Privileged natural product compound classes for anti-inflammatory drug development

Malcolm Z. Y. Choo, Julian A. T. Chua, Sean X. Y. Lee, Yuet Ang, W. S. Fred Wong and Christina L. L. Chai

Nat. Prod. Rep., 2025, 42, 856
DOI: 10.1039/D4NP00066H

Identification of poly(ADP-ribose)polymerase 1 and 2 (PARP1/2) as targets of andrographolide using an integrated chemical biology approach

Wenchao Li, Bowen Pan, Yang Shi, Meiying Wang, Tianjiao Han, Qing Wang, Guifang Duan and Hongzheng Fu

Chem. Commun., 2021, 57, 6308
DOI: 10.1039/D1CC02272E

An improved strategy for identification and annotation of easily in‐sourced dissociation diterpene lactones from plant natural products: Taking Andrographis paniculata (Burm. f.) as an example

Xingdong Wu, Hongwei Ding, Zijia Zhang, Man Zheng, Hui Ni, Zhiyun Huang, Wenyong Wu, Huali Long, Yang Zhou, Feifei Li, Min Lei, Jinjun Hou, Wanying Wu and Dean Guo

Rapid Comm Mass Spectrometry, 2023, 37
DOI: 10.1002/rcm.9483

Andrographolide reverses the susceptibility of Streptococcus suis to aminoglycoside antibiotics by proton motive force

Bingqian Xue, Hailong Li, ShuJi Gao, Yingying Quan, Yuxin Wang, Li Yi and Yang Wang

BMC Vet Res, 2025, 21
DOI: 10.1186/s12917-024-04430-z

Discovery of andrographolide hit analog as a potent cyclooxygenase-2 inhibitor through consensus MD-simulation, electrostatic potential energy simulation and ligand efficiency metrics

Priyanka Jain, Jitendra Satija and C. Sudandiradoss

Sci Rep, 2023, 13
DOI: 10.1038/s41598-023-35192-7

Computational and experimental therapeutic efficacy analysis of andrographolide phospholipid complex self-assembled nanoparticles against Neuro2a cells

Atul Mourya, Purva Pingle, Chanti Katta Babu, Harithasree Veerabomma, Vaskuri G.S. Sainaga Jyothi, Jurica Novak, Prateek Pathak, Maria Grishina, Amita Verma, Rahul Kumar, Pankaj Kumar Singh, Dharmendra Kumar Khatri, Shashi Bala Singh and Jitender Madan

Biochimica et Biophysica Acta (BBA) - General Subjects, 2023, 1867, 130283
DOI: 10.1016/j.bbagen.2022.130283

Natural terpenoids with therapeutic potential against pulmonary arterial hypertension

Kaijie Dang, Junru Zhang, Kexin Yu, Xinyu Liu, Yi Zhu, Xiuli Yang, Xiao Liu and Chuantao Zhang

Front. Pharmacol., 2026, 16
DOI: 10.3389/fphar.2025.1713745

Identification of PDCD2 as a Candidate Target of Andrographolide That Arrests the Tumor Cell Cycle by Human Proteome-Scale Screening

Lei Wang, Caifeng Li, Peng Chen, Chunyuan Liu, Zhao Cui, Shiwen Deng and Hongjun Yang

ACS Pharmacol. Transl. Sci., 2022, 5, 479
DOI: 10.1021/acsptsci.2c00092

Discovery of Novel Andrographolide Derivatives as Antiviral Inhibitors against Human Enterovirus A71

Jie Kai Tan, Ran Chen, Regina Ching Hua Lee, Feng Li, Kun Dai, Guo-Chun Zhou and Justin Jang Hann Chu

Pharmaceuticals, 2022, 15, 115
DOI: 10.3390/ph15020115

New Succinimide–Thiazolidinedione Hybrids as Multitarget Antidiabetic Agents: Design, Synthesis, Bioevaluation, and Molecular Modelling Studies

Mohammed A. Huneif, Mater H. Mahnashi, Muhammad Saeed Jan, Muhammad Shah, Sultan A. Almedhesh, Seham M. Alqahtani, Mohammad Jamaan Alzahrani, Muhammad Ayaz, Farhat Ullah, Umer Rashid and Abdul Sadiq

Molecules, 2023, 28, 1207
DOI: 10.3390/molecules28031207

Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches

Bin Zeng, Ailing Wei, Qiang Zhou, Minghao Yuan, Kelu Lei, Yushi Liu, Jiawen Song, Li Guo and Qiang Ye

Phytotherapy Research, 2022, 36, 336
DOI: 10.1002/ptr.7324

Andrographis paniculata (Burm. f.) Wall. ex Nees: An Updated Review of Phytochemistry, Antimicrobial Pharmacology, and Clinical Safety and Efficacy

Sanower Hossain, Zannat Urbi, Hidayah Karuniawati, Ramisa Binti Mohiuddin, Ahmed Moh Qrimida, Akrm Mohamed Masaud Allzrag, Long Chiau Ming, Ester Pagano and Raffaele Capasso

Life, 2021, 11, 348
DOI: 10.3390/life11040348

Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function

Wupeng Liao, Hazel Yu Ci Foo, Thi Ngoc Quy Tran, Christina Li Lin Chai and Wai Shiu Fred Wong

British J Pharmacology, 2023, 180, 1056
DOI: 10.1111/bph.15993

Andrographolide prevents acute hyperammonemia-induced motor dysfunction in rats. Evidences for its mechanism of action

Arghya Mukherjee and Santosh Singh

Phytomedicine Plus, 2025, 5, 100679
DOI: 10.1016/j.phyplu.2024.100679

Andrographolide and its derivatives: Current achievements and future perspectives

Hang Zhang, Shufeng Li, Yongsheng Si and Haiwei Xu

European Journal of Medicinal Chemistry, 2021, 224, 113710
DOI: 10.1016/j.ejmech.2021.113710

A review of the neuroprotective effects of andrographolide in Alzheimer's disease

Zahra Abedi, Hamidon Basri, Zurina Hassan, Liyana Najwa Inche Mat, Huzwah Khaza’ai and Nur Afiqah Mohamad

ADV TRADIT MED (ADTM), 2021, 21, 253
DOI: 10.1007/s13596-021-00573-8

Biotechnological production of diterpenoid lactones from cell and organ cultures of Andrographis paniculata

Hosakatte Niranjana Murthy and Dayanand Dalawai

Appl Microbiol Biotechnol, 2021, 105, 7683
DOI: 10.1007/s00253-021-11599-y

Exploring Synthesis and Medicinal Applications of Andrographolide Derivatives: A Review

Tanzeela Qadir, Shoaib Shaikh, Saadat A. Kanth, Jyotika Singh, Maria Baby and Praveen Kumar Sharma

COC, 2024, 28, 686
DOI: 10.2174/0113852728296785240308054135

Andrographolide ameliorates vascular injury in hypertension by suppressing EndMT via Sp1–Notch1 signaling

Qiang Tu, Wenling Li, Yanxia Qiu, Yumin Qiu, Zhefu Liu, Meixin Zhang, Zhangchi Liu, Wenhao Xia, Bin Zhang, Zheng Cao and Jun Tao

Phytomedicine, 2026, 153, 157846
DOI: 10.1016/j.phymed.2026.157846

Andrographolide targets syndecan4 to impair its interaction with syntenin and inhibits the biogenesis of small extracellular vesicles

Qing Gong, Weiwei Zhao, Tiantian Wang, Yuting Pan, Can Cui, Yi Qu and Xianglian Zhou

Journal of Biological Chemistry, 2026, 302, 111182
DOI: 10.1016/j.jbc.2026.111182

Practical Three-Component Regioselective Synthesis of Drug-Like 3-Aryl(or heteroaryl)-5,6-dihydrobenzo[h]cinnolines as Potential Non-Covalent Multi-Targeting Inhibitors To Combat Neurodegenerative Diseases

Hossein Mousavi, Mehdi Rimaz and Behzad Zeynizadeh

ACS Chem. Neurosci., 2024, 15, 1828
DOI: 10.1021/acschemneuro.4c00055

Novel copper-ion coordinated andrographolide-loaded hydrogel activates Rac1/JNK1 axis for enhancing diabetic wound healing

Penghui Ye, Yuhe Dai, Qianbo Zhang, Junqi Yang, Lele Liu, Xiuying Guo, Huan Zhu, Jitao Chen, Rifang Gu, Min Tan, Ming Tang, Felicity Han and Xuqiang Nie

npj Regen Med, 2026, 11
DOI: 10.1038/s41536-026-00457-y

Inhibitory Effect of Andrographis paniculata Lactone on Staphylococcus aureus α-Hemolysin

Xin Wang, Qiang Ma, Xiaohao Niu, Zhu Liu, Xinyun Kang, Yanni Mao, Na Li and Guiqin Wang

Front. Pharmacol., 2022, 13
DOI: 10.3389/fphar.2022.891943

Discovery of anti-glioblastoma natural products based on andrographolide derivatives: efficiently identifying potential multi-target and multifunctional molecules through the integration of in silico methods and experimental verification

Ya-Lin Li, Jun Mao, Xin-Yu Zhou, Duan-Na Zhang, Yu-Zhi Li, Zhi-Xing Cao and Ji-Xia Ren

Mol Divers, 2026
DOI: 10.1007/s11030-026-11531-4

Andrographis paniculata Formulations: Impact on Diterpene Lactone Oral Bioavailability

João Paulo Loureiro Damasceno, Hemerson Silva da Rosa, Luciana Silva de Araújo and Niege Araçari Jacometti Cardoso Furtado

Eur J Drug Metab Pharmacokinet, 2022, 47, 19
DOI: 10.1007/s13318-021-00736-7

Reducing allergic reaction and enhancing anti-inflammatory effect of dehydroandrographolide through dehydroandrographolide prodrug liposomes

Yupeng Feng, Peifu Xiao, Zixu Liu, Mei Li, Qingqing Wang, Tian Yin, Yu Zhang, Haibing He, Jingxin Gou, Yanjiao Wang and Xing Tang

Journal of Drug Delivery Science and Technology, 2023, 88, 104928
DOI: 10.1016/j.jddst.2023.104928

Synthesis, antiproliferative activity, and biological profiling of C-19 trityl and silyl ether andrographolide analogs in colon cancer and breast cancer cells

Tiffany Gu, Rushika Raval, Zachary Bashkin, Carina Zhou, Sanghyuk Ko, Natalie Kong, Seoyeon Hong, Aditya Bhaskara, Samarth Shah, Aditi Joshi, Samahith Thellakal, Kaitlyn Rim, Anushree Marimuthu, Srishti Venkatesan, Emma Wang, Sophia Li, Aditi Jayabalan, Alice Tao, Yilin Fang, Lorelei Xia, Aidan Chui, Emily Shu, Tracy Zhang, Zhan Chen and Edward Njoo

Bioorganic & Medicinal Chemistry Letters, 2025, 121, 130163
DOI: 10.1016/j.bmcl.2025.130163

Discovery of C-12 dithiocarbamate andrographolide analogues as inhibitors of SARS-CoV-2 main protease: In vitro and in silico studies

Bodee Nutho, Patcharin Wilasluck, Peerapon Deetanya, Kittikhun Wangkanont, Patcharee Arsakhant, Rungnapha Saeeng and Thanyada Rungrotmongkol

Computational and Structural Biotechnology Journal, 2022, 20, 2784
DOI: 10.1016/j.csbj.2022.05.053

Targeting signaling pathways with andrographolide in cancer therapy (Review)

Nur Shahirah Shaharudin, Gurmeet Kaur Surindar Singh, Teh Kek and Sadia Sultan

Mol Clin Oncol, 2024, 21
DOI: 10.3892/mco.2024.2779

Andrographolide Attenuates Blood–Brain Barrier Disruption, Neuronal Apoptosis, and Oxidative Stress Through Activation of Nrf2/HO-1 Signaling Pathway in Subarachnoid Hemorrhage

Pian Gong, Wei Zhang, Changlin Zou, Shoumeng Han, Qi Tian, Jianfeng Wang, Peibang He, Yujia Guo and Mingchang Li

Neurotox Res, 2022, 40, 508
DOI: 10.1007/s12640-022-00486-7

Andrographolide, a diterpene lactone from the Traditional Chinese Medicine Andrographis paniculate, induces senescence in human lung adenocarcinoma via p53/p21 and Skp2/p27

Junqian Zhang, Chunjie Li, Li Zhang, Yongqing Heng, Shiwen Wang, Yongfu Pan, Lili Cai, Yunjing Zhang, Tong Xu, Xihui Chen, Robert M Hoffman and Lijun Jia

Phytomedicine, 2022, 98, 153933
DOI: 10.1016/j.phymed.2022.153933

ShenQi DiHuang Decoction (SQDHD) Ameliorates Neuroinflammation and Neuropsychiatric Manifestations in Pristane Induced Lupus Mice via Blocking JAK1‐STAT3 Pathway

Jie Chen, Chumiao Cui, Fei Xu, Jiayan Feng, Jingyu Chen, Xueru Wang, Hui Yuan, Chenye Jin, Yutian Li and Yang Yun

CNS Neurosci Ther, 2026, 32
DOI: 10.1002/cns.70814