Design, synthesis, anticancer activity and molecular docking of quinoline-based dihydrazone derivatives

Jia-Xing Lu, Hai-Rong Lan, Dai Zeng, Jun-Ying Song, Ya-Ting Hao, Ai-Ping Xing, Ao Shen and Juan Yuan

RSC Adv., 2025, 15, 231
DOI: 10.1039/D4RA06954D

Advances in pyrazolo[1,5-a]pyrimidines: synthesis and their role as protein kinase inhibitors in cancer treatment

Terungwa H. Iorkula, Osasere Jude-Kelly Osayawe, Daniel A. Odogwu, Latifat Oluwatobi Ganiyu, Emmanuel Faderin, Raymond Femi Awoyemi, Busayo Odunayo Akodu, Ikhazuagbe Hilary Ifijen, Omowunmi Rebecca Aworinde, Peter Agyemang and Odo Lovelyn Onyinyechi

RSC Adv., 2025, 15, 3756
DOI: 10.1039/D4RA07556K

miRNAs as potential game-changers in bone diseases: Future medicinal and clinical uses

Ahmed S. Doghish, Mohammed S. Elballal, Ola Elazazy, Ahmed E. Elesawy, Reem K. Shahin, Heba M. Midan, Al-Aliaa M. Sallam, Abdullah M.M. Elbadry, Aliaa K.I. Mohamed, Nardeen W. Ishak, Kholoud Ali Hassan, Amira M. Ayoub, Rana E. Shalaby and Mahmoud A. Elrebehy

Pathology - Research and Practice, 2023, 245, 154440
DOI: 10.1016/j.prp.2023.154440

LC-ESI-MS/MS-Based Comparative Metabolomic Study, Antioxidant and Antidiabetic Activities of Three Lobelia Species: Molecular Modeling and ADMET Study

Yasmin A. Elkhawas, Haidy A. Gad, Mohamed M. M. AbdelRazek, Asmaa A. Mandour, Mokhtar M. Bishr, Nawal M. Al Musayeib, Mohamed L. Ashour and Noha Khalil

ACS Omega, 2024, 9, 20477
DOI: 10.1021/acsomega.4c01587

miRNAs as potential game-changers in head and neck cancer: Future clinical and medicinal uses

Hesham A. El-Mahdy, Ahmed M. Mohamadin, Ahmed I. Abulsoud, Emad Gamil Khidr, Ahmed A. El-Husseiny, Ahmed Ismail, Elsayed G.E. Elsakka, Hamada Ahmed Mokhlis, Hussein M. El-Husseiny and Ahmed S. Doghish

Pathology - Research and Practice, 2023, 245, 154457
DOI: 10.1016/j.prp.2023.154457

Development of pyrolo[2,3-c]pyrazole, pyrolo[2,3-d]pyrimidine and their bioisosteres as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological evaluation and molecular dynamics investigations

Eman M. Azmy, Mohamed Hagras, Menna A. Ewida, Ahmed S. Doghish, Emad Gamil Khidr, Ahmed A. El-Husseiny, Maher H. Gomaa, Hanan M. Refaat, Nasser S.M. Ismail, Ibrahim F. Nassar and Walaa H. Lashin

Bioorganic Chemistry, 2023, 139, 106729
DOI: 10.1016/j.bioorg.2023.106729

miRNAs as cornerstones in chronic lymphocytic leukemia pathogenesis and therapeutic resistance– An emphasis on the interaction of signaling pathways

Ahmed S. Doghish, Ahmed I. Abulsoud, Shereen Saeid Elshaer, Nourhan M. Abdelmaksoud, Mohamed Bakr Zaki, Hesham A. El-Mahdy, Ahmed Ismail, Doaa Fathi and Elsayed G.E. Elsakka

Pathology - Research and Practice, 2023, 243, 154363
DOI: 10.1016/j.prp.2023.154363

miRNAs role in glioblastoma pathogenesis and targeted therapy: Signaling pathways interplay

Shereen Saeid Elshaer, Ahmed I. Abulsoud, Doaa Fathi, Nourhan M. Abdelmaksoud, Mohamed Bakr Zaki, Hesham A. El-Mahdy, Ahmed Ismail, Elsayed G.E. Elsakka, Mai A. Abd-Elmawla, Logyna A. Abulsoud and Ahmed S. Doghish

Pathology - Research and Practice, 2023, 246, 154511
DOI: 10.1016/j.prp.2023.154511

Design, synthesis, and anticancer evaluation of new pyrazolo[3,4-d]pyrimidine-based derivatives: CDK2 inhibition, apoptosis-inducing activity, molecular modelling studies

Rasha A. Hassan, Hanan H. Kadry, Radwa G. Sayed, Amr M. Abdou and Rana H. Refaey

Bioorganic & Medicinal Chemistry, 2025, 128, 118286
DOI: 10.1016/j.bmc.2025.118286

The interplay of signaling pathways and miRNAs in the pathogenesis and targeted therapy of esophageal cancer

Ahmed S. Doghish, Ahmed A. El-Husseiny, Nourhan M. Abdelmaksoud, Hesham A. El-Mahdy, Elsayed G.E. Elsakka, Sherif S. Abdel Mageed, Abdulla M.A. Mahmoud, Ahmed Amr Raouf, Mohammed S. Elballal, Walaa A. El-Dakroury, Mohamed M.M. AbdelRazek, Mina Noshy, Hussein M. El-Husseiny and Ahmed I. Abulsoud

Pathology - Research and Practice, 2023, 246, 154529
DOI: 10.1016/j.prp.2023.154529

A spotlight on the interplay of signaling pathways and the role of miRNAs in osteosarcoma pathogenesis and therapeutic resistance

Ahmed S. Doghish, Maghawry Hegazy, Ahmed Ismail, Hesham A. El-Mahdy, Elsayed G.E. Elsakka, Samy Y. Elkhawaga, Mohamed A. Elkady, Amr Mohamed Yehia, Nourhan M. Abdelmaksoud and Mahmoud Mohamed Mokhtar

Pathology - Research and Practice, 2023, 245, 154442
DOI: 10.1016/j.prp.2023.154442

Molecular Docking, Dynamics, and Cytotoxicity Assessment of Pyrazolo[1,5‐a]pyrimidine Derivatives Against Breast Cancer

Gaurav Patel, Rizwan Ghumara, Sagarkumar Patel, Pranaykumar Shah, Niyati Patel, Nitin Lunagariya, Purvi Shah, Suraj Mali, Mehul Patel and Umang Shah

Chemistry & Biodiversity, 2025, 22
DOI: 10.1002/cbdv.202501510

Discovery of thiazolo[5′,4′:5,6]pyrido[2,3-d]pyrimidine, thiazolo[5′,4′:5,6]pyrido[2,3-d][1,3]oxazin & thiazolo[4,5-b]pyridine derivatives as novel CDK2 inhibitors: Synthesis, biological evaluation and in-silico studies

Naglaa M․ Anter, Asmaa A. Mandour, Menna A. Ewida, Ahmed F. El Farargy, Ibrahim F. Nassar, Mohamed H. Sobhy, Abdelrahman A. Abuelkhir, Hoda S. El Saeed, Mohamed Hagras and Nasser S.M. Ismail

Journal of Molecular Structure, 2026, 1352, 144514
DOI: 10.1016/j.molstruc.2025.144514

Advances in synthesis and biological evaluation of CDK2 inhibitors for cancer therapy

Dharmesh A. Patel, Siddharth S. Patel and Hitesh D. Patel

Bioorganic Chemistry, 2024, 143, 107045
DOI: 10.1016/j.bioorg.2023.107045

The potential role of miRNAs in the pathogenesis of testicular germ cell tumors - A Focus on signaling pathways interplay

Ahmed S. Doghish, Hebatallah Ahmed Mohamed Moustafa, Mohammed S. Elballal, Al-Aliaa M. Sallam, Walaa A. El-Dakroury, Sherif S. Abdel Mageed, Ahmed E. Elesawy, Nourhan M. Abdelmaksoud, Reem K. Shahin, Heba M. Midan, Mahmoud A. Elrebehy, Ola Elazazy, Yara A. Nassar, Ibrahim M. Elazab, Ahmed S. Elballal, Mai S. Elballal and Ahmed I. Abulsoud

Pathology - Research and Practice, 2023, 248, 154611
DOI: 10.1016/j.prp.2023.154611

Pyrazolopyrimidine fused thiazolidinone hybrids as CDK2 inhibitors: insights from pharmacophore modeling, docking, DFT and molecular dynamics simulations

Bharath Kumar Chagaleti, Venkatesan Saravanan, Ali Oubella, Saad H. Alotaibi, Ali Altharawi and Kathiravan MK

Journal of Molecular Structure, 2025, 1336, 142009
DOI: 10.1016/j.molstruc.2025.142009

Long non-coding RNAs and rheumatoid arthritis: Pathogenesis and clinical implications

Ola Elazazy, Heba M. Midan, Reem K. Shahin, Ahmed E. Elesawy, Mohammed S. Elballal, Al-Aliaa M. Sallam, Abdullah M.M. Elbadry, Mahmoud A. Elrebehy, Abdelmenem Bhnsawy and Ahmed S. Doghish

Pathology - Research and Practice, 2023, 246, 154512
DOI: 10.1016/j.prp.2023.154512

miRNAs orchestration of salivary gland cancer- Particular emphasis on diagnosis, progression, and drug resistance

Ahmed A. El-Husseiny, Nourhan M. Abdelmaksoud, Sherif S. Abdel Mageed, Aya Salman, Mohamed Bakr Zaki, Hesham A. El-Mahdy, Ahmed Ismail, Mai A. Abd-Elmawla, Hussein M. El-Husseiny, Ahmed I. Abulsoud, Shereen Saeid Elshaer, Elsayed G.E. Elsakka, Doaa Fathi, Walaa A. El-Dakroury and Ahmed S. Doghish

Pathology - Research and Practice, 2023, 248, 154590
DOI: 10.1016/j.prp.2023.154590

Current Advances in Synthesis of Pyrazole Derivatives: An Approach Toward Energetic Materials

Jaime Portilla

Journal of Heterocyclic Chem, 2024, 61, 2026
DOI: 10.1002/jhet.4904

Recent Advances in Synthesis and Properties of Pyrazoles

María-Camila Ríos and Jaime Portilla

Chemistry, 2022, 4, 940
DOI: 10.3390/chemistry4030065

Structural investigation, molecular docking, X‐ray studies, and in vitro biological activities of new transition metal complexes based isoleucine‐pyridyl hybrid Schiff base

Mahmoud G. A. Saleh, Fehaid M. Alsubaie, Bassant S. Moustafa, Wael A. El‐Sayed, Ehab M. Zayed and Gehad G. Mohamed

Applied Organom Chemis, 2024, 38
DOI: 10.1002/aoc.7476

Design, Synthesis, In Vitro, and In Silico Studies of New N5-Substituted-pyrazolo[3,4-d]pyrimidinone Derivatives as Anticancer CDK2 Inhibitors

Waheed A. Zaki, Selwan M. El-Sayed, Mohamed Alswah, Ahmed El-Morsy, Ashraf H. Bayoumi, Abrahman S. Mayhoub, Walaa H. Moustafa, Aeshah A. Awaji, Eun Joo Roh, Ahmed H.E. Hassan and Kazem Mahmoud

Pharmaceuticals, 2023, 16, 1593
DOI: 10.3390/ph16111593

The interplay of signaling pathways with miRNAs in cholangiocarcinoma pathogenicity and targeted therapy

Mohamed Bakr Zaki, Ahmed I. Abulsoud, Shereen Saeid Elshaer, Doaa Fathi, Nourhan M. Abdelmaksoud, Hesham A. El-Mahdy, Ahmed Ismail, Elsayed G.E. Elsakka, Al-Aliaa M. Sallam and Ahmed S. Doghish

Pathology - Research and Practice, 2023, 245, 154437
DOI: 10.1016/j.prp.2023.154437

A comprehensive analysis of the role of molecular docking in the development of anticancer agents against the cell cycle CDK enzyme

PRIYANKA SOLANKI, NISARG RANA, PRAKASH C. JHA and ANU MANHAS

BIOCELL, 2023, 47, 707
DOI: 10.32604/biocell.2023.026615

miRNAs as potential game-changers in melanoma: A comprehensive review

Gamil M. Abd-Allah, Ahmed Ismail, Hesham A. El-Mahdy, Elsayed G.E. Elsakka, Ahmed A. El-Husseiny, Nourhan M. Abdelmaksoud, Aya Salman, Samy Y. Elkhawaga and Ahmed S. Doghish

Pathology - Research and Practice, 2023, 244, 154424
DOI: 10.1016/j.prp.2023.154424

An emphasis on the interaction of signaling pathways highlights the role of miRNAs in the etiology and treatment resistance of gastric cancer

Doaa Fathi, Mohammed S. Elballal, Ahmed E. Elesawy, Ahmed I. Abulsoud, Ahmed Elshafei, Elsayed G.E. Elsakka, Ahmed Ismail, Hesham A. El-Mahdy, Mahmoud A. Elrebehy and Ahmed S. Doghish

Life Sciences, 2023, 322, 121667
DOI: 10.1016/j.lfs.2023.121667

miRNAs as potential game-changers in retinoblastoma: Future clinical and medicinal uses

Ahmed S. Doghish, Hebatallah Ahmed Mohamed Moustafa, Mohammed S. Elballal, Omnia M. Sarhan, Samar F. Darwish, Wagiha S. Elkalla, Osama A. Mohammed, Asmaa M. Atta, Nourhan M. Abdelmaksoud, Hesham A. El-Mahdy, Ahmed Ismail, Sherif S. Abdel Mageed, Mahmoud A. Elrebehy, Amr M. Abdelfatah and Ahmed I. Abulsoud

Pathology - Research and Practice, 2023, 247, 154537
DOI: 10.1016/j.prp.2023.154537

miR-509–5p promotes colorectal cancer cell ferroptosis by targeting SLC7A11

Mahmoud A. Elrebehy, Tamer M. Abdelghany, Mostafa M. Elshafey, Maher H. Gomaa and Ahmed S. Doghish

Pathology - Research and Practice, 2023, 247, 154557
DOI: 10.1016/j.prp.2023.154557

Significance of miRNAs on the thyroid cancer progression and resistance to treatment with special attention to the role of cross-talk between signaling pathways

Ahmed S. Doghish, Hesham A. El-Mahdy, Ahmed Ismail, Maghawry Hegazy, Mahmoud Mohamed Mokhtar, Samy Y. Elkhawaga, Mohamed A. Elkady, Amr Mohamed Yehia and Elsayed G.E. Elsakka

Pathology - Research and Practice, 2023, 243, 154371
DOI: 10.1016/j.prp.2023.154371

Exploring new quinazolin‐4(3H)‐one derivatives as CDK2 inhibitors: Design, synthesis, and anticancer evaluation

Basant T. Ibrahim, Heba Abdelrasheed Allam, Nehad M. El‐Dydamony, Marwa A. Fouad and Eman R. Mohammed

Drug Development Research, 2024, 85
DOI: 10.1002/ddr.22163

Role of long non-coding RNAs in pancreatic cancer pathogenesis and treatment resistance- A review

Tohada M. Al-Noshokaty, Abdallah Mansour, Rehab Abdelhamid, Nourhan Abdellatif, Ayat Alaaeldien, Tasnim Reda, Nourhan M. Abdelmaksoud, Ahmed S. Doghish, Ahmed I. Abulsoud and Shereen Saeid Elshaer

Pathology - Research and Practice, 2023, 245, 154438
DOI: 10.1016/j.prp.2023.154438

Design, synthesis and molecular docking of Pyrazolo[3,4-b]pyridine derivatives as potential CDK2 pathway inhibitors in colorectal cancer cells

Doaa A.E. Issa, Zahra A. Kassem, Soumaiah Abou Staiteieh, Ali Youssef, Jamal Nasr, Nadine Darwiche and Raghida Abou Merhi

Bioorganic Chemistry, 2026, 168, 109335
DOI: 10.1016/j.bioorg.2025.109335

Novel pyrano[2,3-c]pyrazolopyrimidines as promising anticancer agents: Design, synthesis, and cell cycle arrest of HepG2 cells at S phase

David S. A. Haneen, Mohamed H. Hekal, Wael S. I. Abou-Elmagd and Wael M. El-Sayed

Synthetic Communications, 2024, 54, 655
DOI: 10.1080/00397911.2024.2327047

Virtual Screening Approach for the Discovery of Selective 5α-Reductase Type II Inhibitors for Benign Prostatic Hyperplasia Treatment

Asmaa A Mandour, Eslam B Elkaeed, Mohamed Hagras, Hanan M Refaat and Nasser SM Ismail

Future Med. Chem., 2023, 15, 2149
DOI: 10.4155/fmc-2023-0065

miRNAs as potential game-changers in renal cell carcinoma: Future clinical and medicinal uses

Mohammed S. Elballal, Al-Aliaa M. Sallam, Ahmed E. Elesawy, Reem K. Shahin, Heba M. Midan, Mahmoud A. Elrebehy, Ola Elazazy, Rawnaa Mohammed El-Boghdady, Shaimaa Hassan Blasy, Nada Mahmoud Amer, Hadeer Ibrahim Farid, Dina Ashraf Mohammed, Shaymaa Adly Ahmed, Sally Samir Mohamed and Ahmed S. Doghish

Pathology - Research and Practice, 2023, 245, 154439
DOI: 10.1016/j.prp.2023.154439

Development of Novel Class of Phenylpyrazolo[3,4-d]pyrimidine-Based Analogs with Potent Anticancer Activity and Multitarget Enzyme Inhibition Supported by Docking Studies

Ahmed K. B. Aljohani, Waheed Ali Zaki El Zaloa, Mohamed Alswah, Mohamed A. Seleem, Mohamed M. Elsebaei, Ashraf H. Bayoumi, Ahmed M. El-Morsy, Mohammed Almaghrabi, Aeshah A. Awaji, Ali Hammad, Marwa Alsulaimany and Hany E. A. Ahmed

IJMS, 2023, 24, 15026
DOI: 10.3390/ijms241915026

Computational antidiabetic assessment of Salvia splendens L. polyphenols: SMOTE, ADME, ProTox, docking, and molecular dynamic studies

Hatun A. Alomar, Wafaa M. El Kady, Asmaa A. Mandour, Amany A. Naim, Neveen I. Ghali, Taghreed A. Ibrahim and Noha Fathallah

Results in Chemistry, 2025, 14, 102081
DOI: 10.1016/j.rechem.2025.102081

The role of miRNAs in laryngeal cancer pathogenesis and therapeutic resistance – A focus on signaling pathways interplay

Maghawry Hegazy, Mohamed A. Elkady, Amr Mohamed Yehia, Elsayed G.E. Elsakka, Ahmed I. Abulsoud, Nourhan M. Abdelmaksoud, Ahmed Elshafei, Tamer M. Abdelghany, Samy Y. Elkhawaga, Ahmed Ismail, Mahmoud Mohamed Mokhtar, Hesham A. El-Mahdy and Ahmed S. Doghish

Pathology - Research and Practice, 2023, 246, 154510
DOI: 10.1016/j.prp.2023.154510

Natural compounds as possible anti–SARS-CoV-2 therapeutic agents: an in-vitro and in-silico study

Riham A. El-Shiekh, Rehab M. S. Ashour, Mona M. Okba, Asmaa A. Mandour, Omnia Kutkat, Yassmin Moatasim and Rana Elshimy

Natural Product Research, 2024, 38, 3836
DOI: 10.1080/14786419.2023.2261069