Dimerizing cascades of enallenamides reveal the visible-light-promoted activation of cumulated C–C double bonds

Andrea Serafino, Maurizio Chiminelli, Davide Balestri, Luciano Marchiò, Franca Bigi, Rai-mondo Maggi, Max Malacria and Giovanni Maestri

Chem. Sci., 2022, 13, 2632
DOI: 10.1039/D1SC06719B

Design strategy and preliminary antiproliferative investigation of a modified lignan skeleton derived from aryne and statin

Yu Lei, Yinshan Wen, Xiaoliang Xu, Qiong Hu, Meng Chang, Ruihua Qiang and Yimin Hu

Org. Biomol. Chem., 2024, 22, 8263
DOI: 10.1039/D4OB01264J

Light-emitting diode enhances the growth and biosynthesis of anticancer lignans in mass shoot culture of Linum album Kotschy ex Boiss. (Linaceae)

Farzaneh Akbari, Mohammad Hossein Mirjalili, Ziba Bakhtiar and Hamid Ahadi

Industrial Crops and Products, 2025, 227, 120730
DOI: 10.1016/j.indcrop.2025.120730

Podophyllotoxin reduces the aggressiveness of human oral squamous cell carcinoma through myeloid cell leukemia‑1

Hyun-Ju Yu, Ji-Ae Shin, Su-Jung Choi and Sung-Dae Cho

Int J Mol Med, 2023, 52
DOI: 10.3892/ijmm.2023.5306

Cannabidiol Enhances the Anticancer Activity of Etoposide on Prostate Cancer Cells

Yalcin Erzurumlu and Deniz Catakli

Cannabis and Cannabinoid Research, 2024
DOI: 10.1089/can.2023.0284

Organocatalytic enantioselective construction of bicyclic γ-butrolactones

Qiang Zhang, Jingxiang Pang, Tian-Zhang Wang, Feng Chen, Minghao Shen, Tianyu Li, Yongshuai Chai, Yu-Feng Liang, Jie Sun and Zhushuang Bai

Chinese Chemical Letters, 2023, 34, 108121
DOI: 10.1016/j.cclet.2022.108121

Advances in nanoscale carrier-based approaches to reduce toxicity and enhance efficacy of podophyllotoxin

Chaozheng Zhang, Yi Zuo, Tingting Zhang, Xin Zhang, Jie Ling, Changqun Liu, Hongyu Chen, Xin Zhou, Maolin Wang, Yun Deng, Yilan Liu and Jun Lu

Acta Materia Medica, 2023, 2
DOI: 10.15212/AMM-2023-0038

Design, synthesis and activity evaluation of reduction-responsive anticancer peptide temporin-1CEa drug conjugates

Zhenbin Han, Yue Wang, Wenxuan Wang, Maosheng Cheng, Huali Yang and Yang Liu

Bioorganic Chemistry, 2025, 154, 108103
DOI: 10.1016/j.bioorg.2024.108103

Smart stimuli-responsive biofunctionalized niosomal nanocarriers for programmed release of bioactive compounds into cancer cells in vitro and in vivo

Najmeh Alsadat Abtahi, Seyed Morteza Naghib, Fatemeh Haghiralsadat, Javad Zavar Reza, Fatemeh Hakimian, Fatemeh Yazdian and Davood Tofighi

Nanotechnology Reviews, 2021, 10, 1895
DOI: 10.1515/ntrev-2021-0119

Picropodophyllotoxin Inhibits Cell Growth and Induces Apoptosis in Gefitinib-Resistant Non-Small Lung Cancer Cells by Dual-Targeting EGFR and MET

Jin-Young Lee, Bok Yun Kang, Sang-Jin Jung, Ah-Won Kwak, Seung-On Lee, Jin Woo Park, Sang Hoon Joo, Goo Yoon, Mee-Hyun Lee and Jung-Hyun Shim

Biomol Ther (Seoul), 2023, 31, 200
DOI: 10.4062/biomolther.2022.113

Computational Drug Repurposing Approach to Identify Novel Inhibitors of ILK Protein for Treatment of Esophageal Squamous Cell Carcinoma

Juan Liu, Xiaoli Ma, Leiyu Cao, Yu Wei, Yan Gao, Chengcheng Qu, Nuersimanguli Maimaitiming, Li Zhang and Shuanglin Qin

Journal of Oncology, 2022, 2022, 1
DOI: 10.1155/2022/3658334

Hierarchical network analysis of co-occurring bioentities in literature

Heejung Yang, Namgil Lee, Beomjun Park, Jinyoung Park, Jiho Lee, Hyeon Seok Jang and Hojin Yoo

Sci Rep, 2022, 12
DOI: 10.1038/s41598-022-12093-9

Design and evaluation of novel N-substituent diphenylamine derivatives as tubulin colchicine binding site inhibitors

Zhong Chen, Da-Wei Geng, Tang-Bo Yuan, Chen Yu, Da-Wei Cai, Yong Yin and Qiang Shen

Bioorganic & Medicinal Chemistry Letters, 2025, 115, 130031
DOI: 10.1016/j.bmcl.2024.130031

Synthesis and biological evaluation of cytotoxic activity of novel podophyllotoxin derivatives incorporating piperazinyl-cinnamic amide moieties

Xin Zhang, Tingting Yang, Xin Jin, Kaige Lin, Xiling Dai, Ting Gao, Guozheng Huang, Minghui Fan, Liang Ma, Zi Liu and Jianguo Cao

Bioorganic Chemistry, 2022, 123, 105761
DOI: 10.1016/j.bioorg.2022.105761

Recent advances in direct asymmetric reaction of furanone

Ling Zhang, Qiang Zhang, Ran Wang, Aiqin Liu, Manfei Liang and Zhushuang Bai

Tetrahedron, 2025, 179, 134627
DOI: 10.1016/j.tet.2025.134627

Synthesis and medicinal chemistry of tetronamides: Promising agrochemicals and antitumoral compounds

Júnio G. Silva, Amanda S. de Miranda, Fyaz M.D. Ismail and Luiz C.A. Barbosa

Bioorganic & Medicinal Chemistry, 2022, 67, 116815
DOI: 10.1016/j.bmc.2022.116815

Identification of Novel 4′-O-Demethyl-epipodophyllotoxin Derivatives as Antitumor Agents Targeting Topoisomerase II

Wenli Xi, Hua Sun, Kenneth F. Bastow, Zhiyan Xiao and Kuo-Hsiung Lee

Molecules, 2022, 27, 5029
DOI: 10.3390/molecules27155029

Design of Podophyllotoxin-based Hybrid Compounds as Potential Anticancer Agents

Hezhen Wang, Xun Sun, Chunyong Wei, Jing Wang and Lei Zhang

LDDD, 2024, 21, 1895
DOI: 10.2174/1570180820666230606161639

Natural-product-based, carrier-free, noncovalent nanoparticles for tumor chemo-photodynamic combination therapy

Zhonglei Wang and Liyan Yang

Pharmacological Research, 2024, 203, 107150
DOI: 10.1016/j.phrs.2024.107150

ROS-Activated homodimeric podophyllotoxin nanomedicine with self-accelerating drug release for efficient cancer eradication

Bingfeng Liang and Dangxia Zhou

Drug Delivery, 2021, 28, 2361
DOI: 10.1080/10717544.2021.1995076

The Cytoprotective, Cytotoxic and Nonprotective Functional Forms of Autophagy Induced by Microtubule Poisons in Tumor Cells—Implications for Autophagy Modulation as a Therapeutic Strategy

Jingwen Xu, Ahmed M. Elshazly and David A. Gewirtz

Biomedicines, 2022, 10, 1632
DOI: 10.3390/biomedicines10071632

Insight Into the Molecular Mechanism of Podophyllotoxin Derivatives as Anticancer Drugs

Hua-yang Fan, Zhuo-li Zhu, Hong-chun Xian, Hao-fan Wang, Bing-jun Chen, Ya-Jie Tang, Ya-ling Tang and Xin-hua Liang

Front. Cell Dev. Biol., 2021, 9
DOI: 10.3389/fcell.2021.709075

Challenges and opportunities for improving the druggability of natural product: Why need drug delivery system?

Peng Tang, Tianze Shen, Hairong Wang, Ruihan Zhang, Xingjie Zhang, Xiaoli Li and Weilie Xiao

Biomedicine & Pharmacotherapy, 2023, 164, 114955
DOI: 10.1016/j.biopha.2023.114955

Design and Synthesis of Novel Podophyllotoxins Hybrids and the Effects of Different Functional Groups on Cytotoxicity

Zhongtao Yang, Zitong Zhou, Xiai Luo, Xiaoling Luo, Hui Luo, Lianxiang Luo and Weiguang Yang

Molecules, 2021, 27, 220
DOI: 10.3390/molecules27010220

Engineering the Entrance of a Flavonoid Glycosyltransferase Promotes the Glycosylation of Etoposide Aglycone

Fei-Fan Tan, Rui Zhu, Bin Xiong, Gui-Min Zhang, Wei Zhao and Kai-Zhi Jia

ACS Synth. Biol., 2022, 11, 1874
DOI: 10.1021/acssynbio.2c00032

Discovery of Epipodophyllotoxin-Derived B2 as Promising XooFtsZ Inhibitor for Controlling Bacterial Cell Division: Structure-Based Virtual Screening, Synthesis, and SAR Study

Ying-Lian Song, Shuai-Shuai Liu, Jie Yang, Jiao Xie, Xiang Zhou, Zhi-Bing Wu, Li-Wei Liu, Pei-Yi Wang and Song Yang

IJMS, 2022, 23, 9119
DOI: 10.3390/ijms23169119

Cytotoxic Cyclolignans Obtained by the Enlargement of the Cyclolignan Skeleton of Podophyllic Aldehyde, a Selective Podophyllotoxin-Derived Cyclolignan

Pablo A. García, Ángela-Patricia Hernández, Mª Antonia Gómez-Zurita, José M. Miguel del Corral, Marina Gordaliza, Andrés Francesch, Arturo San Feliciano and Mª Ángeles Castro

Molecules, 2024, 29, 1442
DOI: 10.3390/molecules29071442

Plant Origin Source, Content Profile and Bioactivity of Podophyllotoxin as an Important Natural Anticancer Agent

Wei Liu, Dan Zhao, Dongxue Yin, Kai Duan and Zhihao Wang

Chemistry & Biodiversity, 2025, 22
DOI: 10.1002/cbdv.202402375

Bioinspired Nano‐Photosensitizer‐Activated Caspase‐3/GSDME Pathway Induces Pyroptosis in Lung Cancer Cells

Min Gao, Qiuting Sun, Huiru Zhang, Mengyu Liu, Rui Peng, Weiji Qin, Qian Wang, Tianhao Yang, Man Zhou, Xiaoyan He and Gengyun Sun

Adv Healthcare Materials, 2024
DOI: 10.1002/adhm.202401616

Podofilox suppresses gastric cancer cell proliferation by regulating cell cycle arrest and the c‑Myc/ATG10 axis

Juan An, Yan Liu, Shenglan Duo, Xiaoming Ma, Ling An, Yunfei Yan, Dongde Ji, Yupeng Yan, Qiliang Cheng and Zhanhai Su

Exp Ther Med, 2021, 22
DOI: 10.3892/etm.2021.10637

Insights into molecular docking and dynamics to reveal therapeutic potential of natural compounds against P53 protein

Bashir Ahmad Malla, Aarif Ali, Irfan Maqbool, Nazir Ahmad Dar, Sheikh Bilal Ahmad, Rana M. Alsaffar and Muneeb U. Rehman

Journal of Biomolecular Structure and Dynamics, 2023, 41, 8762
DOI: 10.1080/07391102.2022.2137241

Establishment and Characterization of an Irinotecan-Resistant Human Colon Cancer Cell Line

Zhuo-Xun Wu, Yuqi Yang, Leli Zeng, Harsh Patel, Letao Bo, Lusheng Lin and Zhe-Sheng Chen

Front. Oncol., 2021, 10
DOI: 10.3389/fonc.2020.624954

The ERF transcription factor LTF1 activates DIR1 to control stereoselective synthesis of antiviral lignans and stress defense in Isatis indigotica roots

Ruibing Chen, Jian Yu, Luyao Yu, Liang Xiao, Ying Xiao, Junfeng Chen, Shouhong Gao, Xianghui Chen, Qing Li, Henan Zhang, Wansheng Chen and Lei Zhang

Acta Pharmaceutica Sinica B, 2024, 14, 405
DOI: 10.1016/j.apsb.2023.08.011

Protective effects of a novel bicyclic γ-butyrolactone compound against H2O2 or corticosterone-induced neural cell apoptosis

Ze Zhang, Xiaochong Li, Qishuai Zhuang, Xueping Xu, Xiaoru Zhang, Mingyu Cui, Yue Wang and Haili Li

Brain Research, 2024, 1842, 149099
DOI: 10.1016/j.brainres.2024.149099

cGAS-STING activation by nanodelivery of teniposide achieves colorectal cancer chemo-immunotherapy

Anqi Liao, Junjun Chen, Fangzhou shi, Lingzhi Wang, Leilei Yang, Yutong Li, Yifang Zou, Jia Shi, Shihan Yu, Zhuo Yu and Jianfeng Guo

European Polymer Journal, 2024, 219, 113379
DOI: 10.1016/j.eurpolymj.2024.113379

Design, synthesis and biological evaluation of novel podophyllotoxin derivatives as tubulin-targeting anticancer agents

Yujin Guo, Beibei Chen, Jinxiu Guo, Pei Jiang, Jianhua Wang and Wenxue Sun

Pharmaceutical Biology, 2024, 62, 233
DOI: 10.1080/13880209.2024.2318350

Potential mechanisms underlying podophyllotoxin-induced cardiotoxicity in male rats: toxicological evidence chain (TEC) concept

Kaiyue Ma, Lu Sun, Chunxue Jia, Hongqian Kui, Jiaqi Xie, Shidan Zang, Shixin Huang, Jinfeng Que, Chuanxin Liu and Jianmei Huang

Front. Pharmacol., 2024, 15
DOI: 10.3389/fphar.2024.1378758

Design, semi-synthesis and bioactivity evaluation of novel podophyllotoxin derivatives as potent anti-tumor agents

Wenxue Sun, Fusheng Sun, Junjun Meng, Xiaohua Cao, Shiyuan Zhao, Changshui Wang, Luning Li and Pei Jiang

Bioorganic Chemistry, 2022, 126, 105906
DOI: 10.1016/j.bioorg.2022.105906

NanoDSF Screening for Anti-tubulin Agents Uncovers New Structure–Activity Insights

Viktoriia Baksheeva, Romain La Rocca, Diane Allegro, Carine Derviaux, Eddy Pasquier, Philippe Roche, Xavier Morelli, François Devred, Andrey V. Golovin and Philipp O. Tsvetkov

J. Med. Chem., 2025
DOI: 10.1021/acs.jmedchem.5c01008

Cytotoxic screening of plants from the Brazilian Atlantic Forest has led to the identification of Casearia arborea and Sorocea hilarii as sources of antitumor compounds

L. A. Rodrigues, A. A. Almeida, A. P. Agrizii, N. Pacheco, B. C. R. Carvalho, A. C. Zanatta, M. Kohlhoff, C. M. M. E. Torres, G. C. Bressan and J. P. V. Leite

Natural Product Research, 2024, 38, 1950
DOI: 10.1080/14786419.2023.2225689

Carvedilol sensitizes chemotherapy by targeting STING to boost anti-tumor immunity

Yifang Dang, Mingtong Ma, Yan Wang, Mengmeng Zhao, Yajuan Cao, Hang Su, Tianhao Liu, Mengge Zheng, Jiani Gao, Xiangyang Wu, Junfang Xu, Li Chen, Jianzhong Jeff Xi, Yiyan Fei and Haipeng Liu

Cell Reports, 2025, 44, 115572
DOI: 10.1016/j.celrep.2025.115572

Cytotoxic lignans from the roots and rhizomes of Diphylleia sinensis, a China’s endemic plant species

Yanjun SUN, Chen ZHAO, Hongyun BAI, Meng LI, Junmin WANG, Zhiyou HAO and Weisheng FENG

Chinese Journal of Natural Medicines, 2024, 22, 831
DOI: 10.1016/S1875-5364(24)60721-1

Argentatin Content in Guayule Leaves (Parthenium argentatum A. Gray)

María Mercedes García-Martínez, Beatriz Gallego, Guayente Latorre, María Engracia Carrión, Miguel Ángel De la Cruz-Morcillo, Amaya Zalacain and Manuel Carmona

Plants, 2023, 12, 2021
DOI: 10.3390/plants12102021

Picropodophyllotoxin Induces G1 Cell Cycle Arrest and Apoptosis in Human Colorectal Cancer Cells via ROS Generation and Activation of p38 MAPK Signaling Pathway

Seung-On Lee, Ah-Won Kwak, Mee-Hyun Lee, Ji-Hye Seo, Seung-Sik Cho, Goo Yoon, Jung-Il Chae, Sang Hoon Joo and Jung-Hyun Shim

J. Microbiol. Biotechnol., 2021, 31, 1615
DOI: 10.4014/jmb.2109.09012

Advances in Multifunctional Chemotherapeutic Prodrugs for Near‐infrared Fluorescence Imaging‐guided Therapy

Jiayu Zeng, Minhui Liu, Songjiao Li, Dan Cheng, Longwei He and Lin Yuan

ChemBioChem, 2023, 24
DOI: 10.1002/cbic.202300035

Synthesis and anticancer activity of podophyllotoxin derivatives with nitrogen-containing heterocycles

Meng Yin, Yongsheng Fang, Xiaotong Sun, Minggao Xue, Caimei Zhang, Zhiyun Zhu, Yamiao Meng, Lingmei Kong, Yi Yi Myint, Yan Li, Jingfeng Zhao and Xiaodong Yang

Front. Chem., 2023, 11
DOI: 10.3389/fchem.2023.1191498

Podophyllotoxin derivatives-tubulin complex reveals a potential binding site of tubulin polymerization inhibitors in α-tubulin adjacent to colchicine site

Wei Zhao, Rong Shen, Hong-Mei Li, Jian-Jiang Zhong and Ya-Jie Tang

International Journal of Biological Macromolecules, 2024, 276, 133678
DOI: 10.1016/j.ijbiomac.2024.133678

Target discovery of bioactive natural products with native-compound-coupled CNBr-activated Sepharose 4B beads (NCCB): Applications, mechanisms and outlooks

Yueteng Zhang, Junjie Zhang, Menglong Li, Yan Qiao, Wei Wang, Lu Ma and Kangdong Liu

Bioorganic & Medicinal Chemistry, 2023, 96, 117483
DOI: 10.1016/j.bmc.2023.117483

Progress in approved drugs from natural product resources

Zhongwen LUO, Fucheng YIN, Xiaobing WANG and Lingyi KONG

Chinese Journal of Natural Medicines, 2024, 22, 195
DOI: 10.1016/S1875-5364(24)60582-0

Triazole/thiadiazole substituted 4′-demethylepipodophyllotoxin derivatives induced apoptosis in HeLa cells by up-regulating TMEM133

Wei Zhao, Ying Duan, Hong-Mei Li, Shengying Li, Yuemao Shen, Youming Zhang, Yue-zhong Li and Ya-Jie Tang

European Journal of Pharmacology, 2021, 905, 174189
DOI: 10.1016/j.ejphar.2021.174189

In Silicomolecular docking and dynamic analysis of natural compounds against major non-structural proteins of SARS-COV-2

Muneeb U. Rehman, Aarif Ali, Ruhban Ansar, Azher Arafah, Zuha Imtiyaz, Tanveer A. Wani, Seema Zargar and Showkat A. Ganie

Journal of Biomolecular Structure and Dynamics, 2023, 41, 9072
DOI: 10.1080/07391102.2022.2139766

Biosynthesis of anticancer phytochemical compounds and their chemistry

Amandeep Dogra and Jitender Kumar

Front. Pharmacol., 2023, 14
DOI: 10.3389/fphar.2023.1136779

Etoposide-Loaded Colloidal Delivery Systems Based on Biodegradable Polymeric Carriers

M. A. Merkulova, N. S. Osipova, A. V. Kalistratova, Yu. V. Ermolenko and S. E. Gel’perina

Kolloidnyj žurnal, 2023, 85, 593
DOI: 10.31857/S0023291223600463

Cyclolignan synthesis streamlined by enantioselective hydrogenation of tetrasubstituted olefins

Wen-Xiu Xu, Zhuo Peng, Qing-Xiu Gu, Yao Zhu, Li-Han Zhao, Fucheng Leng and Hai-Hua Lu

Nat. Synth, 2024, 3, 986
DOI: 10.1038/s44160-024-00564-y

Self-assembled vesicles containing podophyllotoxin covalently modified with polyoxometalates for antitumor therapy

Lingmei Li, Yixiang Song, Jinyu Liu, Quanfu Wang, Jiacheng Wu, Xiaochuan Lu, Dejin Zang and Teng Liu

Polyoxometalates, 2025, 4, 9140085
DOI: 10.26599/POM.2025.9140085

Tellurophene‐Tagging of Teniposide Facilitates Monitoring by Mass Cytometry

Rahul Rana, Ravi N. Vellanki, Bradly G. Wouters and Mark Nitz

ChemBioChem, 2022, 23
DOI: 10.1002/cbic.202200284

Chemistry and Biology of Podophyllotoxins: An Update

Meng Hao and Hui Xu

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202302595

Podophyllotoxin: Recent Advances in the Development of Hybridization Strategies to Enhance Its Antitumoral Profile

Carolina Miranda-Vera, Ángela Patricia Hernández, Pilar García-García, David Díez, Pablo Anselmo García and María Ángeles Castro

Pharmaceutics, 2023, 15, 2728
DOI: 10.3390/pharmaceutics15122728

Etoposide-Loaded Colloidal Delivery Systems Based on Biodegradable Polymeric Carriers

M. A. Merkulova, N. S. Osipova, A. V. Kalistratova, Yu. V. Ermolenko and S. E. Gel’perina

Colloid J, 2023, 85, 712
DOI: 10.1134/S1061933X23600744

Safety and feasibility of intra-arterial delivery of teniposide to high grade gliomas after blood–brain barrier disruption: a case series

Jian Ruan, You Shi, Pengren Luo, Lin Li, Jiashang Huang, Jie Chen and Haifeng Yang

J NeuroIntervent Surg, 2024, 16, 1152
DOI: 10.1136/jnis-2023-021055

Regioselective Olefination and Arylation of Arene-Tethered Diols Using the Easily Foldable Directing Groups

Fucheng Yin, Yifan Chen, Zhongwen Luo, Shang Li, Yonglei Zhang, Siyuan Wan, Xinxin Li, Lingyi Kong and Xiaobing Wang

Org. Lett., 2024, 26, 1463
DOI: 10.1021/acs.orglett.4c00096

Dual targeting of FR+CD44 overexpressing tumors by self-assembled nanoparticles quantitatively conjugating folic acid-hyaluronic acid to the GSH-sensitively modified podophyllotoxin

Chaozheng Zhang, Yao Chen, Yi Zuo, Maolin Wang, Hongyu Chen, Chuanqi Wang, Yuening Cao, Yingjie Zeng, Ying Chen, Tingting Zhang, Xian Ge, Xiujun Cao, Yilan Liu, Hongbin Cheng, Yun Deng and Jun Lu

Chemical Engineering Journal, 2025, 505, 159276
DOI: 10.1016/j.cej.2025.159276

A natural compound-empowered podophyllotoxin prodrug nanoassembly magnifies efficacy-toxicity benefits in cancer chemotherapy

Ziqi Lin, Yuequan Wang, Wenwen Li, Fei Sun, Qingzhi Lv, Shenwu Zhang, Xiaohong Liu, Feng Qin and Cong Luo

Asian Journal of Pharmaceutical Sciences, 2024, 19, 100892
DOI: 10.1016/j.ajps.2024.100892

Supramolecular self-sensitized dual-drug nanoassemblies potentiating chemo-photodynamic therapy for effective cancer treatment

Xu Zhang, Xinyu Lou, Han Qiao, Zhouyu Jiang, Hang Sun, Xianbao Shi, Zhonggui He, Jin Sun and Mengchi Sun

International Journal of Pharmaceutics, 2024, 662, 124496
DOI: 10.1016/j.ijpharm.2024.124496

Design of combination therapy for engineered bacterial therapeutics in non-small cell lung cancer

Dhruba Deb, Yangfan Wu, Courtney Coker, Tetsuhiro Harimoto, Ruoqi Huang and Tal Danino

Sci Rep, 2022, 12
DOI: 10.1038/s41598-022-26105-1

Advances of antitumor drug discovery in traditional Chinese medicine and natural active products by using multi‐active components combination

Wei Zhao, Xiao‐Di Zheng, Paula Yun‐Zhi Tang, Hong‐Mei Li, Xue Liu, Jian‐Jiang Zhong and Ya‐Jie Tang

Medicinal Research Reviews, 2023, 43, 1778
DOI: 10.1002/med.21963

Identifying a Three-Gene Signature and Associated Drugs for Hepatitis B Virus-Related Hepatocellular Carcinoma Using Comprehensive Bioinformatics Analysis

Yan Tan, Meiling Zhang, Xiaoshan Chen and Yongyue Deng

Tohoku J. Exp. Med., 2022, 258, 149
DOI: 10.1620/tjem.2022.J069

Cellular Distribution and Ultrastructural Changes in HaCaT Cells, Induced by Podophyllotoxin and Its Novel Fluorescent Derivative, Supported by the Molecular Docking Studies

Piotr Strus, Karol Sadowski, Julia Kostro, Andrzej Antoni Szczepankiewicz, Hanna Nieznańska, Magdalena Niedzielska, Andrei Zlobin, Pramukti Nawar Ra’idah, Zuzanna Molęda, Joanna Szawkało, Zbigniew Czarnocki, Cezary Wójcik, Łukasz Szeleszczuk and Izabela Młynarczuk-Biały

IJMS, 2024, 25, 5948
DOI: 10.3390/ijms25115948

C-4 analogues of podophyllotoxin as tubulin inhibitors: synthesis, biological evaluation, and structure-activity relationship

Breanna Lu, Lexi Xu, Harriet Chen, Grace Yu, Kimberly Khow, Stella Yang, Arushi Dinker and Edward Njoo

Natural Product Research, 2024, 1
DOI: 10.1080/14786419.2024.2410410

Mitocytosis Mediated by an Enzyme‐Activable Mitochondrion‐Disturbing Polymer‐Drug Conjugate Enhances Active Penetration in Glioblastoma Therapy

Yufan Xiang, Bing Wang, Wanchun Yang, Xiuli Zheng, Rongjun Chen, Qiyong Gong, Zhongwei Gu, Yanhui Liu and Kui Luo

Advanced Materials, 2024, 36
DOI: 10.1002/adma.202311500

Phlomis genus: bridging tradition and science in medicinal Research-a review of phytochemistry and pharmacological properties

Fatemeh Fathali, Manijeh Shokri Saravi, Paria Zarei Vanajemi and Majid Tafrihi

Natural Product Research, 2025, 39, 3281
DOI: 10.1080/14786419.2024.2423029

Gold-Catalyzed Reactions of Enynals with Alkenes for Synthesis Binaphthyl Derivatives

Jun-Jie Hao, Juan Wu, Tao Jiang, Hejiang Luo and Rong-Tao Li

J. Org. Chem., 2024, 89, 6074
DOI: 10.1021/acs.joc.4c00036

Bioconjugation of Podophyllotoxin and Nanosystems: Approaches for Boosting Its Biopharmaceutical and Antitumoral Profile

Carolina Miranda-Vera, Ángela-Patricia Hernández, Pilar García-García, David Díez, Pablo A. García and María Ángeles Castro

Pharmaceuticals, 2025, 18, 169
DOI: 10.3390/ph18020169

A comprehensive review on the pharmacognostic and toxicological profile of Podophyllum peltatum (Bajiaolian)

Natasha Singh and Priya Agrawal

Pharmacological Research - Modern Chinese Medicine, 2024, 10, 100353
DOI: 10.1016/j.prmcm.2023.100353

Advances of podophyllotoxin and its derivatives: Patterns and mechanisms

Rong-jia Shi, Hua-yang Fan, Xiang-hua Yu, Ya-ling Tang, Jian Jiang and Xin-hua Liang

Biochemical Pharmacology, 2022, 200, 115039
DOI: 10.1016/j.bcp.2022.115039

Enhanced delivery of podophyllotoxin for hepatocellular carcinoma therapy using polymersome as an anticancer delivery platform

Parvaneh Peyvand, Zahra Vaezi, Mohsen Sharifi and Hossein Naderi-Manesh

Journal of Biomaterials Science, Polymer Edition, 2025, 1
DOI: 10.1080/09205063.2025.2520687

Podophyllotoxin Alleviates DSS-Induced Ulcerative Colitis via PI3K/AKT Pathway Activation

T Li, X Wang and J Wang

Physiol Res, 2025, 287
DOI: 10.33549/physiolres.935487

From Plant to Patient: A Historical Perspective and Review of Selected Medicinal Plants in Dermatology

Aygun Israyilova, Tsvetomira Zhivkova Peykova, Ben Kittleson, Paul Caleb Sprowl, Taha Osman Mohammed and Cassandra L. Quave

JID Innovations, 2025, 5, 100321
DOI: 10.1016/j.xjidi.2024.100321

Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy

Wei Xu, Guoqiang Guan, Renye Yue, Zhe Dong, Lingling Lei, Heemin Kang and Guosheng Song

Chem. Rev., 2025, 125, 1897
DOI: 10.1021/acs.chemrev.4c00546

Podophyllotoxin: History, Recent Advances and Future Prospects

Zinnia Shah, Umar Farooq Gohar, Iffat Jamshed, Aamir Mushtaq, Hamid Mukhtar, Muhammad Zia-UI-Haq, Sebastian Ionut Toma, Rosana Manea, Marius Moga and Bianca Popovici

Biomolecules, 2021, 11, 603
DOI: 10.3390/biom11040603