Issue 22, 2023

Genetically encoded protein sensors for metal ion detection in biological systems: a review and bibliometric analysis

Abstract

Metal ions are indispensable elements in living organisms and are associated with regulating various biological processes. An imbalance in metal ion content can lead to disorders in normal physiological functions of the human body and cause various diseases. Genetically encoded fluorescent protein sensors have the advantages of low biotoxicity, high specificity, and a long imaging time in vivo and have become a powerful tool to visualize or quantify the concentration level of biomolecules in vivo and in vitro, temporal and spatial distribution, and life activity process. This review analyzes the development status and current research hotspots in the field of genetically encoded fluorescent protein sensors by bibliometric analysis. Based on the results of bibliometric analysis, the research progress of genetically encoded fluorescent protein sensors for metal ion detection is reviewed, and the construction strategies, physicochemical properties, and applications of such sensors in biological imaging are summarized.

Graphical abstract: Genetically encoded protein sensors for metal ion detection in biological systems: a review and bibliometric analysis

Article information

Article type
Tutorial Review
Submitted
17 ส.ค. 2566
Accepted
03 ต.ค. 2566
First published
10 ต.ค. 2566

Analyst, 2023,148, 5564-5581

Genetically encoded protein sensors for metal ion detection in biological systems: a review and bibliometric analysis

Y. Chen, S. Pang, J. Li, Y. Lu, C. Gao, Y. Xiao, M. Chen, M. Wang and X. Ren, Analyst, 2023, 148, 5564 DOI: 10.1039/D3AN01412F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements