Issue 8, 2021

Amphiphilic polymer therapeutics: an alternative platform in the fight against antibiotic resistant bacteria

Abstract

As we are on the cusp of the “post-antibiotic” era due to rapid spread of drug resistant bacteria, there is an urgent need for new antimicrobials that are not susceptible to bacterial resistance mechanisms. In this review, we will discuss the recent development of “polymer therapeutics” with antimicrobial activity. Learning from host-defence peptides, we propose the biomimetic design of synthetic polymers to target bacterial cell membranes, which act by compromising the membrane integrity. The discussion is extended to the future challenges and opportunities of antimicrobial polymers for clinical applications.

Graphical abstract: Amphiphilic polymer therapeutics: an alternative platform in the fight against antibiotic resistant bacteria

Article information

Article type
Review Article
Submitted
02 พ.ย. 2563
Accepted
16 ม.ค. 2564
First published
27 ม.ค. 2564

Biomater. Sci., 2021,9, 2758-2767

Author version available

Amphiphilic polymer therapeutics: an alternative platform in the fight against antibiotic resistant bacteria

H. Takahashi, G. A. Caputo and K. Kuroda, Biomater. Sci., 2021, 9, 2758 DOI: 10.1039/D0BM01865A

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