Designing lanthanide coordination nanoframeworks as X-ray responsive radiosensitizers for efficient cancer therapy

Hanjie Zhang; Kun Ye; Xiaoting Huang; Xia Lin; Li Ma; Tianfeng Chen

doi:10.1039/D1QI00442E

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Designing lanthanide coordination nanoframeworks as X-ray responsive radiosensitizers for efficient cancer therapy†

Hanjie Zhang,‡^a Kun Ye,‡^a Xiaoting Huang,‡^a Xia Lin,^a Li Ma*^a and Tianfeng Chen

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry and Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Jinan University, Guangzhou, 510632, China
E-mail: chem_mali@jnu.edu.cn, tchentf@jnu.edu.cn

Abstract

A series of three-dimensional Ln-based coordination frameworks were designed and synthesized. After nanolization, they show great potential as efficient and low toxic X-ray responsive radiosensitizers for the treatment of cervical cancer. The experimental data showed that these Ln-based nanoframeworks induced G0/G1 arrest mainly through the increase of the intracellular ROS level.

This article is part of the themed collection: 2021 Inorganic Chemistry Frontiers HOT articles

Download options Please wait...

Supplementary files

Supplementary information PDF (887K)

Article information

DOI: https://doi.org/10.1039/D1QI00442E
Article type: Research Article
Submitted: 04 Nis 2021
Accepted: 10 May 2021
First published: 14 May 2021

Download Citation

Inorg. Chem. Front., 2021,8, 3433-3439

Permissions

Request permissions

Designing lanthanide coordination nanoframeworks as X-ray responsive radiosensitizers for efficient cancer therapy

H. Zhang, K. Ye, X. Huang, X. Lin, L. Ma and T. Chen, Inorg. Chem. Front., 2021, 8, 3433 DOI: 10.1039/D1QI00442E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Inorganic Chemistry Frontiers

Designing lanthanide coordination nanoframeworks as X-ray responsive radiosensitizers for efficient cancer therapy†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Designing lanthanide coordination nanoframeworks as X-ray responsive radiosensitizers for efficient cancer therapy

Social activity

Search articles by author

Spotlight

Advertisements