Issue 42, 2019

Synthesis of C2-tetrasubstituted indolin-3-ones via Cu-catalyzed oxidative dimerization of 2-aryl indoles and cross-addition with indoles

Abstract

An efficient protocol for the synthesis of 2,2-disubstituted indolin-3-ones under mild conditions has been developed. This reaction involves the copper-catalyzed in situ oxidative de-aromatization of 2-arylindoles to indol-3-one, followed by self-dimerization as well as cross-addition with indoles under mild conditions. The result generates a wide variety of C2-tetrasubstituted indolin-3-ones with good to high yields (62–82%).

Graphical abstract: Synthesis of C2-tetrasubstituted indolin-3-ones via Cu-catalyzed oxidative dimerization of 2-aryl indoles and cross-addition with indoles

Supplementary files

Article information

Article type
Paper
Submitted
24 มิ.ย. 2562
Accepted
23 ก.ค. 2562
First published
02 ส.ค. 2562
This article is Open Access
Creative Commons BY license

RSC Adv., 2019,9, 24050-24056

Synthesis of C2-tetrasubstituted indolin-3-ones via Cu-catalyzed oxidative dimerization of 2-aryl indoles and cross-addition with indoles

A. Singh, S. Vanaparthi, S. Choudhary, R. Krishnan and I. Kumar, RSC Adv., 2019, 9, 24050 DOI: 10.1039/C9RA04741G

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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