Issue 16, 2018

Asperones A–E, five dimeric polyketides with new carbon skeletons from the fungus Aspergillus sp. AWG 1–15

Abstract

Asperones A–E (1–5), five dimeric polyketides with two distinct skeletons generated by the crucial [3 + 2] and [3 + 3] cycloadditions, were isolated from fungal metabolites of an Aspergillus sp. Their structures were established by spectroscopic data, chemical derivatization, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Compounds 2–4 showed significant nitric oxide (NO) inhibition in lipopolysaccharide (LPS)-induced RAW 264.7 macrophage cells, and exhibited IC50 values of 16.0, 13.2, and 6.0 μM, respectively.

Graphical abstract: Asperones A–E, five dimeric polyketides with new carbon skeletons from the fungus Aspergillus sp. AWG 1–15

Supplementary files

Article information

Article type
Research Article
Submitted
21 Oca 2018
Accepted
14 Mar 2018
First published
15 Mar 2018

Org. Chem. Front., 2018,5, 2432-2436

Asperones A–E, five dimeric polyketides with new carbon skeletons from the fungus Aspergillus sp. AWG 1–15

G. Yin, Y. Wu, C. Han, X. Wang, H. Gao, Y. Yin, L. Kong and M. Yang, Org. Chem. Front., 2018, 5, 2432 DOI: 10.1039/C8QO00070K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements