Issue 50, 2018
From the journal:

Chemical Communications

Design of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications†

Paige J. LeValley,‡a   Elisa M. Ovadia,‡a   Christopher A. Bresette,a   Lisa A. Sawicki,a   Emanual Maverakis,b   Shi Baic  and  April M. Kloxin ORCID logo *ad  

* Corresponding authors

a Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA
E-mail: akloxin@udel.edu

b Department of Dermatology, School of Medicine, University of California Davis, Davis, CA 95616, USA

c Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA

d Department of Material Science and Engineering, University of Delaware, Newark, DE 19716, USA

Abstract

An approach for the design of functionalized cyclic peptides is established for use in 3D cell culture and in cell targeting. Sequential orthogonal click reactions, specifically a photoinitiated thiol–ene and strain promoted azide–alkyne cycloaddition, were utilized for peptide cyclization and conjugation relevant for biomaterial and biomedical applications, respectively.

Graphical abstract: Design of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications

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Article information

DOI
https://doi.org/10.1039/C8CC03218A
Article type
Communication
Submitted
27 Nis 2018
Accepted
24 May 2018
First published
29 May 2018

Chem. Commun., 2018,54, 6923-6926

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Design of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications

P. J. LeValley, E. M. Ovadia, C. A. Bresette, L. A. Sawicki, E. Maverakis, S. Bai and A. M. Kloxin, Chem. Commun., 2018, 54, 6923 DOI: 10.1039/C8CC03218A

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