Volume 219, 2019

UV-responsive cyclic peptide progelator bioinks

Abstract

We describe cyclic peptide progelators which cleave in response to UV light to generate linearized peptides which then self-assemble into gel networks. Cyclic peptide progelators were synthesized, where the peptides were sterically constrained, but upon UV irradiation, predictable cleavage products were generated. Amino acid sequences and formulation conditions were altered to tune the mechanical properties of the resulting gels. Characterization of the resulting morphologies and chemistry was achieved through liquid phase and standard TEM methods, combined with matrix assisted laser desorption ionization imaging mass spectrometry (MALDI-IMS).

Graphical abstract: UV-responsive cyclic peptide progelator bioinks

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Article information

Article type
Paper
Submitted
05 มี.ค. 2562
Accepted
12 เม.ย. 2562
First published
24 ก.ย. 2562

Faraday Discuss., 2019,219, 44-57

Author version available

UV-responsive cyclic peptide progelator bioinks

A. S. Carlini, M. A. Touve, H. Fernández-Caro, M. P. Thompson, M. F. Cassidy, W. Cao and N. C. Gianneschi, Faraday Discuss., 2019, 219, 44 DOI: 10.1039/C9FD00026G

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