Issue 12, 2020

All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery

Abstract

Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral delivery system is reported. Insulin is successfully encapsulated into liposomes, which are coated with chitosan to improve their mucoadhesion. The encapsulation in an enteric polymer offers protection from the harsh gastric conditions. Insulin permeability is enhanced across an intestinal monolayer.

Graphical abstract: All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery

Supplementary files

Article information

Article type
Communication
Submitted
06 พ.ค. 2563
Accepted
26 พ.ค. 2563
First published
27 พ.ค. 2563
This article is Open Access
Creative Commons BY-NC license

Biomater. Sci., 2020,8, 3270-3277

All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery

C. Costa, Z. Liu, J. P. Martins, A. Correia, P. Figueiredo, A. Rahikkala, W. Li, J. Seitsonen, J. Ruokolainen, S. Hirvonen, A. Aguiar-Ricardo, M. L. Corvo and H. A. Santos, Biomater. Sci., 2020, 8, 3270 DOI: 10.1039/D0BM00743A

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