Issue 1, 2016

tRNA – the golden standard in molecular biology

Abstract

Transfer RNAs (tRNAs) represent a major class of RNA molecules. Their primary function is to help decode a messenger RNA (mRNA) sequence in order to synthesize protein and thus ensures the precise translation of genetic information that is imprinted in DNA. The discovery of tRNA in the late 1950's provided critical insight into a genetic machinery when little was known about the central dogma of molecular biology. In 1965, Robert Holley determined the first nucleotide sequence of alanine transfer RNA (tRNAAla) which earned him the 1968 Nobel Prize in Physiology or Medicine. Today, tRNA is one of the best described and characterized biological molecules. Here we review some of the key historical events in tRNA research which led to breakthrough discoveries and new developments in molecular biology.

Graphical abstract: tRNA – the golden standard in molecular biology

Article information

Article type
Review Article
Submitted
18 Ağu 2015
Accepted
27 Eki 2015
First published
30 Eki 2015

Mol. BioSyst., 2016,12, 12-17

tRNA – the golden standard in molecular biology

M. Z. Barciszewska, P. M. Perrigue and J. Barciszewski, Mol. BioSyst., 2016, 12, 12 DOI: 10.1039/C5MB00557D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements