Issue 16, 2022

Radical addition to the C[double bond, length as m-dash]C bond meets (1,n)-HAT: recent advances in the remote C(sp3)–H or C(sp2)–H functionalization of alkenes

Abstract

In recent years, remarkable advances in the functionalization of remote alkyl C(sp3)–H bonds or aldehydic C(sp2)–H bonds enabled by intermolecular radical addition to C[double bond, length as m-dash]C bond/(1,n)-HAT tandem sequences have been witnessed, which provided an efficient and versatile platform to construct structurally diverse and functionalized scaffolds with functional groups not only added across unsaturated CC double bonds, but also incorporated at the remote C(sp3)- or C(sp2)-positions from readily available alkenes with good to excellent site-selectivities. This review highlights the recent developments in this robust topic and the mechanistic scenarios governing these transformations.

Graphical abstract: Radical addition to the C [[double bond, length as m-dash]] C bond meets (1,n)-HAT: recent advances in the remote C(sp3)–H or C(sp2)–H functionalization of alkenes

Article information

Article type
Review Article
Submitted
16 May 2022
Accepted
01 Tem 2022
First published
05 Tem 2022

Org. Chem. Front., 2022,9, 4490-4506

Radical addition to the C[double bond, length as m-dash]C bond meets (1,n)-HAT: recent advances in the remote C(sp3)–H or C(sp2)–H functionalization of alkenes

J. Xi and W. Liao, Org. Chem. Front., 2022, 9, 4490 DOI: 10.1039/D2QO00793B

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