DNA-compatible synthesis of enaminones via amination of allenic ketones

Huihong Wang, Xiaohong Fan, Teng Chen, Yangfeng Li, Gong Zhang, Wei Fang and Yizhou Li

Org. Chem. Front., 2023, 10, 4105
DOI: 10.1039/D3QO00901G

Development of on-DNA vinyl sulfone synthesis for DNA-encoded chemical libraries

Yuting Gao, Yang Sun, Xianfu Fang, Guixian Zhao, Xufeng Li, Gong Zhang, Yangfeng Li and Yizhou Li

Org. Chem. Front., 2022, 9, 4542
DOI: 10.1039/D2QO00881E

Innovative, combinatorial and high-throughput approaches to degrader synthesis

Rebecca Stevens, James D. F. Thompson, Julie C. L. Fournier, Glenn A. Burley, David J. Battersby and Afjal H. Miah

Chem. Soc. Rev., 2024, 53, 4838
DOI: 10.1039/D3CS01127E

Aryl diazonium intermediates enable mild DNA-compatible C–C bond formation for medicinally relevant combinatorial library synthesis

Xianfeng Li, Juan Zhang, Changyang Liu, Jie Sun, Yangfeng Li, Gong Zhang and Yizhou Li

Chem. Sci., 2022, 13, 13100
DOI: 10.1039/D2SC04482J

Synthesis of thiazolo[4,5-d]pyrimidine derivatives based on purine via solid-phase synthesis

Jimin Moon, Hyojin Lee, Jungtae Kim, Shuanghui Hua, GeonHo Yoon, Hyeokjin Lee, Sugyeong Seo, Yoojin Joo, Heong-Seop Yim and Taeho Lee

Org. Biomol. Chem., 2025, 23, 7165
DOI: 10.1039/D5OB00963D

Dearomative intermolecular [2 + 2] photocycloaddition for construction of C(sp3)-rich heterospirocycles on-DNA

Longbo Li, Bianca Matsuo, Guillaume Levitre, Edward J. McClain, Eric A. Voight, Erika A. Crane and Gary A. Molander

Chem. Sci., 2023, 14, 2713
DOI: 10.1039/D3SC00144J

In-solution direct oxidative coupling for the integration of sulfur/selenium into DNA-encoded chemical libraries

Shilian Yang, Guixian Zhao, Yuting Gao, Yang Sun, Gong Zhang, Xiaohong Fan, Yangfeng Li and Yizhou Li

Chem. Sci., 2022, 13, 2604
DOI: 10.1039/D1SC06268A

Vinyl azide as a synthon for DNA-compatible divergent transformations into N-heterocycles

Jie Sun, Qigui Nie, Xianfu Fang, Zhiwei He, Gong Zhang, Yangfeng Li and Yizhou Li

Org. Biomol. Chem., 2022, 20, 5045
DOI: 10.1039/D2OB00862A

De novo generated combinatorial library design

Simon Viet Johansson, Morteza Haghir Chehreghani, Ola Engkvist and Alexander Schliep

Digital Discovery, 2024, 3, 122
DOI: 10.1039/D3DD00095H

Conjugation of oligonucleotides with activated carbamate reagents prepared by the Ugi reaction for oligonucleotide library synthesis

Ryosuke Kita, Takashi Osawa and Satoshi Obika

RSC Chem. Biol., 2022, 3, 728
DOI: 10.1039/D1CB00240F

Photochemical C–H arylation of heteroarenes for DNA-encoded library synthesis

Matthias Krumb, Lisa Marie Kammer, Shorouk O. Badir, María Jesús Cabrera-Afonso, Victoria E. Wu, Minxue Huang, Adam Csakai, Lisa A. Marcaurelle and Gary A. Molander

Chem. Sci., 2022, 13, 1023
DOI: 10.1039/D1SC05683B

Integration of palladium-catalyzed C–N coupling into self-encoded libraries for accelerated hit discovery

Edith van der Nol, Zhenshuo Luo, Qing Qing Gao, Nils Alexander Haupt, Sebastian Böcker and Sebastian Pomplun

RSC Chem. Biol., 2026
DOI: 10.1039/D5CB00303B

Isothiocyanate intermediates facilitate divergent synthesis of N-heterocycles for DNA-encoded libraries

Huihong Wang, Teng Chen, Xiaohong Fan, Yangfeng Li, Wei Fang, Gong Zhang and Yizhou Li

Chem. Commun., 2024, 60, 7638
DOI: 10.1039/D4CC02547D

Traceless solid-phase synthesis of thiazolo[4,5-b] pyridin-7(4H)-one derivatives

Shuanghui Hua, Jimin Moon, Hyojin Lee, Jungtae Kim, Geonho Yoon, Dong Jae Baek and Taeho Lee

RSC Adv., 2025, 15, 38597
DOI: 10.1039/D5RA05809K

DNA-Compatible Synthesis of Thiazolidione Derivatives via Three-Component Annulation and Knoevenagel Condensation

Yiting Wang, Xianfu Fang, Huilin Liao, Gong Zhang, Yangfeng Li and Yizhou Li

Org. Lett., 2023, 25, 4473
DOI: 10.1021/acs.orglett.3c01482

Identification of Structurally Novel KRASG12C Inhibitors through Covalent DNA-Encoded Library Screening

David Huang, Francesco Manoni, Zhen Sun, Rongfeng Liu, Jennifer R. Allen, Abhisek Banerjee, Victor J. Cee, Josephine Eshon, Michael J. Frohn, Matthew R. Kaller, Heejun Lee, Cui Li, Xun Li, Patricia Lopez, Vu Ma, Jose M. Medina, Christopher Mohr, Olga A. Mukhina, Alexander J. Pickrell, John Stellwagen, Wenting Wu, Wenhan Zhang, Kai Zhu, Upendra P. Dahal, Liaoyuan A. Hu, Monica Leavitt, Wencui Li, Yu Li, Yingli Ma, Karen Rex, Anne Y. Saiki, Paul Wang, Yaping Sun, Dongcheng Dai, Nuria A. Tamayo and Brian A. Lanman

J. Med. Chem., 2025, 68, 4801
DOI: 10.1021/acs.jmedchem.4c03071

Reversible Covalent Headpiece Enables Interconversion between Double‐ and Single‐Stranded DNA‐Encoded Chemical Libraries

Guixian Zhao, Shuting Zhong, Gong Zhang, Yangfeng Li and Yizhou Li

Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202115157

A novel cyclic peptide library immobilized on gel‐type beads focusing on rapid construction and characterization for comprehensive drug discovery

Toru Sasaki, Takeshi Kasama and Kiyoshi Nokihara

Chem Biol Drug Des, 2023, 102, 1327
DOI: 10.1111/cbdd.14331

Tandem In Situ Nitro Reduction and Cyclization for the On-DNA Synthesis of Traditionally Privileged Skeletons

Xuanjing Shen, Xudong Wang, Zijian Liu, Yueyue Xia, Xinyuan Wu, Hanqing Zhao, Caini He, Hongbin Xu and Zhiqiang Duan

Bioconjugate Chem., 2026
DOI: 10.1021/acs.bioconjchem.6c00057

Surf–DNA-Enabled DNA-Encoded Library-Compatible Amino Radical Transfer C(sp2)–C(sp3) Coupling

Dominic S. Finis, Nicholas Simmons, Zhicai Shi and Pratik R. Chheda

Org. Lett., 2025, 27, 9036
DOI: 10.1021/acs.orglett.5c02769

Developing Methods for the Synthesis of Ligand–Oligonucleotide Conjugates for Drug Discovery Applications

Takashi Osawa

Chem. Pharm. Bull., 2025, 73, 762
DOI: 10.1248/cpb.c25-00387

Photoredox Deaminative Alkylation in DNA-Encoded Library Synthesis

Yurong Shen, Guanyu Yang, Wei Huang, Alex Shaginian, Qian Lin, Jinqiao Wan, Jin Li, Yun Deng and Guansai Liu

Org. Lett., 2022, 24, 2650
DOI: 10.1021/acs.orglett.2c00697

Oxoammonium Salt-Mediated On-DNA Alcohol Oxidation for DEL Synthesis

Pratik R. Chheda, Nicholas Simmons and Zhicai Shi

Org. Lett., 2024, 26, 6754
DOI: 10.1021/acs.orglett.4c02474

The expanding reaction toolkit for DNA-encoded libraries

Richard J. Fair, Ryan T. Walsh and Christopher D. Hupp

Bioorganic & Medicinal Chemistry Letters, 2021, 51, 128339
DOI: 10.1016/j.bmcl.2021.128339

sp3‐Rich Heterocycle Synthesis on DNA: Application to DNA‐Encoded Library Production

Felix Gruber, Anthony W. McDonagh, Victoria Rose, James Hunter, Laura Guasch, Rainer E. Martin, Stefanie N. Geigle and Robert Britton

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202319836

Using DNA-encoded libraries of fragments for hit discovery of challenging therapeutic targets

Guixian Zhao, Mengping Zhu, Yangfeng Li, Gong Zhang and Yizhou Li

Expert Opinion on Drug Discovery, 2024, 19, 725
DOI: 10.1080/17460441.2024.2354287

Synthesis of DNA-Encoded Bicyclic Peptides via Cysteine-Promoted Cyclization and Amide Condensation Reaction

Yi Gan, Yumei Zeng, Haojie Guan, Wenjun Li, Alex Shaginian, Jin Li, Sen Gao and Guansai Liu

Bioconjugate Chem., 2025, 36, 2336
DOI: 10.1021/acs.bioconjchem.5c00455

Application of DNA‐Conjugated Aryl Diazonium Intermediates in DNA‐Encoded Libraries

Xiaohong Fan, Xianfeng Li, Yangfeng Li and Yizhou Li

Eur J Org Chem, 2024, 27
DOI: 10.1002/ejoc.202301172

The Growing Importance of Chirality in 3D Chemical Space Exploration and Modern Drug Discovery Approaches for Hit-ID

Ilaria Proietti Silvestri and Paul J. J. Colbon

ACS Med. Chem. Lett., 2021, 12, 1220
DOI: 10.1021/acsmedchemlett.1c00251

Synthesis of Coumarin–oligonucleiotide Conjugates for Application in DNA-encoded Libraries

Takashi Osawa

YAKUGAKU ZASSHI, 2024, 144, 931
DOI: 10.1248/yakushi.24-00134

Enhancing the Potential of Miniature-Scale DNA-Compatible Radical Reactions via an Electron Donor–Acceptor Complex and a Reversible Adsorption to Solid Support Strategy

Bizhen Lin, Weiwei Lu, Zhen-yu Chen, Yue Zhang, Yin-zhe Duan, Xiaojie Lu, Ming Yan and Xue-jing Zhang

Org. Lett., 2021, 23, 7381
DOI: 10.1021/acs.orglett.1c02562

Digital Barcodes for High-Throughput Screening

Ze Yang, Jingyi Chen, Yao Xiao, Chenjing Yang, Chun-Xia Zhao, Dong Chen and David A. Weitz

Chem Bio Eng., 2024, 1, 2
DOI: 10.1021/cbe.3c00085

Palladium-Mediated Hydroamination of DNA-Conjugated Aryl Alkenes

Kunliang Cai, Yuzhao Ran, Wenbo Sun, Sen Gao, Jin Li, Jinqiao Wan and Guansai Liu

Front. Chem., 2022, 10
DOI: 10.3389/fchem.2022.851674

One Reaction Served Three Ways: The On-DNA Ugi 4C-3C Reaction for the Formation of Lactams

Mark A. Mantell, Lisa Marcaurelle and Yun Ding

Org. Lett., 2023, 25, 1241
DOI: 10.1021/acs.orglett.2c04043

DNA-Compatible Synthesis of α-Aminophosphonate Scaffolds via Kabachnik–Fields Reaction

Ik Hwan Choi, Jihoon Lee, Hyewon Seo, Ki Tae Kim, Minsoo Song and Gil Tae Hwang

Org. Lett., 2025, 27, 13374
DOI: 10.1021/acs.orglett.5c04477

Heterocyclization vs Coupling Reactions: A DNA-Encoded Libraries Case

Oleksandr V. Oksiuta, Alexander E. Pashenko, Radomyr V. Smalii, Dmitry M. Volochnyuk and Serhii V. Ryabukhin

J. Org. Pharm. Chem., 2023, 21, 3
DOI: 10.24959/ophcj.23.275133

Recording Binding Information Directly into DNA-Encoded Libraries Using Terminal Deoxynucleotidyl Transferase

Lukas A. Schneider, Basilius Sauter, Koder Dagher and Dennis Gillingham

J. Am. Chem. Soc., 2023, 145, 20874
DOI: 10.1021/jacs.3c05961

Isotope Ratio Encoding of Sequence-Defined Oligomers

Márton Zwillinger, Lucile Fischer, Gergő Sályi, Soma Szabó, Márton Csékei, Ivan Huc and András Kotschy

J. Am. Chem. Soc., 2022, 144, 19078
DOI: 10.1021/jacs.2c08135

DNA-Compatible Synthesis of α,β-Epoxyketones for DNA-Encoded Chemical Libraries

Yuting Gao, Guixian Zhao, Pengyang He, Gong Zhang, Yangfeng Li and Yizhou Li

Bioconjugate Chem., 2022, 33, 105
DOI: 10.1021/acs.bioconjchem.1c00567

DNA Compatible Oxidization and Amidation of Terminal Alkynes

Zhaomei Sun, Jie Zhang, Huanqing Zhang, Hongli Cao, Lingqian Xiao, Kexin Yang and Yun Jin Hu

Bioconjugate Chem., 2022, 33, 1585
DOI: 10.1021/acs.bioconjchem.2c00340

Hydrophobic Surfactant–DNA Complex (Surf-DNA) Enables DNA-Encoded-Library-Compatible Decarboxylative Arylation under Anhydrous Conditions

Pratik R. Chheda, Nicholas Simmons and Zhicai Shi

Org. Lett., 2024, 26, 4365
DOI: 10.1021/acs.orglett.4c01398

On-DNA Mannich Reaction for DNA-Encoded Library Synthesis

Danila Ryzhikh, Hyewon Seo, Jihoon Lee, Jieon Lee, Myung Hee Nam, Minsoo Song and Gil Tae Hwang

J. Org. Chem., 2024, 89, 16957
DOI: 10.1021/acs.joc.4c02098

Strategies for developing DNA-encoded libraries beyond binding assays

Yiran Huang, Yizhou Li and Xiaoyu Li

Nat. Chem., 2022, 14, 129
DOI: 10.1038/s41557-021-00877-x

Anhydrous Carbene Insertion Reactions: A Synthetic Platform for DNA‐Encoded Library

Xiao‐can Su, Wen‐xia Shi, Yue Zhang, Wen‐jie Xiao, Jia‐ying Xue, Xin‐hai Zhu, Ming Yan and Xue‐jing Zhang

Adv Synth Catal, 2024, 366, 285
DOI: 10.1002/adsc.202300844

Discovery of Potent Isoindolinone Inhibitors that Target an Active Conformation of PARP1 Using DNA‐Encoded Libraries

Kelly A. McCarthy, Douglas J. Marcotte, Sangram Parelkar, Crystal L. McKinnon, Lindsay E. Trammell, Eric L. Stangeland and Rachael R. Jetson

ChemMedChem, 2024, 19
DOI: 10.1002/cmdc.202400093

Reversible Covalent Headpiece Enables Interconversion between Double‐ and Single‐Stranded DNA‐Encoded Chemical Libraries

Guixian Zhao, Shuting Zhong, Gong Zhang, Yangfeng Li and Yizhou Li

Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202115157

Enzymatic Bioconjugation: A Perspective from the Pharmaceutical Industry

Aaron Debon, Elina Siirola and Radka Snajdrova

JACS Au, 2023, 3, 1267
DOI: 10.1021/jacsau.2c00617

Evaluation of the Topology Space of DNA-Encoded Libraries

William K. Weigel, Alba L. Montoya and Raphael M. Franzini

J. Chem. Inf. Model., 2023, 63, 4641
DOI: 10.1021/acs.jcim.3c01008

DNA-Encoded Libraries (DELs) for Discovering New Molecular Probes: Application to Live-Cell Bioimaging and Personalized Theranostics

Julien Poupart, Sunit Kumar Jana, Sasmita Tripathy and Anne Marinier

Bioconjugate Chem., 2026, 37, 511
DOI: 10.1021/acs.bioconjchem.5c00661

On-DNA Synthesis of Multisubstituted Indoles

András Gy. Németh, Levente Kollár, Krisztina Németh, Gitta Schlosser, Annamária Minus and György M. Keserű

Org. Lett., 2024, 26, 2517
DOI: 10.1021/acs.orglett.3c03602

Photochemical Methods Applied to DNA Encoded Library (DEL) Synthesis

Bianca Matsuo, Albert Granados, Guillaume Levitre and Gary A. Molander

Acc. Chem. Res., 2023, 56, 385
DOI: 10.1021/acs.accounts.2c00778

Permutational Encoding Strategy Accelerates HIT Validation from Single-Stranded DNA-Encoded Libraries

Sara Puglioli, Mosè Fabbri, Claudia Comacchio, Laura Alvigini, Roberto De Luca, Sebastian Oehler, Ettore Gilardoni, Gabriele Bassi, Samuele Cazzamalli, Dario Neri and Nicholas Favalli

Bioconjugate Chem., 2024, 35, 1033
DOI: 10.1021/acs.bioconjchem.4c00233

Combinatorial technology revitalized by DNA‐encoding

Árpád Furka

MedComm, 2021, 2, 481
DOI: 10.1002/mco2.84

DNA-encoded C H functionality via photoredox-mediated hydrogen atom transformation catalysis

Jinming Shan, Xing Ling, JiaXiang Liu, Xuan Wang and Xiaojie Lu

Bioorganic & Medicinal Chemistry, 2021, 42, 116234
DOI: 10.1016/j.bmc.2021.116234

The Time and Place for Nature in Drug Discovery

Robert J. Young, Sabine L. Flitsch, Michael Grigalunas, Paul D. Leeson, Ronald J. Quinn, Nicholas J. Turner and Herbert Waldmann

JACS Au, 2022, 2, 2400
DOI: 10.1021/jacsau.2c00415

Discovery of NSD2‐Degraders from Novel and Selective DEL Hits

Jan LegaardAndersson, Jesper Christensen, Daniela Kleine‐Kohlbrecher, Itys Vacher Comet, Jonatan Fullerton Støier, Yasuko Antoku, Visnja Poljak, Loris Moretti, Johannes Dolberg, Tomas Jacso, Søren Jensby Nielsen, Mads Nørregaard‐Madsen, Thomas Franch, Kristian Helin and Paul A. C. Cloos

ChemBioChem, 2023, 24
DOI: 10.1002/cbic.202300515

Unexpected Cyclization Product Discovery from the Photoinduced Bioconjugation Chemistry between Tetrazole and Amine

Juan Zhang, Jinlu Liu, Xianfeng Li, Yunzhu Ju, Yangfeng Li, Gong Zhang and Yizhou Li

J. Am. Chem. Soc., 2024, 146, 2122
DOI: 10.1021/jacs.3c11574

DNA-Compatible ortho-Phthalaldehyde (OPA)-Mediated 2-Substituted Isoindole Core Formation and Applications

Qigui Nie, Xianfu Fang, Changyang Liu, Gong Zhang, Xiaohong Fan, Yangfeng Li and Yizhou Li

J. Org. Chem., 2022, 87, 2551
DOI: 10.1021/acs.joc.1c02496

Ruthenium-Mediated N-Arylation for DNA-Encoded Libraries

Suraj Kanoo, Eduardo de Pedro Beato, Tim Schulte, Lara Vogelsang, Luca Torkowski, Felix Waldbach, Philipp Hartmann, Riya Kayal, Karl-Josef Dietz and Tobias Ritter

J. Am. Chem. Soc., 2025, 147, 35011
DOI: 10.1021/jacs.5c11842

Synthesis of Coumarin-Conjugated Oligonucleotides via Knoevenagel Condensation to Prepare an Oligonucleotide Library

Takashi Osawa and Satoshi Obika

Chem. Pharm. Bull., 2024, 72, 143
DOI: 10.1248/cpb.c23-00295

Enhanced screening via a pure DNA-encoded peptide library enabled by an Fmoc modification

Qiujin He, Yanhui Wang, Xiyuan Tang, Jianwei Zhang, Yuyu Xing, Zhaoyun Zong, Mohamed A. Elhamouly, Kaixian Chen and Shiyu Chen

Proc. Natl. Acad. Sci. U.S.A., 2026, 123
DOI: 10.1073/pnas.2524999123

Recent Advances on the Selection Methods of DNA‐Encoded Libraries

Yiran Huang and Xiaoyu Li

ChemBioChem, 2021, 22, 2384
DOI: 10.1002/cbic.202100144

Switchable DNA‐Encoded Chemical Library: Interconversion between Double‐ and Single‐Stranded DNA Formats

Guixian Zhao, Xiaohong Fan, Yangfeng Li, Gong Zhang and Yizhou Li

ChemBioChem, 2022, 23
DOI: 10.1002/cbic.202200025

On-DNA C–H functionalization of electron-rich arenes for DNA-encoded libraries

Eduardo de Pedro Beato, Luca Torkowski, Philipp Hartmann, Lara Vogelsang, Karl-Josef Dietz and Tobias Ritter

Nat. Chem., 2025, 17, 1340
DOI: 10.1038/s41557-025-01844-6

AutoDesigner - Core Design, a De Novo Design Algorithm for Chemical Scaffolds: Application to the Design and Synthesis of Novel Selective Wee1 Inhibitors

Pieter H. Bos, Fabio Ranalli, Emelie Flood, Shawn Watts, Daigo Inoyama, Jennifer L. Knight, Anthony J. Clark, Andrew Placzeck, Jiashi Wang, Aleksey I. Gerasyuto, Sarah Silvergleid, Wu Yin, Shaoxian Sun, Robert Abel and Sathesh Bhat

J. Chem. Inf. Model., 2024, 64, 7513
DOI: 10.1021/acs.jcim.4c01031

sp3‐Rich Heterocycle Synthesis on DNA: Application to DNA‐Encoded Library Production

Felix Gruber, Anthony W. McDonagh, Victoria Rose, James Hunter, Laura Guasch, Rainer E. Martin, Stefanie N. Geigle and Robert Britton

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202319836

Kinugasa Reaction for DNA-Encoded β-Lactam Library Synthesis

Ayun Luo, Ziqi Zhang, Fanming Zeng, Xiuming Wang, Xue Zhao, Kexin Yang and Yun Jin Hu

Org. Lett., 2022, 24, 5756
DOI: 10.1021/acs.orglett.2c02237

Protein-templated ligand discovery via the selection of DNA-encoded dynamic libraries

Yu Zhou, Wenyin Shen, Ying Gao, Jianzhao Peng, Qingrong Li, Xueying Wei, Shihao Liu, Fong Sang Lam, Joan Mayol-Llinàs, Guixian Zhao, Gang Li, Yizhou Li, Hongzhe Sun, Yan Cao and Xiaoyu Li

Nat. Chem., 2024, 16, 543
DOI: 10.1038/s41557-024-01442-y

Development of an oxazole-based cleavable linker for peptides

Elizabeth L. Taggart, Evan J. Wolff, Pamira Yanar, John P. Blobe and Christopher R. Shugrue

Bioorganic & Medicinal Chemistry, 2024, 102, 117663
DOI: 10.1016/j.bmc.2024.117663

Accelerating the Hit-To-Lead Optimization of a SARS-CoV-2 Mpro Inhibitor Series by Combining High-Throughput Medicinal Chemistry and Computational Simulations

Julien Hazemann, Thierry Kimmerlin, Aengus Mac Sweeney, Geoffroy Bourquin, Roland Lange, Daniel Ritz, Sylvia Richard-Bildstein, Sylvain Regeon and Paul Czodrowski

J. Med. Chem., 2025, 68, 8269
DOI: 10.1021/acs.jmedchem.4c02941

Development of Phosphoramidite Reagents for the Synthesis of Base-Labile Oligonucleotides Modified with a Linear Aminoalkyl and Amino-PEG Linker at the 3′-End

Takashi Osawa, Qin Ren and Satoshi Obika

Molecules, 2022, 27, 8501
DOI: 10.3390/molecules27238501

On-DNA Synthesis of β-Sulfonyl-α,β-Unsaturated Carbonyl Scaffolds via Hydrosulfonation of Alkynylcarbonyl Compounds

Ji Young Ryu, Dohui Ku, Hayeong Shin, Yoojin Park, Hokyung Kim, Jihoon Lee, Gil Tae Hwang, Minsoo Song and Ki Tae Kim

Org. Lett., 2025, 27, 13134
DOI: 10.1021/acs.orglett.5c04328

High-yield and high-purity amide bond formation using DMTMM PF6 for DNA-encoded libraries

Takumi Hosozawa, Masatoshi Niwa, Hisayuki Takeuchi, Takehiko Inohana, Kaori Okumura and Shin Itoh

Bioorganic & Medicinal Chemistry Letters, 2024, 110, 129859
DOI: 10.1016/j.bmcl.2024.129859

Divergent On-DNA Transformations from DNA-Linked Piperidones

Xing Ling, Weiwei Lu, Lin Miao, Lisa A. Marcaurelle, Xuan Wang, Yun Ding and Xiaojie Lu

J. Org. Chem., 2022, 87, 1971
DOI: 10.1021/acs.joc.1c00670

The Cyanopyridine–Aminothiol Click Reaction: Expanding Horizons in Chemical Biology

Christoph Nitsche

Synlett, 2024, 35, 1067
DOI: 10.1055/a-2214-7612

The Facile Solid-Phase Synthesis of Thiazolo-Pyrimidinone Derivatives

Shuanghui Hua, Jimin Moon and Taeho Lee

Molecules, 2025, 30, 430
DOI: 10.3390/molecules30020430

Second-generation DNA-encoded multiple display on a constant macrocyclic scaffold enabled by an orthogonal protecting group strategy

Qigui Nie, Shuting Zhong, Yangfeng Li, Gong Zhang and Yizhou Li

Chinese Chemical Letters, 2022, 33, 2559
DOI: 10.1016/j.cclet.2021.09.041

Functionalization of DNA-Tagged Alkenes Enabled by Visible-Light-Induced C–H Activation of N-Aryl Tertiary Amines

Rongfeng Wu, Tian Du, Wenbo Sun, Alex Shaginian, Sen Gao, Jin Li, Jinqiao Wan and Guansai Liu

Org. Lett., 2021, 23, 3486
DOI: 10.1021/acs.orglett.1c00924

Recent Developments in Mass Spectrometry to Support Next-Generation Synthesis and Screening

Nari N. Talaty, Robert W. Johnson, James Sawicki, Omprakash Nacham and Stevan W. Djuric

ACS Med. Chem. Lett., 2023, 14, 711
DOI: 10.1021/acsmedchemlett.3c00040

Diversity‐Oriented Synthesis (DOS) of On‐DNA Peptidomimetics from Acid‐Derived Phosphonium Ylides

Yashoda Krishna Sunkari, Vijay Kumar Siripuram and Marc Flajolet

Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202203037

Visible Light-Promoted Divergent Benzoheterocyclization from Aldehydes for DNA-Encoded Chemical Libraries

Xianfu Fang, Yiting Wang, Pengyang He, Huilin Liao, Gong Zhang, Yangfeng Li and Yizhou Li

Org. Lett., 2022, 24, 3291
DOI: 10.1021/acs.orglett.2c01187

Squaramide Formation for DNA-Encoded Library Synthesis

Antoine Douchez, Julien Poupart, Gaoqiang Yang, Louis Vaillancourt and Anne Marinier

Bioconjugate Chem., 2024, 35, 963
DOI: 10.1021/acs.bioconjchem.4c00160

DNA-Compatible Diversification of Indole π-Activated Alcohols via a Direct Dehydrative Coupling Strategy

Shuting Zhong, Xianfu Fang, Yiting Wang, Gong Zhang, Yangfeng Li and Yizhou Li

Org. Lett., 2022, 24, 1022
DOI: 10.1021/acs.orglett.1c04169

Diversity-oriented synthesis encoded by deoxyoligonucleotides

Liam Hudson, Jeremy W. Mason, Matthias V. Westphal, Matthieu J. R. Richter, Jonathan R. Thielman, Bruce K. Hua, Christopher J. Gerry, Guoqin Xia, Heather L. Osswald, John M. Knapp, Zher Yin Tan, Praveen Kokkonda, Ben I. C. Tresco, Shuang Liu, Andrew G. Reidenbach, Katherine S. Lim, Jennifer Poirier, John Capece, Simone Bonazzi, Christian M. Gampe, Nichola J. Smith, James E. Bradner, Connor W. Coley, Paul A. Clemons, Bruno Melillo, C. Suk-Yee Hon, Johannes Ottl, Christoph E. Dumelin, Jonas V. Schaefer, Ann Marie E. Faust, Frédéric Berst, Stuart L. Schreiber, Frédéric J. Zécri and Karin Briner

Nat Commun, 2023, 14
DOI: 10.1038/s41467-023-40575-5

Light‐Mediated Modification and Manipulation of Nucleic Acids

Yujie Jiang, Yutong Zhou, Ruoqian Xie, Yangyan Li, Raghunath Bag and Gang Chen

ChemPhotoChem, 2025, 9
DOI: 10.1002/cptc.202500098

DNA-Compatible Suzuki-Miyaura Cross-Coupling Reaction of Aryl Iodides With (Hetero)Aryl Boronic Acids for DNA-Encoded Libraries

Vijay Kumar Siripuram, Yashoda Krishna Sunkari, Thu-Lan Nguyen and Marc Flajolet

Front. Chem., 2022, 10
DOI: 10.3389/fchem.2022.894603

CoLiNN: A Tool for Fast Chemical Space Visualization of Combinatorial Libraries Without Enumeration

Regina Pikalyova, Tagir Akhmetshin, Dragos Horvath and Alexandre Varnek

Molecular Informatics, 2025, 44
DOI: 10.1002/minf.202400263

Groebke–Blackburn–Bienaymé Reaction for DNA-Encoded Library Technology

Yujin An, Juyeon Lee, Hyewon Seo, Seri Bae, Jihee Kang, Jieon Lee, Jinwoo Kim, Myung Hee Nam, Minsoo Song and Gil Tae Hwang