Biocatalytic synthesis of chiral cyclic γ-oxoesters by sequential C–H hydroxylation, alcohol oxidation and alkene reduction

Elisabetta Brenna, Michele Crotti, Francesco G. Gatti, Daniela Monti, Fabio Parmeggiani, Andrea Pugliese and Francesca Tentori

Green Chem., 2017, 19, 5122
DOI: 10.1039/C7GC02215H

Synthesis of cyclically constrained sugar derived α/β- and α/γ-peptides

Antonio Franconetti, Sorel Jatunov, Pastora Borrachero, Manuel Gómez-Guillén and Francisca Cabrera-Escribano

Org. Biomol. Chem., 2013, 11, 676
DOI: 10.1039/C2OB26992A

Mutual kinetic resolution: probing enantiorecognition phenomena and screening for kinetic resolution with racemic reagents

Stephen G. Davies, Ai M. Fletcher, Paul M. Roberts and James E. Thomson

Org. Biomol. Chem., 2021, 19, 2847
DOI: 10.1039/D0OB02151B

Doubly diastereoselective conjugate addition of homochiral lithium amides to homochiral α,β-unsaturated esters containing cis- and trans-dioxolane units

Stephen G. Davies, Matthew J. Durbin, Euan C. Goddard, Peter M. Kelly, Wataru Kurosawa, James A. Lee, Rebecca L. Nicholson, Paul D. Price, Paul M. Roberts, Angela J. Russell, Philip M. Scott and Andrew D. Smith

Org. Biomol. Chem., 2009, 7, 761
DOI: 10.1039/b818298a

The thio-adduct facilitated, enzymatic kinetic resolution of 4-hydroxycyclopentenone and 4-hydroxycyclohexenone

Aisling O'Byrne, Cian Murray, Dearbhla Keegan, Carole Palacio, Paul Evans and Ben S. Morgan

Org. Biomol. Chem., 2010, 8, 539
DOI: 10.1039/B916506A

Asymmetric syntheses of enantiopure C(5)-substituted transpentacins via diastereoselective Ireland–Claisen rearrangements

Stephen G. Davies, Ai M. Fletcher, Paul M. Roberts, James E. Thomson and Charlotte M. Zammit

Chem. Commun., 2013, 49, 7037
DOI: 10.1039/c3cc43250e

Diastereoselective Ireland–Claisen rearrangements of substituted allyl β-amino esters: applications in the asymmetric synthesis of C(5)-substituted transpentacins

Stephen G. Davies, Ai M. Fletcher, James A. Lee, Paul M. Roberts, Myriam Y. Souleymanou, James E. Thomson and Charlotte M. Zammit

Org. Biomol. Chem., 2014, 12, 2702
DOI: 10.1039/c4ob00274a

Double asymmetric induction as a mechanistic probe: the doubly diastereoselective conjugate addition of enantiopure lithium amides to enantiopure α,β-unsaturated esters and enantiopure α,β-unsaturated hydroxamates

Stephen G. Davies, James A. Lee, Paul M. Roberts, James E. Thomson and Jingda Yin

Tetrahedron, 2011, 67, 6382
DOI: 10.1016/j.tet.2011.05.102

The stereodivergent asymmetric synthesis of a range of 2-(1′-hydroxyalkyl)phenols

Stephen G. Davies, W. Ewan Hume, Paul M. Roberts and James E. Thomson

Tetrahedron, 2010, 66, 8076
DOI: 10.1016/j.tet.2010.07.058

Catalytic Parallel Kinetic Resolution under Homogeneous Conditions

Trisha A. Duffey, James A. MacKay and Edwin Vedejs

J. Org. Chem., 2010, 75, 4674
DOI: 10.1021/jo100695z

Syntheses of (R)-sitagliptin

Stephen G. Davies, Ai M. Fletcher and James E. Thomson

Tetrahedron: Asymmetry, 2015, 26, 1109
DOI: 10.1016/j.tetasy.2015.09.010

Parallel Kinetic Resolution of Acyclic γ-Amino-α,β-unsaturated Esters: Application to the Asymmetric Synthesis of 4-Aminopyrrolidin-2-ones

Stephen G. Davies, James A. Lee, Paul M. Roberts, James E. Thomson and Jingda Yin

Org. Lett., 2012, 14, 218
DOI: 10.1021/ol203011u

Trading N and O: asymmetric syntheses of β-hydroxy-α-amino acids via α-hydroxy-β-amino esters

Stephen G. Davies, Ai M. Fletcher, Aileen B. Frost, James A. Lee, Paul M. Roberts and James E. Thomson

Tetrahedron, 2013, 69, 8885
DOI: 10.1016/j.tet.2013.08.007

The conjugate addition of enantiomerically pure lithium amides as chiral ammonia equivalents part II: 2005−2011

Stephen G. Davies, Ai M. Fletcher, Paul M. Roberts and James E. Thomson

Tetrahedron: Asymmetry, 2012, 23, 1111
DOI: 10.1016/j.tetasy.2012.08.009

Conjugate addition of lithium N-tert-butyldimethylsilyloxy-N-(α-methylbenzyl)amide: asymmetric synthesis of β2,2,3-trisubstituted amino acids

Scott A. Bentley, Stephen G. Davies, James A. Lee, Paul M. Roberts, Angela J. Russell, James E. Thomson and Steven M. Toms

Tetrahedron, 2010, 66, 4604
DOI: 10.1016/j.tet.2010.04.027

Achieving Regio‐ and Enantioselectivity of P450‐Catalyzed Oxidative CH Activation of Small Functionalized Molecules by Structure‐Guided Directed Evolution

Rubén Agudo, Gheorghe‐Doru Roiban and Manfred T. Reetz

ChemBioChem, 2012, 13, 1465
DOI: 10.1002/cbic.201200244

Crystal Structures of Dipeptides Derived from the β-Amino Acids (1R,2S)-2-Aminocyclopentanecarboxylic Acid and (1S,2R,3S)-2-Amino-3-methylcyclopentanecarboxylic Acid

Elin Abraham, Stephen G. Davies, Paul M. Roberts, Amber L. Thompson and James E. Thomson

J Chem Crystallogr, 2011, 41, 1722
DOI: 10.1007/s10870-011-0164-x

Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) andtrans-γ-Hydroxycrotonic Acid (T-HCA) Analogs

Jacob Krall, Claus Hatt Jensen, Francesco Bavo, Christina Birkedahl Falk-Petersen, Anne Stæhr Haugaard, Stine Byskov Vogensen, Yongsong Tian, Mia Nittegaard-Nielsen, Sara Björk Sigurdardóttir, Jan Kehler, Kenneth Thermann Kongstad, David E. Gloriam, Rasmus Prætorius Clausen, Kasper Harpsøe, Petrine Wellendorph and Bente Frølund

J. Med. Chem., 2017, 60, 9022
DOI: 10.1021/acs.jmedchem.7b01351

The asymmetric synthesis of enantiopure C(5)-substituted transpentacins via diastereoselective conjugate additions to a β′-amino-α,β-unsaturated ester

Stephen G. Davies, Ai M. Fletcher, Paul M. Roberts, James E. Thomson and Charlotte M. Zammit

Tetrahedron: Asymmetry, 2016, 27, 208
DOI: 10.1016/j.tetasy.2016.01.012

A systematic study of the solid state and solution phase conformational preferences of β-peptides derived from C(3)-alkyl substituted transpentacin derivatives

Elin Abraham, Timothy D.W. Claridge, Stephen G. Davies, Barbara Odell, Paul M. Roberts, Angela J. Russell, Andrew D. Smith, Lorna J. Smith, Helen R. Storr, Miles J. Sweet, Amber L. Thompson, James E. Thomson, George E. Tranter and David J. Watkin

Tetrahedron: Asymmetry, 2011, 22, 69
DOI: 10.1016/j.tetasy.2010.12.007

Efficient parallel resolution of pentafluorophenyl active esters using quasi-enantiomeric combinations of oxazolidin-2-ones

Najla Al Shaye, Sameer Chavda, Elliot Coulbeck, Jason Eames and Yonas Yohannes

Tetrahedron: Asymmetry, 2011, 22, 439
DOI: 10.1016/j.tetasy.2011.02.021

Asymmetric syntheses of (+)-negamycin, (+)-3-epi-negamycin and sperabillin C via lithium amide conjugate addition

Stephen G. Davies, Osamu Ichihara, Paul M. Roberts and James E. Thomson

Tetrahedron, 2011, 67, 216
DOI: 10.1016/j.tet.2010.10.067

Resolution of pentafluorophenyl 2-phenylpropanoate using combinations of quasi-enantiomeric oxazolidin-2-ones

Najla Al Shaye, David M. Benoit, Sameer Chavda, Elliot Coulbeck, Marco Dingjan, Jason Eames and Yonas Yohannes

Tetrahedron: Asymmetry, 2011, 22, 413
DOI: 10.1016/j.tetasy.2011.02.022

Asymmetric syntheses of dihydroxyhomoprolines via doubly diastereoselective lithium amide conjugate addition reactions

Stephen G. Davies, Emma M. Foster, James A. Lee, Paul M. Roberts and James E. Thomson

Tetrahedron, 2013, 69, 8680
DOI: 10.1016/j.tet.2013.07.096

Preparation of Cyclic β-Amino Acid Derivatives with Quaternary Carbon Center via a Radical Addition-Cyclization Sequence

Okiko Miyata, Norihiko Takeda, Masafumi Ueda, Seiko Kajisa, Kenji Matsuno and Takeaki Naito

HETEROCYCLES, 2014, 89, 143
DOI: 10.3987/COM-13-12881

Asymmetric synthesis of piperidines and octahydroindolizines using a one-pot ring-closure/N-debenzylation procedure

Stephen G. Davies, Ai M. Fletcher, Deri G. Hughes, James A. Lee, Paul D. Price, Paul M. Roberts, Angela J. Russell, Andrew D. Smith, James E. Thomson and Oliver M.H. Williams

Tetrahedron, 2011, 67, 9975
DOI: 10.1016/j.tet.2011.09.038

Asymmetric synthesis of (−)-(S,S)-homaline

Stephen G. Davies, James A. Lee, Paul M. Roberts, Jeffrey P. Stonehouse and James E. Thomson

Tetrahedron Letters, 2012, 53, 1119
DOI: 10.1016/j.tetlet.2011.12.088

Asymmetric syntheses of 3,4-syn- and 3,4-anti-3-substituted-4-aminopiperidin-2-ones: application to the asymmetric synthesis of (+)-(3S,4R)-cisapride

Stephen G. Davies, Rosemary Huckvale, James A. Lee, Thomas J.A. Lorkin, Paul M. Roberts and James E. Thomson

Tetrahedron, 2012, 68, 3263
DOI: 10.1016/j.tet.2011.12.084

Doubly diastereoselective conjugate addition of enantiopure lithium amides to enantiopure N-enoyl oxazolidin-2-ones: a mechanistic probe

Stephen G. Davies, Ai M. Fletcher, Gesine J. Hermann, Giovanna Poce, Paul M. Roberts, Andrew D. Smith, Miles J. Sweet and James E. Thomson

Tetrahedron: Asymmetry, 2010, 21, 1635
DOI: 10.1016/j.tetasy.2010.03.033

Asymmetric synthesis of syn- and anti-α-deuterio-β3-phenylalanine derivatives

Stephen G. Davies, Emma M. Foster, Catherine R. McIntosh, Paul M. Roberts, Timothy E. Rosser, Andrew D. Smith and James E. Thomson

Tetrahedron: Asymmetry, 2011, 22, 1035
DOI: 10.1016/j.tetasy.2011.06.008

Parallel kinetic resolution of tert-butyl (RS)-6-alkyl-cyclohex-1-ene-carboxylates for the asymmetric synthesis of 6-alkyl-substituted cishexacin derivatives

Stephen G. Davies, Matthew J. Durbin, Scott J.S. Hartman, Ai Matsuno, Paul M. Roberts, Angela J. Russell, Andrew D. Smith, James E. Thomson and Steven M. Toms

Tetrahedron: Asymmetry, 2008, 19, 2870
DOI: 10.1016/j.tetasy.2008.11.019

Asymmetric synthesis of (−)-(1R,7aS)-absouline

Stephen G. Davies, Ai M. Fletcher, Clément Lebée, Paul M. Roberts, James E. Thomson and Jingda Yin

Tetrahedron, 2013, 69, 1369
DOI: 10.1016/j.tet.2012.11.080

Asymmetric synthesis of (−)-(R)-sitagliptin

Stephen G. Davies, Ai M. Fletcher, Linlu Lv, Paul M. Roberts and James E. Thomson

Tetrahedron Letters, 2012, 53, 3052
DOI: 10.1016/j.tetlet.2012.04.025

Novel and practical asymmetric synthesis of β 2,3 -amino esters using asymmetric Michael addition of chiral amine

Minoru Ozeki, Honoka Egawa, Toshiki Takano, Hideki Mizutani, Narumi Yasuda, Kenji Arimitsu, Tetsuya Kajimoto, Shinzo Hosoi, Hiroki Iwasaki, Naoto Kojima, Manabu Node and Masayuki Yamashita

Tetrahedron, 2017, 73, 2014
DOI: 10.1016/j.tet.2017.02.037

Conjugate Addition of Lithium N-Phenyl-N-(α-methylbenzyl)amide: Application to the Asymmetric Synthesis of (R)-(−)-Angustureine

Scott A. Bentley, Stephen G. Davies, James A. Lee, Paul M. Roberts and James E. Thomson

Org. Lett., 2011, 13, 2544
DOI: 10.1021/ol200625h

A Tandem Conjugate Addition/Cyclization Protocol for the Asymmetric Synthesis of 2-Aryl-4-aminotetrahydroquinoline-3-carboxylic Acid Derivatives

Stephen G. Davies, Nadeam Mujtaba, Paul M. Roberts, Andrew D. Smith and James E. Thomson

Org. Lett., 2009, 11, 1959
DOI: 10.1021/ol9004118

Trading N and O. Part 2: Exploiting aziridinium intermediates for the synthesis of β-hydroxy-α-amino acids

Stephen G. Davies, Ai M. Fletcher, Aileen B. Frost, Paul M. Roberts and James E. Thomson

Tetrahedron, 2014, 70, 5849
DOI: 10.1016/j.tet.2014.06.057