Issue 42, 2013

A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide

Abstract

A small molecule, protein mimetic based approach is shown to specifically inhibit lipid catalysed self-assembly of islet amyloid polypeptide (IAPP). The lipid-bound oligomerization of this peptide is implicated in cellular dysfunction of insulin secreting β-cells in type II diabetes.

Graphical abstract: A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide

Supplementary files

Article information

Article type
Communication
Submitted
25 ก.พ. 2556
Accepted
03 เม.ย. 2556
First published
04 เม.ย. 2556

Chem. Commun., 2013,49, 4749-4751

A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide

S. Kumar and A. D. Miranker, Chem. Commun., 2013, 49, 4749 DOI: 10.1039/C3CC41452C

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