Ramesh Mudududdla, Siu Wai Wong, Nghi Nguyen, Lian Xue, Michael A. Stashko, Xiaodong Wang, Lucy Vivash, Michele D. Binder, Uwe Ackermann, Ylva E. Bozikis, Trevor J. Kilpatrick and Jonathan B. Baell
RSC Med. Chem., 2026,17, 581-589
Abstract
Fluorinated pyrimidine-5-carboxamide MERTK inhibitors with nanomolar potency and >5-fold selectivity over AXL, TYRO3, and FLT3, with leading compounds being 1a, 2c and 3b. Potential 18F-PET radioligands to image protective microglia in MS.
Adewale Olufunsho Adeloye, Damilare David Babatunde, Kgaugelo Cornelius Tapala and Nomampondo Penelope Magwa
New J. Chem., 2025,49, 20586-20603
Abstract
Several synthesized ruthenium(II) complexes, which are used as metallo-drug agents for cancer treatment, have fallen short of meeting expectations.
Najla A. Altwaijry, Ismail M. M. Othman, Manal M. Anwar, Soha S. Nosier, Asmaa Saleh, Nada Y. Tashkandi and Eman S. Nossier
RSC Adv., 2026,16, 14010-14026
Abstract
In the current medical landscape, multi-targeting by a single small molecule is recognized as an effective strategy in the fight against cancer.
Krishna Murthy Potla, Suneetha Vankayalapati, Francisco A. P. Osório, Clodoaldo Valverde, Raja Murugesan, Zainab M. Almarhoon, Mahboob Alam and Mohammad Shahidul Islam
New J. Chem., 2025,49, 12439-12452
Abstract
The study investigates the mechanoluminescence and nonlinear optical properties of the self-assembled piperazine compound MPNPP, which could be useful in the design of organic mechano-optical devices.
Allison L. Kempen, Nickolas R. Brauer and Herman O. Sintim
RSC Med. Chem., 2023,14, 1743-1754
From themed collection:
World Cancer Day 2024: Showcasing cancer research across the RSC
Abstract
The 3H-pyrazolo[4,3-f]quinoline core, a privileged fusion moiety from quinoline and indazole, facilely synthesized in a one flask multi-component Doebner–Povarov reaction, is a newly described kinase hinge binder.