Lu Wang, Yan Geng, Lifang Liu, Jun Wang, Jiaxin Chen, Yunying Li, Jingbo Wang, Liyan Song, Kexin Sun, Yajie Yan, Shiqing Zhou, Dan Tian, Ran Lin and Hongliang Yao

European Journal of Medicinal Chemistry, 2025, 289, 117461
DOI: 10.1016/j.ejmech.2025.117461

Diorganyl Diselenides and Iron(III) Chloride Drive the Regio- and Stereoselectivity in the Selenation of Ynamides

Tales A. C. Goulart, Davi Fernando Back, Sidnei Moura E. Silva and Gilson Zeni

J. Org. Chem., 2021, 86, 980
DOI: 10.1021/acs.joc.0c02480

Structures and Reactivities of N-Alkenyl-Substituted Anilides: The “Magic” Methyl Effect on Alkene

Ryu Yamasaki, Mariko Ono, Kento Morita, Ai Ito, Kazuo Fukuda and Iwao Okamoto

J. Org. Chem., 2023, 88, 14487
DOI: 10.1021/acs.joc.3c01487

Solid‐Phase Total Synthesis of Yaku'amide B Enabled by Traceless Staudinger Ligation

Hiroaki Itoh, Kensuke Miura, Koichi Kamiya, Tomoya Yamashita and Masayuki Inoue

Angew Chem Int Ed, 2020, 59, 4564
DOI: 10.1002/anie.201916517

Synthesis of (Z)‐β‐(Carbonylamino)alkenylindium through Regioselective anti‐Carboindation of Ynamides and Its Transformation to Multisubstituted Enamides

Kyoungmin Kang, Kosuke Sakamoto, Yoshihiro Nishimoto and Makoto Yasuda

Chemistry A European J, 2020, 26, 4930
DOI: 10.1002/chem.201905175

Towards the total synthesis of chondrochloren A: synthesis of the (Z)-enamide fragment

Jan Geldsetzer and Markus Kalesse

Beilstein J. Org. Chem., 2020, 16, 670
DOI: 10.3762/bjoc.16.64

Regioselective TfOH-mediated hydroamidation of ynamides with nitriles

Wan-Shu Wang, Ping Chen and Yu Tang

Tetrahedron, 2017, 73, 2731
DOI: 10.1016/j.tet.2017.03.060

Ru(II)-Catalyzed Oxidative Functionalization of Arylhydrazine-1,2-dicarboxylates with Internal Alkynes for the Synthesis of Enecarbamates

Chatrala Ravikumar Reddy, Balasubramanian Sridhar and Basi V. Subba Reddy

ACS Omega, 2018, 3, 9746
DOI: 10.1021/acsomega.8b01118

Tertiary Enamides: Versatile and Available Substrates in Synthetic Chemistry

Xiaohua Cai, Mengzhi Yang and Hui Guo

COS, 2019, 16, 70
DOI: 10.2174/1570179415666181107122814

Mechanistic Considerations of the Catalytic Guanylation Reaction of Amines with Carbodiimides for Guanidine Synthesis

Ling Xu, Wen-Xiong Zhang and Zhenfeng Xi

Organometallics, 2015, 34, 1787
DOI: 10.1021/acs.organomet.5b00251

Asymmetric Organocatalyzed Cyclization Cascade Reactions of 3,3-Difluoro-2-aryl-3H-indoles and Enamides

Xiu-Xiu Qiao, Shi-Na Zhao, Qian Li, Tao Ma, Ganpeng Li, Yonghui He and Xiao-Jing Zhao

Org. Lett., 2024, 26, 1154
DOI: 10.1021/acs.orglett.3c04162

Total syntheses of nobilamides B and D: application of traceless Staudinger ligation

Tomoya Yamashita, Hiroaki Matoba, Takefumi Kuranaga and Masayuki Inoue

Tetrahedron, 2014, 70, 7746
DOI: 10.1016/j.tet.2014.05.091

Bulky α,β-dehydroamino acids: their occurrence in nature, synthesis, and applications

Jintao Jiang, Zhiwei Ma and Steven L. Castle

Tetrahedron, 2015, 71, 5431
DOI: 10.1016/j.tet.2015.06.001

Transition metal-free diastereospecific synthesis of (Z)-2-arylidene-2,3-dihydrobenzo[b][1,4]dioxines by reaction of (Z)-1,2-dibromo-3-aryl-2-propenes with catechols

Szymon P. Rekowski, Aabid A. Wani, Jürgen Conrad, Prasad V. Bharatam, Wolfgang Frey and Uwe Beifuss

Tetrahedron, 2020, 76, 131482
DOI: 10.1016/j.tet.2020.131482

Solid-Phase Total Synthesis of Bogorol A: Stereocontrolled Construction of Thermodynamically Unfavored (E)-2-Amino-2-butenamide

Tomoya Yamashita, Takefumi Kuranaga and Masayuki Inoue

Org. Lett., 2015, 17, 2170
DOI: 10.1021/acs.orglett.5b00769

A General Medium-to-Large Sized Ring Synthesis Enabled by Copper-Catalyzed Difluoroalkylamidation Cyclization of Alkynes

Jing Ren, Linfeng He, Jinlong Li, Ning Wang, Xinyu Long, Jiayin Yang and Kaizhi Li

Org. Lett., 2025, 27, 5253
DOI: 10.1021/acs.orglett.5c01459

Visible light induced β-C(sp2)-H alkylsulfonylation of enamides with phenyliodine(III) dicarboxylates and DABCO-(SO2)2

Tiehan Xu, Xi Chen, Xia Zhao and Kui Lu

Tetrahedron Letters, 2025, 167, 155663
DOI: 10.1016/j.tetlet.2025.155663

Facile Access to Amides from Oxygenated or Unsaturated Organic Compounds by Metal Oxide Nanocatalysts Derived from Single-Source Molecular Precursors

Akbar Mohammad, Prakash Chandra, Topi Ghosh, Mauro Carraro and Shaikh M. Mobin

Inorg. Chem., 2017, 56, 10596
DOI: 10.1021/acs.inorgchem.7b01576

Chemical Synthesis of Bioactive Naturally Derived Cyclic Peptides Containing Ene‐Like Rigidifying Motifs

Luis M. De Leon Rodriguez, Elyse T. Williams and Margaret A. Brimble

Chemistry A European J, 2018, 24, 17869
DOI: 10.1002/chem.201802533

Highly Regio‐ and Stereoselective Intermolecular Seleno‐ and Thioamination of Alkynes

Guangfan Zheng, Jinbo Zhao, Zhanyu Li, Qiao Zhang, Jiaqiong Sun, Haizhu Sun and Qian Zhang

Chemistry A European J, 2016, 22, 3513
DOI: 10.1002/chem.201504534

Chiral trifluoromethylated enamides: Synthesis and applications

Alexandru Postole, Pablo Martínez-Pardo, Víctor García-Vázquez and Belén Martín-Matute

Chem Catalysis, 2023, 3, 100813
DOI: 10.1016/j.checat.2023.100813

Stereoselective Synthesis of 2‐Oxyenamides**

Sara‐Cathrin Krieg, Jennifer Grimmer, Annika Maria Pick, Harald Kelm, Martin Breugst and Georg Manolikakes

Eur J Org Chem, 2022, 2022
DOI: 10.1002/ejoc.202200772

Synthesis of Enamides by Ruthenium‐Catalyzed Reaction of Alkyl Azides with Acid Anhydrides in Ionic Liquid

Han Kyu Pak, Junghoon Han, Mina Jeon, Yongjin Kim, Yearang Kwon, Jin Yong Park, Young Ho Rhee and Jaiwook Park

ChemCatChem, 2015, 7, 4030
DOI: 10.1002/cctc.201500935

Discovery and Biosynthetic Investigation of a New Antibacterial Dehydrated Non‐Ribosomal Tripeptide

Shan Wang, Qing Fang, Zhou Lu, Yingli Gao, Laurent Trembleau, Rainer Ebel, Jeanette H. Andersen, Carol Philips, Samantha Law and Hai Deng

Angewandte Chemie, 2021, 133, 3266
DOI: 10.1002/ange.202012902

Haloalkenyl Imidoyl Halides as Multifacial Substrates in the Stereoselective Synthesis of N‐Alkenyl Compounds

Athanasios Markos, Lukáš Janecký, Tomáš Chvojka, Tomáš Martinek, Hector Martinez‐Seara, Blanka Klepetářová and Petr Beier

Adv Synth Catal, 2021, 363, 3258
DOI: 10.1002/adsc.202100009

Metal‐Free Stereoconvergent C−H Borylation of Enamides

Tianhang Wang, Zheng‐Jun Wang, Minyan Wang, Lei Wu, Xiaowu Fang, Yong Liang, Jiahang Lv and Zhuangzhi Shi

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202313205

Theoretical insights into Rh-catalyzed hydroamidation: Mechanism and chemoselectivity

Juping Wang, Zhenjie Zheng, Kangcheng Zheng, Qifeng Jiang and Yang Hu

Molecular Catalysis, 2024, 558, 114043
DOI: 10.1016/j.mcat.2024.114043

Au-Catalyzed [2 + 3] Annulation of Enamides with Propargyl Esters: Total Synthesis of Cephalotaxine and Cephalezomine H

Xiao-Yan Ma, Xian-Tao An, Xian-He Zhao, Ji-Yuan Du, Yu-Hua Deng, Xiang-Zhi Zhang and Chun-An Fan

Org. Lett., 2017, 19, 2965
DOI: 10.1021/acs.orglett.7b01202

Synthesis of Tertiary Enamides by Ag2CO3-Promoted Pd-Catalyzed Alkenylation of Acyclic Secondary Amides

Arnaud Delforge, Irene Georgiou, Adrian Kremer, Johan Wouters and Davide Bonifazi

Org. Lett., 2016, 18, 4844
DOI: 10.1021/acs.orglett.6b02305

Applications of the Cu(I)‐Catalyzed Aryl Amidation in Total Synthesis of Complex Molecules

Xin Hu, Hai‐Jin Huang and Cong‐Bin Ji

ChemistrySelect, 2024, 9
DOI: 10.1002/slct.202403372

Chemo- and Regioselective Asymmetric Synthesis of Cyclic Enamides through the Catalytic Umpolung Organocascade Reaction of α-Imino Amides

Yasushi Yoshida, Tomohiko Hiroshige, Kazuki Omori, Takashi Mino and Masami Sakamoto

J. Org. Chem., 2019, 84, 7362
DOI: 10.1021/acs.joc.9b01036

Catalytic Oxidation of Benzyl Alcohol to Efficiently Synthesize Amide by (−CF3) Substituted Copper Phthalocyanine Based Composite Catalyst

Luying Wang, Xudong Zheng, Yuzhe Zhang, Man Zhou, Qiang Liang, Song Xu and Zhongyu Li

ChemistrySelect, 2021, 6, 11961
DOI: 10.1002/slct.202102512

Target Identification of Yaku’amide B and Its Two Distinct Activities against Mitochondrial FoF1-ATP Synthase

Kai Kitamura, Hiroaki Itoh, Kaori Sakurai, Shingo Dan and Masayuki Inoue

J. Am. Chem. Soc., 2018, 140, 12189
DOI: 10.1021/jacs.8b07339

Studies on the synthesis of peptides containing dehydrovaline and dehydroisoleucine based on copper-mediated enamide formation

Franziska Gille and Andreas Kirschning

Beilstein J. Org. Chem., 2016, 12, 564
DOI: 10.3762/bjoc.12.55

Direct Synthesis of Amides from Oxidative Coupling of Benzyl Alcohols or Benzylamines with N‐Substituted Formamides Using a Cu‐Fe‐Based Heterogeneous Catalyst

Shyam Sunder R. Gupta, Akhil V. Nakhate, Gunjan P. Deshmukh, Selvakannan Periasamy, Priya S. Samudrala, Suresh K. Bhargava and Mannepalli Lakshmi Kantam

ChemistrySelect, 2018, 3, 8436
DOI: 10.1002/slct.201801297

Synthesis of marine brominated alkaloid amathamide F: a palladium-catalyzed enamide synthesis

Saeed Ahmad, Sumit Choudhury and Faiz Ahmed Khan

Tetrahedron, 2015, 71, 4192
DOI: 10.1016/j.tet.2015.04.091

Discovery and Biosynthetic Investigation of a New Antibacterial Dehydrated Non‐Ribosomal Tripeptide

Shan Wang, Qing Fang, Zhou Lu, Yingli Gao, Laurent Trembleau, Rainer Ebel, Jeanette H. Andersen, Carol Philips, Samantha Law and Hai Deng

Angew Chem Int Ed, 2021, 60, 3229
DOI: 10.1002/anie.202012902

Stereoselective Synthesis of Dehydroamino Acids and Its Application to the Synthesis of Nitrogen-containing Natural Products

Yoko Yasuno, Hironori Okamura and Tetsuro Shinada

J. Synth. Org. Chem. Jpn., 2022, 80, 331
DOI: 10.5059/yukigoseikyokaishi.80.331

Electrochemically Induced Regio‐ and Stereoselective (E)‐β‐C(sp2)−H Trifluoromethylation and Arylsulfonylation of Enamides

Fukuan Zhang, Xuefei Zhao, Jie Zhang, Lili Zhao, Lin Li, Jiayi Yang, Hao Li and Haiqing Luo

Adv Synth Catal, 2022, 364, 4036
DOI: 10.1002/adsc.202200934

Charge transfer complex enabled photoreduction of ether phosphonium salts for the selective oxyalkylation of enamides

Sen Qiao, Kunquan Chen, Qiang Liu, Zhixiang Wang and Xiangyu Chen

Chinese Chemical Letters, 2024, 35, 108979
DOI: 10.1016/j.cclet.2023.108979

Cyclopeptide alkaloids

Emmy Tuenter, Vassiliki Exarchou, Sandra Apers and Luc Pieters

Phytochem Rev, 2017, 16, 623
DOI: 10.1007/s11101-016-9484-y

Reactivity of ynamides with AlCl3 and ICl: Ready access to (E)-α-chloroenamides and (E/Z)-α-chloro-β-iodo-enamides

Alla Siva Reddy, Mandala Anitha, Suraj and K C Kumara Swamy

J Chem Sci, 2021, 133
DOI: 10.1007/s12039-020-01880-4

Synthesis, evaluation and mechanism study of novel pyrazole enamides to alleviate lung injury

Guoping Zhang, Mengjie Li, Yanghui Ou, Liya Ma, Jiayu Li, Kexin Sun, Tingting Xia, Jingbo Wang, Liyan Song, Yang Liu, Ran Lin and Hongliang Yao

European Journal of Medicinal Chemistry, 2025, 282, 117068
DOI: 10.1016/j.ejmech.2024.117068

Irradiation-induced palladium-catalyzed decarboxylative desaturation enabled by a dual ligand system

Wan-Min Cheng, Rui Shang and Yao Fu

Nat Commun, 2018, 9
DOI: 10.1038/s41467-018-07694-w

Total Synthesis of Sanctolide A and Formal Synthesis of (2S)-Sanctolide A

Gihan C. Dissanayake, Cornelius N. Ndi, Jana L. Markley, James B. Martinez and Paul R. Hanson

J. Org. Chem., 2023, 88, 805
DOI: 10.1021/acs.joc.2c01922

Metal‐Free Stereoconvergent C−H Borylation of Enamides

Tianhang Wang, Zheng‐Jun Wang, Minyan Wang, Lei Wu, Xiaowu Fang, Yong Liang, Jiahang Lv and Zhuangzhi Shi

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202313205

Solvent-Controlled, Atom-Economic, and Highly Regio- and Stereoselective Halo-Chalcogenations of Ynamides: Green Synthesis of Stereodefined Tetrasubstituted Alkenes Bearing Four Different Functional Groups

Appanapalli N. V. Satyanarayana, Paramita Pattanayak and Tanmay Chatterjee

J. Org. Chem., 2024, 89, 11455
DOI: 10.1021/acs.joc.4c01134

Recent Advances in Cobalt‐Catalyzed, Directing‐Group‐Assisted C−H Bond Amidation Reactions

Sereena Sunny and Ramasamy Karvembu

Adv Synth Catal, 2021, 363, 4309
DOI: 10.1002/adsc.202100558

Cobalt-Catalyzed Regio- and Stereoselective C(sp2)–H Alkylation of Enamides with 4-Alkyl-1,4-dihydropyridines

Meng-Wei Sheng, Meng-Liang Deng, Xu-Kang Wen, Meng-Yang Wang, Meng-Ting Chu, Teck-Peng Loh and Ming-Zhu Lu

Org. Lett., 2025, 27, 5299
DOI: 10.1021/acs.orglett.5c01577

Synthesis of Z-Enamides through Heterogeneous Gold-Catalyzed Stereoselective Hydrogenation of Ynamides

Long Lin, Xiaojun Zeng and Bo Xu

J. Org. Chem., 2019, 84, 11240
DOI: 10.1021/acs.joc.9b01450

Merging NiH Catalysis and Inner-Sphere Metal-Nitrenoid Transfer for Hydroamidation of Alkynes

Xiang Lyu, Jianbo Zhang, Dongwook Kim, Sangwon Seo and Sukbok Chang

J. Am. Chem. Soc., 2021, 143, 5867
DOI: 10.1021/jacs.1c01138

The Total Synthesis of Chondrochloren A

Yannick Linne, Elisa Bonandi, Christopher Tabet, Jan Geldsetzer and Markus Kalesse

Angewandte Chemie, 2021, 133, 7014
DOI: 10.1002/ange.202016072

Stereodivergent Construction of Enamides via a Radical-Mediated Isodesmic Reaction

Yingying Xu, Xin Zhang, Xiao Kang, Kai Xu, Gangguo Zhu and Xi-Jia Liu

ACS Catal., 2025, 15, 6749
DOI: 10.1021/acscatal.5c00583

Photoredox/Nickel Dual-Catalyzed Stereoselective Synthesis of Distal Cyano-Substituted Enamides

Xiao-Yu Lu, Jun-Chao Wang, Xiao-Mei Sun, Meng-Ting Gao, Weng-Jing Ying, Meng-Yuan Ge, Zheng-Huan Wei, Zi Liu and Xing-Ke Chen

J. Org. Chem., 2023, 88, 513
DOI: 10.1021/acs.joc.2c02497

Pd-catalyzed chemo- and regioselective cross-coupling of two enamides

Hong-Mei Liu, Wen Lu, Cui-Ping Luo and Luo Yang

Tetrahedron Letters, 2016, 57, 4243
DOI: 10.1016/j.tetlet.2016.08.026

Total Synthesis of the Cyclic Depsipeptide Vioprolide D via its (Z)‐Diastereoisomer

Hanusch A. Grab, Volker C. Kirsch, Stephan A. Sieber and Thorsten Bach

Angew Chem Int Ed, 2020, 59, 12357
DOI: 10.1002/anie.202002328

Isomerization of N-Allyl Amides To Form Geometrically Defined Di-, Tri-, and Tetrasubstituted Enamides

Barry M. Trost, James J. Cregg and Nicolas Quach

J. Am. Chem. Soc., 2017, 139, 5133
DOI: 10.1021/jacs.7b00564

Synthesis of Polysubstituted Enamides by Hydrogen Atom Transfer Alkene Isomerization Using Dual Cobalt/Photoredox Catalysis

Yusuke Seino, Yuto Yamaguchi, Akihiko Suzuki, Masaaki Yamashita, Yuji Kamei, Futa Kamiyama, Tatsuhiko Yoshino, Masahiro Kojima and Shigeki Matsunaga

Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202300804

Chemo- and Site-Selective Replacement of N-Terminal Carbamates in Peptides

Miho Ibara, Takumi Abe and Daisuke Sawada

Org. Lett., 2022, 24, 2131
DOI: 10.1021/acs.orglett.2c00370

Base-Promoted Stereoselective Hydrogenation of Ynamides with Sulfonyl Hydrazide to Give Z-Enamides

Zemin Zhao, Qingyu Tian, Yanhui Chen, Si Wen, Yuqing Zhang and Guolin Cheng

J. Org. Chem., 2021, 86, 10407
DOI: 10.1021/acs.joc.1c01085

Decarboxylative stereoretentive C–N coupling by harnessing aminating reagent

Jeonguk Kweon, Bumsu Park, Dongwook Kim and Sukbok Chang

Nat Commun, 2024, 15
DOI: 10.1038/s41467-024-48075-w

Stereoretentive Decarboxylative Amidation of α,β-Unsaturated Carboxylic Acids to Access Enamides

Jeonguk Kweon, Minjeong Lee, Dongwook Kim and Sukbok Chang

Org. Lett., 2024, 26, 11167
DOI: 10.1021/acs.orglett.4c04234

Easy Access to Amides through Aldehydic C–H Bond Functionalization Catalyzed by Heterogeneous Co-Based Catalysts

Cuihua Bai, Xianfang Yao and Yingwei Li

ACS Catal., 2015, 5, 884
DOI: 10.1021/cs501822r

Solid‐Phase Total Synthesis of Yaku'amide B Enabled by Traceless Staudinger Ligation

Hiroaki Itoh, Kensuke Miura, Koichi Kamiya, Tomoya Yamashita and Masayuki Inoue

Angewandte Chemie, 2020, 132, 4594
DOI: 10.1002/ange.201916517

Metal- and solvent-free synthesis of amides using substitute formamides as an amino source under mild conditions

Feng Zhang, Lesong Li, Jingyu Zhang and Hang Gong

Sci Rep, 2019, 9
DOI: 10.1038/s41598-019-39240-z

Totalsynthese des cyclischen Depsipeptids Vioprolid D über sein (Z)‐Diastereomer

Hanusch A. Grab, Volker C. Kirsch, Stephan A. Sieber and Thorsten Bach

Angewandte Chemie, 2020, 132, 12456
DOI: 10.1002/ange.202002328

α-Haloenamides: Synthesis and Subsequent Transformations

Laurence Feray, Michèle P. Bertrand and Aurélien Galibert-Guijarro

Synthesis, 2023, 55, 27
DOI: 10.1055/a-1921-8710

Unusual substrate and halide versatility of phenolic halogenase PltM

Shogo Mori, Allan H. Pang, Nishad Thamban Chandrika, Sylvie Garneau-Tsodikova and Oleg V. Tsodikov

Nat Commun, 2019, 10
DOI: 10.1038/s41467-019-09215-9

Stereodivergent Synthesis of Trisubstituted Enamides: Direct Access to Both Pure Geometrical Isomers

Luca Massaro, Jianping Yang, Suppachai Krajangsri, Emanuele Silvi, Thishana Singh and Pher G. Andersson

J. Org. Chem., 2019, 84, 13540
DOI: 10.1021/acs.joc.9b01803

Nickel-Catalyzed Synthesis of Stereochemically Defined Enamides via Bi- and Tricomponent Coupling Reaction

Y. Liu, A. De Nisi, A. Cerveri, M. Monari and M. Bandini

Org. Lett., 2017, 19, 5034
DOI: 10.1021/acs.orglett.7b02166

Cyclic (Alkyl)amino Carbene Complex of Aluminum(III) in Catalytic Guanylation Reaction of Carbodiimides

Pavan K. Vardhanapu, Varun Bheemireddy, Mrinal Bhunia, Gonela Vijaykumar and Swadhin K. Mandal

Organometallics, 2018, 37, 2602
DOI: 10.1021/acs.organomet.8b00358