Themed collection In vivo analysis

This Editorial introduces Analyst's themed collection on In Vivo Analysis, guest edited by Lanqun Mao.

We review the work of “voltammetry next to a microdialysis probe” as measured by dopamine and the surrounding tissue.

Among all the analytical techniques capable of monitoring exocytosis in real time at the single cell level, electrochemistry (particularly amperometry at a constant potential) using ultramicroelectrodes has been demonstrated to be an important and convenient tool for more than two decades.

Review of in vivo analysis of brain chemicals in invertebrates.

The mass transport of neurochemicals in the brain and how this flux affects chemical measurements and data interpretation is reviewed.

Chemical tools that can report radioactive isotopes would be of interest to the defense community.

Chromatograms of 5-HT in 20 μl microdialysate of MVN in the USSCO group (solid line), in the control group (dotted line) before surgery (black), and postoperative days one (red), three (blue), and five (green).

A modified histamine selective waveform with fast scan cyclic voltametry provides a stimulation-locked and unique electrochemical signal towards histamine in vivo & in vitro.

Schematic representation of the degree of intoxicant-induced liver injury and regeneration and the minimally invasive analysis using autofluorescence spectral features.

We present a new NIR fluorescent probe for the biosynthetic pathways of H₂S_n in living cells and in vivo.

Lab-on-a-sheep: on-animal sensor using microdialysis coupled to microchip electrophoresis with electrochemical detection.

This study demonstrated the unaltered dopamine release in the striatum in a schizophrenia model dysbindin−/− mice.

This study demonstrates a new electrochemical microbiosensor for selective in vivo monitoring of glucose in rat brains.

Electrochemical assay for the universal biomarker of several cancers, urokinase plasminogen activator, uPA, based on uPA-specific fluorinated RNA aptamer and methylene blue redox indicator, allows 1 pM uPA analysis in serum, making it practically useful for clinical applications.

We present a self-supported nanoporous gold/PtNPs microelectrode with the sub-nanomolar sensitivity to detect H₂O₂ release from single cells.

Changes in the striatal NMDA receptor-mediated control over striatofugal pathways in Parkinson's disease, as revealed by dual-probe microdialysis.

An on-line and continuous approach was demonstrated for in vivo measurement of bisulfide in rat's brain.

Schematic representation of overall workflow for sampling secreted neuropeptides from the hemolymph by using a needle attached to a syringe or in vivo microdialysis.

This study demonstrates an online electrochemical system (OECS) for selective and continuous measurements of acetylcholine (ACh) through efficiently integrating in vivo microdialysis, a multi-enzyme microreactor and an electrochemical detector.

A first generation Pt-based polymer enzyme composite biosensor developed for real-time neurochemical monitoring was characterised in vivo for sensitive and selective detection of choline.

A non-enzymatic electrochemical H₂O₂ sensor was developed by in situ fabrication of biocompatible chitosan hydrogels, in which a specific recognition molecule for H₂O₂ – thionine – was stably immobilized via one-step electrodeposition.