Recent updates on the biological efficacy of approved drugs and potent synthetic compounds against SARS-CoV-2

Anjani, Sumit Kumar, Brijesh Rathi and Poonam

RSC Adv., 2023, 13, 3677
DOI: 10.1039/D2RA06834F

Investigating the anti-inflammatory potential of N-amidic acid organoselenium candidates: biological assessments, molecular docking, and molecular dynamics simulations

Hanan A. Althikrallah, Saad Shaaban, Ayman Abo Elmaaty, Hussein Ba-Ghazal, Mohammed N. Almarri, Marwa Sharaky, Radwan Alnajjar and Ahmed A. Al-Karmalawy

RSC Adv., 2024, 14, 31990
DOI: 10.1039/D4RA04762A

Design, synthesis, biological evaluation, and SAR studies of novel cyclopentaquinoline derivatives as DNA intercalators, topoisomerase II inhibitors, and apoptotic inducers

Mohamed M. Hammoud, Alaa S. Nageeb, M. A. Morsi, Esam A. Gomaa, Ayman Abo Elmaaty and Ahmed A. Al-Karmalawy

New J. Chem., 2022, 46, 11422
DOI: 10.1039/D2NJ01646J

Synergistic effects of steric constraints and non-covalent interactions in copper(ii) chloro-nitro-benzoato complexes: synthesis, structural characterization, theoretical investigations, antimicrobial studies, and molecular docking analyses

Chetan Chauhan, Santosh Kumar, Rajesh Kumar, Anju Saini and Thammarat Aree

New J. Chem., 2024, 48, 3829
DOI: 10.1039/D3NJ05361J

Design and synthesis of novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators

Marwa Abdel-Motaal, Dalal Ali Aldakhili, Ayman B. Farag, Ayman Abo Elmaaty, Marwa Sharaky, Nadia A. Mohamed, Saad Shaaban, Abdullah Yahya Abdullah Alzahrani and Ahmed A. Al-Karmalawy

RSC Med. Chem., 2024, 15, 3800
DOI: 10.1039/D4MD00585F

Quinoxaline derivatives as a promising scaffold for breast cancer treatment

Rogy R. Ezz Eldin, Ahmed A. Al-Karmalawy, Mohammad Hayal Alotaibi and Marwa A. Saleh

New J. Chem., 2022, 46, 9975
DOI: 10.1039/D2NJ00050D

Donepezil-based rational design of N-substituted quinazolinthioacetamide candidates as potential acetylcholine esterase inhibitors for the treatment of Alzheimer's disease: in vitro and in vivo studies

Ahmed A. Al-Karmalawy, Ahmed F. Mohamed, Heba Nasr Shalaby, Ayman Abo Elmaaty, Riham A. El-Shiekh, Mohamed A. Zeidan, Radwan Alnajjar, Abdullah Yahya Abdullah Alzahrani, Mohammed H. AL Mughram, Moataz A. Shaldam and Haytham O. Tawfik

RSC Med. Chem., 2025, 16, 2078
DOI: 10.1039/D4MD00778F

Design and synthesis of novel chloropyridazine hybrids as promising anticancer agents acting by apoptosis induction and PARP-1 inhibition through a molecular hybridization strategy

Norhan A. Abdelrahman, Ahmed A. Al-Karmalawy, Maiy Y. Jaballah, Galal Yahya, Marwa Sharaky and Khaled A. M. Abouzid

RSC Med. Chem., 2024, 15, 981
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Unveiling the anti-inflammatory potential of organoselenium Schiff bases: computational and in vitro studies

Saad Shaaban, Tarek A. Yousef, Hanan A Althikrallah, Yasair S. Al-Faiyz, Ibrahim Elghamry, Marwa Sharaky, Radwan Alnajjar and Ahmed A. Al-Karmalawy

New J. Chem., 2025, 49, 321
DOI: 10.1039/D4NJ04376F

Exploring the anticancer potential of new pyrazolopyrimidine analogues as multi-target directed EGFR/STAT3 downregulatory candidates with apoptotic potential

Ahmed A. Al-Karmalawy, Ayman Abo Elmaaty, Aya Yaseen Mahmood Alabdali, Saad Shaaban, Arwa Omar Al Khatib, Magda H. Abdellattif, Alaa Abu Alnjaa, Marwa Sharaky, Wagdy M. Eldehna and Ahmed A. Gaber

New J. Chem., 2025, 49, 6025
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Dual EGFR and telomerase inhibitory potential of new triazole tethered Schiff bases endowed with apoptosis: design, synthesis, and biological assessments

Mohamed A. Zeidan, Heba F. Ashour, Asmaa S. A. Yassen, Ayman Abo Elmaaty, Ayman B. Farag, Marwa Sharaky, Abdullah Yahya Abdullah Alzahrani, Mohammed H. AL Mughram and Ahmed A. Al-Karmalawy

RSC Med. Chem., 2025, 16, 1208
DOI: 10.1039/D4MD00750F

Biological and computational assessments of thiazole derivative-reinforced bile salt enriched nano carriers: a new gate in targeting SARS-CoV-2 spike protein

Mohamed Y. Zakaria, Ayman Abo Elmaaty, Rabeh El-Shesheny, Radwan Alnajjar, Omnia Kutkat, Sana Ben Moussa, Abdullah Yahya Abdullah Alzahrani, Sally A. El-Zahaby and Ahmed A. Al-Karmalawy

RSC Adv., 2024, 14, 38778
DOI: 10.1039/D4RA07316A

Design and synthesis of novel quinazolinone–chalcone hybrids as potential apoptotic candidates targeting caspase-3 and PARP-1:in vitro, molecular docking, and SAR studies

Eman A. Madbouly, El-Sayed M. Lashine, Ahmed A. Al-Karmalawy, Mahmoud M. Sebaiy, Harris Pratsinis, Dimitris Kletsas and Kamel Metwally

New J. Chem., 2022, 46, 22013
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Investigating the Promising Anticancer Activity of Cetuximab and Fenbendazole Combination as Dual CBS and VEGFR‐2 Inhibitors and Endowed with Apoptotic Potential

Norhan M. Eid, Ahmed A. Al‐Karmalawy, Taha M. A. Eldebss and Heba K. A. Elhakim

Chemistry & Biodiversity, 2024, 21
DOI: 10.1002/cbdv.202302081

Integrated data-driven and experimental approaches to accelerate lead optimization targeting SARS-CoV-2 main protease

Rohith Anand Varikoti, Katherine J. Schultz, Chathuri J. Kombala, Agustin Kruel, Kristoffer R. Brandvold, Mowei Zhou and Neeraj Kumar

J Comput Aided Mol Des, 2023, 37, 339
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Novel 2-Indolinone Derivatives as Promising Agents against Respiratory Syncytial and Yellow Fever Viruses

Çağla Begüm Apaydın, Füsun Göktaş, Lieve Naesens and Nilgün Karalı

Future Med. Chem., 2024, 16, 295
DOI: 10.4155/fmc-2023-0179

Exploring chromone‐2‐carboxamide derivatives for triple‐negative breast cancer targeting EGFR, FGFR3, and VEGF pathways: Design, synthesis, and preclinical insights

Dalia S. El‐Gamil, Mohamed Y. Zaky, Patrick M. Maximous, Marwa Sharaky, Ahmed M. El‐Dessouki, Noura M. Riad, Saad Shaaban, Mohammad Abdel‐Halim and Ahmed A. Al‐Karmalawy

Drug Development Research, 2024, 85
DOI: 10.1002/ddr.22228

Experimental design of D-α-tocopherol polyethylene glycol 1000 succinate stabilized bile salt based Nano-vesicles for improved cytotoxicity and bioavailability of colchicine binding site inhibitor Candidates: In Vitro, in silico, and pharmacokinetic studies

Ayman Abo Elmaaty, Ahmed A. Al‐Karmalawy, Mohamed S. Nafie, Marium M. Shamaa, Islam Zaki, Radwan Alnajjar and Mohamed Y. Zakaria

International Journal of Pharmaceutics, 2023, 640, 122980
DOI: 10.1016/j.ijpharm.2023.122980

Recent advances in small-molecular therapeutics for COVID-19

Lei Zhong, Zhipeng Zhao, Xuerun Peng, Jun Zou and Shengyong Yang

Precision Clinical Medicine, 2022, 5
DOI: 10.1093/pcmedi/pbac024

Rationale design and synthesis of new roflumilast analogues as preferential selective and potent PDE-4B inhibitors

Ahmed M. Moussa, Heba Abdelrasheed Allam, Mohamed K. El-Ashrey, Marwa A. Fouad and Ahmed A. Al‐Karmalawy

Bioorganic Chemistry, 2024, 153, 107911
DOI: 10.1016/j.bioorg.2024.107911

Investigation of Pyrrole Analogues Inhibition on Main Protease by Spectroscopic Analysis, Molecular Docking, and Enzyme Activity

Nuoya Wang, Leyao Chen, Wenjun Ye, Wenquan Yu, Xiaoyu Chang and Ruiyong Wang

Chemistry & Biodiversity, 2025, 22
DOI: 10.1002/cbdv.202403242

Undescribed cytotoxic butenolides; asperterreunolides A-E, isolated from endophytic fungus Aspergillus terreus derived from Artemisia arborescens L. supported with in silico study

Mamdouh Nabil Samy, Eman Zekry Attia, Basmaa Ali Khalifa, Ahmed G. Darwish, Ahmed A. Al-Karmalawy, Radwan Alnajjar, Usama Ramadan Abdelmohsen, Mohamed Ali Ibrahim and Samir Anis Ross

Phytochemistry, 2025, 232, 114377
DOI: 10.1016/j.phytochem.2024.114377

Anticoagulants as Potential SARS-CoV-2 Mpro Inhibitors for COVID-19 Patients: In Vitro, Molecular Docking, Molecular Dynamics, DFT, and SAR Studies

Ayman Abo Elmaaty, Wagdy Eldehna, Muhammad Khattab, Omnia Kutkat, Radwan Alnajjar, Ahmed El-Taweel, Sara Al-Rashood, Mohammed Abourehab, Faizah Binjubair, Mohamed Saleh, Amany Belal and Ahmed Al-Karmalawy

IJMS, 2022, 23, 12235
DOI: 10.3390/ijms232012235

Ligand-based design, synthesis, computational insights, and in vitro studies of novel N -(5-Nitrothiazol-2-yl)-carboxamido derivatives as potent inhibitors of SARS-CoV-2 main protease

Mohamed Elagawany, Ayman Abo Elmaaty, Ahmed Mostafa, Noura M. Abo Shama, Eman Y. Santali, Bahaa Elgendy and Ahmed A. Al-Karmalawy

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 37, 2112
DOI: 10.1080/14756366.2022.2105322

Synthesis, crystal structure, DFT calculation and confirmation of absolute configuration of empagliflozin

CenJun Li, Chao fan, Chunchao Wang, Jianchao Chen, Chengjun Wu and TieMin Sun

Journal of Molecular Structure, 2024, 1301, 137331
DOI: 10.1016/j.molstruc.2023.137331

Design, Synthesis, Biological Evaluation, and Molecular Dynamics Studies of Novel Lapatinib Derivatives

Ahmed Elkamhawy, Seohyun Son, Hwa Young Lee, Mahmoud H. El-Maghrabey, Mohamed A. El Hamd, Saud O. Alshammari, Abeer A. Abdelhameed, Qamar A. Alshammari, Ahmed Abdeen, Samah F. Ibrahim, Wael A. Mahdi, Sultan Alshehri, Radwan Alnajjar, Won Jun Choi, Ahmed A. Al-Karmalawy and Kyeong Lee

Pharmaceuticals, 2022, 16, 43
DOI: 10.3390/ph16010043

Development of new TAK-285 derivatives as potent EGFR/HER2 inhibitors possessing antiproliferative effects against 22RV1 and PC3 prostate carcinoma cell lines

Seohyun Son, Ahmed Elkamhawy, Anam Rana Gul, Ahmed A. Al‐Karmalawy, Radwan Alnajjar, Ahmed Abdeen, Samah F. Ibrahim, Saud O. Alshammari, Qamar A. Alshammari, Won Jun Choi, Tae Jung Park and Kyeong Lee

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, 38
DOI: 10.1080/14756366.2023.2202358

Ligand-based design and synthesis of N' -Benzylidene-3,4-dimethoxybenzohydrazide derivatives as potential antimicrobial agents; evaluation by in vitro , in vivo, and in silico approaches with SAR studies

Rogy R. Ezz Eldin, Marwa A. Saleh, Mohammad Hayal Alotaibi, Reem K. Alsuair, Yahya A. Alzahrani, Feras A. Alshehri, Amany F. Mohamed, Shaimaa M. Hafez, Azza Ali Althoqapy, Seham K. Khirala, Mona M. Amin, Yousuf A. F, Azza H. AbdElwahab, Mohamed S. Alesawy, Ayman Abo Elmaaty and Ahmed A. Al-Karmalawy

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 37, 1098
DOI: 10.1080/14756366.2022.2063282

Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations

Ahmed A. Al-Karmalawy, Mohamed S. Nafie, Moataz A. Shaldam, Ayman Abo Elmaaty, Samar A. Antar, Anwar A. El-Hamaky, Mohamed A. Saleh, Ahmed Elkamhawy and Haytham O. Tawfik

J. Med. Chem., 2023, 66, 777
DOI: 10.1021/acs.jmedchem.2c01668

RETRACTED: Design and Synthesis of Novel 5-((3-(Trifluoromethyl)piperidin-1-yl)sulfonyl)indoline-2,3-dione Derivatives as Promising Antiviral Agents: In Vitro, In Silico, and Structure–Activity Relationship Studies

Rogy Ezz Eldin, Marwa Saleh, Sefat Alwarsh, Areej Rushdi, Azza Althoqapy, Hoda El Saeed and Ayman Abo Elmaaty

Pharmaceuticals, 2023, 16, 1247
DOI: 10.3390/ph16091247

Metformin ameliorates doxorubicin-induced cardiotoxicity targeting HMGB1/TLR4/NLRP3 signaling pathway in mice

Amany A. Alzokaky, Ahmed A. Al-Karmalawy, Mohamed A. Saleh, Walied Abdo, Amira E. Farage, Amany Belal, Mohammed A.S. Abourehab and Samar A. Antar

Life Sciences, 2023, 316, 121390
DOI: 10.1016/j.lfs.2023.121390

Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro , molecular docking, molecular dynamics, and SAR studies

Faten Farouk, Ayman Abo Elmaaty, Ahmed Elkamhawy, Haytham O. Tawfik, Radwan Alnajjar, Mohammed A. S. Abourehab, Mohamed A. Saleh, Wagdy M. Eldehna and Ahmed A. Al‐Karmalawy

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, 38
DOI: 10.1080/14756366.2023.2171029

A Systematic Review of the Global Intervention for SARS-CoV-2 Combating: From Drugs Repurposing to Molnupiravir Approval

Nada A Ashour, Ayman Abo Elmaaty, Amany A Sarhan, Eslam B Elkaeed, Ahmed M Moussa, Ibrahim Ali Erfan and Ahmed A Al-Karmalawy

DDDT, 2022, Volume 16, 685
DOI: 10.2147/DDDT.S354841

Navigating the COVID-19 Therapeutic Landscape: Unveiling Novel Perspectives on FDA-Approved Medications, Vaccination Targets, and Emerging Novel Strategies

Reham F. Barghash, Donato Gemmati, Ahmed M. Awad, Mustafa M. M. Elbakry, Veronica Tisato, Kareem Awad and Ajay Vikram Singh

Molecules, 2024, 29, 5564
DOI: 10.3390/molecules29235564

Design and synthesis of new 1,2,3-triazole derivatives as VEGFR-2/telomerase downregulatory candidates endowed with apoptotic potential for cancer treatment

Ahmed A. Al-Karmalawy, Mohamed A. Zeidan, Ayman Abo Elmaaty, Marwa Sharaky, Asmaa S.A. Yassen, Eman F. Khaleel, Wagdy M. Eldehna and Heba F. Ashour

Bioorganic Chemistry, 2025, 156, 108159
DOI: 10.1016/j.bioorg.2025.108159

Synthesis of New Organoselenium-Based Succinanilic and Maleanilic Derivatives and In Silico Studies as Possible SARS-CoV-2 Main Protease Inhibitors

Saad Shaaban, Yasair S. Al-Faiyz, Ghayah M. Alsulaim, Mohamed Alaasar, Nasser Amri, Hussein Ba-Ghazal, Ahmed A. Al-Karmalawy and Aly Abdou

Inorganics, 2023, 11, 321
DOI: 10.3390/inorganics11080321

Investigating the Potential Anti-SARS-CoV-2 and Anti-MERS-CoV Activities of Yellow Necklacepod among Three Selected Medicinal Plants: Extraction, Isolation, Identification, In Vitro, Modes of Action, and Molecular Docking Studies

Howaida I. Abd-Alla, Omnia Kutkat, Heba-tollah M. Sweelam, Wagdy M. Eldehna, Marwa A. Mostafa, Magda T. Ibrahim, Yassmin Moatasim, Mohamed GabAllah and Ahmed A. Al-Karmalawy

Metabolites, 2022, 12, 1109
DOI: 10.3390/metabo12111109

Functionalized nanostructures and targeted delivery systems with a focus on plant-derived natural agents for COVID-19 therapy: A review and outlook

Khaled AbouAitah, Beom Soo Kim and Witold Lojkowski

Nanotechnology Reviews, 2024, 13
DOI: 10.1515/ntrev-2024-0102

Design, synthesis, and SAR studies of novel 4-methoxyphenyl pyrazole and pyrimidine derivatives as potential dual tyrosine kinase inhibitors targeting both EGFR and VEGFR-2

Abeer M. El-Naggar, A.M.A. Hassan, Eslam B. Elkaeed, Mohamed S. Alesawy and Ahmed A. Al‐Karmalawy

Bioorganic Chemistry, 2022, 123, 105770
DOI: 10.1016/j.bioorg.2022.105770

Investigating the possible mechanisms of pirfenidone to be targeted as a promising anti-inflammatory, anti-fibrotic, anti-oxidant, anti-apoptotic, anti-tumor, and/or anti-SARS-CoV-2

Samar A. Antar, Mohamed A. Saleh and Ahmed A. Al-Karmalawy

Life Sciences, 2022, 309, 121048
DOI: 10.1016/j.lfs.2022.121048

Multi-target rational design and synthesis of novel diphenyl-tethered pyrazolopyrimidines targeting EGFR and topoisomerase II with potential DNA intercalation and apoptosis induction

Ahmed A Gaber, Ayman Abo Elmaaty, Marwa Sharaky, Aliaa A. Mosa, Abdullah Yahya Abdullah Alzahrani, Saad Shaaban, Wagdy M. Eldehna and Ahmed A. Al-Karmalawy

Bioorganic Chemistry, 2024, 145, 107223
DOI: 10.1016/j.bioorg.2024.107223

Multi-target activity of copper complexes: Antibacterial, DNA binding, and molecular docking with SARS-CoV-2 receptor

Padmanathan Arthi, Mahendiran Dharmasivam, Busra Kaya and Aziz Kalilur Rahiman

Chemico-Biological Interactions, 2023, 373, 110349
DOI: 10.1016/j.cbi.2023.110349

Isatin Derivatives: A Frontier in Antimicrobial Agents

Shareef Shaik, Manish Chaudhary, Charanjit Kaur, Rajesh Kumar and Gurvinder Singh

LOC, 2024, 21, 333
DOI: 10.2174/0115701786268852230921113433

Investigating the superiority of chitosan/D-alpha-tocopheryl polyethylene glycol succinate binary coated bilosomes in promoting the cellular uptake and anti-SARS-CoV-2 activity of polyphenolic herbal drug candidate

Mohamed Y. Zakaria, Marwa Sharaky, Ayman M. Noreddin, Radwan Alnajjar, Rabeh EL-Shesheny, Omnia Kutkat, Mohamed E. El‐Beeh, Mohammed A.S. Abourehab and Ahmed A. Al-Karmalawy

International Journal of Pharmaceutics, 2023, 646, 123385
DOI: 10.1016/j.ijpharm.2023.123385

Investigation of the phytochemical composition, antioxidant, antibacterial, anti-osteoarthritis, and wound healing activities of selected vegetable waste

Mohamed A. Salem, Osama G. Mohamed, Esraa M. Mosalam, Aya Ibrahim Elberri, Hend Mohamed Abdel-Bar, Mariam Hassan, Ahmed A. Al-Karmalawy, Ashootosh Tripathi, Shahira M. Ezzat and Hend E. Abo Mansour

Sci Rep, 2023, 13
DOI: 10.1038/s41598-023-38591-y

Zn(II), Cu(II), and Fe(III) complexes of 2-(((4-(Methylselanyl)phenyl)imino)methyl)phenol: Synthesis, characterization, and multidisciplinary investigations

Saad Shaaban, Tarek A. Yousef, Ahmed S.M. Al-Janabi, Tarek Alammar, Mohamed Alaasar, Kamal Shalabi, Ahmed A. Al-Karmalawy, Hela Ferjani, Abdullah Al-Dakhil and Ahmed M. Abu-Dief

Polyhedron, 2025, 279, 117652
DOI: 10.1016/j.poly.2025.117652

New Phenylthiazoles: Design, Synthesis, and Biological Evaluation as Antibacterial, Antifungal, and Anti‐COVID‐19 Candidates

Inas G. Shahin, Khaled O. Mohamed, Azza T. Taher, Mohamed M. Elsebaei, Abdelrahman S. Mayhoub, Asmaa E. Kassab and Ahmed Elshewy

Chemistry & Biodiversity, 2023, 20
DOI: 10.1002/cbdv.202301143

Glimepiride ameliorates renal toxicity induced by cadmium in mice: Modulation of Jun N terminal kinase (JNK)/nuclear factor kappa B (NF-κB) and phosphatidylinositol 3-kinases (PI3K)/protein kinase (AKT) pathways

Mohamed Kh. ElMahdy, Mennatallah O. Zaki, Ahmed A. Al-Karmalawy, Walied Abdo, Sulaiman Mohammed Alnasser and Samar A. Antar

Life Sciences, 2022, 311, 121184
DOI: 10.1016/j.lfs.2022.121184

Anticholinesterase Activity of Budmunchiamine Alkaloids Revealed by Comparative Chemical Profiling of Two Albizia spp., Molecular Docking and Dynamic Studies

Mai E. Hussein, Osama G. Mohamed, Ahlam M. El-Fishawy, Hesham I. El-Askary, Ahmed A. Hamed, Marwa M. Abdel-Aziz, Radwan Alnajjar, Amany Belal, Ahmed M. Naglah, Abdulrahman A. Almehizia, Ahmed A. Al-Karmalawy, Ashootosh Tripathi and Amira S. El Senousy

Plants, 2022, 11, 3286
DOI: 10.3390/plants11233286

Design, synthesis, and biological evaluation of thienopyrimidine derivatives as multifunctional agents against Alzheimer's disease

Kholoud I. Eissa, Mona M. Kamel, Lamia W. Mohamed, Ahmed S. Doghish, Radwan Alnajjar, Ahmed A. Al‐Karmalawy and Asmaa E. Kassab

Drug Development Research, 2023, 84, 937
DOI: 10.1002/ddr.22064

Design and synthesis of novel benzoazoninone derivatives as potential CBSIs and apoptotic inducers: In Vitro, in Vivo, molecular docking, molecular dynamics, and SAR studies

Mohamed M. Hammouda, Ayman Abo Elmaaty, Mohamed S. Nafie, Marwa Abdel-Motaal, Noha S. Mohamed, Mohamed A. Tantawy, Amany Belal, Radwan Alnajjar, Wagdy M. Eldehna and Ahmed A. Al‐Karmalawy

Bioorganic Chemistry, 2022, 127, 105995
DOI: 10.1016/j.bioorg.2022.105995

LC‐HRMS Profiling and Cytotoxic Potential of Actinomycetes Associated with the Red Sea Soft Coral Sarcophyton glaucum: In vitro and In silico Studies

Seham S. El‐Hawary, Marwa H. A. Hassan, Ahmed O. Hudhud, Ahmed A. Al‐Karmalawy, Muhamad Mustafa, Elsayed A. E. Hamed, Usama Ramadan Abdelmohsen. and Rabab Mohammed

Chemistry & Biodiversity, 2024, 21
DOI: 10.1002/cbdv.202301617

Synthesis, structural characterization, DFT calculations, molecular docking, and molecular dynamics simulations of a novel ferrocene derivative to unravel its potential antitumor activity

Mohamed M. Hammoud, Muhammad Khattab, Marwa Abdel-Motaal, Johan Van der Eycken, Radwan Alnajjar, Hamada S. Abulkhair and Ahmed Ali Al‐Karmalawy

Journal of Biomolecular Structure and Dynamics, 2022, 1
DOI: 10.1080/07391102.2022.2082533

Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and biological assessments

Ahmed A. Al-Karmalawy, Mahmoud Rashed, Marwa Sharaky, Hamada S. Abulkhair, Mohamed M. Hammouda, Haytham O. Tawfik and Moataz A. Shaldam

European Journal of Medicinal Chemistry, 2023, 259, 115661
DOI: 10.1016/j.ejmech.2023.115661

A novel role of Nano selenium and sildenafil on streptozotocin-induced diabetic nephropathy in rats by modulation of inflammatory, oxidative, and apoptotic pathways

Mona F. El-Azab, Ahmed A. Al-Karmalawy, Samar A. Antar, Pierre A. Hanna, Karim M. Tawfik and Reem M. Hazem

Life Sciences, 2022, 303, 120691
DOI: 10.1016/j.lfs.2022.120691

Recent advances in COVID-19-induced liver injury: causes, diagnosis, and management

Samar A. Antar, Nada A. Ashour, Amir O. Hamouda, Ayman M. Noreddin and Ahmed A. Al‐Karmalawy

Inflammopharmacol, 2024, 32, 2649
DOI: 10.1007/s10787-024-01535-7

Comparative Study of the Synthetic Approaches and Biological Activities of the Bioisosteres of 1,3,4-Oxadiazoles and 1,3,4-Thiadiazoles over the Past Decade

Rana M. El-Masry, Hanan H. Kadry, Azza T. Taher and Sahar M. Abou-Seri

Molecules, 2022, 27, 2709
DOI: 10.3390/molecules27092709

Design and statistical optimisation of emulsomal nanoparticles for improved anti-SARS-CoV-2 activity of N -(5-nitrothiazol-2-yl)-carboxamido candidates: in vitro and in silico studies

Ahmed A. Al-Karmalawy, Dalia S. El-Gamil, Rabeh El-Shesheny, Marwa Sharaky, Radwan Alnajjar, Omnia Kutkat, Yassmin Moatasim, Mohamed Elagawany, Sara T. Al-Rashood, Faizah A. Binjubair, Wagdy M. Eldehna, Ayman M. Noreddin and Mohamed Y. Zakaria

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, 38
DOI: 10.1080/14756366.2023.2202357

Potential topoisomerases inhibitors from Aspergillus terreus using virtual screening

Eman Zekry Attia, Basma Ali Khalifa, Gehan M. Shaban, Mohamed N. Amin, Lina Akil, Ibrahim Khadra, Ahmed A. Al Karmalawy, Radwan Alnajjar, Marco Y.W. Zaki, Omar M. Aly, Mo'men H. El-Katatny and Usama Ramadan Abdelmohsen

South African Journal of Botany, 2022, 149, 632
DOI: 10.1016/j.sajb.2022.06.051