Merging directed sp3 and nondirected sp2 C–H functionalization for Pd-catalyzed polydeuteration of (hetero)arenes

Soo Eun Park, Sungjun Choi, Chaewon Lim, Sang Hak Lee, Siyeon Jeong and Jung Min Joo

Chem. Sci., 2025, 16, 10349
DOI: 10.1039/D5SC01407G

Selective deuteration of pyridine using barium oxide and D2 gas

Yun Wang, Yongli Cai, Jingai Hao, Zhiwei Li, Tianyu Cheng, Xinping Yang, Qingda An and Jianping Guo

New J. Chem., 2024, 48, 14512
DOI: 10.1039/D4NJ02512A

Mechanistic insights into the base-mediated deuteration of pyridyl phosphonium and ammonium salts

Arianna Montoli, Alessandro Dimasi, Miriana Guarnaccia, Andrea Citarella, Paolo Ronchi, Delia Blasi, Sergio Rossi, Daniele Passarella and Valerio Fasano

RSC Adv., 2025, 15, 870
DOI: 10.1039/D4RA07557A

Divergent and chemoselective deuteration of N-unsubstituted imidazoles enabled by precise acid/base control

Atsushi Kaga, Hayate Saito and Mitsuhisa Yamano

Chem. Commun., 2024, 60, 8920
DOI: 10.1039/D4CC02471K

Rational design of Au@Pd core–shell cocatalyst on titanium dioxide enabling selective photocatalytic formation of deuterated alkane from lauric acid and heavy water

Haifan Huang and Hisao Yoshida

RSC Adv., 2026, 16, 1193
DOI: 10.1039/D5RA08602G

Nickel-catalyzed regioselective hydrogen isotope exchange accelerated by 2-pyridones

Zhi-Jiang Jiang, Si-Han Xu, Yuhang Su, Erxun Hu, Jiawei Han, Jian-Fei Bai, Bencan Tang, Jia Chen and Zhanghua Gao

Chem. Commun., 2024, 60, 384
DOI: 10.1039/D3CC05257E

Advances of well-defined alkali metal complexes in organic synthesis

Kimberly Martinez-Fair, Dinora N. Rodriguez, Kayla Bui, Alexander Dua and Sam Yruegas

Org. Biomol. Chem., 2026, 24, 1734
DOI: 10.1039/D5OB01668A

Late-Stage C–H Deuteration of (Hetero)Arenes via Deuterium-Bonding Enhanced Rhenium Catalysis

Liqun Hu, Yao Xiang, Qing Huang, Hui Zhou and Youwei Xie

ACS Catal., 2025, 15, 4711
DOI: 10.1021/acscatal.5c00304

Base Promoted Hydrogenation of N-Heteroarenes with Ammonia Borane and DMSO

Doudou Jia, Zhituan Ai, Xinya Yuan, Guangbin Zhou, Guodong Zhang, Pan Gao and Feng Chen

Org. Lett., 2025, 27, 4294
DOI: 10.1021/acs.orglett.5c00997

The Recent Progress in Introducing Deuterium with D2O

Ping Li, Xu Wang, Jian Wei, Huaibin Jiang and Yang’en You

Adv Synth Catal, 2026, 368
DOI: 10.1002/adsc.70185

Core–shell Au@Pd cocatalyst for efficient and selective photocatalytic synthesis of deuterated alkanes from lauric acid and heavy water

Haifan Huang, Akira Yamamoto, Rikuto Sugiyama, Atsuhiro Tanaka, Hiroshi Kominami and Hisao Yoshida

Catalysis Today, 2026, 461, 115520
DOI: 10.1016/j.cattod.2025.115520

Direct C–H Hydroxylation of N-Heteroarenes and Benzenes via Base-Catalyzed Halogen Transfer

Kendelyn I. Bone, Thomas R. Puleo and Jeffrey S. Bandar

J. Am. Chem. Soc., 2024, 146, 9755
DOI: 10.1021/jacs.3c14058

Directed Aromatic Deuteration and Tritiation of Pharmaceuticals by Heavy Alkali Metal Amide Catalysts

Hui-Zhen Du, Jingwei Li, Stella Christodoulou, Si-Yuan Li, Yun-Shu Cui, Junliang Wu, Sumei Ren, Laurent Maron, Zhang-Jie Shi and Bing-Tao Guan

ACS Catal., 2024, 14, 9640
DOI: 10.1021/acscatal.4c01807

Direct Aziridine Synthesis from Amines and Styrene Derivatives via a Base-Promoted Oxidative Cascade Reaction

Cristian Vásquez Tapia Vera, William B. Hughes, Danielle R. Klaus, Robert S. Paton and Jeffrey S. Bandar

J. Am. Chem. Soc., 2026, 148, 494
DOI: 10.1021/jacs.5c14493

Precise synthesis of ortho-deuterated aromatic derivatives: An arylthianthrenium salt-based platform approach

Yunhao Guan, Xia Peng, Rong Fan, Xiaoying Feng, Hongguang Du and Jiajing Tan

Chinese Chemical Letters, 2026, 37, 111132
DOI: 10.1016/j.cclet.2025.111132

Fabrication of atomically dispersed barium hydride catalysts for the synthesis of deuterated alkylarenes

Yongli Cai, Li Rao, Yun Wang, Fei Chang, Teng He, Yang Zhao, Jiafeng Yu, Hong Wen, Jingai Hao, Anan Wu, Bing-Tao Guan, Jianping Guo and Ping Chen

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-57207-9

Deuterated Alkyl Sulfonium Salt Reagents; Importance of H/D Exchange Methods in Drug Discovery

Riku Ogasahara, Kazuho Ban, Miyu Mae, Shuji Akai and Yoshinari Sawama

ChemMedChem, 2024, 19
DOI: 10.1002/cmdc.202400201

Alkali-Metal Heavyweights: Up and Coming Contenders in Homogeneous Catalysis?

David Sánchez Roa, Robert E. Mulvey and Eva Hevia

ACS Catal., 2026, 16, 2935
DOI: 10.1021/acscatal.5c08156

Metal‐Free, Selective Ortho‐Deuteration of N‐Heterocyclic Oxides

Arianna Montoli, Alessandro Dimasi, Andrea Citarella, Paolo Ronchi, Daniele Passarella and Valerio Fasano

Adv Synth Catal, 2025, 367
DOI: 10.1002/adsc.202401585

Sustainable synthetic routes to deuterium-labelled organic compounds using immobilized and recyclable (bio)catalysts

Luka Jedlovčnik, Jakob Höfferle, Aljaž Gaber, Fjoralb Pashaj, Jerneja Kladnik, Janez Košmrlj, Volker Derdau and Ross D. Jansen-van Vuuren

Green Synthesis and Catalysis, 2025, 6, 1
DOI: 10.1016/j.gresc.2024.09.008

Selective Hydrogen Isotope Exchange Catalysed by Simple Alkali‐Metal Bases in DMSO

Melina S. Tschopp, Andreu Tortajada and Eva Hevia

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202421736

H/D Exchange of Aromatic Sulfones via Base Promotion and Silver Catalysis

Hui Xu, Zhi-Jiang Jiang, Yun Jia, Yuhang Su, Jian-Fei Bai, Zhanghua Gao, Jia Chen and Kun Gao

J. Org. Chem., 2024, 89, 8468
DOI: 10.1021/acs.joc.4c00352

Site-Selective and Late-Stage Deuteration of (Hetero)arenes with Supported Iridium Nanoparticles

Chengbo Yao and Christophe Copéret

ACS Catal., 2025, 15, 2822
DOI: 10.1021/acscatal.4c07364

Selective Hydrogen Isotope Exchange Catalysed by Simple Alkali‐Metal Bases in DMSO

Melina S. Tschopp, Andreu Tortajada and Eva Hevia

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202421736

Synthesis of Silylated Azauracil 1-Oxides by Metal-Free Direct Silylation

Frenki Mahato, Asim Kumar Ghosh and Alakananda Hajra

Synlett, 2025, 36, 2371
DOI: 10.1055/a-2566-7469

Masters of Mediation: MN(SiMe3)2 in Functionalization of C(sp3)−H Latent Nucleophiles

Ramdas Sreedharan and Thirumanavelan Gandhi

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202400435

Development of Sterically Hindered and Basic Sodium Amides for Catalytic Hydrogen Isotope Exchange

Melina S. Tschopp, Andrew W. J. Platten, Eva Hevia and Andreu Tortajada

Eur J Inorg Chem, 2024, 27
DOI: 10.1002/ejic.202400200