Issue 16, 2022

Diastereoselective palladium-catalyzed functionalization of prochiral C(sp3)–H bonds of aliphatic and alicyclic compounds

Abstract

We highlight the reported developments of the palladium-catalyzed C–H activation and functionalization of the inactive/unreactive prochiral C(sp3)–H bonds of aliphatic and alicyclic compounds. There exist numerous classical methods for generating contiguous stereogenic centers in a compound with a high degree of stereocontrol. Along similar lines, the Pd(II)-catalyzed, directing group-aided functionalization of inactive prochiral/diastereotopic C(sp3)–H bonds have been exploited to accomplish the stereoselective construction of stereo-arrays in organic compounds. We present a concise discussion on how specific strategies consisting of Pd(II)-catalyzed, directing group-aided C(sp3)–H functionalization have been utilized to generate two or more stereogenic centers in aliphatic and alicyclic compounds.

Graphical abstract: Diastereoselective palladium-catalyzed functionalization of prochiral C(sp3)–H bonds of aliphatic and alicyclic compounds

Article information

Article type
Feature Article
Submitted
06 ต.ค. 2564
Accepted
13 ม.ค. 2565
First published
14 ม.ค. 2565

Chem. Commun., 2022,58, 2612-2633

Diastereoselective palladium-catalyzed functionalization of prochiral C(sp3)–H bonds of aliphatic and alicyclic compounds

S. A. Babu, Y. Aggarwal, P. Patel and R. Tomar, Chem. Commun., 2022, 58, 2612 DOI: 10.1039/D1CC05649B

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