Chronic inflammatory disorders are often accompanied by persistent pain, yet current therapies remain limited by modest efficacy and adverse effects.
A new family of polysubstituted pyrroles became readily accessible in a simple one-step procedure from acetylenes and nitriles under mild (room temperature, 15 min), transition-metal-free conditions.
A new family of natural-related bicyclic ketals became readily accessible in a simple atom-economic two-step procedure from acetylenes and ketones under mild transition-metal-free conditions.
New meso-substituted AB3-type phenothiazinyl porphyrins and ferrocenylvinyl phenothiazinyl porphyrin were synthesised by Suzuki–Miyaura and Mizoroki–Heck cross-coupling reactions, respectively.
Replacing peat, with a more sustainable alternative, in the malting process, a key step in the production of Scotch Whisky.