

Evsen Yavuz Guzel, Aslı Atasoy Aydin, İsmail Ethem Gören, Necdet Unuvar and Nebile Daglioglu

Drug Testing and Analysis, 2024, 16, 1295
DOI: 10.1002/dta.3646

Insights into the efficient degradation of metformin - An emerging antidiabetic medicine by UV/Sulfite process

Yurong Gu, Xiaoming Liu, Qi Han, Feng Wang, F.K. Yuen, A.-S. Nizami and J. Wen

E3S Web of Conf., 2024, 536, 03012
DOI: 10.1051/e3sconf/202453603012

Incomplete aerobic degradation of the antidiabetic drug Metformin and identification of the bacterial dead-end transformation product Guanylurea

Christoph Trautwein and Klaus Kümmerer

Chemosphere, 2011, 85, 765
DOI: 10.1016/j.chemosphere.2011.06.057

Development of a capillary electrophoresis–mass spectrometry method for the analysis of metformin and its transformation product guanylurea in biota

Sarah Knoll, Stefanie Jacob, Susanna Mieck, Rita Triebskorn, Thomas Braunbeck and Carolin Huhn

Anal Bioanal Chem, 2020, 412, 4985
DOI: 10.1007/s00216-020-02759-6

Human health risk assessment of the mixture of pharmaceuticals in Dutch drinking water and its sources based on frequent monitoring data

Corine J. Houtman, Jan Kroesbergen, Karin Lekkerkerker-Teunissen and Jan Peter van der Hoek

Science of The Total Environment, 2014, 496, 54
DOI: 10.1016/j.scitotenv.2014.07.022

Ecotoxicological effects, water quality standards and risk assessment for the anti-diabetic metformin

Aline Andrade Godoy, Inês Domingues, António José Arsénia Nogueira and Fábio Kummrow

Environmental Pollution, 2018, 243, 534
DOI: 10.1016/j.envpol.2018.09.031

Adsorptive potential of Zea mays tassel activated carbon towards the removal of metformin hydrochloride from pharmaceutical effluent

Menala Kalumpha, Upenyu Guyo, Ngceboyakwethu P. Zinyama, Felistus Muhle Vakira and Benias C. Nyamunda

International Journal of Phytoremediation, 2020, 22, 148
DOI: 10.1080/15226514.2019.1652561

Occurrence and removal of chemicals of emerging concern in wastewater treatment plants and their impact on receiving water systems

Oksana Golovko, Stefan Örn, Mattias Sörengård, Kim Frieberg, Winnie Nassazzi, Foon Yin Lai and Lutz Ahrens

Science of The Total Environment, 2021, 754, 142122
DOI: 10.1016/j.scitotenv.2020.142122

Efficient metformin transformation in sulfite/UV process co-present with oxygen

Yurong Gu, Yi Zhang, Chengchun Jiang, Zijun Dong and Xue Bai

Front. Environ. Sci., 2023, 10
DOI: 10.3389/fenvs.2022.1071963

Multi-layer solid-phase extraction and evaporation—enrichment methods for polar organic chemicals from aqueous matrices

Niklas Köke, Daniel Zahn, Thomas P. Knepper and Tobias Frömel

Anal Bioanal Chem, 2018, 410, 2403
DOI: 10.1007/s00216-018-0921-1

Effects of guanylurea, the transformation product of the antidiabetic drug metformin, on the health of brown trout (Salmo trutta f. fario)

Stefanie Jacob, Sarah Knoll, Carolin Huhn, Heinz-R. Köhler, Selina Tisler, Christian Zwiener and Rita Triebskorn

PeerJ, 2019, 7, e7289
DOI: 10.7717/peerj.7289

Occurrence of the antidiabetic drug Metformin and its ultimate transformation product Guanylurea in several compartments of the aquatic cycle

Christoph Trautwein, Jean-Daniel Berset, Hendrik Wolschke and Klaus Kümmerer

Environment International, 2014, 70, 203
DOI: 10.1016/j.envint.2014.05.008

Spatial analysis of metformin use compared with nicotine and caffeine consumption through wastewater-based epidemiology in China

Xue-Ting Shao, Zi-Xiang Cong, Si-Yu Liu, Zhuang Wang, Xiao-Yu Zheng and De-Gao Wang

Ecotoxicology and Environmental Safety, 2021, 208, 111623
DOI: 10.1016/j.ecoenv.2020.111623

Online solid phase extraction liquid chromatography using bonded zwitterionic stationary phases and tandem mass spectrometry for rapid environmental trace analysis of highly polar hydrophilic compounds – Application for the antiviral drug Zanamivir

Richard H. Lindberg, Ganna Fedorova, Kristin M. Blum, Jolanta Pulit-Prociak, Anna Gillman, Josef Järhult, Patrik Appelblad and Hanna Söderström

Talanta, 2015, 141, 164
DOI: 10.1016/j.talanta.2015.03.066

Metformin Removal from Water Using Fixed-bed Column of Silica-Alumina Composite

Afif Hethnawi, Maysam Alnajjar, Abdallah D. Manasrah, Azfar Hassan, Gerardo Vitale, Robin Jeong and Nashaat N. Nassar

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2020, 597, 124814
DOI: 10.1016/j.colsurfa.2020.124814

Risk assessment based prioritization of 200 organic micropollutants in 4 Iberian rivers

Maja Kuzmanović, Antoni Ginebreda, Mira Petrović and Damia Barceló

Science of The Total Environment, 2015, 503-504, 289
DOI: 10.1016/j.scitotenv.2014.06.056

Carbon Paste Electrode Modified with BiVO4 to Sense Metformin

L.M. Blanco Jerez, U.M. García-Pérez, P. Zambrano-Robledo and J. Hernández-Moreira

International Journal of Electrochemical Science, 2014, 9, 4643
DOI: 10.1016/S1452-3981(23)08121-X

Antidiabetic II Drug Metformin in Plants: Uptake and Translocation to Edible Parts of Cereals, Oily Seeds, Beans, Tomato, Squash, Carrots, and Potatoes

Trine Eggen and Cathrine Lillo

J. Agric. Food Chem., 2012, 60, 6929
DOI: 10.1021/jf301267c

E. coli K-12 recA::gfp microbial biosensor used for screening of anticancer and antidiabetic pharmacist residues

Marzena Matejczyk, Włodzimierz Lewandowski and Stanisław Józef Rosochacki

Desalination and Water Treatment, 2016, 57, 1582
DOI: 10.1080/19443994.2014.996013

COVID-19 drugs in aquatic systems: a review

Willis Gwenzi, Rangabhashiyam Selvasembian, Nnanake-Abasi O. Offiong, Alaa El Din Mahmoud, Edmond Sanganyado and Joyabrata Mal

Environ Chem Lett, 2022, 20, 1275
DOI: 10.1007/s10311-021-01356-y

Efficiency of micropollutant removal through artificial recharge and riverbank filtration: case studies of Káraný, Czech Republic and Dresden-Hosterwitz, Germany

Zbyněk Hrkal, Yasmin Adomat, David Rozman and Thomas Grischek

Environ Earth Sci, 2023, 82
DOI: 10.1007/s12665-023-10785-7

Prediction of concentration levels of metformin and other high consumption pharmaceuticals in wastewater and regional surface water based on sales data

Mathijs Oosterhuis, Frank Sacher and Thomas L. ter Laak

Science of The Total Environment, 2013, 442, 380
DOI: 10.1016/j.scitotenv.2012.10.046

Development of a maleic acid-based material to selectively solid-phase extract basic compounds from environmental samples

N. Fontanals, J. Zohar, F. Borrull, S. Ronka and R.M. Marcé

Journal of Chromatography A, 2021, 1647, 462165
DOI: 10.1016/j.chroma.2021.462165

A Strategy for Complete Degradation of Metformin Using Vortex-Based Hydrodynamic Cavitation

Pravin B. Patil, Pooja Thanekar and Vinay M. Bhandari

Ind. Eng. Chem. Res., 2022
DOI: 10.1021/acs.iecr.2c02519

Development and validation of a hydrophilic interaction liquid chromatography-tandem mass spectrometry method for the quantification of the antidiabetic drug metformin and six others pharmaceuticals in wastewater

Reinhard Oertel, Julien Baldauf and Julia Rossmann

Journal of Chromatography A, 2018, 1556, 73
DOI: 10.1016/j.chroma.2018.04.068

Assessment of a Ficus benjamina wood chip‐based aerated biofilter used for the removal of metformin and ciprofloxacin during domestic wastewater treatment

Liliana García‐Sánchez, Tania Gutiérrez‐Macías and Edson Baltazar Estrada‐Arriaga

J of Chemical Tech & Biotech, 2019, 94, 1870
DOI: 10.1002/jctb.5962

Metformin-induced endocrine disruption and oxidative stress of Oryzias latipes on two-generational condition

Jin Wuk Lee, Yu-Jin Shin, Hokyun Kim, Heejung Kim, Jieun Kim, Su-A Min, Pilje Kim, Seung Do Yu and Kyunghwa Park

Journal of Hazardous Materials, 2019, 367, 171
DOI: 10.1016/j.jhazmat.2018.12.084

Optimization and validation of a hydrophilic interaction liquid chromatography–tandem mass spectrometry method for the determination of 13 top-prescribed pharmaceuticals in influent wastewater

Alexander L. N. van Nuijs, Isabela Tarcomnicu, Ward Simons, Lieven Bervoets, Ronny Blust, Philippe G. Jorens, Hugo Neels and Adrian Covaci

Anal Bioanal Chem, 2010, 398, 2211
DOI: 10.1007/s00216-010-4101-1

Prioritization methodology for the monitoring of active pharmaceutical ingredients in hospital effluents

Silwan Daouk, Nathalie Chèvre, Nathalie Vernaz, Pascal Bonnabry, Pierre Dayer, Youssef Daali and Sandrine Fleury-Souverain

Journal of Environmental Management, 2015, 160, 324
DOI: 10.1016/j.jenvman.2015.06.037

Potential of plant species for phytoremediation of metformin from solutions

R. Moogouei, M. Borghei, S. Hosseini and G. Tajadod

Int. J. Environ. Sci. Technol., 2018, 15, 593
DOI: 10.1007/s13762-017-1538-1

Metformin as an Emerging Pollutant in the Aquatic Environment: Occurrence, Analysis, and Toxicity

Yueyue Zheng, Yongjian Shao, Yinan Zhang, Zhiquan Liu, Zirui Zhao, Ranyun Xu, Jiafeng Ding, Wenbing Li, Binhao Wang and Hangjun Zhang

Toxics, 2024, 12, 483
DOI: 10.3390/toxics12070483

Redox coupling induced by nitrite in the UV/sulfite system: Mechanisms and pathways of metformin degradation

Wenyao Liang, Ziqi Zheng, Jiazhen Zheng, Xinjiang Hu, Haoxiang Zhong, Chao Zhang, Changlan Hou, Ying Fang, Hui Wang, Meifang Li, Xi Hu, Jiaqin Deng and Chunfang Tang

Journal of Environmental Chemical Engineering, 2026, 14, 121648
DOI: 10.1016/j.jece.2026.121648

Impact assessment of emission management strategies of the pharmaceuticals Metformin and Metoprolol to the aquatic environment using Bayesian networks

Caterina Brandmayr, Heide Kerber, Martina Winker and Engelbert Schramm

Science of The Total Environment, 2015, 532, 605
DOI: 10.1016/j.scitotenv.2015.05.074

Wie wird unser Trinkwasser überwacht?

Frank Sacher

Chemie in nserer Zeit, 2013, 47, 148
DOI: 10.1002/ciuz.201300595

Filling in the Gaps in Metformin Biodegradation: a New Enzyme and a Metabolic Pathway for Guanylurea

Lambros J. Tassoulas, Ashley Robinson, Betsy Martinez-Vaz, Kelly G. Aukema, Lawrence P. Wackett and Hideaki Nojiri

Appl Environ Microbiol, 2021, 87
DOI: 10.1128/AEM.03003-20

A multicomponent snapshot of pharmaceuticals and pesticides in the river Meuse basin

Corine J. Houtman, Rob ten Broek, Kevin de Jong, Bart Pieterse and Jan Kroesbergen

Environmental Toxicology and Chemistry, 2013, 32, 2449
DOI: 10.1002/etc.2351

Environmental risk assessment of metformin and its transformation product guanylurea: II. Occurrence in surface waters of Europe and the United States and derivation of predicted no-effect concentrations

Daniel J. Caldwell, Vincent D'Aco, Todd Davidson, Kelly Kappler, Richard J. Murray-Smith, Stewart F. Owen, Paul F. Robinson, Brigitte Simon-Hettich, Jürg Oliver Straub and Joan Tell

Chemosphere, 2019, 216, 855
DOI: 10.1016/j.chemosphere.2018.10.038

Graphene-Based Composites as Catalysts for the Degradation of Pharmaceuticals

Olalekan C. Olatunde and Damian C. Onwudiwe

IJERPH, 2021, 18, 1529
DOI: 10.3390/ijerph18041529

Ecological risk assessment of fifty pharmaceuticals and personal care products (PPCPs) in Chinese surface waters: A proposed multiple-level system

Na Liu, Xiaowei Jin, Chenglian Feng, Zijian Wang, Fengchang Wu, Andrew C. Johnson, Hongxia Xiao, Henner Hollert and John P. Giesy

Environment International, 2020, 136, 105454
DOI: 10.1016/j.envint.2019.105454

Ozonation products from trace organic chemicals in municipal wastewater and from metformin: peering through the keyhole with supercritical fluid chromatography-mass spectrometry

Bettina Seiwert, Maolida Nihemaiti, Coretta Bauer, Matthias Muschket, Daniel Sauter, Regina Gnirss and Thorsten Reemtsma

Water Research, 2021, 196, 117024
DOI: 10.1016/j.watres.2021.117024

Selective materials for solid-phase extraction in environmental analysis

Núria Gilart, Francesc Borrull, Núria Fontanals and Rosa Maria Marcé

Trends in Environmental Analytical Chemistry, 2014, 1, e8
DOI: 10.1016/j.teac.2013.11.002

Age-dependent effects in fathead minnows from the anti-diabetic drug metformin

Jordan Crago, Cindy Bui, Sanji Grewal and Daniel Schlenk

General and Comparative Endocrinology, 2016, 232, 185
DOI: 10.1016/j.ygcen.2015.12.030

Fathead minnow exposed to environmentally relevant concentrations of metformin for one life cycle show no adverse effects

Joanne L. Parrott, Grazina Pacepavicius, Kallie Shires, Stacey Clarence, Hufsa Khan, Madelaine Gardiner, Cheryl Sullivan, Mehran Alaee and Jeff C. Clements

FACETS, 2021, 6, 998
DOI: 10.1139/facets-2020-0106

Detection and quantification of residues and metabolites of medicinal products in environmental compartments, food commodities and workplaces. A review

Paola Bottoni and Sergio Caroli

Journal of Pharmaceutical and Biomedical Analysis, 2015, 106, 3
DOI: 10.1016/j.jpba.2014.12.019

Direct injection analysis of oxypurinol and metformin in wastewater by hydrophilic interaction liquid chromatography coupled to tandem mass spectrometry

Qiuda Zheng, Pradeep Dewapriya, Geoff Eaglesham, Tim Reeks, Jack Thompson, Fahad Ahmed, Pritesh Prasad, Kevin V. Thomas, Jochen F. Mueller and Phong K. Thai

Drug Testing and Analysis, 2022, 14, 1519
DOI: 10.1002/dta.3266

Feasibility study of metformin removal from synthetic wastewater using doped-TiO2 as catalyst and UVA-LED

Sepideh Besharatian, Gholamreza Asadollahfardi and Gholamreza Moussavi

Desalination and Water Treatment, 2020, 175, 68
DOI: 10.5004/dwt.2020.24883

Community-level responses and environmental fate of metformin in freshwater mesocosms

Nicholas C. Blandford, Vince Palace, José Luis Rodríguez-Gil, Lauren Timlick, Madeline Stanley, Richard A. Frank, Sheena Campbell, Martina Rudy, Stephanie Marshall, Abby Wynia, Thomas Clark, Jessie Cunningham, Mehran Alaee, Joanne Parrott, Karen A. Kidd, Kathleen Stevack, Lyne Sabourin, Justin B. Renaud, Mark W. Sumarah, Kristin Nielsen, Mark E. McMaster and Erin Ussery

Science of The Total Environment, 2024, 957, 177493
DOI: 10.1016/j.scitotenv.2024.177493

Multiclass target analysis of contaminants of emerging concern including transformation products, soil bioavailability assessment and retrospective screening as tools to evaluate risks associated with reclaimed water reuse

Vasiliki G. Beretsou, Maria-Christina Nika, Kyriakos Manoli, Costas Michael, Qian Sui, Lian Lundy, D. Michael Revitt, Nikolaos S. Thomaidis and Despo Fatta-Kassinos

Science of The Total Environment, 2022, 852, 158391
DOI: 10.1016/j.scitotenv.2022.158391

Screening of pharmaceuticals and hormones at the regional scale, in surface and groundwaters intended to human consumption

Emmanuelle Vulliet and Cécile Cren-Olivé

Environmental Pollution, 2011, 159, 2929
DOI: 10.1016/j.envpol.2011.04.033

Mixed-mode ion-exchange polymeric sorbents in environmental analysis

Núria Fontanals, Francesc Borrull and Rosa Maria Marcé

Journal of Chromatography A, 2020, 1609, 460531
DOI: 10.1016/j.chroma.2019.460531

Monitoring of a Broad Set of Pharmaceuticals in Wastewaters by High-Resolution Mass Spectrometry and Evaluation of Heterogenous Catalytic Ozonation for Their Removal in a Pre-Industrial Level Unit

Christina Nannou, Efthimia Kaprara, Savvina Psaltou, Maria Salapasidou, Panagiota-Aikaterini Palasantza, Panagiotis Diamantopoulos, Dimitra A. Lambropoulou, Manassis Mitrakas and Anastasios Zouboulis

Analytica, 2022, 3, 195
DOI: 10.3390/analytica3020014

Use of Terrestrial Plants for Phytoremediation of Pollutants from Solutions

Roxana Moogouei

Iran J Sci Technol Trans Sci, 2018, 42, 1753
DOI: 10.1007/s40995-017-0356-0

Sensitive detection of antidiabetic compounds and one degradation product in wastewater samples by a new SPE-LC-MS/MS method

Vasile-Ion Iancu, Roxana-Elena Scutariu, Florentina-Laura Chiriac and Gabriel-Lucian Radu

Journal of Environmental Science and Health, Part A, 2021, 56, 310
DOI: 10.1080/10934529.2021.1873671

Metformin environmental exposure: A systematic review

Eliane Papa Ambrosio-Albuquerque, Luis Fernando Cusioli, Rosângela Bergamasco, Adriana Aparecida Sinópolis Gigliolli, Luara Lupepsa, Brennda Ribeiro Paupitz, Pablo Américo Barbieri, Luciana Andreia Borin-Carvalho and Ana Luiza de Brito Portela-Castro

Environmental Toxicology and Pharmacology, 2021, 83, 103588
DOI: 10.1016/j.etap.2021.103588

Identification of genotoxic transformation products by effect-directed analysis with high-performance thin-layer chromatography and non-target screening

Lena Stütz, Patricia Leitner, Wolfgang Schulz and Rudi Winzenbacher

JPC - Journal of Planar Chromatography - Modern TLC, 2019, 32, 173
DOI: 10.1556/1006.2019.32.3.1

Pharmaceutical and transformation products during unplanned water reuse: Insights into natural attenuation, plant uptake and human health impact under field conditions

Raffaella Meffe, Ana de Santiago-Martín, Gloria Teijón, Virtudes Martínez Hernández, Isabel López-Heras, Leonor Nozal and Irene de Bustamante

Environment International, 2021, 157, 106835
DOI: 10.1016/j.envint.2021.106835

Sulfite-synergized VUV photolytic decomposition of metformin: A combined experimental and theoretical study

Yurong Gu, Zijun Dong, Qi Han, Liao Ouyang and Yihua Chen

Journal of Water Process Engineering, 2025, 77, 108443
DOI: 10.1016/j.jwpe.2025.108443

Spectroscopy Determination of Metformin in Drinking Water, Tablet, Human Serum, and Urine Based on the Aggregation of Nanoparticles

M. Moradi, M. R. Sohrabi and S. Mortazavinik

J Appl Spectrosc, 2021, 88, 63
DOI: 10.1007/s10812-021-01141-3

Application of liquid chromatography-tandem mass spectrometry in quantitative bioanalyses of organic molecules in aquatic environment and organisms

Ugo Bussy, Ke Li and Weiming Li

Environ Sci Pollut Res, 2016, 23, 9459
DOI: 10.1007/s11356-016-6433-7

The impact of the anti-diabetic drug metformin on the intestinal microbiome of larval brown trout (Salmo trutta f. fario)

Eike Thorben Rogall, Stefanie Jacob, Rita Triebskorn and Thomas Schwartz

Environ Sci Eur, 2020, 32
DOI: 10.1186/s12302-020-00341-6

Microbial degradation of contaminants of emerging concern: metabolic, genetic and omics insights for enhanced bioremediation

Bhavik A. Shah, Harshit Malhotra, Sandesh E. Papade, Tushar Dhamale, Omkar P. Ingale, Sravanti T. Kasarlawar and Prashant S. Phale

Front. Bioeng. Biotechnol., 2024, 12
DOI: 10.3389/fbioe.2024.1470522

Metformin as an emerging concern in wastewater: Occurrence, analysis and treatment methods

Akash Balakrishnan, Mika Sillanpää, Meenu Mariam Jacob and Dai-Viet N. Vo

Environmental Research, 2022, 213, 113613
DOI: 10.1016/j.envres.2022.113613

Metformin degradation in aqueous solutions by electro-activation of persulfate and hydrogen peroxide using natural and synthetic ferrous ion sources

Elham Aseman-Bashiz and Hossein Sayyaf

Journal of Molecular Liquids, 2020, 300, 112285
DOI: 10.1016/j.molliq.2019.112285

Optimization of Capillary Electrophoresis by Central Composite Design for Separation of Pharmaceutical Contaminants in Water Quality Testing

Eman T. Elmorsi and Edward P. C. Lai

Environments, 2025, 12, 22
DOI: 10.3390/environments12010022

Assessment of full-scale biological nutrient removal systems upgraded with physico-chemical processes for the removal of emerging pollutants present in wastewaters from Mexico

Edson Baltazar Estrada-Arriaga, Juana Enriqueta Cortés-Muñoz, Arturo González-Herrera, César Guillermo Calderón-Mólgora, Ma. de Lourdes Rivera-Huerta, Esperanza Ramírez-Camperos, Leticia Montellano-Palacios, Silvia Lucila Gelover-Santiago, Sara Pérez-Castrejón, Lina Cardoso-Vigueros, Alejandra Martín-Domínguez and Liliana García-Sánchez

Science of The Total Environment, 2016, 571, 1172
DOI: 10.1016/j.scitotenv.2016.07.118

Multi-residue ultra-performance liquid chromatography coupled with tandem mass spectrometry method for comprehensive multi-class anthropogenic compounds of emerging concern analysis in a catchment-based exposure-driven study

Kathryn Proctor, Bruce Petrie, Ruth Barden, Tom Arnot and Barbara Kasprzyk-Hordern

Anal Bioanal Chem, 2019, 411, 7061
DOI: 10.1007/s00216-019-02091-8

Impact of Metformin and Increased Temperature on Blue Mussels Mytilus edulis - Evidence for Synergism

Wulan Koagouw and Corina Ciocan

Journal of Shellfish Research, 2018, 37, 467
DOI: 10.2983/035.037.0301

Widespread occurrence and potential for biodegradation of bioactive contaminants in Congaree National Park, USA

Paul M. Bradley, William A. Battaglin, Jimmy M. Clark, Frank P. Henning, Michelle L. Hladik, Luke R. Iwanowicz, Celeste A. Journey, Jeffrey W. Riley and Kristin M. Romanok

Environmental Toxicology and Chemistry, 2017, 36, 3045
DOI: 10.1002/etc.3873

Diffusion of hydrophilic organic micropollutants in granular activated carbon with different pore sizes

Laura Piai, Jouke E. Dykstra, Mahesa G. Adishakti, Marco Blokland, Alette A.M. Langenhoff and Albert van der Wal

Water Research, 2019, 162, 518
DOI: 10.1016/j.watres.2019.06.012

Photocatalytic degradation of metformin using TiO2-CuO heterojunctions synthesized by green chemistry and immobilized on beach sand granules in fluidized bed annular photoreactor (FBAP)

Ricardo Solano, Liset Mallarino, Miguel Mueses and Adriana Herrera

Journal of Environmental Chemical Engineering, 2024, 12, 113576
DOI: 10.1016/j.jece.2024.113576

Rapid degradation of pharmaceutical pollutants using poly(1-naphthylamine) decorated BaFe2O4 nanohybrids under microwave irradiation

Shayista Gaffar, S. M. Ashraf and Ufana Riaz

J Environ Health Sci Engineer, 2024, 23
DOI: 10.1007/s40201-024-00931-z

Ultimate biodegradability and ecotoxicity of orally administered antidiabetic drugs

Marta Markiewicz, Christian Jungnickel, Stefan Stolte, Anna Białk-Bielińska, Jolanta Kumirska and Wojciech Mrozik

Journal of Hazardous Materials, 2017, 333, 154
DOI: 10.1016/j.jhazmat.2017.03.030

Biochemical and genomic evidence for converging metabolic routes of metformin and biguanide breakdown in environmental Pseudomonads

Katie B. Wissbroecker, Anthony J. Zmuda, Harsheeth Karumanchi and Thomas D. Niehaus

Journal of Biological Chemistry, 2024, 300, 107935
DOI: 10.1016/j.jbc.2024.107935

Sorption and mobility of metformin and guanylurea in soils as affected by biosolid amendment: Batch and column tests

Rowena M. Briones and Ajit K. Sarmah

Environmental Pollution, 2019, 244, 19
DOI: 10.1016/j.envpol.2018.10.025

Modelling degradation kinetics of metformin and guanylurea in soil microcosms to derive degradation end-points

Rowena M. Briones and Ajit K. Sarmah

Environmental Pollution, 2019, 245, 735
DOI: 10.1016/j.envpol.2018.11.045

Impact of the Antidiabetic Drug Metformin and Its Transformation Product Guanylurea on the Health of the Big Ramshorn Snail (Planorbarius corneus)

Stefanie Jacob, Heinz-R. Köhler, Selina Tisler, Christian Zwiener and Rita Triebskorn

Front. Environ. Sci., 2019, 7
DOI: 10.3389/fenvs.2019.00045

Protonation–deprotonation and structural dynamics of antidiabetic drug metformin

Belén Hernández, Fernando Pflüger, Sergei G. Kruglik, Régis Cohen and Mahmoud Ghomi

Journal of Pharmaceutical and Biomedical Analysis, 2015, 114, 42
DOI: 10.1016/j.jpba.2015.04.041

Environmental risk assessment of metformin and its transformation product guanylurea. I. Environmental fate

Jürg Oliver Straub, Daniel J. Caldwell, Todd Davidson, Vincent D'Aco, Kelly Kappler, Paul F. Robinson, Brigitte Simon-Hettich and Joan Tell

Chemosphere, 2019, 216, 844
DOI: 10.1016/j.chemosphere.2018.10.036

Investigating antimicrobial resistance determinants and micropollutants in urban sewage treatment plants of India: Occurrence, removal and ecotoxicological risk

Rishabh Shukla, Deepak Kumar Prasad and Shaikh Ziauddin Ahammad

Journal of Environmental Chemical Engineering, 2024, 12, 111654
DOI: 10.1016/j.jece.2023.111654

Performance assessment of a modified trickling filter and conventional activated sludge process along with tertiary treatment in removing emerging pollutants from urban sewage

Rishabh Shukla and Shaikh Ziauddin Ahammad

Science of The Total Environment, 2023, 858, 159833
DOI: 10.1016/j.scitotenv.2022.159833

New chemicals fuel the evolution of microbial biodegradation

Lawrence P. Wackett and Jan Roelof van der Meer

Microbiol Mol Biol Rev, 2025, 89
DOI: 10.1128/mmbr.00207-24

New Potentiometric Sensor for Determination of Metformin

Zh. Kormosh, N. Kormosh, S. Golub, Yu. Pachenko, O. Yurchenko, T. Savchuk, S. Korolchuk, S. Borkova and S. Suprunovich

Pharm Chem J, 2022, 56, 1140
DOI: 10.1007/s11094-022-02765-1

Wastewater-based estimation of diabetes mellitus prevalence in 237 cities: A cross-China study

Xinxin Zhou, Shucheng Liu, Manlei Zhang, Chen Shi, Mengyi Chen, Chenzhi Hou and Bin Di

Science of The Total Environment, 2024, 924, 171659
DOI: 10.1016/j.scitotenv.2024.171659

Comprehensive study of the antidiabetic drug metformin and its transformation product guanylurea in Greek wastewaters

Christina I. Kosma, Dimitra A. Lambropoulou and Triantafyllos A. Albanis

Water Research, 2015, 70, 436
DOI: 10.1016/j.watres.2014.12.010

Ecological Risk Assessment of Pharmaceuticals in the Transboundary Vecht River (Germany and The Netherlands)

Daniel J. Duarte, Gunnar Niebaum, Volker Lämmchen, Eri van Heijnsbergen, Rik Oldenkamp, Lucia Hernández-Leal, Heike Schmitt, Ad M. J. Ragas and Jörg Klasmeier

Environmental Toxicology and Chemistry, 2022, 41, 648
DOI: 10.1002/etc.5062

Sorption Behavior of Charged and Neutral Polar Organic Compounds on Solid Phase Extraction Materials: Which Functional Group Governs Sorption?

Patrick S. Bäuerlein, Jodie E. Mansell, Thomas L. ter Laak and Pim de Voogt

Environ. Sci. Technol., 2012, 46, 954
DOI: 10.1021/es203404x

Formation and occurrence of transformation products of metformin in wastewater and surface water

Selina Tisler and Christian Zwiener

Science of The Total Environment, 2018, 628-629, 1121
DOI: 10.1016/j.scitotenv.2018.02.105

High-performance liquid chromatography quadrupole time-of-flight mass spectrometry method for the analysis of antidiabetic drugs in aqueous environmental samples

Julia Martín, Wolfgang Buchberger, Juan Luis Santos, Esteban Alonso and Irene Aparicio

Journal of Chromatography B, 2012, 895-896, 94
DOI: 10.1016/j.jchromb.2012.03.023

Experimental design approach for the removal of the antidiabetic drug, metformin at a high concentration by photocatalytic processes

Edson Baltazar Estrada‐Arriaga, Liliana García‐Sánchez and Axel Falcón‐Rojas

Water & Environment J, 2021, 35, 759
DOI: 10.1111/wej.12668

Metformin Contamination in Global Waters: Biotic and Abiotic Transformation, Byproduct Generation and Toxicity, and Evaluation as a Pharmaceutical Indicator

Yuanzhen He, Yanyan Zhang and Feng Ju

Environ. Sci. Technol., 2022, 56, 13528
DOI: 10.1021/acs.est.2c02495

Pharmaceuticals suppress algal growth and microbial respiration and alter bacterial communities in stream biofilms

Emma J. Rosi-Marshall, Dustin W. Kincaid, Heather A. Bechtold, Todd V. Royer, Miguel Rojas and John J. Kelly

Ecological Applications, 2013, 23, 583
DOI: 10.1890/12-0491.1

The behavior of pharmaceutically active compounds and contrast agents during wastewater treatment – Combining sampling strategies and analytical techniques: A critical review

Lena Telgmann and Harald Horn

Science of The Total Environment, 2024, 946, 174344
DOI: 10.1016/j.scitotenv.2024.174344

Screening of French groundwater for regulated and emerging contaminants

Benjamin Lopez, Patrick Ollivier, Anne Togola, Nicole Baran and Jean-Philippe Ghestem

Science of The Total Environment, 2015, 518-519, 562
DOI: 10.1016/j.scitotenv.2015.01.110

Multi-region assessment of pharmaceutical exposures and predicted effects in USA wadeable urban-gradient streams

Paul M. Bradley, Celeste A. Journey, Daniel T. Button, Daren M. Carlisle, Bradley J. Huffman, Sharon L. Qi, Kristin M. Romanok, Peter C. Van Metre and Miguel Cañedo-Argüelles Iglesias

PLoS ONE, 2020, 15, e0228214
DOI: 10.1371/journal.pone.0228214

Silica-alumina composite as an effective adsorbent for the removal of metformin from water

Maysam Alnajjar, Afif Hethnawi, Ghada Nafie, Azfar Hassan, Gerardo Vitale and Nashaat N. Nassar

Journal of Environmental Chemical Engineering, 2019, 7, 102994
DOI: 10.1016/j.jece.2019.102994

Occurrence and indicators of pharmaceuticals in Chinese streams: A nationwide study

Bo Yao, Shuwen Yan, Lushi Lian, Xin Yang, Chunli Wan, Hengtao Dong and Weihua Song

Environmental Pollution, 2018, 236, 889
DOI: 10.1016/j.envpol.2017.10.032

An efficient removal approach for degradation of metformin from aqueous solutions with sulfate radicals

A. Parra-Marfil, M.V. López-Ramón, A. Aguilar-Aguilar, I.A. García-Silva, S. Rosales-Mendoza, L.A. Romero-Cano, E. Bailón-García and R. Ocampo-Pérez

Environmental Research, 2023, 217, 114852
DOI: 10.1016/j.envres.2022.114852

Emerging nitrogenous disinfection byproducts: Transformation of the antidiabetic drug metformin during chlorine disinfection of water

Dominic Armbruster, Oliver Happel, Marco Scheurer, Klaus Harms, Torsten C. Schmidt and Heinz-Jürgen Brauch

Water Research, 2015, 79, 104
DOI: 10.1016/j.watres.2015.04.020

Hydrophilic interaction chromatography in drug analysis

Ana Ares and José Bernal

Open Chemistry, 2012, 10, 534
DOI: 10.2478/s11532-012-0003-8

Hydrophilic interaction liquid chromatography coupled to mass spectrometry-based detection to determine emerging organic contaminants in environmental samples

Daniela Salas, Francesc Borrull, Núria Fontanals and Rosa Maria Marcé

TrAC Trends in Analytical Chemistry, 2017, 94, 141
DOI: 10.1016/j.trac.2017.07.017

Pharmaceuticals and personal care products found in the Great Lakes above concentrations of environmental concern

Benjamin D. Blair, Jordan P. Crago, Curtis J. Hedman and Rebecca D. Klaper

Chemosphere, 2013, 93, 2116
DOI: 10.1016/j.chemosphere.2013.07.057

Occurrence and fate of pharmaceutically active compounds in the largest municipal wastewater treatment plant in Southwest China: Mass balance analysis and consumption back-calculated model

Qing Yan, Xu Gao, Lei Huang, Xiu-Mei Gan, Yi-Xin Zhang, You-Peng Chen, Xu-Ya Peng and Jin-Song Guo

Chemosphere, 2014, 99, 160
DOI: 10.1016/j.chemosphere.2013.10.062

A multi-marker assessment of sewage contamination in streams using human-associated indicator bacteria, human-specific viruses, and pharmaceuticals

Peter L. Lenaker, Matthew A. Pronschinske, Steven R. Corsi, Joel P. Stokdyk, Hayley T. Olds, Deborah K. Dila and Sandra L. McLellan

Science of The Total Environment, 2024, 930, 172505
DOI: 10.1016/j.scitotenv.2024.172505

Advantage of liquid chromatography with high‐resolution mass spectrometry for the detection of the small and polar molecules trifluoroacetic acid and sulfamic acid

Wolfram Seitz, Wolfgang Schulz and Rudi Winzenbacher

J of Separation Science, 2018, 41, 4437
DOI: 10.1002/jssc.201800723

Trends in sample preparation and separation methods for the analysis of very polar and ionic compounds in environmental water and biota samples

Sarah Knoll, Tobias Rösch and Carolin Huhn

Anal Bioanal Chem, 2020, 412, 6149
DOI: 10.1007/s00216-020-02811-5

Unique Features of Metformin: A Combined Experimental, Theoretical, and Simulation Study of Its Structure, Dynamics, and Interaction Energetics with DNA Grooves

Sayantan Mondal, Rudra N. Samajdar, Saumyak Mukherjee, Aninda J. Bhattacharyya and Biman Bagchi

J. Phys. Chem. B, 2018, 122, 2227
DOI: 10.1021/acs.jpcb.7b11928

Occurrence and Spatiotemporal Dynamics of Pharmaceuticals in a Temperate-Region Wastewater Effluent-Dominated Stream: Variable Inputs and Differential Attenuation Yield Evolving Complex Exposure Mixtures

Hui Zhi, Dana W. Kolpin, Rebecca D. Klaper, Luke R. Iwanowicz, Shannon M. Meppelink and Gregory H. LeFevre

Environ. Sci. Technol., 2020, 54, 12967
DOI: 10.1021/acs.est.0c02328

Removal of charged micropollutants from water by ion-exchange polymers – Effects of competing electrolytes

Patrick S. Bäuerlein, Thomas L. ter Laak, Roberta C.H.M. Hofman-Caris, Pim de Voogt and Steven T.J. Droge

Water Research, 2012, 46, 5009
DOI: 10.1016/j.watres.2012.06.048

Sale-based estimation of pharmaceutical concentrations and associated environmental risk in the Japanese wastewater system

Kai He, Alistair G. Borthwick, Yingchao Lin, Yuening Li, Jie Fu, Yongjie Wong and Wen Liu

Environment International, 2020, 139, 105690
DOI: 10.1016/j.envint.2020.105690