Issue 44, 2021

Synthesis of tetracyclic spiroindolines by an interrupted Bischler–Napieralski reaction: total synthesis of akuammicine

Abstract

Judicious substrate design allows interruption of the classical Bischler–Napieralski reaction, providing access to a range of diversely substituted tetracyclic spiroindolines. These complex polycyclic scaffolds are valuable building blocks for the construction of indole alkaloids, as showcased in a concise total synthesis of (±)-akuammicine.

Graphical abstract: Synthesis of tetracyclic spiroindolines by an interrupted Bischler–Napieralski reaction: total synthesis of akuammicine

Supplementary files

Article information

Article type
Communication
Submitted
07 ต.ค. 2564
Accepted
27 ต.ค. 2564
First published
27 ต.ค. 2564
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2021,19, 9641-9644

Synthesis of tetracyclic spiroindolines by an interrupted Bischler–Napieralski reaction: total synthesis of akuammicine

M. Faltracco and E. Ruijter, Org. Biomol. Chem., 2021, 19, 9641 DOI: 10.1039/D1OB01966J

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