Issue 13, 2023

Cancer nanomedicine: a review of nano-therapeutics and challenges ahead

Abstract

Cancer is known as the most dangerous disease in the world in terms of mortality and lack of effective treatment. Research on cancer treatment is still active and of great social importance. Since 1930, chemotherapeutics have been used to treat cancer. However, such conventional treatments are associated with pain, side effects, and a lack of targeting. Nanomedicines are an emerging alternative due to their targeting, bioavailability, and low toxicity. Nanoparticles target cancer cells via active and passive mechanisms. Since FDA approval for Doxil®, several nano-therapeutics have been developed, and a few have received approval for use in cancer treatment. Along with liposomes, solid lipid nanoparticles, polymeric nanoparticles, and nanoemulsions, even newer techniques involving extracellular vesicles (EVs) and thermal nanomaterials are now being researched and implemented in practice. This review highlights the evolution and current status of cancer therapy, with a focus on clinical/pre-clinical nanomedicine cancer studies. Insight is also provided into the prospects in this regard.

Graphical abstract: Cancer nanomedicine: a review of nano-therapeutics and challenges ahead

Article information

Article type
Review Article
Submitted
09 ธ.ค. 2565
Accepted
07 มี.ค. 2566
First published
14 มี.ค. 2566
This article is Open Access
Creative Commons BY license

RSC Adv., 2023,13, 8606-8629

Cancer nanomedicine: a review of nano-therapeutics and challenges ahead

M. J. Nirmala, U. Kizhuveetil, A. Johnson, B. G, R. Nagarajan and V. Muthuvijayan, RSC Adv., 2023, 13, 8606 DOI: 10.1039/D2RA07863E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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