Issue 36, 2019

Multi-stimuli responsive trigger for temporally controlled depolymerization of self-immolative polymers

Abstract

For many decades, stimuli-responsive materials have been studied and utilized in various fields, ranging from chemical sensors to controlled drug release. Among these responsive materials are self-immolative polymers (SIPs) that allow for end-to-end depolymerization and the ability to release a desired cargo on demand or amplify analyte detection. However, in typical SIP systems, the triggering event leads to a relatively uncontrolled degradation process. Herein we present a multi-stimuli trigger that utilizes the combination of heat and acid to impart control over the trigger event and thus the degradation process. By controlling this reaction, we achieve temporal control over the trigger cleavage and subsequent depolymerization and release of cargo from the SIP.

Graphical abstract: Multi-stimuli responsive trigger for temporally controlled depolymerization of self-immolative polymers

Supplementary files

Article information

Article type
Communication
Submitted
24 ก.พ. 2562
Accepted
09 ส.ค. 2562
First published
12 ส.ค. 2562

Polym. Chem., 2019,10, 4914-4919

Multi-stimuli responsive trigger for temporally controlled depolymerization of self-immolative polymers

M. F. Nichol, K. D. Clark, N. D. Dolinski and J. Read de Alaniz, Polym. Chem., 2019, 10, 4914 DOI: 10.1039/C9PY00301K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements